Q969Z0 (TBRG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TBRG4

Alternative name(s):
Cell cycle progression restoration protein 2
Short name=Cell cycle progression protein 2
FAST kinase domain-containing protein 4
Transforming growth factor beta regulator 4

Gene names

Name:	TBRG4
Synonyms:	CPR2, FASTKD4, KIAA0948

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	631 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in cell cycle progression. Ref.8
Tissue specificity	Ubiquitously expressed. Ref.9
Sequence similarities	Belongs to the FAST kinase family. Contains 1 RAP domain.
Sequence caution	The sequence AAB69312.1 differs from that shown. Reason: Frameshift at positions 211, 479, 498 and 576. The sequence BAA76792.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1 phase of mitotic cell cycle Traceable author statement Ref.8. Source: UniProtKB cell cycle arrest Traceable author statement Ref.8. Source: UniProtKB cellular respiration Inferred from sequence or structural similarity PubMed 20869947. Source: UniProtKB positive regulation of cell proliferation Traceable author statement Ref.8. Source: UniProtKB protein phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	mitochondrion Inferred from direct assay PubMed 20869947. Source: UniProtKB
Molecular_function	protein kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ASAP2	O43150	1	EBI-702328,EBI-310968

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q969Z0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q969Z0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     246-355: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 631	631	Protein TBRG4		PRO_0000273026
Regions
	Domain	561 – 619	59	RAP
Natural variations
	Alternative sequence	246 – 355	110	Missing in isoform 2.		VSP_022460
	Natural variant	22	1	A → S. Ref.4 Corresponds to variant rs2304694 [ dbSNP | Ensembl ].		VAR_030071
	Natural variant	57	1	P → L. Ref.4 Corresponds to variant rs2304693 [ dbSNP | Ensembl ].		VAR_030072
Experimental info
	Sequence conflict	365	1	T → A in BAD96663. Ref.3
	Sequence conflict	489	1	V → E in AAB69312. Ref.8
	Sequence conflict	524	1	A → S in AAB69312. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 4EFC3AF5D5BBABD3	FASTA	631	70,738
	10 20 30 40 50 60 MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL PGSLMEPVEK 70 80 90 100 110 120 ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA AMVLIRLSHL LSEKPEDKGL 130 140 150 160 170 180 LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL GSLYALGIPK ASKELQSVEQ EVRWRMRKLK 190 200 210 220 230 240 YKHLAFLAES CATLSQEQHS QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN 250 260 270 280 290 300 RLEDKCLELV EHFGPNELRK VLVMLAAQSR RSVPLLRAIS YHLVQKPFSL TKDVLLDVAY 310 320 330 340 350 360 AYGKLSFHQT QVSQRLATDL LSLMPSLTSG EVAHCAKSFA LLKWLSLPLF EAFAQHVLNR 370 380 390 400 410 420 AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE LPGLEPALQV DLVWALCVLQ 430 440 450 460 470 480 QAREAELQAV LHPEFHIQFL GGKSQKDQNT FQKLLHINAT ALLEYPEYSG PLLPASAVAP 490 500 510 520 530 540 GPSALDRKVT PLQKELQETL KGLLGSADKG SLEVATQYGW VLDAEVLLDS DGEFLPVRDF 550 560 570 580 590 600 VAPHLAQPTG SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV AAGFLIVDVP 610 620 630 FYEWLELKSE WQKGAYLKDK MRKAVAEELA K
	Isoform 2 [UniParc]. Checksum: CE2A279B0BFEE5B6	FASTA	521	58,443
