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Q969Z0 (TBRG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein TBRG4
Alternative name(s):
Cell cycle progression restoration protein 2
Short name=Cell cycle progression protein 2
FAST kinase domain-containing protein 4
Transforming growth factor beta regulator 4
Gene names
Name:TBRG4
Synonyms:CPR2, FASTKD4, KIAA0948
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length631 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in cell cycle progression. Ref.8

Tissue specificity

Ubiquitously expressed. Ref.9

Sequence similarities

Belongs to the FAST kinase family.

Contains 1 RAP domain.

Sequence caution

The sequence AAB69312.1 differs from that shown. Reason: Frameshift at positions 211, 479, 498 and 576.

The sequence BAA76792.2 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ASAP2O431501EBI-702328,EBI-310968

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q969Z0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q969Z0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     246-355: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 631631Protein TBRG4
PRO_0000273026

Regions

Domain561 – 61959RAP

Natural variations

Alternative sequence246 – 355110Missing in isoform 2.
VSP_022460
Natural variant221A → S. Ref.4
Corresponds to variant rs2304694 [ dbSNP | Ensembl ].
VAR_030071
Natural variant571P → L. Ref.4
Corresponds to variant rs2304693 [ dbSNP | Ensembl ].
VAR_030072

Experimental info

Sequence conflict3651T → A in BAD96663. Ref.3
Sequence conflict4891V → E in AAB69312. Ref.8
Sequence conflict5241A → S in AAB69312. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4EFC3AF5D5BBABD3

FASTA63170,738
        10         20         30         40         50         60 
MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL PGSLMEPVEK 

        70         80         90        100        110        120 
ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA AMVLIRLSHL LSEKPEDKGL 

       130        140        150        160        170        180 
LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL GSLYALGIPK ASKELQSVEQ EVRWRMRKLK 

       190        200        210        220        230        240 
YKHLAFLAES CATLSQEQHS QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN 

       250        260        270        280        290        300 
RLEDKCLELV EHFGPNELRK VLVMLAAQSR RSVPLLRAIS YHLVQKPFSL TKDVLLDVAY 

       310        320        330        340        350        360 
AYGKLSFHQT QVSQRLATDL LSLMPSLTSG EVAHCAKSFA LLKWLSLPLF EAFAQHVLNR 

       370        380        390        400        410        420 
AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE LPGLEPALQV DLVWALCVLQ 

       430        440        450        460        470        480 
QAREAELQAV LHPEFHIQFL GGKSQKDQNT FQKLLHINAT ALLEYPEYSG PLLPASAVAP 

       490        500        510        520        530        540 
GPSALDRKVT PLQKELQETL KGLLGSADKG SLEVATQYGW VLDAEVLLDS DGEFLPVRDF 

       550        560        570        580        590        600 
VAPHLAQPTG SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV AAGFLIVDVP 

       610        620        630 
FYEWLELKSE WQKGAYLKDK MRKAVAEELA K 

« Hide

Isoform 2 [UniParc].

Checksum: CE2A279B0BFEE5B6
Show »

FASTA52158,443

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]Ohara O., Nagase T., Kikuno R.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Kidney.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-22 AND LEU-57.
Tissue: Mammary cancer.
[5]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung and Uterus.
[8]"Human CPR (cell cycle progression restoration) genes impart a Far-phenotype on yeast cells."
Edwards M.C., Liegeois N., Horecka J., DePinho R.A., Sprague G.F. Jr., Tyers M., Elledge S.J.
Genetics 147:1063-1076(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-615 (ISOFORM 1), FUNCTION.
Tissue: Hepatoma.
[9]"Pig whey acidic protein gene is surrounded by two ubiquitously expressed genes."
Rival-Gervier S., Thepot D., Jolivet G., Houdebine L.-M.
Biochim. Biophys. Acta 1627:7-14(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
Tissue: Lung.
[10]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023165 mRNA. Translation: BAA76792.2. Different initiation.
AK222943 mRNA. Translation: BAD96663.1.
AL833840 mRNA. Translation: CAD38700.1.
CH236960 Genomic DNA. Translation: EAL23744.1.
CH236960 Genomic DNA. Translation: EAL23745.1.
CH471128 Genomic DNA. Translation: EAW61051.1.
CH471128 Genomic DNA. Translation: EAW61052.1.
CH471128 Genomic DNA. Translation: EAW61054.1.
CH471128 Genomic DNA. Translation: EAW61055.1.
BC002732 mRNA. Translation: AAH02732.2.
BC014918 mRNA. Translation: AAH14918.1.
BC017235 mRNA. Translation: AAH17235.1.
AF011792 mRNA. Translation: AAB69312.1. Frameshift.
CCDSCCDS5501.1. [Q969Z0-1]
CCDS5502.1. [Q969Z0-2]
RefSeqNP_004740.2. NM_004749.3. [Q969Z0-1]
NP_112162.1. NM_030900.3. [Q969Z0-2]
NP_954573.1. NM_199122.2. [Q969Z0-2]
UniGeneHs.231411.
Hs.741611.

3D structure databases

ProteinModelPortalQ969Z0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114666. 5 interactions.
IntActQ969Z0. 3 interactions.
MINTMINT-1429254.
STRING9606.ENSP00000258770.

PTM databases

PhosphoSiteQ969Z0.

Polymorphism databases

DMDM74731072.

Proteomic databases

MaxQBQ969Z0.
PaxDbQ969Z0.
PeptideAtlasQ969Z0.
PRIDEQ969Z0.

Protocols and materials databases

DNASU9238.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258770; ENSP00000258770; ENSG00000136270. [Q969Z0-1]
ENST00000361278; ENSP00000354992; ENSG00000136270. [Q969Z0-2]
ENST00000395655; ENSP00000379016; ENSG00000136270. [Q969Z0-2]
ENST00000494076; ENSP00000420597; ENSG00000136270. [Q969Z0-1]
GeneID9238.
KEGGhsa:9238.
UCSCuc003tmu.3. human. [Q969Z0-1]
uc003tmw.4. human. [Q969Z0-2]

Organism-specific databases

CTD9238.
GeneCardsGC07M045139.
HGNCHGNC:17443. TBRG4.
HPAHPA020582.
HPA050430.
MIM611325. gene.
neXtProtNX_Q969Z0.
PharmGKBPA134882196.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72063.
HOVERGENHBG094028.
InParanoidQ969Z0.
OMAKVGHLSE.
OrthoDBEOG7TBC2C.
PhylomeDBQ969Z0.
TreeFamTF324885.

Gene expression databases

ArrayExpressQ969Z0.
BgeeQ969Z0.
CleanExHS_TBRG4.
GenevestigatorQ969Z0.

Family and domain databases

InterProIPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamPF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTSM00952. RAP. 1 hit.
[Graphical view]
PROSITEPS51286. RAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTBRG4. human.
GeneWikiTBRG4.
GenomeRNAi9238.
NextBio34633.
PROQ969Z0.
SOURCESearch...

Entry information

Entry nameTBRG4_HUMAN
AccessionPrimary (citable) accession number: Q969Z0
Secondary accession number(s): A4D2L2 expand/collapse secondary AC list , A4D2L3, D3DVL5, D3DVL6, O14710, Q53GI8, Q8NDM4, Q9BUC6, Q9Y2F6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM