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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Gene

ST6GALNAC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)).2 Publications

Kineticsi

  1. KM=0.33 mM for GM1b1 Publication
  2. KM=0.46 mM for sialyl-Lc41 Publication

    GO - Molecular functioni

    GO - Biological processi

    • cell-cell recognition Source: BHF-UCL
    • ganglioside biosynthetic process Source: BHF-UCL
    • glycoprotein metabolic process Source: BHF-UCL
    • glycosphingolipid metabolic process Source: BHF-UCL
    • glycosylceramide metabolic process Source: BHF-UCL
    • oligosaccharide biosynthetic process Source: BHF-UCL
    • oligosaccharide metabolic process Source: GO_Central
    • protein N-linked glycosylation via asparagine Source: GO_Central
    Complete GO annotation...

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.99.7. 2681.
    ReactomeiR-HSA-4085001. Sialic acid metabolism.

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Chemistry

    SwissLipidsiSLP:000001366.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC:2.4.99.-)
    Alternative name(s):
    GalNAc alpha-2,6-sialyltransferase VI
    ST6GalNAc VI
    Short name:
    ST6GalNAcVI
    Short name:
    hST6GalNAc VI
    Sialyltransferase 7F
    Short name:
    SIAT7-F
    Gene namesi
    Name:ST6GALNAC6
    Synonyms:SIAT7F
    ORF Names:UNQ708/PRO1359
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:23364. ST6GALNAC6.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343CytoplasmicSequence analysisAdd
    BLAST
    Transmembranei44 – 6421Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
    BLAST
    Topological domaini65 – 333269LumenalSequence analysisAdd
    BLAST

    GO - Cellular componenti

    • cytoplasm Source: BHF-UCL
    • Golgi membrane Source: Reactome
    • integral component of membrane Source: ProtInc
    • plasma membrane Source: ProtInc
    Complete GO annotation...

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891331.

    Polymorphism and mutation databases

    DMDMi74751728.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6PRO_0000314795Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
    Disulfide bondi108 ↔ 256By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ969X2.
    PeptideAtlasiQ969X2.
    PRIDEiQ969X2.

    PTM databases

    iPTMnetiQ969X2.
    PhosphoSiteiQ969X2.

    Expressioni

    Tissue specificityi

    Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.2 Publications

    Inductioni

    Down-regulated in renal cancers.

    Gene expression databases

    BgeeiQ969X2.
    CleanExiHS_ST6GALNAC6.
    ExpressionAtlasiQ969X2. baseline and differential.
    GenevisibleiQ969X2. HS.

    Organism-specific databases

    HPAiHPA018890.

    Interactioni

    Protein-protein interaction databases

    BioGridi119039. 3 interactions.
    IntActiQ969X2. 2 interactions.
    MINTiMINT-2872718.
    STRINGi9606.ENSP00000291839.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969X2.
    SMRiQ969X2. Positions 76-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 334Poly-Arg
    Compositional biasi112 – 1154Poly-Ser

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG2692. Eukaryota.
    ENOG410XT8P. LUCA.
    GeneTreeiENSGT00550000074444.
    HOGENOMiHOG000293316.
    HOVERGENiHBG058710.
    InParanoidiQ969X2.
    KOiK03376.
    OMAiPARMQQF.
    OrthoDBiEOG78SQJV.
    PhylomeDBiQ969X2.
    TreeFamiTF323961.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q969X2-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MACSRPPSQC EPTSLPPGPP AGRRHLPLSR RRREMSSNKE QRSAVFVILF
    60 70 80 90 100
    ALITILILYS SNSANEVFHY GSLRGRSRRP VNLKKWSITD GYVPILGNKT
    110 120 130 140 150
    LPSRCHQCVI VSSSSHLLGT KLGPEIERAE CTIRMNDAPT TGYSADVGNK
    160 170 180 190 200
    TTYRVVAHSS VFRVLRRPQE FVNRTPETVF IFWGPPSKMQ KPQGSLVRVI
    210 220 230 240 250
    QRAGLVFPNM EAYAVSPGRM RQFDDLFRGE TGKDREKSHS WLSTGWFTMV
    260 270 280 290 300
    IAVELCDHVH VYGMVPPNYC SQRPRLQRMP YHYYEPKGPD ECVTYIQNEH
    310 320 330
    SRKGNHHRFI TEKRVFSSWA QLYGITFSHP SWT
    Length:333
    Mass (Da):38,068
    Last modified:December 1, 2001 - v1
    Checksum:i5DB6FFA7D7A707C0
    GO
    Isoform 2 (identifier: Q969X2-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-34: Missing.

