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Protein

Tumor necrosis factor receptor superfamily member 19L

Gene

RELT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates activation of NF-kappa-B. May play a role in T-cell activation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19L
Alternative name(s):
Receptor expressed in lymphoid tissues
Gene namesi
Name:RELT
Synonyms:TNFRSF19L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:13764. RELT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 162137ExtracellularSequence analysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Topological domaini184 – 430247CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401092.

Polymorphism and mutation databases

BioMutaiRELT.
DMDMi21264092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25252 PublicationsAdd
BLAST
Chaini26 – 430405Tumor necrosis factor receptor superfamily member 19LPRO_0000034599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 65By similarity
Disulfide bondi71 ↔ 90By similarity
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence analysis
Modified residuei223 – 2231PhosphothreonineCombined sources

Post-translational modificationi

Phosphorylated in vitro by OXSR1.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ969Z4.
PaxDbiQ969Z4.
PeptideAtlasiQ969Z4.
PRIDEiQ969Z4.

PTM databases

iPTMnetiQ969Z4.
PhosphoSiteiQ969Z4.

Expressioni

Tissue specificityi

Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ969Z4.
CleanExiHS_RELT.
ExpressionAtlasiQ969Z4. baseline and differential.
GenevisibleiQ969Z4. HS.

Interactioni

Subunit structurei

Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1.2 Publications

Protein-protein interaction databases

BioGridi124388. 18 interactions.
STRINGi9606.ENSP00000064780.

Structurei

3D structure databases

ProteinModelPortaliQ969Z4.
SMRiQ969Z4. Positions 45-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 9041TNFR-CysAdd
BLAST

Sequence similaritiesi

Belongs to the RELT family.Curated
Contains 1 TNFR-Cys repeat.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJV. Eukaryota.
ENOG410YDMP. LUCA.
GeneTreeiENSGT00530000063385.
HOGENOMiHOG000134238.
HOVERGENiHBG062274.
InParanoidiQ969Z4.
KOiK05156.
OMAiLCRSCPP.
OrthoDBiEOG7P8P81.
PhylomeDBiQ969Z4.
TreeFamiTF332339.

Family and domain databases

InterProiIPR022248. TNF_rcpt_RELT.
IPR022333. TNFR_19-like.
[Graphical view]
PfamiPF12606. RELT. 1 hit.
[Graphical view]
PRINTSiPR01970. TNFACTORR19L.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSLLCRPL SCFLMLLPWP LATLTSTTLW QCPPGEEPDL DPGQGTLCRP
60 70 80 90 100
CPPGTFSAAW GSSPCQPHAR CSLWRRLEAQ VGMATRDTLC GDCWPGWFGP
110 120 130 140 150
WGVPRVPCQP CSWAPLGTHG CDEWGRRARR GVEVAAGASS GGETRQPGNG
160 170 180 190 200
TRAGGPEETA AQYAVIAIVP VFCLMGLLGI LVCNLLKRKG YHCTAHKEVG
210 220 230 240 250
PGPGGGGSGI NPAYRTEDAN EDTIGVLVRL ITEKKENAAA LEELLKEYHS
260 270 280 290 300
KQLVQTSHRP VSKLPPAPPN VPHICPHRHH LHTVQGLASL SGPCCSRCSQ
310 320 330 340 350
KKWPEVLLSP EAVAATTPVP SLLPNPTRVP KAGAKAGRQG EITILSVGRF
360 370 380 390 400
RVARIPEQRT SSMVSEVKTI TEAGPSWGDL PDSPQPGLPP EQQALLGSGG
410 420 430
SRTKWLKPPA ENKAEENRYV VRLSESNLVI
Length:430
Mass (Da):46,092
Last modified:December 1, 2001 - v1
Checksum:i4A5AB9AE32D36101
GO

Sequence cautioni

The sequence BAB84954.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221D → S in BAB84954 (Ref. 4) Curated
Sequence conflicti187 – 1871K → E in BAB55441 (PubMed:14702039).Curated
Sequence conflicti273 – 2731H → R in BAB55441 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321A → V.1 Publication
Corresponds to variant rs12362779 [ dbSNP | Ensembl ].
VAR_022614

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319553 mRNA. Translation: AAK77356.1.
AK027899 mRNA. Translation: BAB55441.1.
BC001812 mRNA. No translation available.
BC017279 mRNA. Translation: AAH17279.1.
BC051810 mRNA. Translation: AAH51810.2.
AK074128 mRNA. Translation: BAB84954.1. Frameshift.
CCDSiCCDS8222.1.
RefSeqiNP_116260.2. NM_032871.3.
NP_689408.1. NM_152222.1.
UniGeneiHs.533720.

