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Q96A05

- VATE2_HUMAN

UniProt

Q96A05 - VATE2_HUMAN

Protein

V-type proton ATPase subunit E 2

Gene

ATP6V1E2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome By similarity.By similarity

    GO - Molecular functioni

    1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: Ensembl
    2. proton-transporting ATPase activity, rotational mechanism Source: InterPro

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: Ensembl
    2. cellular iron ion homeostasis Source: Reactome
    3. insulin receptor signaling pathway Source: Reactome
    4. interaction with host Source: Reactome
    5. phagosome maturation Source: Reactome
    6. transferrin transport Source: Reactome
    7. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:HS10256-MONOMER.
    ReactomeiREACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit E 2
    Short name:
    V-ATPase subunit E 2
    Alternative name(s):
    Vacuolar proton pump subunit E 2
    Gene namesi
    Name:ATP6V1E2
    Synonyms:ATP6E1, ATP6EL2, ATP6V1EL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:18125. ATP6V1E2.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. cytosol Source: Reactome
    3. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25159.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226V-type proton ATPase subunit E 2PRO_0000282344Add
    BLAST

    Proteomic databases

    PaxDbiQ96A05.
    PRIDEiQ96A05.

    PTM databases

    PhosphoSiteiQ96A05.

    Expressioni

    Tissue specificityi

    Testis specific.1 Publication

    Gene expression databases

    BgeeiQ96A05.
    CleanExiHS_ATP6V1E2.
    GenevestigatoriQ96A05.

    Organism-specific databases

    HPAiHPA052784.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

    Protein-protein interaction databases

    BioGridi124715. 1 interaction.
    IntActiQ96A05. 1 interaction.
    STRINGi9606.ENSP00000304891.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A05.
    SMRiQ96A05. Positions 2-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase E subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG1390.
    HOGENOMiHOG000202506.
    HOVERGENiHBG002309.
    InParanoidiQ96A05.
    KOiK02150.
    OMAiAIPEYMT.
    OrthoDBiEOG70PC01.
    PhylomeDBiQ96A05.
    TreeFamiTF313479.

    Family and domain databases

    HAMAPiMF_00311. ATP_synth_E_arch.
    InterProiIPR002842. ATPase_V1/A1-cplx_esu.
    [Graphical view]
    PfamiPF01991. vATP-synt_E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96A05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSDVDVKK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR    50
    LKIMEYYEKK EKQIEQQKKI LMSTMRNQAR LKVLRARNDL ISDLLSEAKL 100
    RLSRIVEDPE VYQGLLDKLV LQGLLRLLEP VMIVRCRPQD LLLVEAAVQK 150
    AIPEYMTISQ KHVEVQIDKE AYLAVNAAGG VEVYSGNQRI KVSNTLESRL 200
    DLSAKQKMPE IRMALFGANT NRKFFI 226
    Length:226
    Mass (Da):26,074
    Last modified:December 1, 2001 - v1
    Checksum:i40546707D944ED20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB074759 mRNA. Translation: BAC00847.1.
    AK058055 mRNA. Translation: BAB71643.1.
    AC018682 Genomic DNA. Translation: AAY14833.1.
    BC008981 mRNA. Translation: AAH08981.1.
    BC034808 mRNA. Translation: AAH34808.1.
    CCDSiCCDS1826.1.
    RefSeqiNP_542384.1. NM_080653.3.
    XP_005264690.1. XM_005264633.1.
    XP_005264691.1. XM_005264634.1.
    UniGeneiHs.659656.

    Genome annotation databases

    EnsembliENST00000306448; ENSP00000304891; ENSG00000250565.
    ENST00000522587; ENSP00000428141; ENSG00000250565.
    GeneIDi90423.
    KEGGihsa:90423.
    UCSCiuc002ruy.3. human.

    Polymorphism databases

    DMDMi74731076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB074759 mRNA. Translation: BAC00847.1 .
    AK058055 mRNA. Translation: BAB71643.1 .
    AC018682 Genomic DNA. Translation: AAY14833.1 .
    BC008981 mRNA. Translation: AAH08981.1 .
    BC034808 mRNA. Translation: AAH34808.1 .
    CCDSi CCDS1826.1.
    RefSeqi NP_542384.1. NM_080653.3.
    XP_005264690.1. XM_005264633.1.
    XP_005264691.1. XM_005264634.1.
    UniGenei Hs.659656.

    3D structure databases

    ProteinModelPortali Q96A05.
    SMRi Q96A05. Positions 2-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124715. 1 interaction.
    IntActi Q96A05. 1 interaction.
    STRINGi 9606.ENSP00000304891.

    PTM databases

    PhosphoSitei Q96A05.

    Polymorphism databases

    DMDMi 74731076.

    Proteomic databases

    PaxDbi Q96A05.
    PRIDEi Q96A05.

    Protocols and materials databases

    DNASUi 90423.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306448 ; ENSP00000304891 ; ENSG00000250565 .
    ENST00000522587 ; ENSP00000428141 ; ENSG00000250565 .
    GeneIDi 90423.
    KEGGi hsa:90423.
    UCSCi uc002ruy.3. human.

    Organism-specific databases

    CTDi 90423.
    GeneCardsi GC02M046717.
    HGNCi HGNC:18125. ATP6V1E2.
    HPAi HPA052784.
    neXtProti NX_Q96A05.
    PharmGKBi PA25159.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1390.
    HOGENOMi HOG000202506.
    HOVERGENi HBG002309.
    InParanoidi Q96A05.
    KOi K02150.
    OMAi AIPEYMT.
    OrthoDBi EOG70PC01.
    PhylomeDBi Q96A05.
    TreeFami TF313479.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS10256-MONOMER.
    Reactomei REACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Miscellaneous databases

    GeneWikii ATP6V1E2.
    GenomeRNAii 90423.
    NextBioi 76752.
    PROi Q96A05.

    Gene expression databases

    Bgeei Q96A05.
    CleanExi HS_ATP6V1E2.
    Genevestigatori Q96A05.

    Family and domain databases

    HAMAPi MF_00311. ATP_synth_E_arch.
    InterProi IPR002842. ATPase_V1/A1-cplx_esu.
    [Graphical view ]
    Pfami PF01991. vATP-synt_E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E."
      Imai-Senga Y., Sun-Wada G.H., Wada Y., Futai M.
      Gene 289:7-12(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Cervix.

    Entry informationi

    Entry nameiVATE2_HUMAN
    AccessioniPrimary (citable) accession number: Q96A05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3