Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q969X1

- LFG3_HUMAN

UniProt

Q969X1 - LFG3_HUMAN

Protein

Protein lifeguard 3

Gene

TMBIM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.

    GO - Molecular functioni

    1. death receptor binding Source: UniProt

    GO - Biological processi

    1. negative regulation of establishment of protein localization to plasma membrane Source: UniProt
    2. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: UniProt
    3. negative regulation of Fas signaling pathway Source: UniProt
    4. negative regulation of metalloenzyme activity Source: UniProt
    5. positive regulation of blood vessel remodeling Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lifeguard 3
    Alternative name(s):
    Protein RECS1 homolog
    Transmembrane BAX inhibitor motif-containing protein 1
    Gene namesi
    Name:TMBIM1
    Synonyms:LFG3, RECS1
    ORF Names:PP1201, PSEC0158
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:23410. TMBIM1.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity. Lysosome membrane 1 Publication. Endosome membrane 1 Publication

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. Golgi apparatus Source: UniProt
    4. integral component of membrane Source: UniProtKB-KW
    5. lysosomal membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670804.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Protein lifeguard 3PRO_0000179090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei81 – 811PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ969X1.
    PaxDbiQ969X1.
    PRIDEiQ969X1.

    PTM databases

    PhosphoSiteiQ969X1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ969X1.
    BgeeiQ969X1.
    CleanExiHS_TMBIM1.
    GenevestigatoriQ969X1.

    Organism-specific databases

    HPAiHPA012093.

    Interactioni

    Protein-protein interaction databases

    BioGridi122070. 4 interactions.
    IntActiQ969X1. 6 interactions.
    STRINGi9606.ENSP00000258412.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969X1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BI1 family. LFG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0670.
    HOGENOMiHOG000060393.
    HOVERGENiHBG012084.
    InParanoidiQ969X1.
    KOiK06890.
    OMAiPGEWDDR.
    OrthoDBiEOG7VB2G8.
    PhylomeDBiQ969X1.
    TreeFamiTF319996.

    Family and domain databases

    InterProiIPR006214. Bax_inhibitor_1-related.
    [Graphical view]
    PANTHERiPTHR23291. PTHR23291. 1 hit.
    PfamiPF01027. Bax1-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q969X1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNPSAPPPY EDRNPLYPGP PPPGGYGQPS VLPGGYPAYP GYPQPGYGHP    50
    AGYPQPMPPT HPMPMNYGPG HGYDGEERAV SDSFGPGEWD DRKVRHTFIR 100
    KVYSIISVQL LITVAIIAIF TFVEPVSAFV RRNVAVYYVS YAVFVVTYLI 150
    LACCQGPRRR FPWNIILLTL FTFAMGFMTG TISSMYQTKA VIIAMIITAV 200
    VSISVTIFCF QTKVDFTSCT GLFCVLGIVL LVTGIVTSIV LYFQYVYWLH 250
    MLYAALGAIC FTLFLAYDTQ LVLGNRKHTI SPEDYITGAL QIYTDIIYIF 300
    TFVLQLMGDR N 311
    Length:311
    Mass (Da):34,607
    Last modified:March 7, 2006 - v2
    Checksum:i12B5741A60C1487F
    GO

    Sequence cautioni

    The sequence AAH26693.1 differs from that shown. Reason: Frameshift at position 6.
    The sequence BAB55346.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC11636.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191I → T in BAC04516. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211P → L.3 Publications
    Corresponds to variant rs2292553 [ dbSNP | Ensembl ].
    VAR_017382

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027755 mRNA. Translation: BAB55346.1. Different initiation.
    AK090618 mRNA. Translation: BAG52198.1.
    AK095270 mRNA. Translation: BAC04516.1. Sequence problems.
    AF193045 mRNA. Translation: AAG22473.1.
    AK075465 mRNA. Translation: BAC11636.1. Different initiation.
    CH471063 Genomic DNA. Translation: EAW70607.1.
    BC007980 mRNA. Translation: AAH07980.1.
    BC013428 mRNA. Translation: AAH13428.1.
    BC026348 mRNA. Translation: AAH26348.1.
    BC026693 mRNA. Translation: AAH26693.1. Frameshift.
    CCDSiCCDS2412.1.
    RefSeqiNP_071435.2. NM_022152.4.
    XP_005246815.1. XM_005246758.1.
    XP_005246818.1. XM_005246761.1.
    XP_005246819.1. XM_005246762.1.
    UniGeneiHs.591605.

