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Q969Z0

- TBRG4_HUMAN

UniProt

Q969Z0 - TBRG4_HUMAN

Protein

Protein TBRG4

Gene

TBRG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May play a role in cell cycle progression.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein kinase activity Source: InterPro

    GO - Biological processi

    1. cell cycle arrest Source: UniProtKB
    2. cellular respiration Source: UniProtKB
    3. mitotic G1 phase Source: UniProtKB
    4. positive regulation of cell proliferation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein TBRG4
    Alternative name(s):
    Cell cycle progression restoration protein 2
    Short name:
    Cell cycle progression protein 2
    FAST kinase domain-containing protein 4
    Transforming growth factor beta regulator 4
    Gene namesi
    Name:TBRG4
    Synonyms:CPR2, FASTKD4, KIAA0948
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:17443. TBRG4.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134882196.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 631631Protein TBRG4PRO_0000273026Add
    BLAST

    Proteomic databases

    MaxQBiQ969Z0.
    PaxDbiQ969Z0.
    PeptideAtlasiQ969Z0.
    PRIDEiQ969Z0.

    PTM databases

    PhosphoSiteiQ969Z0.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ969Z0.
    BgeeiQ969Z0.
    CleanExiHS_TBRG4.
    GenevestigatoriQ969Z0.

    Organism-specific databases

    HPAiHPA020582.
    HPA050430.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ASAP2O431501EBI-702328,EBI-310968

    Protein-protein interaction databases

    BioGridi114666. 5 interactions.
    IntActiQ969Z0. 3 interactions.
    MINTiMINT-1429254.
    STRINGi9606.ENSP00000258770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969Z0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini561 – 61959RAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAST kinase family.Curated
    Contains 1 RAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG72063.
    HOVERGENiHBG094028.
    InParanoidiQ969Z0.
    OMAiKVGHLSE.
    OrthoDBiEOG7TBC2C.
    PhylomeDBiQ969Z0.
    TreeFamiTF324885.

    Family and domain databases

    InterProiIPR013579. FAST_2.
    IPR010622. FAST_Leu-rich.
    IPR013584. RAP.
    [Graphical view]
    PfamiPF06743. FAST_1. 1 hit.
    PF08368. FAST_2. 1 hit.
    PF08373. RAP. 1 hit.
    [Graphical view]
    SMARTiSM00952. RAP. 1 hit.
    [Graphical view]
    PROSITEiPS51286. RAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969Z0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL    50
    PGSLMEPVEK ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA 100
    AMVLIRLSHL LSEKPEDKGL LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL 150
    GSLYALGIPK ASKELQSVEQ EVRWRMRKLK YKHLAFLAES CATLSQEQHS 200
    QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN RLEDKCLELV 250
    EHFGPNELRK VLVMLAAQSR RSVPLLRAIS YHLVQKPFSL TKDVLLDVAY 300
    AYGKLSFHQT QVSQRLATDL LSLMPSLTSG EVAHCAKSFA LLKWLSLPLF 350
    EAFAQHVLNR AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE 400
    LPGLEPALQV DLVWALCVLQ QAREAELQAV LHPEFHIQFL GGKSQKDQNT 450
    FQKLLHINAT ALLEYPEYSG PLLPASAVAP GPSALDRKVT PLQKELQETL 500
    KGLLGSADKG SLEVATQYGW VLDAEVLLDS DGEFLPVRDF VAPHLAQPTG 550
    SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV AAGFLIVDVP 600
    FYEWLELKSE WQKGAYLKDK MRKAVAEELA K 631
    Length:631
    Mass (Da):70,738
    Last modified:December 1, 2001 - v1
    Checksum:i4EFC3AF5D5BBABD3
    GO
    Isoform 2 (identifier: Q969Z0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         246-355: Missing.

    Show »
    Length:521
    Mass (Da):58,443
    Checksum:iCE2A279B0BFEE5B6
    GO

    Sequence cautioni

    The sequence AAB69312.1 differs from that shown. Reason: Frameshift at positions 211, 479, 498 and 576.
    The sequence BAA76792.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti365 – 3651T → A in BAD96663. 1 PublicationCurated
    Sequence conflicti489 – 4891V → E in AAB69312. (PubMed:9383053)Curated
    Sequence conflicti524 – 5241A → S in AAB69312. (PubMed:9383053)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221A → S.1 Publication
    Corresponds to variant rs2304694 [ dbSNP | Ensembl ].
    VAR_030071
    Natural varianti57 – 571P → L.1 Publication
    Corresponds to variant rs2304693 [ dbSNP | Ensembl ].
    VAR_030072

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei246 – 355110Missing in isoform 2. 2 PublicationsVSP_022460Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023165 mRNA. Translation: BAA76792.2. Different initiation.
    AK222943 mRNA. Translation: BAD96663.1.
    AL833840 mRNA. Translation: CAD38700.1.
    CH236960 Genomic DNA. Translation: EAL23744.1.
    CH236960 Genomic DNA. Translation: EAL23745.1.
    CH471128 Genomic DNA. Translation: EAW61051.1.
    CH471128 Genomic DNA. Translation: EAW61052.1.
    CH471128 Genomic DNA. Translation: EAW61054.1.
    CH471128 Genomic DNA. Translation: EAW61055.1.
    BC002732 mRNA. Translation: AAH02732.2.
    BC014918 mRNA. Translation: AAH14918.1.
    BC017235 mRNA. Translation: AAH17235.1.
    AF011792 mRNA. Translation: AAB69312.1. Frameshift.
    CCDSiCCDS5501.1. [Q969Z0-1]
    CCDS5502.1. [Q969Z0-2]
    RefSeqiNP_004740.2. NM_004749.3. [Q969Z0-1]
    NP_112162.1. NM_030900.3. [Q969Z0-2]
    NP_954573.1. NM_199122.2. [Q969Z0-2]
    UniGeneiHs.231411.
    Hs.741611.

