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Protein

RILP-like protein 2

Gene

RILPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
RILP-like protein 2
Alternative name(s):
Rab-interacting lysosomal protein-like 2
p40phox-binding protein
Gene namesi
Name:RILPL2
Synonyms:RLP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000150977.10.
HGNCiHGNC:28787. RILPL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150977.
PharmGKBiPA162401325.

Polymorphism and mutation databases

BioMutaiRILPL2.
DMDMi74731067.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170051 – 211RILP-like protein 2Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ969X0.
MaxQBiQ969X0.
PaxDbiQ969X0.
PeptideAtlasiQ969X0.
PRIDEiQ969X0.
TopDownProteomicsiQ969X0.

PTM databases

iPTMnetiQ969X0.
PhosphoSitePlusiQ969X0.

Expressioni

Tissue specificityi

Widely expressed. Expressed at higher level in lung.1 Publication

Gene expression databases

BgeeiENSG00000150977.
CleanExiHS_RILPL2.
GenevisibleiQ969X0. HS.

Organism-specific databases

HPAiHPA028958.

Interactioni

Subunit structurei

Interacts with RAC1. Homodimer. Interacts (via N-terminus) with MYO5A, the interaction is required for its role in dendrite formation (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-717552,EBI-717552

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128200. 6 interactors.
IntActiQ969X0. 6 interactors.
MINTiMINT-1400379.
STRINGi9606.ENSP00000280571.

Structurei

3D structure databases

ProteinModelPortaliQ969X0.
SMRiQ969X0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 106RH1PROSITE-ProRule annotationAdd BLAST83
Domaini130 – 201RH2PROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 164Sequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 19Poly-GluAdd BLAST12

Sequence similaritiesi

Belongs to the RILPL family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFJ1. Eukaryota.
ENOG4111K48. LUCA.
GeneTreeiENSGT00530000063269.
HOGENOMiHOG000154130.
HOVERGENiHBG108409.
InParanoidiQ969X0.
OMAiLGPDKMV.
OrthoDBiEOG091G0TGK.
PhylomeDBiQ969X0.
TreeFamiTF313489.

Family and domain databases

InterProiView protein in InterPro
IPR034743. RH1.
IPR034744. RH2.
IPR021563. RILP_dimer.
PfamiView protein in Pfam
PF11461. RILP. 1 hit.
PROSITEiView protein in PROSITE
PS51776. RH1. 1 hit.
PS51777. RH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q969X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPPVREEE EEEGEEDEER DEVGPEGALG KSPFQLTAED VYDISYLLGR
60 70 80 90 100
ELMALGSDPR VTQLQFKVVR VLEMLEALVN EGSLALEELK MERDHLRKEV
110 120 130 140 150
EGLRRQSPPA SGEVNLGPNK MVVDLTDPNR PRFTLQELRD VLQERNKLKS
160 170 180 190 200
QLLVVQEELQ CYKSGLIPPR EGPGGRREKD AVVTSAKNAG RNKEEKTIIK
210
KLFFFRSGKQ T
Length:211
Mass (Da):23,986
Last modified:December 1, 2001 - v1
Checksum:i5F9C132B6E81DFDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085763 mRNA. Translation: BAC76826.1.
AK056934 mRNA. Translation: BAB71313.1.
CH471054 Genomic DNA. Translation: EAW98411.1.
BC013042 mRNA. Translation: AAH13042.1.
CCDSiCCDS9248.1.
RefSeqiNP_659495.1. NM_145058.2.
UniGeneiHs.488173.

Genome annotation databases

EnsembliENST00000280571; ENSP00000280571; ENSG00000150977.
GeneIDi196383.
KEGGihsa:196383.
UCSCiuc001uey.2. human.

Similar proteinsi

Entry informationi

Entry nameiRIPL2_HUMAN
AccessioniPrimary (citable) accession number: Q969X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families