    Show »
    Length:299
    Mass (Da):34,291
    Checksum:iF9DAFF04008A0C5F
    GO
    Isoform 3 (identifier: Q969X2-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         272-333: QRPRLQRMPY...GITFSHPSWT → GPASSACPTT...AGVSPSQSGP

    Show »
    Length:374
    Mass (Da):40,781
    Checksum:i04DCE408DBED314E
    GO

    Sequence cautioni

    The sequence CAI12610.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
    The sequence CAI12611.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
    The sequence EAW87712.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731L → M in BC036102 (PubMed:15489334).Curated
    Sequence conflicti174 – 1741R → Q in BC036102 (PubMed:15489334).Curated
    Sequence conflicti228 – 2281R → Q in BC036102 (PubMed:15489334).Curated
    Sequence conflicti249 – 2491M → T in BAB14715 (PubMed:12975309).Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3434Missing in isoform 2. 5 PublicationsVSP_030359Add
    BLAST
    Alternative sequencei272 – 33362QRPRL…HPSWT → GPASSACPTTTTSPRGRTNV SPTSRMSTVARATTTASSPR KGSSHRGPSCMASPSPTPPG PRPPSLWDLRRVRGEAASAQ PLGQGPSSGQSRLAGVSPSQ SGP in isoform 3. 1 PublicationVSP_055722Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ507293 mRNA. Translation: CAD45373.1.
    AB035173 mRNA. Translation: BAA87035.1.
    AY358672 mRNA. Translation: AAQ89035.1.
    AK023900 mRNA. Translation: BAB14715.1.
    AK057100 mRNA. Translation: BAG51863.1.
    CR457318 mRNA. Translation: CAG33599.1.
    AL157935 Genomic DNA. Translation: CAI12609.1.
    AL157935 Genomic DNA. Translation: CAI12610.1. Sequence problems.
    AL157935 Genomic DNA. Translation: CAI12611.1. Sequence problems.
    AL157935 Genomic DNA. Translation: CAI12612.1.
    CH471090 Genomic DNA. Translation: EAW87711.1.
    CH471090 Genomic DNA. Translation: EAW87712.1. Sequence problems.
    CH471090 Genomic DNA. Translation: EAW87714.1.
    BC006564 mRNA. Translation: AAH06564.1.
    BC007802 mRNA. Translation: AAH07802.1.
    BC016299 mRNA. Translation: AAH16299.1.
    BC036102 mRNA. No translation available.
    CCDSiCCDS6882.1. [Q969X2-1]
    CCDS69668.1. [Q969X2-2]
    CCDS69669.1. [Q969X2-3]
    RefSeqiNP_001273928.1. NM_001286999.1. [Q969X2-3]
    NP_001273929.1. NM_001287000.1. [Q969X2-2]
    NP_001273930.1. NM_001287001.1. [Q969X2-2]
    NP_001273931.1. NM_001287002.1. [Q969X2-2]
    NP_001273932.1. NM_001287003.1.
    NP_038471.2. NM_013443.4. [Q969X2-1]
    XP_011516912.1. XM_011518610.1. [Q969X2-1]
    XP_011516913.1. XM_011518611.1. [Q969X2-2]
    UniGeneiHs.109672.

    Genome annotation databases

    EnsembliENST00000291839; ENSP00000291839; ENSG00000160408. [Q969X2-1]
    ENST00000373141; ENSP00000362234; ENSG00000160408. [Q969X2-2]
    ENST00000373142; ENSP00000362235; ENSG00000160408. [Q969X2-3]
    ENST00000373144; ENSP00000362237; ENSG00000160408. [Q969X2-2]
    ENST00000373146; ENSP00000362239; ENSG00000160408. [Q969X2-1]
    ENST00000622357; ENSP00000477575; ENSG00000160408. [Q969X2-2]
    GeneIDi30815.
    KEGGihsa:30815.
    UCSCiuc004bsn.3. human. [Q969X2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    ST6GalNAc VI

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ507293 mRNA. Translation: CAD45373.1.
    AB035173 mRNA. Translation: BAA87035.1.
    AY358672 mRNA. Translation: AAQ89035.1.
    AK023900 mRNA. Translation: BAB14715.1.
    AK057100 mRNA. Translation: BAG51863.1.
    CR457318 mRNA. Translation: CAG33599.1.
    AL157935 Genomic DNA. Translation: CAI12609.1.
    AL157935 Genomic DNA. Translation: CAI12610.1. Sequence problems.
    AL157935 Genomic DNA. Translation: CAI12611.1. Sequence problems.
    AL157935 Genomic DNA. Translation: CAI12612.1.
    CH471090 Genomic DNA. Translation: EAW87711.1.
    CH471090 Genomic DNA. Translation: EAW87712.1. Sequence problems.
    CH471090 Genomic DNA. Translation: EAW87714.1.
    BC006564 mRNA. Translation: AAH06564.1.
    BC007802 mRNA. Translation: AAH07802.1.
    BC016299 mRNA. Translation: AAH16299.1.
    BC036102 mRNA. No translation available.
    CCDSiCCDS6882.1. [Q969X2-1]
    CCDS69668.1. [Q969X2-2]
    CCDS69669.1. [Q969X2-3]
    RefSeqiNP_001273928.1. NM_001286999.1. [Q969X2-3]
    NP_001273929.1. NM_001287000.1. [Q969X2-2]
    NP_001273930.1. NM_001287001.1. [Q969X2-2]
    NP_001273931.1. NM_001287002.1. [Q969X2-2]
    NP_001273932.1. NM_001287003.1.
    NP_038471.2. NM_013443.4. [Q969X2-1]
    XP_011516912.1. XM_011518610.1. [Q969X2-1]
    XP_011516913.1. XM_011518611.1. [Q969X2-2]
    UniGeneiHs.109672.