    Genome annotation databases

    EnsembliENST00000258770; ENSP00000258770; ENSG00000136270. [Q969Z0-1]
    ENST00000361278; ENSP00000354992; ENSG00000136270. [Q969Z0-2]
    ENST00000395655; ENSP00000379016; ENSG00000136270. [Q969Z0-2]
    ENST00000494076; ENSP00000420597; ENSG00000136270. [Q969Z0-1]
    GeneIDi9238.
    KEGGihsa:9238.
    UCSCiuc003tmu.3. human. [Q969Z0-1]
    uc003tmw.4. human. [Q969Z0-2]

    Polymorphism databases

    DMDMi74731072.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023165 mRNA. Translation: BAA76792.2 . Different initiation.
    AK222943 mRNA. Translation: BAD96663.1 .
    AL833840 mRNA. Translation: CAD38700.1 .
    CH236960 Genomic DNA. Translation: EAL23744.1 .
    CH236960 Genomic DNA. Translation: EAL23745.1 .
    CH471128 Genomic DNA. Translation: EAW61051.1 .
    CH471128 Genomic DNA. Translation: EAW61052.1 .
    CH471128 Genomic DNA. Translation: EAW61054.1 .
    CH471128 Genomic DNA. Translation: EAW61055.1 .
    BC002732 mRNA. Translation: AAH02732.2 .
    BC014918 mRNA. Translation: AAH14918.1 .
    BC017235 mRNA. Translation: AAH17235.1 .
    AF011792 mRNA. Translation: AAB69312.1 . Frameshift.
    CCDSi CCDS5501.1. [Q969Z0-1 ]
    CCDS5502.1. [Q969Z0-2 ]
    RefSeqi NP_004740.2. NM_004749.3. [Q969Z0-1 ]
    NP_112162.1. NM_030900.3. [Q969Z0-2 ]
    NP_954573.1. NM_199122.2. [Q969Z0-2 ]
    UniGenei Hs.231411.
    Hs.741611.

    3D structure databases

    ProteinModelPortali Q969Z0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114666. 5 interactions.
    IntActi Q969Z0. 3 interactions.
    MINTi MINT-1429254.
    STRINGi 9606.ENSP00000258770.

    PTM databases

    PhosphoSitei Q969Z0.

    Polymorphism databases

    DMDMi 74731072.

    Proteomic databases

    MaxQBi Q969Z0.
    PaxDbi Q969Z0.
    PeptideAtlasi Q969Z0.
    PRIDEi Q969Z0.

    Protocols and materials databases

    DNASUi 9238.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258770 ; ENSP00000258770 ; ENSG00000136270 . [Q969Z0-1 ]
    ENST00000361278 ; ENSP00000354992 ; ENSG00000136270 . [Q969Z0-2 ]
    ENST00000395655 ; ENSP00000379016 ; ENSG00000136270 . [Q969Z0-2 ]
    ENST00000494076 ; ENSP00000420597 ; ENSG00000136270 . [Q969Z0-1 ]
    GeneIDi 9238.
    KEGGi hsa:9238.
    UCSCi uc003tmu.3. human. [Q969Z0-1 ]
    uc003tmw.4. human. [Q969Z0-2 ]

    Organism-specific databases

    CTDi 9238.
    GeneCardsi GC07M045139.
    HGNCi HGNC:17443. TBRG4.
    HPAi HPA020582.
    HPA050430.
    MIMi 611325. gene.
    neXtProti NX_Q969Z0.
    PharmGKBi PA134882196.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72063.
    HOVERGENi HBG094028.
    InParanoidi Q969Z0.
    OMAi KVGHLSE.
    OrthoDBi EOG7TBC2C.
    PhylomeDBi Q969Z0.
    TreeFami TF324885.

    Miscellaneous databases

    ChiTaRSi TBRG4. human.
    GeneWikii TBRG4.
    GenomeRNAii 9238.
    NextBioi 34633.
    PROi Q969Z0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969Z0.
    Bgeei Q969Z0.
    CleanExi HS_TBRG4.
    Genevestigatori Q969Z0.

    Family and domain databases

    InterProi IPR013579. FAST_2.
    IPR010622. FAST_Leu-rich.
    IPR013584. RAP.
    [Graphical view ]
    Pfami PF06743. FAST_1. 1 hit.
    PF08368. FAST_2. 1 hit.
    PF08373. RAP. 1 hit.
    [Graphical view ]
    SMARTi SM00952. RAP. 1 hit.
    [Graphical view ]
    PROSITEi PS51286. RAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. Ohara O., Nagase T., Kikuno R.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-22 AND LEU-57.
      Tissue: Mammary cancer.
    5. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Uterus.
    8. "Human CPR (cell cycle progression restoration) genes impart a Far-phenotype on yeast cells."
      Edwards M.C., Liegeois N., Horecka J., DePinho R.A., Sprague G.F. Jr., Tyers M., Elledge S.J.
      Genetics 147:1063-1076(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-615 (ISOFORM 1), FUNCTION.
      Tissue: Hepatoma.
    9. "Pig whey acidic protein gene is surrounded by two ubiquitously expressed genes."
      Rival-Gervier S., Thepot D., Jolivet G., Houdebine L.-M.
      Biochim. Biophys. Acta 1627:7-14(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
      Tissue: Lung.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTBRG4_HUMAN
    AccessioniPrimary (citable) accession number: Q969Z0
    Secondary accession number(s): A4D2L2
    , A4D2L3, D3DVL5, D3DVL6, O14710, Q53GI8, Q8NDM4, Q9BUC6, Q9Y2F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3