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Q969W3 (F104A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM104A
Gene names
Name:FAM104A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM104 family.

Sequence caution

The sequence AAH11054.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH25238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB55292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC11183.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q969W3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q969W3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: E → ETVPVMRNSKENRLRGNKAFCA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186Protein FAM104A
PRO_0000236182

Regions

Compositional bias94 – 14552Ser-rich

Natural variations

Alternative sequence1071E → ETVPVMRNSKENRLRGNKAF CA in isoform 2.
VSP_039868

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: BE96E7F6BC18DEB4

FASTA18619,484
        10         20         30         40         50         60 
MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV PSLRGAAPRS 

        70         80         90        100        110        120 
FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF QDSWDTESSG SDSGGSSSSS 

       130        140        150        160        170        180 
SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ PVPEQSALCQ GLYFHINQTL REAHFHSLQH 


RGRPLT 

« Hide

Isoform 2 [UniParc].

Checksum: 76275AFA9982B1B6
Show »

FASTA20721,858

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Teratocarcinoma and Uterus.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-186 (ISOFORM 1).
Tissue: Brain and Rhabdomyosarcoma.
[5]"Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method."
Reddy P.H., Stockburger E., Gillevet P., Tagle D.A.
Genomics 46:174-182(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-186 (ISOFORM 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027681 mRNA. Translation: BAB55292.1. Different initiation.
AK074755 mRNA. Translation: BAC11183.1. Different initiation.
AK304556 mRNA. Translation: BAG65351.1.
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89116.1.
BC011054 mRNA. Translation: AAH11054.1. Different initiation.
BC025238 mRNA. Translation: AAH25238.1. Different initiation.
U92989 mRNA. No translation available.
CCDSCCDS11693.2. [Q969W3-1]
CCDS45766.1. [Q969W3-2]
RefSeqNP_001092302.1. NM_001098832.1. [Q969W3-2]
NP_001276339.1. NM_001289410.1.
NP_001276340.1. NM_001289411.1.
NP_001276341.1. NM_001289412.1.
NP_116226.2. NM_032837.2. [Q969W3-1]
UniGeneHs.741276.

3D structure databases

ProteinModelPortalQ969W3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124358. 1 interaction.

PTM databases

PhosphoSiteQ969W3.

Polymorphism databases

DMDM308153443.

Proteomic databases

MaxQBQ969W3.
PaxDbQ969W3.
PRIDEQ969W3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000403627; ENSP00000384648; ENSG00000133193. [Q969W3-1]
ENST00000405159; ENSP00000384832; ENSG00000133193. [Q969W3-2]
GeneID84923.
KEGGhsa:84923.
UCSCuc002jji.4. human. [Q969W3-1]
uc002jjj.4. human. [Q969W3-2]

Organism-specific databases

CTD84923.
GeneCardsGC17M071203.
H-InvDBHIX0014136.
HIX0019625.
HGNCHGNC:25918. FAM104A.
HPAHPA021459.
HPA056782.
neXtProtNX_Q969W3.
PharmGKBPA142671787.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47228.
HOGENOMHOG000231053.
HOVERGENHBG059882.
OMAKSECTEI.
PhylomeDBQ969W3.
TreeFamTF335777.

Gene expression databases

ArrayExpressQ969W3.
BgeeQ969W3.
CleanExHS_FAM104A.
GenevestigatorQ969W3.

Family and domain databases

InterProIPR029222. FAM104.
[Graphical view]
PfamPF15434. FAM104. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAM104A. human.
GenomeRNAi84923.
NextBio75336.
PROQ969W3.

Entry information

Entry nameF104A_HUMAN
AccessionPrimary (citable) accession number: Q969W3
Secondary accession number(s): B4E339
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM