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Q969X1

- LFG3_HUMAN

UniProt

Q969X1 - LFG3_HUMAN

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Protein

Protein lifeguard 3

Gene
TMBIM1, LFG3, RECS1, PP1201, PSEC0158
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.

GO - Molecular functioni

  1. death receptor binding Source: UniProt

GO - Biological processi

  1. negative regulation of establishment of protein localization to plasma membrane Source: UniProt
  2. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: UniProt
  3. negative regulation of Fas signaling pathway Source: UniProt
  4. negative regulation of metalloenzyme activity Source: UniProt
  5. positive regulation of blood vessel remodeling Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 3
Alternative name(s):
Protein RECS1 homolog
Transmembrane BAX inhibitor motif-containing protein 1
Gene namesi
Name:TMBIM1
Synonyms:LFG3, RECS1
ORF Names:PP1201, PSEC0158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:23410. TMBIM1.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity. Lysosome membrane. Endosome membrane 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei110 – 13021Helical; Reviewed predictionAdd
BLAST
Transmembranei134 – 15421Helical; Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Reviewed predictionAdd
BLAST
Transmembranei190 – 21021Helical; Reviewed predictionAdd
BLAST
Transmembranei221 – 24121Helical; Reviewed predictionAdd
BLAST
Transmembranei246 – 26621Helical; Reviewed predictionAdd
BLAST
Transmembranei286 – 30621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. Golgi apparatus Source: UniProt
  4. integral component of membrane Source: UniProtKB-KW
  5. lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Protein lifeguard 3PRO_0000179090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ969X1.
PaxDbiQ969X1.
PRIDEiQ969X1.

PTM databases

PhosphoSiteiQ969X1.

Expressioni

Gene expression databases

ArrayExpressiQ969X1.
BgeeiQ969X1.
CleanExiHS_TMBIM1.
GenevestigatoriQ969X1.

Organism-specific databases

HPAiHPA012093.

Interactioni

Protein-protein interaction databases

BioGridi122070. 4 interactions.
IntActiQ969X1. 6 interactions.
STRINGi9606.ENSP00000258412.

Structurei

3D structure databases

ProteinModelPortaliQ969X1.

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ969X1.
KOiK06890.
OMAiPGEWDDR.
OrthoDBiEOG7VB2G8.
PhylomeDBiQ969X1.
TreeFamiTF319996.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969X1-1 [UniParc]FASTAAdd to Basket

« Hide

MSNPSAPPPY EDRNPLYPGP PPPGGYGQPS VLPGGYPAYP GYPQPGYGHP    50
AGYPQPMPPT HPMPMNYGPG HGYDGEERAV SDSFGPGEWD DRKVRHTFIR 100
KVYSIISVQL LITVAIIAIF TFVEPVSAFV RRNVAVYYVS YAVFVVTYLI 150
LACCQGPRRR FPWNIILLTL FTFAMGFMTG TISSMYQTKA VIIAMIITAV 200
VSISVTIFCF QTKVDFTSCT GLFCVLGIVL LVTGIVTSIV LYFQYVYWLH 250
MLYAALGAIC FTLFLAYDTQ LVLGNRKHTI SPEDYITGAL QIYTDIIYIF 300
TFVLQLMGDR N 311
Length:311
Mass (Da):34,607
Last modified:March 7, 2006 - v2
Checksum:i12B5741A60C1487F
GO

Sequence cautioni

The sequence AAH26693.1 differs from that shown. Reason: Frameshift at position 6.
The sequence BAB55346.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC11636.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211P → L.3 Publications
Corresponds to variant rs2292553 [ dbSNP | Ensembl ].
VAR_017382

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191I → T in BAC04516. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027755 mRNA. Translation: BAB55346.1. Different initiation.
AK090618 mRNA. Translation: BAG52198.1.
AK095270 mRNA. Translation: BAC04516.1. Sequence problems.
AF193045 mRNA. Translation: AAG22473.1.
AK075465 mRNA. Translation: BAC11636.1. Different initiation.
CH471063 Genomic DNA. Translation: EAW70607.1.
BC007980 mRNA. Translation: AAH07980.1.
BC013428 mRNA. Translation: AAH13428.1.
BC026348 mRNA. Translation: AAH26348.1.
BC026693 mRNA. Translation: AAH26693.1. Frameshift.
CCDSiCCDS2412.1.
RefSeqiNP_071435.2. NM_022152.4.
XP_005246815.1. XM_005246758.1.
XP_005246818.1. XM_005246761.1.
XP_005246819.1. XM_005246762.1.
UniGeneiHs.591605.

