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Q969X1 (LFG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein lifeguard 3
Alternative name(s):
Protein RECS1 homolog
Transmembrane BAX inhibitor motif-containing protein 1
Gene names
Name:TMBIM1
Synonyms:LFG3, RECS1
ORF Names:PP1201, PSEC0158
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Lysosome membrane. Endosome membrane Ref.6.

Sequence similarities

Belongs to the BI1 family. LFG subfamily.

Sequence caution

The sequence AAH26693.1 differs from that shown. Reason: Frameshift at position 6.

The sequence BAB55346.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC11636.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Protein lifeguard 3
PRO_0000179090

Regions

Transmembrane110 – 13021Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane246 – 26621Helical; Potential
Transmembrane286 – 30621Helical; Potential

Amino acid modifications

Modified residue811Phosphoserine By similarity

Natural variations

Natural variant211P → L. Ref.1 Ref.2 Ref.3
Corresponds to variant rs2292553 [ dbSNP | Ensembl ].
VAR_017382

Experimental info

Sequence conflict1191I → T in BAC04516. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q969X1 [UniParc].

Last modified March 7, 2006. Version 2.
Checksum: 12B5741A60C1487F

FASTA31134,607
        10         20         30         40         50         60 
MSNPSAPPPY EDRNPLYPGP PPPGGYGQPS VLPGGYPAYP GYPQPGYGHP AGYPQPMPPT 

        70         80         90        100        110        120 
HPMPMNYGPG HGYDGEERAV SDSFGPGEWD DRKVRHTFIR KVYSIISVQL LITVAIIAIF 

       130        140        150        160        170        180 
TFVEPVSAFV RRNVAVYYVS YAVFVVTYLI LACCQGPRRR FPWNIILLTL FTFAMGFMTG 

       190        200        210        220        230        240 
TISSMYQTKA VIIAMIITAV VSISVTIFCF QTKVDFTSCT GLFCVLGIVL LVTGIVTSIV 

       250        260        270        280        290        300 
LYFQYVYWLH MLYAALGAIC FTLFLAYDTQ LVLGNRKHTI SPEDYITGAL QIYTDIIYIF 

       310 
TFVLQLMGDR N 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-21.
Tissue: Placenta and Tongue.
[2]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-21.
[3]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-21.
Tissue: Placenta.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Colon and Pancreas.
[6]"RECS1 deficiency in mice induces susceptibility to cystic medial degeneration."
Zhao H., Ito A., Kimura S.H., Yabuta N., Sakai N., Ikawa M., Okabe M., Matsuzawa Y., Yamashita S., Nojima H.
Genes Genet. Syst. 81:41-50(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[8]"LFG: a candidate apoptosis regulatory gene family."
Hu L., Smith T.F., Goldberger G.
Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027755 mRNA. Translation: BAB55346.1. Different initiation.
AK090618 mRNA. Translation: BAG52198.1.
AK095270 mRNA. Translation: BAC04516.1. Sequence problems.
AF193045 mRNA. Translation: AAG22473.1.
AK075465 mRNA. Translation: BAC11636.1. Different initiation.
CH471063 Genomic DNA. Translation: EAW70607.1.
BC007980 mRNA. Translation: AAH07980.1.
BC013428 mRNA. Translation: AAH13428.1.
BC026348 mRNA. Translation: AAH26348.1.
BC026693 mRNA. Translation: AAH26693.1. Frameshift.
CCDSCCDS2412.1.
RefSeqNP_071435.2. NM_022152.4.
XP_005246815.1. XM_005246758.1.
XP_005246818.1. XM_005246761.1.
XP_005246819.1. XM_005246762.1.
UniGeneHs.591605.

3D structure databases

ProteinModelPortalQ969X1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122070. 4 interactions.
IntActQ969X1. 6 interactions.
STRING9606.ENSP00000258412.

PTM databases

PhosphoSiteQ969X1.

Polymorphism databases

DMDM93117549.

Proteomic databases

MaxQBQ969X1.
PaxDbQ969X1.
PRIDEQ969X1.

Protocols and materials databases

DNASU64114.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258412; ENSP00000258412; ENSG00000135926.
ENST00000396809; ENSP00000380025; ENSG00000135926.
ENST00000444881; ENSP00000409738; ENSG00000135926.
GeneID64114.
KEGGhsa:64114.
UCSCuc002vho.1. human.

Organism-specific databases

CTD64114.
GeneCardsGC02M219139.
HGNCHGNC:23410. TMBIM1.
HPAHPA012093.
MIM610364. gene.
neXtProtNX_Q969X1.
PharmGKBPA142670804.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0670.
HOGENOMHOG000060393.
HOVERGENHBG012084.
InParanoidQ969X1.
KOK06890.
OMAPGEWDDR.
OrthoDBEOG7VB2G8.
PhylomeDBQ969X1.
TreeFamTF319996.

Gene expression databases

ArrayExpressQ969X1.
BgeeQ969X1.
CleanExHS_TMBIM1.
GenevestigatorQ969X1.

Family and domain databases

InterProIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERPTHR23291. PTHR23291. 1 hit.
PfamPF01027. Bax1-I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi64114.
NextBio65980.
PROQ969X1.
SOURCESearch...

Entry information

Entry nameLFG3_HUMAN
AccessionPrimary (citable) accession number: Q969X1
Secondary accession number(s): B3KQY6 expand/collapse secondary AC list , Q8N1R3, Q8TAM3, Q96K13
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 7, 2006
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM