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Q96A05

- VATE2_HUMAN

UniProt

Q96A05 - VATE2_HUMAN

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Protein

V-type proton ATPase subunit E 2

Gene

ATP6V1E2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity).By similarity

GO - Molecular functioni

  1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: Ensembl
  2. proton-transporting ATPase activity, rotational mechanism Source: InterPro

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: Ensembl
  2. cellular iron ion homeostasis Source: Reactome
  3. insulin receptor signaling pathway Source: Reactome
  4. interaction with host Source: Reactome
  5. phagosome maturation Source: Reactome
  6. transferrin transport Source: Reactome
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS10256-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit E 2
Short name:
V-ATPase subunit E 2
Alternative name(s):
Vacuolar proton pump subunit E 2
Gene namesi
Name:ATP6V1E2
Synonyms:ATP6E1, ATP6EL2, ATP6V1EL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:18125. ATP6V1E2.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. cytosol Source: Reactome
  3. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226V-type proton ATPase subunit E 2PRO_0000282344Add
BLAST

Proteomic databases

MaxQBiQ96A05.
PaxDbiQ96A05.
PRIDEiQ96A05.

PTM databases

PhosphoSiteiQ96A05.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiQ96A05.
CleanExiHS_ATP6V1E2.
GenevestigatoriQ96A05.

Organism-specific databases

HPAiHPA052784.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi124715. 3 interactions.
IntActiQ96A05. 1 interaction.
STRINGi9606.ENSP00000304891.

Structurei

3D structure databases

ProteinModelPortaliQ96A05.
SMRiQ96A05. Positions 2-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase E subunit family.Curated

Phylogenomic databases

eggNOGiCOG1390.
GeneTreeiENSGT00390000002730.
HOGENOMiHOG000202506.
HOVERGENiHBG002309.
InParanoidiQ96A05.
KOiK02150.
OMAiAIPEYMT.
OrthoDBiEOG70PC01.
PhylomeDBiQ96A05.
TreeFamiTF313479.

Family and domain databases

HAMAPiMF_00311. ATP_synth_E_arch.
InterProiIPR002842. ATPase_V1/A1-cplx_esu.
[Graphical view]
PfamiPF01991. vATP-synt_E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96A05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSDVDVKK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR
60 70 80 90 100
LKIMEYYEKK EKQIEQQKKI LMSTMRNQAR LKVLRARNDL ISDLLSEAKL
110 120 130 140 150
RLSRIVEDPE VYQGLLDKLV LQGLLRLLEP VMIVRCRPQD LLLVEAAVQK
160 170 180 190 200
AIPEYMTISQ KHVEVQIDKE AYLAVNAAGG VEVYSGNQRI KVSNTLESRL
210 220
DLSAKQKMPE IRMALFGANT NRKFFI
Length:226
Mass (Da):26,074
Last modified:December 1, 2001 - v1
Checksum:i40546707D944ED20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB074759 mRNA. Translation: BAC00847.1.
AK058055 mRNA. Translation: BAB71643.1.
AC018682 Genomic DNA. Translation: AAY14833.1.
BC008981 mRNA. Translation: AAH08981.1.
BC034808 mRNA. Translation: AAH34808.1.
CCDSiCCDS1826.1.
RefSeqiNP_542384.1. NM_080653.3.
XP_005264690.1. XM_005264633.1.
XP_005264691.1. XM_005264634.1.
UniGeneiHs.659656.

Genome annotation databases

EnsembliENST00000306448; ENSP00000304891; ENSG00000250565.
ENST00000522587; ENSP00000428141; ENSG00000250565.
GeneIDi90423.
KEGGihsa:90423.
UCSCiuc002ruy.3. human.

Polymorphism databases

DMDMi74731076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB074759 mRNA. Translation: BAC00847.1 .
AK058055 mRNA. Translation: BAB71643.1 .
AC018682 Genomic DNA. Translation: AAY14833.1 .
BC008981 mRNA. Translation: AAH08981.1 .
BC034808 mRNA. Translation: AAH34808.1 .
CCDSi CCDS1826.1.
RefSeqi NP_542384.1. NM_080653.3.
XP_005264690.1. XM_005264633.1.
XP_005264691.1. XM_005264634.1.
UniGenei Hs.659656.

3D structure databases

ProteinModelPortali Q96A05.
SMRi Q96A05. Positions 2-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124715. 3 interactions.
IntActi Q96A05. 1 interaction.
STRINGi 9606.ENSP00000304891.

PTM databases

PhosphoSitei Q96A05.

Polymorphism databases

DMDMi 74731076.

Proteomic databases

MaxQBi Q96A05.
PaxDbi Q96A05.
PRIDEi Q96A05.

Protocols and materials databases

DNASUi 90423.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306448 ; ENSP00000304891 ; ENSG00000250565 .
ENST00000522587 ; ENSP00000428141 ; ENSG00000250565 .
GeneIDi 90423.
KEGGi hsa:90423.
UCSCi uc002ruy.3. human.

Organism-specific databases

CTDi 90423.
GeneCardsi GC02M046717.
HGNCi HGNC:18125. ATP6V1E2.
HPAi HPA052784.
neXtProti NX_Q96A05.
PharmGKBi PA25159.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1390.
GeneTreei ENSGT00390000002730.
HOGENOMi HOG000202506.
HOVERGENi HBG002309.
InParanoidi Q96A05.
KOi K02150.
OMAi AIPEYMT.
OrthoDBi EOG70PC01.
PhylomeDBi Q96A05.
TreeFami TF313479.

Enzyme and pathway databases

BioCyci MetaCyc:HS10256-MONOMER.
Reactomei REACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

GeneWikii ATP6V1E2.
GenomeRNAii 90423.
NextBioi 76752.
PROi Q96A05.

Gene expression databases

Bgeei Q96A05.
CleanExi HS_ATP6V1E2.
Genevestigatori Q96A05.

Family and domain databases

HAMAPi MF_00311. ATP_synth_E_arch.
InterProi IPR002842. ATPase_V1/A1-cplx_esu.
[Graphical view ]
Pfami PF01991. vATP-synt_E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E."
    Imai-Senga Y., Sun-Wada G.H., Wada Y., Futai M.
    Gene 289:7-12(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Cervix.

Entry informationi

Entry nameiVATE2_HUMAN
AccessioniPrimary (citable) accession number: Q96A05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3