Genome annotation databases

EnsembliENST00000258412; ENSP00000258412; ENSG00000135926.
ENST00000396809; ENSP00000380025; ENSG00000135926.
ENST00000444881; ENSP00000409738; ENSG00000135926.
GeneIDi64114.
KEGGihsa:64114.
UCSCiuc002vho.1. human.

Polymorphism databases

DMDMi93117549.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027755 mRNA. Translation: BAB55346.1 . Different initiation.
AK090618 mRNA. Translation: BAG52198.1 .
AK095270 mRNA. Translation: BAC04516.1 . Sequence problems.
AF193045 mRNA. Translation: AAG22473.1 .
AK075465 mRNA. Translation: BAC11636.1 . Different initiation.
CH471063 Genomic DNA. Translation: EAW70607.1 .
BC007980 mRNA. Translation: AAH07980.1 .
BC013428 mRNA. Translation: AAH13428.1 .
BC026348 mRNA. Translation: AAH26348.1 .
BC026693 mRNA. Translation: AAH26693.1 . Frameshift.
CCDSi CCDS2412.1.
RefSeqi NP_071435.2. NM_022152.4.
XP_005246815.1. XM_005246758.1.
XP_005246818.1. XM_005246761.1.
XP_005246819.1. XM_005246762.1.
UniGenei Hs.591605.

3D structure databases

ProteinModelPortali Q969X1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122070. 4 interactions.
IntActi Q969X1. 6 interactions.
STRINGi 9606.ENSP00000258412.

PTM databases

PhosphoSitei Q969X1.

Polymorphism databases

DMDMi 93117549.

Proteomic databases

MaxQBi Q969X1.
PaxDbi Q969X1.
PRIDEi Q969X1.

Protocols and materials databases

DNASUi 64114.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258412 ; ENSP00000258412 ; ENSG00000135926 .
ENST00000396809 ; ENSP00000380025 ; ENSG00000135926 .
ENST00000444881 ; ENSP00000409738 ; ENSG00000135926 .
GeneIDi 64114.
KEGGi hsa:64114.
UCSCi uc002vho.1. human.

Organism-specific databases

CTDi 64114.
GeneCardsi GC02M219139.
HGNCi HGNC:23410. TMBIM1.
HPAi HPA012093.
MIMi 610364. gene.
neXtProti NX_Q969X1.
PharmGKBi PA142670804.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0670.
HOGENOMi HOG000060393.
HOVERGENi HBG012084.
InParanoidi Q969X1.
KOi K06890.
OMAi PGEWDDR.
OrthoDBi EOG7VB2G8.
PhylomeDBi Q969X1.
TreeFami TF319996.

Miscellaneous databases

GenomeRNAii 64114.
NextBioi 65980.
PROi Q969X1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q969X1.
Bgeei Q969X1.
CleanExi HS_TMBIM1.
Genevestigatori Q969X1.

Family and domain databases

InterProi IPR006214. Bax_inhibitor_1-related.
[Graphical view ]
PANTHERi PTHR23291. PTHR23291. 1 hit.
Pfami PF01027. Bax1-I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-21.
    Tissue: Placenta and Tongue.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-21.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-21.
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Colon and Pancreas.
  6. "RECS1 deficiency in mice induces susceptibility to cystic medial degeneration."
    Zhao H., Ito A., Kimura S.H., Yabuta N., Sakai N., Ikawa M., Okabe M., Matsuzawa Y., Yamashita S., Nojima H.
    Genes Genet. Syst. 81:41-50(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  8. "LFG: a candidate apoptosis regulatory gene family."
    Hu L., Smith T.F., Goldberger G.
    Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiLFG3_HUMAN
AccessioniPrimary (citable) accession number: Q969X1
Secondary accession number(s): B3KQY6
, Q8N1R3, Q8TAM3, Q96K13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 7, 2006
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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