ID   VCF1_HUMAN              Reviewed;         186 AA.
AC   Q969W3; B4E339;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   27-MAR-2024, entry version 137.
DE   RecName: Full=Protein VCF1;
DE   AltName: Full=VCP nuclear cofactor family member 1 {ECO:0000312|HGNC:HGNC:25918};
GN   Name=VCF1 {ECO:0000312|HGNC:HGNC:25918}; Synonyms=FAM104A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Teratocarcinoma, and Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-186 (ISOFORM 1).
RC   TISSUE=Brain, and Rhabdomyosarcoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 57-186 (ISOFORM 2).
RX   PubMed=9417904; DOI=10.1006/geno.1997.5044;
RA   Reddy P.H., Stockburger E., Gillevet P., Tagle D.A.;
RT   "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human
RT   brain derived by the oligo capture method.";
RL   Genomics 46:174-182(1997).
RN   [6]
RP   METHYLATION [LARGE SCALE ANALYSIS] AT ARG-4, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Colon carcinoma;
RX   PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA   Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA   Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
CC   -!- INTERACTION:
CC       Q969W3; P17612: PRKACA; NbExp=3; IntAct=EBI-10281506, EBI-476586;
CC       Q969W3; P50454: SERPINH1; NbExp=3; IntAct=EBI-10281506, EBI-350723;
CC       Q969W3; P37173: TGFBR2; NbExp=3; IntAct=EBI-10281506, EBI-296151;
CC       Q969W3; Q14CS0: UBXN2B; NbExp=3; IntAct=EBI-10281506, EBI-1993619;
CC       Q969W3; P55072: VCP; NbExp=9; IntAct=EBI-10281506, EBI-355164;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q969W3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q969W3-2; Sequence=VSP_039868;
CC   -!- SIMILARITY: Belongs to the VCF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH11054.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH25238.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB55292.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC11183.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK027681; BAB55292.1; ALT_INIT; mRNA.
DR   EMBL; AK074755; BAC11183.1; ALT_INIT; mRNA.
DR   EMBL; AK304556; BAG65351.1; -; mRNA.
DR   EMBL; AC097641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471099; EAW89116.1; -; Genomic_DNA.
DR   EMBL; BC011054; AAH11054.1; ALT_INIT; mRNA.
DR   EMBL; BC025238; AAH25238.1; ALT_INIT; mRNA.
DR   EMBL; U92989; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS11693.2; -. [Q969W3-1]
DR   CCDS; CCDS45766.1; -. [Q969W3-2]
DR   RefSeq; NP_001092302.1; NM_001098832.1. [Q969W3-2]
DR   RefSeq; NP_001276339.1; NM_001289410.1.
DR   RefSeq; NP_001276340.1; NM_001289411.1.
DR   RefSeq; NP_001276341.1; NM_001289412.1.
DR   RefSeq; NP_116226.2; NM_032837.2. [Q969W3-1]
DR   AlphaFoldDB; Q969W3; -.
DR   BioGRID; 124358; 6.
DR   IntAct; Q969W3; 6.
DR   STRING; 9606.ENSP00000384832; -.
DR   iPTMnet; Q969W3; -.
DR   PhosphoSitePlus; Q969W3; -.
DR   BioMuta; FAM104A; -.
DR   DMDM; 308153443; -.
DR   EPD; Q969W3; -.
DR   jPOST; Q969W3; -.
DR   MassIVE; Q969W3; -.
DR   MaxQB; Q969W3; -.
DR   PeptideAtlas; Q969W3; -.
DR   ProteomicsDB; 75860; -. [Q969W3-1]
DR   ProteomicsDB; 75861; -. [Q969W3-2]
DR   Pumba; Q969W3; -.
DR   Antibodypedia; 19372; 21 antibodies from 6 providers.
DR   DNASU; 84923; -.
DR   Ensembl; ENST00000403627.7; ENSP00000384648.3; ENSG00000133193.13. [Q969W3-1]
DR   Ensembl; ENST00000405159.8; ENSP00000384832.3; ENSG00000133193.13. [Q969W3-2]
DR   GeneID; 84923; -.
DR   KEGG; hsa:84923; -.
DR   MANE-Select; ENST00000405159.8; ENSP00000384832.3; NM_001098832.2; NP_001092302.1. [Q969W3-2]
DR   UCSC; uc002jji.5; human. [Q969W3-1]
DR   AGR; HGNC:25918; -.
DR   CTD; 84923; -.
DR   DisGeNET; 84923; -.
DR   GeneCards; VCF1; -.
DR   HGNC; HGNC:25918; VCF1.
DR   HPA; ENSG00000133193; Tissue enhanced (testis).
DR   neXtProt; NX_Q969W3; -.
DR   OpenTargets; ENSG00000133193; -.
DR   PharmGKB; PA142671787; -.
DR   VEuPathDB; HostDB:ENSG00000133193; -.
DR   GeneTree; ENSGT00940000163640; -.
DR   HOGENOM; CLU_117251_0_0_1; -.
DR   InParanoid; Q969W3; -.
DR   OMA; AVFQDSW; -.
DR   OrthoDB; 4237107at2759; -.
DR   PhylomeDB; Q969W3; -.
DR   TreeFam; TF335777; -.
DR   PathwayCommons; Q969W3; -.
DR   SignaLink; Q969W3; -.
DR   BioGRID-ORCS; 84923; 28 hits in 1166 CRISPR screens.
DR   ChiTaRS; FAM104A; human.
DR   GenomeRNAi; 84923; -.
DR   Pharos; Q969W3; Tdark.
DR   PRO; PR:Q969W3; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q969W3; Protein.
DR   Bgee; ENSG00000133193; Expressed in sperm and 188 other cell types or tissues.
DR   ExpressionAtlas; Q969W3; baseline and differential.
DR   InterPro; IPR029222; FAM104.
DR   PANTHER; PTHR34763; PROTEIN FAM104A; 1.
DR   PANTHER; PTHR34763:SF1; PROTEIN FAM104A; 1.
DR   Pfam; PF15434; FAM104; 1.
DR   Genevisible; Q969W3; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Methylation; Reference proteome.
FT   CHAIN           1..186
FT                   /note="Protein VCF1"
FT                   /id="PRO_0000236182"
FT   REGION          1..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..155
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         4
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0007744|PubMed:24129315"
FT   VAR_SEQ         107
FT                   /note="E -> ETVPVMRNSKENRLRGNKAFCA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:9417904"
FT                   /id="VSP_039868"
SQ   SEQUENCE   186 AA;  19484 MW;  BE96E7F6BC18DEB4 CRC64;
     MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV PSLRGAAPRS
     FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF QDSWDTESSG SDSGGSSSSS
     SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ PVPEQSALCQ GLYFHINQTL REAHFHSLQH
     RGRPLT
//