    3D structure databases

    ProteinModelPortaliQ969X2.
    SMRiQ969X2. Positions 76-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi119039. 3 interactions.
    IntActiQ969X2. 2 interactions.
    MINTiMINT-2872718.
    STRINGi9606.ENSP00000291839.

    Chemistry

    SwissLipidsiSLP:000001366.

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    PTM databases

    iPTMnetiQ969X2.
    PhosphoSiteiQ969X2.

    Polymorphism and mutation databases

    DMDMi74751728.

    Proteomic databases

    PaxDbiQ969X2.
    PeptideAtlasiQ969X2.
    PRIDEiQ969X2.

    Protocols and materials databases

    DNASUi30815.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000291839; ENSP00000291839; ENSG00000160408. [Q969X2-1]
    ENST00000373141; ENSP00000362234; ENSG00000160408. [Q969X2-2]
    ENST00000373142; ENSP00000362235; ENSG00000160408. [Q969X2-3]
    ENST00000373144; ENSP00000362237; ENSG00000160408. [Q969X2-2]
    ENST00000373146; ENSP00000362239; ENSG00000160408. [Q969X2-1]
    ENST00000622357; ENSP00000477575; ENSG00000160408. [Q969X2-2]
    GeneIDi30815.
    KEGGihsa:30815.
    UCSCiuc004bsn.3. human. [Q969X2-1]

    Organism-specific databases

    CTDi30815.
    GeneCardsiST6GALNAC6.
    H-InvDBHIX0008413.
    HGNCiHGNC:23364. ST6GALNAC6.
    HPAiHPA018890.
    MIMi610135. gene.
    neXtProtiNX_Q969X2.
    PharmGKBiPA134891331.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG2692. Eukaryota.
    ENOG410XT8P. LUCA.
    GeneTreeiENSGT00550000074444.
    HOGENOMiHOG000293316.
    HOVERGENiHBG058710.
    InParanoidiQ969X2.
    KOiK03376.
    OMAiPARMQQF.
    OrthoDBiEOG78SQJV.
    PhylomeDBiQ969X2.
    TreeFamiTF323961.

    Enzyme and pathway databases

    BRENDAi2.4.99.7. 2681.
    ReactomeiR-HSA-4085001. Sialic acid metabolism.

    Miscellaneous databases

    ChiTaRSiST6GALNAC6. human.
    GeneWikiiST6GALNAC6.
    GenomeRNAii30815.
    PROiQ969X2.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ969X2.
    CleanExiHS_ST6GALNAC6.
    ExpressionAtlasiQ969X2. baseline and differential.
    GenevisibleiQ969X2. HS.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides."
      Tsuchida A., Okajima T., Furukawa K., Ando T., Ishida H., Yoshida A., Nakamura Y., Kannagi R., Kiso M., Furukawa K.
      J. Biol. Chem. 278:22787-22794(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    2. "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
      Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
      Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Small intestine and Thyroid.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain and Muscle.
    9. "Identification of linkage-specific sequence motifs in sialyltransferases."
      Patel R.Y., Balaji P.V.
      Glycobiology 16:108-116(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    10. "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers."
      Senda M., Ito A., Tsuchida A., Hagiwara T., Kaneda T., Nakamura Y., Kasama K., Kiso M., Yoshikawa K., Katagiri Y., Ono Y., Ogiso M., Urano T., Furukawa K., Oshima S., Furukawa K.
      Biochem. J. 402:459-470(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    11. "Carbohydrate antigen sialyl Lewis a - its pathophysiological significance and induction mechanism in cancer progression."
      Kannagi R.
      Chang Gung Med. J. 30:189-209(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON SIALYL LEWIS ANTIGENS.

    Entry informationi

    Entry nameiSIA7F_HUMAN
    AccessioniPrimary (citable) accession number: Q969X2
    Secondary accession number(s): B3KQ01
    , Q5T9C4, Q5T9C5, Q9H8A2, Q9ULB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 1, 2001
    Last modified: July 6, 2016
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of circulating cancer cells to vascular endothelium (PubMed:17760270).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.