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Protein

V-type proton ATPase subunit E 2

Gene

ATP6V1E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS10256-MONOMER.
ReactomeiR-HSA-1222556. ROS, RNS production in phagocytes.
R-HSA-77387. Insulin receptor recycling.
R-HSA-917977. Transferrin endocytosis and recycling.
R-HSA-983712. Ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit E 2
Short name:
V-ATPase subunit E 2
Alternative name(s):
Vacuolar proton pump subunit E 2
Gene namesi
Name:ATP6V1E2
Synonyms:ATP6E1, ATP6EL2, ATP6V1EL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18125. ATP6V1E2.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000250565.
PharmGKBiPA25159.

Polymorphism and mutation databases

BioMutaiATP6V1E2.
DMDMi74731076.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002823441 – 226V-type proton ATPase subunit E 2Add BLAST226

Proteomic databases

EPDiQ96A05.
MaxQBiQ96A05.
PaxDbiQ96A05.
PeptideAtlasiQ96A05.
PRIDEiQ96A05.

PTM databases

iPTMnetiQ96A05.
PhosphoSitePlusiQ96A05.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000250565.
CleanExiHS_ATP6V1E2.
ExpressionAtlasiQ96A05. baseline and differential.
GenevisibleiQ96A05. HS.

Organism-specific databases

HPAiHPA052784.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124715. 4 interactors.
IntActiQ96A05. 3 interactors.
STRINGi9606.ENSP00000304891.

Structurei

3D structure databases

ProteinModelPortaliQ96A05.
SMRiQ96A05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase E subunit family.Curated

Phylogenomic databases

eggNOGiKOG1664. Eukaryota.
COG1390. LUCA.
GeneTreeiENSGT00390000002730.
HOGENOMiHOG000202506.
HOVERGENiHBG002309.
InParanoidiQ96A05.
KOiK02150.
OMAiKIQMSTM.
OrthoDBiEOG091G0OGO.
PhylomeDBiQ96A05.
TreeFamiTF313479.

Family and domain databases

HAMAPiMF_00311. ATP_synth_E_arch. 1 hit.
InterProiView protein in InterPro
IPR002842. ATPase_V1/A1-cplx_esu.
PfamiView protein in Pfam
PF01991. vATP-synt_E. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96A05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSDVDVKK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR
60 70 80 90 100
LKIMEYYEKK EKQIEQQKKI LMSTMRNQAR LKVLRARNDL ISDLLSEAKL
110 120 130 140 150
RLSRIVEDPE VYQGLLDKLV LQGLLRLLEP VMIVRCRPQD LLLVEAAVQK
160 170 180 190 200
AIPEYMTISQ KHVEVQIDKE AYLAVNAAGG VEVYSGNQRI KVSNTLESRL
210 220
DLSAKQKMPE IRMALFGANT NRKFFI
Length:226
Mass (Da):26,074
Last modified:December 1, 2001 - v1
Checksum:i40546707D944ED20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074759 mRNA. Translation: BAC00847.1.
AK058055 mRNA. Translation: BAB71643.1.
AC018682 Genomic DNA. Translation: AAY14833.1.
BC008981 mRNA. Translation: AAH08981.1.
BC034808 mRNA. Translation: AAH34808.1.
CCDSiCCDS1826.1.
RefSeqiNP_001304992.1. NM_001318063.1.
XP_005264690.1. XM_005264633.2.
XP_005264691.1. XM_005264634.2.
XP_011531450.1. XM_011533148.2.
XP_011531451.1. XM_011533149.2.
XP_011531452.1. XM_011533150.2.
XP_011531453.1. XM_011533151.2.
XP_011531454.1. XM_011533152.2.
XP_011531455.1. XM_011533153.2.
XP_016860714.1. XM_017005225.1.
XP_016860715.1. XM_017005226.1.
UniGeneiHs.659656.

Genome annotation databases

EnsembliENST00000306448; ENSP00000304891; ENSG00000250565.
ENST00000522587; ENSP00000428141; ENSG00000250565.
GeneIDi90423.
KEGGihsa:90423.
UCSCiuc002ruy.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVATE2_HUMAN
AccessioniPrimary (citable) accession number: Q96A05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families