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Q969Z0

- TBRG4_HUMAN

UniProt

Q969Z0 - TBRG4_HUMAN

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Protein

Protein TBRG4

Gene

TBRG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in cell cycle progression.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein kinase activity Source: InterPro

GO - Biological processi

  1. cell cycle arrest Source: UniProtKB
  2. cellular respiration Source: UniProtKB
  3. positive regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TBRG4
Alternative name(s):
Cell cycle progression restoration protein 2
Short name:
Cell cycle progression protein 2
FAST kinase domain-containing protein 4
Transforming growth factor beta regulator 4
Gene namesi
Name:TBRG4
Synonyms:CPR2, FASTKD4, KIAA0948
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:17443. TBRG4.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134882196.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Protein TBRG4PRO_0000273026Add
BLAST

Proteomic databases

MaxQBiQ969Z0.
PaxDbiQ969Z0.
PeptideAtlasiQ969Z0.
PRIDEiQ969Z0.

PTM databases

PhosphoSiteiQ969Z0.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ969Z0.
CleanExiHS_TBRG4.
ExpressionAtlasiQ969Z0. baseline and differential.
GenevestigatoriQ969Z0.

Organism-specific databases

HPAiHPA020582.
HPA050430.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASAP2O431501EBI-702328,EBI-310968

Protein-protein interaction databases

BioGridi114666. 10 interactions.
IntActiQ969Z0. 3 interactions.
MINTiMINT-1429254.
STRINGi9606.ENSP00000258770.

Structurei

3D structure databases

ProteinModelPortaliQ969Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini561 – 61959RAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FAST kinase family.Curated
Contains 1 RAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG72063.
GeneTreeiENSGT00530000063266.
HOVERGENiHBG094028.
InParanoidiQ969Z0.
OMAiKVGHLSE.
OrthoDBiEOG7TBC2C.
PhylomeDBiQ969Z0.
TreeFamiTF324885.

Family and domain databases

InterProiIPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamiPF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTiSM00952. RAP. 1 hit.
[Graphical view]
PROSITEiPS51286. RAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969Z0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL
60 70 80 90 100
PGSLMEPVEK ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA
110 120 130 140 150
AMVLIRLSHL LSEKPEDKGL LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL
160 170 180 190 200
GSLYALGIPK ASKELQSVEQ EVRWRMRKLK YKHLAFLAES CATLSQEQHS
210 220 230 240 250
QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN RLEDKCLELV
260 270 280 290 300
EHFGPNELRK VLVMLAAQSR RSVPLLRAIS YHLVQKPFSL TKDVLLDVAY
310 320 330 340 350
AYGKLSFHQT QVSQRLATDL LSLMPSLTSG EVAHCAKSFA LLKWLSLPLF
360 370 380 390 400
EAFAQHVLNR AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE
410 420 430 440 450
LPGLEPALQV DLVWALCVLQ QAREAELQAV LHPEFHIQFL GGKSQKDQNT
460 470 480 490 500
FQKLLHINAT ALLEYPEYSG PLLPASAVAP GPSALDRKVT PLQKELQETL
510 520 530 540 550
KGLLGSADKG SLEVATQYGW VLDAEVLLDS DGEFLPVRDF VAPHLAQPTG
560 570 580 590 600
SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV AAGFLIVDVP
610 620 630
FYEWLELKSE WQKGAYLKDK MRKAVAEELA K
Length:631
Mass (Da):70,738
Last modified:December 1, 2001 - v1
Checksum:i4EFC3AF5D5BBABD3
GO
Isoform 2 (identifier: Q969Z0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-355: Missing.

Show »
Length:521
Mass (Da):58,443
Checksum:iCE2A279B0BFEE5B6
GO

Sequence cautioni

The sequence AAB69312.1 differs from that shown. Reason: Frameshift at positions 211, 479, 498 and 576. Curated
The sequence BAA76792.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti365 – 3651T → A in BAD96663. 1 PublicationCurated
Sequence conflicti489 – 4891V → E in AAB69312. (PubMed:9383053)Curated
Sequence conflicti524 – 5241A → S in AAB69312. (PubMed:9383053)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221A → S.1 Publication
Corresponds to variant rs2304694 [ dbSNP | Ensembl ].
VAR_030071
Natural varianti57 – 571P → L.1 Publication
Corresponds to variant rs2304693 [ dbSNP | Ensembl ].
VAR_030072

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei246 – 355110Missing in isoform 2. 2 PublicationsVSP_022460Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023165 mRNA. Translation: BAA76792.2. Different initiation.
AK222943 mRNA. Translation: BAD96663.1.
AL833840 mRNA. Translation: CAD38700.1.
CH236960 Genomic DNA. Translation: EAL23744.1.
CH236960 Genomic DNA. Translation: EAL23745.1.
CH471128 Genomic DNA. Translation: EAW61051.1.
CH471128 Genomic DNA. Translation: EAW61052.1.
CH471128 Genomic DNA. Translation: EAW61054.1.
CH471128 Genomic DNA. Translation: EAW61055.1.
BC002732 mRNA. Translation: AAH02732.2.
BC014918 mRNA. Translation: AAH14918.1.
BC017235 mRNA. Translation: AAH17235.1.
AF011792 mRNA. Translation: AAB69312.1. Frameshift.
CCDSiCCDS5501.1. [Q969Z0-1]
CCDS5502.1. [Q969Z0-2]
RefSeqiNP_004740.2. NM_004749.3. [Q969Z0-1]
NP_112162.1. NM_030900.3. [Q969Z0-2]
NP_954573.1. NM_199122.2. [Q969Z0-2]
UniGeneiHs.231411.
Hs.741611.

