Q96A05 (VATE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 82.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: V-type proton ATPase subunit E 2 Short name=V-ATPase subunit E 2 Alternative name(s): Vacuolar proton pump subunit E 2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 226 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome By similarity. |
| Subunit structure | V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). |
| Tissue specificity | Testis specific. Ref.1 |
| Sequence similarities | Belongs to the V-ATPase E subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Hydrogen ion transport Ion transport Transport |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cellular iron ion homeostasis Traceable author statement. Source: Reactome insulin receptor signaling pathwayTraceable author statement. Source: Reactome transferrin transportTraceable author statement. Source: Reactome |
| Cellular component | cytosol Traceable author statement. Source: Reactome proton-transporting two-sector ATPase complex, catalytic domainInferred from electronic annotation. Source: InterPro |
| Molecular function | proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB074759 mRNA. Translation: BAC00847.1. AK058055 mRNA. Translation: BAB71643.1. AC018682 Genomic DNA. Translation: AAY14833.1. BC008981 mRNA. Translation: AAH08981.1. BC034808 mRNA. Translation: AAH34808.1. |
| IPI | IPI00059139. |
| RefSeq | NP_542384.1. NM_080653.3. |
| UniGene | Hs.437691. Hs.659656. |
3D structure databases | |
| ProteinModelPortal | Q96A05. |
| SMR | Q96A05. Positions 2-64, 89-217. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q96A05. |
PTM databases | |
| PhosphoSite | Q96A05. |
Polymorphism databases | |
| DMDM | 74731076. |
Proteomic databases | |
| PRIDE | Q96A05. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000306448; ENSP00000304891; ENSG00000171142. |
| GeneID | 90423. |
| KEGG | hsa:90423. |
| UCSC | uc002ruy.1. human. |
Organism-specific databases | |
| CTD | 90423. |
| GeneCards | GC02M046738. |
| H-InvDB | HIX0002029. |
| HGNC | HGNC:18125. ATP6V1E2. |
| neXtProt | NX_Q96A05. |
| PharmGKB | PA25159. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG15653. |
| GeneTree | ENSGT00390000002730. |
| HOGENOM | HBG525538. |
| HOVERGEN | HBG002309. |
| InParanoid | Q96A05. |
| OMA | KILMSTM. |
| OrthoDB | EOG479F86. |
| PhylomeDB | Q96A05. |
Enzyme and pathway databases | |
| Reactome | REACT_111102. Signal Transduction. REACT_15518. Transmembrane transport of small molecules. |
Gene expression databases | |
| ArrayExpress | Q96A05. |
| Bgee | Q96A05. |
| CleanEx | HS_ATP6V1E2. |
| Genevestigator | Q96A05. |
Family and domain databases | |
| InterPro | IPR002842. ATPase_V1/A1-cplx_esu. [Graphical view] |
| KO | K02150. |
| Pfam | PF01991. vATP-synt_E. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 76752. |
Entry information
| Entry name | VATE2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96A05 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with