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Protein
Submitted name:

Delta-like 1 homolog (Drosophila)

Gene

DLK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Delta-like 1 homolog (Drosophila)Imported
Gene namesi
Name:DLK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei307 – 328HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501014767824 – 383Sequence analysisAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 54PROSITE-ProRule annotation
Disulfide bondi115 ↔ 124PROSITE-ProRule annotation
Disulfide bondi158 ↔ 167PROSITE-ProRule annotation
Disulfide bondi196 ↔ 205PROSITE-ProRule annotation
Disulfide bondi235 ↔ 244PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

IntActiQ969Y6. 1 interactor.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 55EGF-likeInterPro annotationAdd BLAST34
Domaini88 – 125EGF-likeInterPro annotationAdd BLAST38
Domaini127 – 168EGF-likeInterPro annotationAdd BLAST42
Domaini170 – 206EGF-likeInterPro annotationAdd BLAST37
Domaini208 – 245EGF-likeInterPro annotationAdd BLAST38

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOVERGENiHBG007065.

Family and domain databases

InterProiView protein in InterPro
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
PfamiView protein in Pfam
PF00008. EGF. 4 hits.
SMARTiView protein in SMART
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.

Sequencei

Sequence statusi: Complete.

Q969Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATEALLRV LLLLLAFGHS TYGAECFPAC NPQNGFCEDD NVCRCQPGWQ
60 70 80 90 100
GPLCDQCVTS PGCLHGLCGE PGQCICTDGW DGELCDRDVR ACSSAPCANN
110 120 130 140 150
GTCVSLDDGL YECSCAPGYS GKDCQKKDGP CVINGSPCQH GGTCVDDEGR
160 170 180 190 200
ASHASCLCPP GFSGNFCEIV ANSCTPNPCE NDGVCTDIGG DFRCRCPAGF
210 220 230 240 250
IDKTCSRPVT NCASSPCQNG GTCLQHTQVS YECLCKPEFT GLTCVKKRAL
260 270 280 290 300
SPQQVTRLPN GYGLAYRLTP GVHELPVQQP EHRILKVSMK ELNKKTPLLT
310 320 330 340 350
EGQAICFTIL GVLTSLVVLG TVGIVFLNKC ETWVSNLRYN HMLRKKKNLL
360 370 380
LQYNSGEDLA VNIIFPEKID MTTFSKEAGD EEI
Length:383
Mass (Da):41,228
Last modified:December 1, 2001 - v1
Checksum:i5158E6EF3516915A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007741 mRNA. Translation: AAH07741.1.
BC014015 mRNA. Translation: AAH14015.1.
UniGeneiHs.116631.
Hs.533717.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ969Y6_HUMAN
AccessioniPrimary (citable) accession number: Q969Y6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 5, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation