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Q96A05 (VATE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type proton ATPase subunit E 2

Short name=V-ATPase subunit E 2
Alternative name(s):
Vacuolar proton pump subunit E 2
Gene names
Name:ATP6V1E2
Synonyms:ATP6E1, ATP6EL2, ATP6V1EL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform isessential for energy coupling involved in acidification of acrosome By similarity. HAMAP-Rule MF_00311

Subunit structure

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Tissue specificity

Testis specific. Ref.1

Sequence similarities

Belongs to the V-ATPase E subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226V-type proton ATPase subunit E 2 HAMAP-Rule MF_00311
PRO_0000282344

Sequences

Sequence LengthMass (Da)Tools
Q96A05 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 40546707D944ED20

FASTA22626,074
        10         20         30         40         50         60 
MALSDVDVKK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR LKIMEYYEKK 

        70         80         90        100        110        120 
EKQIEQQKKI LMSTMRNQAR LKVLRARNDL ISDLLSEAKL RLSRIVEDPE VYQGLLDKLV 

       130        140        150        160        170        180 
LQGLLRLLEP VMIVRCRPQD LLLVEAAVQK AIPEYMTISQ KHVEVQIDKE AYLAVNAAGG 

       190        200        210        220 
VEVYSGNQRI KVSNTLESRL DLSAKQKMPE IRMALFGANT NRKFFI 

« Hide

References

« Hide 'large scale' references
[1]"A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E."
Imai-Senga Y., Sun-Wada G.H., Wada Y., Futai M.
Gene 289:7-12(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Cervix.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB074759 mRNA. Translation: BAC00847.1.
AK058055 mRNA. Translation: BAB71643.1.
AC018682 Genomic DNA. Translation: AAY14833.1.
BC008981 mRNA. Translation: AAH08981.1.
BC034808 mRNA. Translation: AAH34808.1.
RefSeqNP_542384.1. NM_080653.3.
XP_005264690.1. XM_005264633.1.
XP_005264691.1. XM_005264634.1.
UniGeneHs.659656.

3D structure databases

ProteinModelPortalQ96A05.
SMRQ96A05. Positions 2-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124715. 1 interaction.
IntActQ96A05. 1 interaction.
STRING9606.ENSP00000304891.

PTM databases

PhosphoSiteQ96A05.

Polymorphism databases

DMDM74731076.

Proteomic databases

PaxDbQ96A05.
PRIDEQ96A05.

Protocols and materials databases

DNASU90423.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306448; ENSP00000304891; ENSG00000250565.
ENST00000522587; ENSP00000428141; ENSG00000250565.
GeneID90423.
KEGGhsa:90423.
UCSCuc002ruy.3. human.

Organism-specific databases

CTD90423.
GeneCardsGC02M046717.
HGNCHGNC:18125. ATP6V1E2.
HPAHPA052784.
neXtProtNX_Q96A05.
PharmGKBPA25159.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1390.
HOGENOMHOG000202506.
HOVERGENHBG002309.
InParanoidQ96A05.
KOK02150.
OMAQRMPEIR.
OrthoDBEOG70PC01.
PhylomeDBQ96A05.
TreeFamTF313479.

Enzyme and pathway databases

BioCycMetaCyc:HS10256-MONOMER.
ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ96A05.
CleanExHS_ATP6V1E2.
GenevestigatorQ96A05.

Family and domain databases

HAMAPMF_00311. ATP_synth_E_arch.
InterProIPR002842. ATPase_V1/A1-cplx_esu.
[Graphical view]
PfamPF01991. vATP-synt_E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiATP6V1E2.
GenomeRNAi90423.
NextBio76752.
PROQ96A05.

Entry information

Entry nameVATE2_HUMAN
AccessionPrimary (citable) accession number: Q96A05
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM