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Protein

V-type proton ATPase subunit E 2

Gene

ATP6V1E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS10256-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit E 2
Short name:
V-ATPase subunit E 2
Alternative name(s):
Vacuolar proton pump subunit E 2
Gene namesi
Name:ATP6V1E2
Synonyms:ATP6E1, ATP6EL2, ATP6V1EL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000250565.6
HGNCiHGNC:18125 ATP6V1E2
MIMi617385 gene
neXtProtiNX_Q96A05

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000250565
PharmGKBiPA25159

Polymorphism and mutation databases

BioMutaiATP6V1E2
DMDMi74731076

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002823441 – 226V-type proton ATPase subunit E 2Add BLAST226

Proteomic databases

EPDiQ96A05
MaxQBiQ96A05
PaxDbiQ96A05
PeptideAtlasiQ96A05
PRIDEiQ96A05

PTM databases

iPTMnetiQ96A05
PhosphoSitePlusiQ96A05

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000250565
CleanExiHS_ATP6V1E2
ExpressionAtlasiQ96A05 baseline and differential
GenevisibleiQ96A05 HS

Organism-specific databases

HPAiHPA052784

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124715, 5 interactors
IntActiQ96A05, 3 interactors
MINTiQ96A05
STRINGi9606.ENSP00000304891

Structurei

3D structure databases

ProteinModelPortaliQ96A05
SMRiQ96A05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase E subunit family.Curated

Phylogenomic databases

eggNOGiKOG1664 Eukaryota
COG1390 LUCA
GeneTreeiENSGT00390000002730
HOGENOMiHOG000202506
HOVERGENiHBG002309
InParanoidiQ96A05
KOiK02150
OMAiKIQMSTM
OrthoDBiEOG091G0OGO
PhylomeDBiQ96A05
TreeFamiTF313479

Family and domain databases

Gene3Di3.30.2320.30, 1 hit
HAMAPiMF_00311 ATP_synth_E_arch, 1 hit
InterProiView protein in InterPro
IPR038495 ATPase_E_C
IPR002842 ATPase_V1_Esu
PfamiView protein in Pfam
PF01991 vATP-synt_E, 1 hit

Sequencei

Sequence statusi: Complete.

Q96A05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSDVDVKK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR
60 70 80 90 100
LKIMEYYEKK EKQIEQQKKI LMSTMRNQAR LKVLRARNDL ISDLLSEAKL
110 120 130 140 150
RLSRIVEDPE VYQGLLDKLV LQGLLRLLEP VMIVRCRPQD LLLVEAAVQK
160 170 180 190 200
AIPEYMTISQ KHVEVQIDKE AYLAVNAAGG VEVYSGNQRI KVSNTLESRL
210 220
DLSAKQKMPE IRMALFGANT NRKFFI
Length:226
Mass (Da):26,074
Last modified:December 1, 2001 - v1
Checksum:i40546707D944ED20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074759 mRNA Translation: BAC00847.1
AK058055 mRNA Translation: BAB71643.1
AC018682 Genomic DNA Translation: AAY14833.1
BC008981 mRNA Translation: AAH08981.1
BC034808 mRNA Translation: AAH34808.1
CCDSiCCDS1826.1
RefSeqiNP_001304992.1, NM_001318063.1
XP_005264690.1, XM_005264633.2
XP_005264691.1, XM_005264634.2
XP_011531450.1, XM_011533148.2
XP_011531451.1, XM_011533149.2
XP_011531452.1, XM_011533150.2
XP_011531453.1, XM_011533151.2
XP_011531454.1, XM_011533152.2
XP_011531455.1, XM_011533153.2
XP_016860714.1, XM_017005225.1
XP_016860715.1, XM_017005226.1
UniGeneiHs.437691
Hs.659656

Genome annotation databases

EnsembliENST00000306448; ENSP00000304891; ENSG00000250565
ENST00000522587; ENSP00000428141; ENSG00000250565
GeneIDi90423
KEGGihsa:90423
UCSCiuc002ruy.3 human

Similar proteinsi

Entry informationi

Entry nameiVATE2_HUMAN
AccessioniPrimary (citable) accession number: Q96A05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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