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Protein

TSSK6-activating co-chaperone protein

Gene

TSACC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that facilitates HSP-mediated activation of TSSK6.1 Publication

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163467-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TSSK6-activating co-chaperone protein
Alternative name(s):
SSTK-interacting protein
Short name:
SSTK-IP
Gene namesi
Name:TSACC
Synonyms:C1orf182
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30636. TSACC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi128229.
OpenTargetsiENSG00000163467.
PharmGKBiPA142672430.

Polymorphism and mutation databases

BioMutaiTSACC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710731 – 125TSSK6-activating co-chaperone proteinAdd BLAST125

Proteomic databases

PaxDbiQ96A04.
PRIDEiQ96A04.

PTM databases

iPTMnetiQ96A04.
PhosphoSitePlusiQ96A04.

Expressioni

Tissue specificityi

Expressed in testis but is absent from mature sperm.1 Publication

Gene expression databases

BgeeiENSG00000163467.
CleanExiHS_C1orf182.
ExpressionAtlasiQ96A04. baseline and differential.
GenevisibleiQ96A04. HS.

Organism-specific databases

HPAiHPA029897.

Interactioni

Subunit structurei

Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FOXP2O154095EBI-740411,EBI-983612

GO - Molecular functioni

  • chaperone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126101. 3 interactors.
IntActiQ96A04. 3 interactors.
MINTiMINT-8417629.
STRINGi9606.ENSP00000357234.

Structurei

3D structure databases

ProteinModelPortaliQ96A04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TSACC family.Curated

Phylogenomic databases

eggNOGiENOG410J2HG. Eukaryota.
ENOG41115PX. LUCA.
GeneTreeiENSGT00390000012524.
HOGENOMiHOG000111265.
HOVERGENiHBG080977.
InParanoidiQ96A04.
OMAiGNAVPLC.
OrthoDBiEOG091G0Z2M.
PhylomeDBiQ96A04.
TreeFamiTF337043.

Family and domain databases

InterProiIPR031679. SSTK-IP.
[Graphical view]
PfamiPF15836. SSTK-IP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96A04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERHTSHPNR KVPAKEEANA VPLCRAKPSP SYINLQASSP PATFLNIQTT
60 70 80 90 100
KLPSVDHKPK ECLGLLECMY ANLQLQTQLA QQQMAVLEHL QASVTQLAPG
110 120
RGSNNSSLPA LSPNPLLNHL PQFSK
Length:125
Mass (Da):13,670
Last modified:December 1, 2001 - v1
Checksum:i40FE1D7B77204DB4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06156754S → L.Corresponds to variant rs41265043dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048672 mRNA. Translation: AAL07513.1.
AY048673 mRNA. Translation: AAL07514.1.
AL589685 Genomic DNA. Translation: CAI14171.1.
CH471121 Genomic DNA. Translation: EAW52964.1.
CH471121 Genomic DNA. Translation: EAW52965.1.
BC014605 mRNA. Translation: AAH14605.1.
CCDSiCCDS1141.1.
RefSeqiNP_001291746.1. NM_001304817.1.
NP_001291747.1. NM_001304818.1.
NP_001291748.1. NM_001304819.1.
NP_001291749.1. NM_001304820.1.
NP_001291750.1. NM_001304821.1.
NP_001291751.1. NM_001304822.1.
NP_001291752.1. NM_001304823.1.
NP_001291753.1. NM_001304824.1.
NP_001291754.1. NM_001304825.1.
NP_001291755.1. NM_001304826.1.
NP_653228.1. NM_144627.4.
UniGeneiHs.534539.

Genome annotation databases

EnsembliENST00000368251; ENSP00000357234; ENSG00000163467.
ENST00000368252; ENSP00000357235; ENSG00000163467.
ENST00000368253; ENSP00000357236; ENSG00000163467.
ENST00000368254; ENSP00000357237; ENSG00000163467.
ENST00000368255; ENSP00000357238; ENSG00000163467.
GeneIDi128229.
KEGGihsa:128229.
UCSCiuc001foo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048672 mRNA. Translation: AAL07513.1.
AY048673 mRNA. Translation: AAL07514.1.
AL589685 Genomic DNA. Translation: CAI14171.1.
CH471121 Genomic DNA. Translation: EAW52964.1.
CH471121 Genomic DNA. Translation: EAW52965.1.
BC014605 mRNA. Translation: AAH14605.1.
CCDSiCCDS1141.1.
RefSeqiNP_001291746.1. NM_001304817.1.
NP_001291747.1. NM_001304818.1.
NP_001291748.1. NM_001304819.1.
NP_001291749.1. NM_001304820.1.
NP_001291750.1. NM_001304821.1.
NP_001291751.1. NM_001304822.1.
NP_001291752.1. NM_001304823.1.
NP_001291753.1. NM_001304824.1.
NP_001291754.1. NM_001304825.1.
NP_001291755.1. NM_001304826.1.
NP_653228.1. NM_144627.4.
UniGeneiHs.534539.

3D structure databases

ProteinModelPortaliQ96A04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126101. 3 interactors.
IntActiQ96A04. 3 interactors.
MINTiMINT-8417629.
STRINGi9606.ENSP00000357234.

PTM databases

iPTMnetiQ96A04.
PhosphoSitePlusiQ96A04.

Polymorphism and mutation databases

BioMutaiTSACC.

Proteomic databases

PaxDbiQ96A04.
PRIDEiQ96A04.

Protocols and materials databases

DNASUi128229.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368251; ENSP00000357234; ENSG00000163467.
ENST00000368252; ENSP00000357235; ENSG00000163467.
ENST00000368253; ENSP00000357236; ENSG00000163467.
ENST00000368254; ENSP00000357237; ENSG00000163467.
ENST00000368255; ENSP00000357238; ENSG00000163467.
GeneIDi128229.
KEGGihsa:128229.
UCSCiuc001foo.4. human.

Organism-specific databases

CTDi128229.
DisGeNETi128229.
GeneCardsiTSACC.
HGNCiHGNC:30636. TSACC.
HPAiHPA029897.
neXtProtiNX_Q96A04.
OpenTargetsiENSG00000163467.
PharmGKBiPA142672430.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2HG. Eukaryota.
ENOG41115PX. LUCA.
GeneTreeiENSGT00390000012524.
HOGENOMiHOG000111265.
HOVERGENiHBG080977.
InParanoidiQ96A04.
OMAiGNAVPLC.
OrthoDBiEOG091G0Z2M.
PhylomeDBiQ96A04.
TreeFamiTF337043.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163467-MONOMER.

Miscellaneous databases

GenomeRNAii128229.
PROiQ96A04.

Gene expression databases

BgeeiENSG00000163467.
CleanExiHS_C1orf182.
ExpressionAtlasiQ96A04. baseline and differential.
GenevisibleiQ96A04. HS.

Family and domain databases

InterProiIPR031679. SSTK-IP.
[Graphical view]
PfamiPF15836. SSTK-IP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSACC_HUMAN
AccessioniPrimary (citable) accession number: Q96A04
Secondary accession number(s): D3DVB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.