	10 20 30 40 50 60 MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL PGSLMEPVEK 70 80 90 100 110 120 ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA AMVLIRLSHL LSEKPEDKGL 130 140 150 160 170 180 LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL GSLYALGIPK ASKELQSVEQ EVRWRMRKLK 190 200 210 220 230 240 YKHLAFLAES CATLSQEQHS QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN 250 260 270 280 290 300 RLEDKHVLNR AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE LPGLEPALQV 310 320 330 340 350 360 DLVWALCVLQ QAREAELQAV LHPEFHIQFL GGKSQKDQNT FQKLLHINAT ALLEYPEYSG 370 380 390 400 410 420 PLLPASAVAP GPSALDRKVT PLQKELQETL KGLLGSADKG SLEVATQYGW VLDAEVLLDS 430 440 450 460 470 480 DGEFLPVRDF VAPHLAQPTG SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV 490 500 510 520 AAGFLIVDVP FYEWLELKSE WQKGAYLKDK MRKAVAEELA K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	Ohara O., Nagase T., Kikuno R. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Kidney.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-22 AND LEU-57. Tissue: Mammary cancer.
[5]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung and Uterus.
[8]	"Human CPR (cell cycle progression restoration) genes impart a Far-phenotype on yeast cells." Edwards M.C., Liegeois N., Horecka J., DePinho R.A., Sprague G.F. Jr., Tyers M., Elledge S.J. Genetics 147:1063-1076(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-615 (ISOFORM 1), FUNCTION. Tissue: Hepatoma.
[9]	"Pig whey acidic protein gene is surrounded by two ubiquitously expressed genes." Rival-Gervier S., Thepot D., Jolivet G., Houdebine L.-M. Biochim. Biophys. Acta 1627:7-14(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY. Tissue: Lung.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023165 mRNA. Translation: BAA76792.2. Different initiation. AK222943 mRNA. Translation: BAD96663.1. AL833840 mRNA. Translation: CAD38700.1. CH236960 Genomic DNA. Translation: EAL23744.1. CH236960 Genomic DNA. Translation: EAL23745.1. CH471128 Genomic DNA. Translation: EAW61051.1. CH471128 Genomic DNA. Translation: EAW61052.1. CH471128 Genomic DNA. Translation: EAW61054.1. CH471128 Genomic DNA. Translation: EAW61055.1. BC002732 mRNA. Translation: AAH02732.2. BC014918 mRNA. Translation: AAH14918.1. BC017235 mRNA. Translation: AAH17235.1. AF011792 mRNA. Translation: AAB69312.1. Frameshift.
IPI	IPI00329625. IPI00477123.
RefSeq	NP_004740.2. NM_004749.3. NP_112162.1. NM_030900.3. NP_954573.1. NM_199122.2.
UniGene	Hs.231411. Hs.741611.
3D structure databases
ProteinModelPortal	Q969Z0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q969Z0. 3 interactions.
MINT	MINT-1429254.
STRING	9606.ENSP00000258770.
PTM databases
PhosphoSite	Q969Z0.
Polymorphism databases
DMDM	74731072.
Proteomic databases
PaxDb	Q969Z0.
PeptideAtlas	Q969Z0.
PRIDE	Q969Z0.
Protocols and materials databases
DNASU	9238.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258770; ENSP00000258770; ENSG00000136270. ENST00000361278; ENSP00000354992; ENSG00000136270. ENST00000395655; ENSP00000379016; ENSG00000136270. ENST00000494076; ENSP00000420597; ENSG00000136270.
GeneID	9238.
KEGG	hsa:9238.
UCSC	uc003tmu.3. human. uc003tmw.3. human.
Organism-specific databases
CTD	9238.
GeneCards	GC07M045139.
HGNC	HGNC:17443. TBRG4.
HPA	HPA020582.
MIM	611325. gene.
neXtProt	NX_Q969Z0.
PharmGKB	PA134882196.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72063.
HOVERGEN	HBG094028.
InParanoid	Q969Z0.
OMA	KVGHLSE.
OrthoDB	EOG4H72B8.
PhylomeDB	Q969Z0.
Gene expression databases
ArrayExpress	Q969Z0.
Bgee	Q969Z0.
CleanEx	HS_TBRG4.
Genevestigator	Q969Z0.
Family and domain databases
InterPro	IPR013579. FAST_2. IPR010622. FAST_Leu-rich. IPR013584. RAP. [Graphical view]
Pfam	PF06743. FAST_1. 1 hit. PF08368. FAST_2. 1 hit. PF08373. RAP. 1 hit. [Graphical view]
SMART	SM00952. RAP. 1 hit. [Graphical view]
PROSITE	PS51286. RAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TBRG4. human.
GenomeRNAi	9238.
NextBio	34633.
SOURCE	Search...

Entry information

Entry name

TBRG4_HUMAN

Accession

Primary (citable) accession number: Q969Z0
Secondary accession number(s): A4D2L2 , A4D2L3, D3DVL5, D3DVL6, O14710, Q53GI8, Q8NDM4, Q9BUC6, Q9Y2F6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.