Genome annotation databases

EnsembliENST00000064780; ENSP00000064780; ENSG00000054967.
ENST00000393580; ENSP00000377207; ENSG00000054967.
GeneIDi84957.
KEGGihsa:84957.
UCSCiuc001otv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319553 mRNA. Translation: AAK77356.1.
AK027899 mRNA. Translation: BAB55441.1.
BC001812 mRNA. No translation available.
BC017279 mRNA. Translation: AAH17279.1.
BC051810 mRNA. Translation: AAH51810.2.
AK074128 mRNA. Translation: BAB84954.1. Frameshift.
CCDSiCCDS8222.1.
RefSeqiNP_116260.2. NM_032871.3.
NP_689408.1. NM_152222.1.
UniGeneiHs.533720.

3D structure databases

ProteinModelPortaliQ969Z4.
SMRiQ969Z4. Positions 45-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124388. 18 interactions.
STRINGi9606.ENSP00000064780.

PTM databases

iPTMnetiQ969Z4.
PhosphoSiteiQ969Z4.

Polymorphism and mutation databases

BioMutaiRELT.
DMDMi21264092.

Proteomic databases

MaxQBiQ969Z4.
PaxDbiQ969Z4.
PeptideAtlasiQ969Z4.
PRIDEiQ969Z4.

Protocols and materials databases

DNASUi84957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000064780; ENSP00000064780; ENSG00000054967.
ENST00000393580; ENSP00000377207; ENSG00000054967.
GeneIDi84957.
KEGGihsa:84957.
UCSCiuc001otv.4. human.

Organism-specific databases

CTDi84957.
GeneCardsiRELT.
HGNCiHGNC:13764. RELT.
MIMi611211. gene.
neXtProtiNX_Q969Z4.
PharmGKBiPA162401092.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJV. Eukaryota.
ENOG410YDMP. LUCA.
GeneTreeiENSGT00530000063385.
HOGENOMiHOG000134238.
HOVERGENiHBG062274.
InParanoidiQ969Z4.
KOiK05156.
OMAiLCRSCPP.
OrthoDBiEOG7P8P81.
PhylomeDBiQ969Z4.
TreeFamiTF332339.

Miscellaneous databases

ChiTaRSiRELT. human.
GeneWikiiRELT.
GenomeRNAii84957.
PROiQ969Z4.
SOURCEiSearch...

Gene expression databases

BgeeiQ969Z4.
CleanExiHS_RELT.
ExpressionAtlasiQ969Z4. baseline and differential.
GenevisibleiQ969Z4. HS.

Family and domain databases

InterProiIPR022248. TNF_rcpt_RELT.
IPR022333. TNFR_19-like.
[Graphical view]
PfamiPF12606. RELT. 1 hit.
[Graphical view]
PRINTSiPR01970. TNFACTORR19L.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB."
    Sica G.L., Zhu G., Tamada K., Liu D., Ni J., Chen L.
    Blood 97:2702-2707(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, INTERACTION WITH TRAF1.
    Tissue: Lymphoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retinoblastoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-332.
    Tissue: Blood, Colon and Eye.
  4. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 121-430.
    Tissue: Spleen.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-40.
  6. "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1."
    Cusick J.K., Xu L.-G., Bin L.-H., Han K.-J., Shu H.-B.
    Biochem. Biophys. Res. Commun. 340:535-543(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH RELL1; RELL2 AND OXSR1, PHOSPHORYLATION.
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiTR19L_HUMAN
AccessioniPrimary (citable) accession number: Q969Z4
Secondary accession number(s): Q86V34, Q96JU1, Q9BUX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.