    Genome annotation databases

    EnsembliENST00000258412; ENSP00000258412; ENSG00000135926.
    ENST00000396809; ENSP00000380025; ENSG00000135926.
    ENST00000444881; ENSP00000409738; ENSG00000135926.
    GeneIDi64114.
    KEGGihsa:64114.
    UCSCiuc002vho.1. human.

    Polymorphism databases

    DMDMi93117549.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027755 mRNA. Translation: BAB55346.1 . Different initiation.
    AK090618 mRNA. Translation: BAG52198.1 .
    AK095270 mRNA. Translation: BAC04516.1 . Sequence problems.
    AF193045 mRNA. Translation: AAG22473.1 .
    AK075465 mRNA. Translation: BAC11636.1 . Different initiation.
    CH471063 Genomic DNA. Translation: EAW70607.1 .
    BC007980 mRNA. Translation: AAH07980.1 .
    BC013428 mRNA. Translation: AAH13428.1 .
    BC026348 mRNA. Translation: AAH26348.1 .
    BC026693 mRNA. Translation: AAH26693.1 . Frameshift.
    CCDSi CCDS2412.1.
    RefSeqi NP_071435.2. NM_022152.4.
    XP_005246815.1. XM_005246758.1.
    XP_005246818.1. XM_005246761.1.
    XP_005246819.1. XM_005246762.1.
    UniGenei Hs.591605.

    3D structure databases

    ProteinModelPortali Q969X1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122070. 4 interactions.
    IntActi Q969X1. 6 interactions.
    STRINGi 9606.ENSP00000258412.

    PTM databases

    PhosphoSitei Q969X1.

    Polymorphism databases

    DMDMi 93117549.

    Proteomic databases

    MaxQBi Q969X1.
    PaxDbi Q969X1.
    PRIDEi Q969X1.

    Protocols and materials databases

    DNASUi 64114.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258412 ; ENSP00000258412 ; ENSG00000135926 .
    ENST00000396809 ; ENSP00000380025 ; ENSG00000135926 .
    ENST00000444881 ; ENSP00000409738 ; ENSG00000135926 .
    GeneIDi 64114.
    KEGGi hsa:64114.
    UCSCi uc002vho.1. human.

    Organism-specific databases

    CTDi 64114.
    GeneCardsi GC02M219139.
    HGNCi HGNC:23410. TMBIM1.
    HPAi HPA012093.
    MIMi 610364. gene.
    neXtProti NX_Q969X1.
    PharmGKBi PA142670804.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0670.
    HOGENOMi HOG000060393.
    HOVERGENi HBG012084.
    InParanoidi Q969X1.
    KOi K06890.
    OMAi PGEWDDR.
    OrthoDBi EOG7VB2G8.
    PhylomeDBi Q969X1.
    TreeFami TF319996.

    Miscellaneous databases

    GenomeRNAii 64114.
    NextBioi 65980.
    PROi Q969X1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969X1.
    Bgeei Q969X1.
    CleanExi HS_TMBIM1.
    Genevestigatori Q969X1.

    Family and domain databases

    InterProi IPR006214. Bax_inhibitor_1-related.
    [Graphical view ]
    PANTHERi PTHR23291. PTHR23291. 1 hit.
    Pfami PF01027. Bax1-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-21.
      Tissue: Placenta and Tongue.
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-21.
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-21.
      Tissue: Placenta.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Colon and Pancreas.
    6. "RECS1 deficiency in mice induces susceptibility to cystic medial degeneration."
      Zhao H., Ito A., Kimura S.H., Yabuta N., Sakai N., Ikawa M., Okabe M., Matsuzawa Y., Yamashita S., Nojima H.
      Genes Genet. Syst. 81:41-50(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    8. "LFG: a candidate apoptosis regulatory gene family."
      Hu L., Smith T.F., Goldberger G.
      Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiLFG3_HUMAN
    AccessioniPrimary (citable) accession number: Q969X1
    Secondary accession number(s): B3KQY6
    , Q8N1R3, Q8TAM3, Q96K13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3