Genome annotation databases

EnsembliENST00000258770; ENSP00000258770; ENSG00000136270. [Q969Z0-1]
ENST00000361278; ENSP00000354992; ENSG00000136270. [Q969Z0-2]
ENST00000395655; ENSP00000379016; ENSG00000136270. [Q969Z0-2]
ENST00000494076; ENSP00000420597; ENSG00000136270. [Q969Z0-1]
GeneIDi9238.
KEGGihsa:9238.
UCSCiuc003tmu.3. human. [Q969Z0-1]
uc003tmw.4. human. [Q969Z0-2]

Polymorphism databases

DMDMi74731072.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023165 mRNA. Translation: BAA76792.2 . Different initiation.
AK222943 mRNA. Translation: BAD96663.1 .
AL833840 mRNA. Translation: CAD38700.1 .
CH236960 Genomic DNA. Translation: EAL23744.1 .
CH236960 Genomic DNA. Translation: EAL23745.1 .
CH471128 Genomic DNA. Translation: EAW61051.1 .
CH471128 Genomic DNA. Translation: EAW61052.1 .
CH471128 Genomic DNA. Translation: EAW61054.1 .
CH471128 Genomic DNA. Translation: EAW61055.1 .
BC002732 mRNA. Translation: AAH02732.2 .
BC014918 mRNA. Translation: AAH14918.1 .
BC017235 mRNA. Translation: AAH17235.1 .
AF011792 mRNA. Translation: AAB69312.1 . Frameshift.
CCDSi CCDS5501.1. [Q969Z0-1 ]
CCDS5502.1. [Q969Z0-2 ]
RefSeqi NP_004740.2. NM_004749.3. [Q969Z0-1 ]
NP_112162.1. NM_030900.3. [Q969Z0-2 ]
NP_954573.1. NM_199122.2. [Q969Z0-2 ]
UniGenei Hs.231411.
Hs.741611.

3D structure databases

ProteinModelPortali Q969Z0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114666. 10 interactions.
IntActi Q969Z0. 3 interactions.
MINTi MINT-1429254.
STRINGi 9606.ENSP00000258770.

PTM databases

PhosphoSitei Q969Z0.

Polymorphism databases

DMDMi 74731072.

Proteomic databases

MaxQBi Q969Z0.
PaxDbi Q969Z0.
PeptideAtlasi Q969Z0.
PRIDEi Q969Z0.

Protocols and materials databases

DNASUi 9238.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258770 ; ENSP00000258770 ; ENSG00000136270 . [Q969Z0-1 ]
ENST00000361278 ; ENSP00000354992 ; ENSG00000136270 . [Q969Z0-2 ]
ENST00000395655 ; ENSP00000379016 ; ENSG00000136270 . [Q969Z0-2 ]
ENST00000494076 ; ENSP00000420597 ; ENSG00000136270 . [Q969Z0-1 ]
GeneIDi 9238.
KEGGi hsa:9238.
UCSCi uc003tmu.3. human. [Q969Z0-1 ]
uc003tmw.4. human. [Q969Z0-2 ]

Organism-specific databases

CTDi 9238.
GeneCardsi GC07M045139.
HGNCi HGNC:17443. TBRG4.
HPAi HPA020582.
HPA050430.
MIMi 611325. gene.
neXtProti NX_Q969Z0.
PharmGKBi PA134882196.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72063.
GeneTreei ENSGT00530000063266.
HOVERGENi HBG094028.
InParanoidi Q969Z0.
OMAi KVGHLSE.
OrthoDBi EOG7TBC2C.
PhylomeDBi Q969Z0.
TreeFami TF324885.

Miscellaneous databases

ChiTaRSi TBRG4. human.
GeneWikii TBRG4.
GenomeRNAii 9238.
NextBioi 34633.
PROi Q969Z0.
SOURCEi Search...

Gene expression databases

Bgeei Q969Z0.
CleanExi HS_TBRG4.
ExpressionAtlasi Q969Z0. baseline and differential.
Genevestigatori Q969Z0.

Family and domain databases

InterProi IPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view ]
Pfami PF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view ]
SMARTi SM00952. RAP. 1 hit.
[Graphical view ]
PROSITEi PS51286. RAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. Ohara O., Nagase T., Kikuno R.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-22 AND LEU-57.
    Tissue: Mammary cancer.
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Uterus.
  8. "Human CPR (cell cycle progression restoration) genes impart a Far-phenotype on yeast cells."
    Edwards M.C., Liegeois N., Horecka J., DePinho R.A., Sprague G.F. Jr., Tyers M., Elledge S.J.
    Genetics 147:1063-1076(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-615 (ISOFORM 1), FUNCTION.
    Tissue: Hepatoma.
  9. "Pig whey acidic protein gene is surrounded by two ubiquitously expressed genes."
    Rival-Gervier S., Thepot D., Jolivet G., Houdebine L.-M.
    Biochim. Biophys. Acta 1627:7-14(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Tissue: Lung.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTBRG4_HUMAN
AccessioniPrimary (citable) accession number: Q969Z0
Secondary accession number(s): A4D2L2
, A4D2L3, D3DVL5, D3DVL6, O14710, Q53GI8, Q8NDM4, Q9BUC6, Q9Y2F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3