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Protein

Zinc finger protein 566

Gene

ZNF566

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 193C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST113
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 566
Gene namesi
Name:ZNF566
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000186017.14.
HGNCiHGNC:25919. ZNF566.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186017.
PharmGKBiPA134977695.

Polymorphism and mutation databases

BioMutaiZNF566.
DMDMi55976754.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476561 – 418Zinc finger protein 566Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki314Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki328Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ969W8.
MaxQBiQ969W8.
PaxDbiQ969W8.
PeptideAtlasiQ969W8.
PRIDEiQ969W8.

PTM databases

iPTMnetiQ969W8.
PhosphoSitePlusiQ969W8.

Expressioni

Gene expression databases

BgeeiENSG00000186017.
CleanExiHS_ZNF566.
ExpressionAtlasiQ969W8. baseline and differential.
GenevisibleiQ969W8. HS.

Organism-specific databases

HPAiHPA023456.

Interactioni

Protein-protein interaction databases

BioGridi124359. 5 interactors.
IntActiQ969W8. 3 interactors.
STRINGi9606.ENSP00000376010.

Structurei

3D structure databases

ProteinModelPortaliQ969W8.
SMRiQ969W8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 193C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST113
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ969W8.
KOiK09228.
OMAiTRGQWPV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ969W8.
TreeFamiTF338743.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQESVMFSD VSVDFSQEEW ECLNDDQRDL YRDVMLENYS NLVSMGHSIS
60 70 80 90 100
KPNVISYLEQ GKEPWLADRE LTRGQWPVLE SRCETKKLFL KKEIYEIEST
110 120 130 140 150
QWEIMEKLTR RDFQCSSFRD DWECNRQFKK ELGSQGGHFN QLVFTHEDLP
160 170 180 190 200
TLSHHPSFTL QQIINSKKKF CASKEYRKTF RHGSQFATHE IIHTIEKPYE
210 220 230 240 250
CKECGKSFRH PSRLTHHQKI HTGKKPFECK ECGKTFICGS DLTRHHRIHT
260 270 280 290 300
GEKPYECKEC GKAFSSGSNF TRHQRIHTGE KPYECKECGK AFSSGSNFTQ
310 320 330 340 350
HQRIHTGEKP YECKECGNAF SQSSQLIKHQ RIHTGEKPYE CKECEKAFRS
360 370 380 390 400
GSDLTRHQRI HTGEKPYECK ICGKAYSQSS QLISHHRIHT SEKPYEYREC
410
GKNFNYDPQL IQHQNLYW
Length:418
Mass (Da):49,219
Last modified:December 1, 2001 - v1
Checksum:i619047F0565141C2
GO
Isoform 2 (identifier: Q969W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-45: M → MA

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):49,290
Checksum:iD243A398597A2634
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04341945M → MA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027685 mRNA. Translation: BAB55296.1.
AC092295 Genomic DNA. No translation available.
AC092296 Genomic DNA. No translation available.
BC007064 mRNA. Translation: AAH07064.1.
BC104886 mRNA. Translation: AAI04887.1.
BC104888 mRNA. Translation: AAI04889.1.
BC143658 mRNA. Translation: AAI43659.1.
CCDSiCCDS12494.1. [Q969W8-1]
CCDS46061.1. [Q969W8-2]
RefSeqiNP_001138815.1. NM_001145343.1. [Q969W8-2]
NP_001138816.1. NM_001145344.1. [Q969W8-1]
NP_001138817.1. NM_001145345.1. [Q969W8-1]
NP_001287899.1. NM_001300970.1.
NP_116227.1. NM_032838.4. [Q969W8-1]
XP_006723510.1. XM_006723447.2. [Q969W8-2]
UniGeneiHs.533939.

Genome annotation databases

EnsembliENST00000392170; ENSP00000376010; ENSG00000186017. [Q969W8-2]
ENST00000424129; ENSP00000401259; ENSG00000186017. [Q969W8-1]
ENST00000434377; ENSP00000415520; ENSG00000186017. [Q969W8-1]
GeneIDi84924.
KEGGihsa:84924.
UCSCiuc002oea.4. human. [Q969W8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN566_HUMAN
AccessioniPrimary (citable) accession number: Q969W8
Secondary accession number(s): B7ZL95, Q2M3J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families