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Q969W3

- F104A_HUMAN

UniProt

Q969W3 - F104A_HUMAN

Protein

Protein FAM104A

Gene

FAM104A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM104A
    Gene namesi
    Name:FAM104A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:25918. FAM104A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671787.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186Protein FAM104APRO_0000236182Add
    BLAST

    Proteomic databases

    MaxQBiQ969W3.
    PaxDbiQ969W3.
    PRIDEiQ969W3.

    PTM databases

    PhosphoSiteiQ969W3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ969W3.
    BgeeiQ969W3.
    CleanExiHS_FAM104A.
    GenevestigatoriQ969W3.

    Organism-specific databases

    HPAiHPA021459.
    HPA056782.

    Interactioni

    Protein-protein interaction databases

    BioGridi124358. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969W3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi94 – 14552Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAM104 family.Curated

    Phylogenomic databases

    eggNOGiNOG47228.
    HOGENOMiHOG000231053.
    HOVERGENiHBG059882.
    OMAiKSECTEI.
    PhylomeDBiQ969W3.
    TreeFamiTF335777.

    Family and domain databases

    InterProiIPR029222. FAM104.
    [Graphical view]
    PfamiPF15434. FAM104. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969W3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV    50
    PSLRGAAPRS FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF 100
    QDSWDTESSG SDSGGSSSSS SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ 150
    PVPEQSALCQ GLYFHINQTL REAHFHSLQH RGRPLT 186
    Length:186
    Mass (Da):19,484
    Last modified:October 5, 2010 - v2
    Checksum:iBE96E7F6BC18DEB4
    GO
    Isoform 2 (identifier: Q969W3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         107-107: E → ETVPVMRNSKENRLRGNKAFCA

    Show »
    Length:207
    Mass (Da):21,858
    Checksum:i76275AFA9982B1B6
    GO

    Sequence cautioni

    The sequence AAH11054.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH25238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB55292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC11183.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei107 – 1071E → ETVPVMRNSKENRLRGNKAF CA in isoform 2. 1 PublicationVSP_039868

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027681 mRNA. Translation: BAB55292.1. Different initiation.
    AK074755 mRNA. Translation: BAC11183.1. Different initiation.
    AK304556 mRNA. Translation: BAG65351.1.
    AC097641 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89116.1.
    BC011054 mRNA. Translation: AAH11054.1. Different initiation.
    BC025238 mRNA. Translation: AAH25238.1. Different initiation.
    U92989 mRNA. No translation available.
    CCDSiCCDS11693.2. [Q969W3-1]
    CCDS45766.1. [Q969W3-2]
    RefSeqiNP_001092302.1. NM_001098832.1. [Q969W3-2]
    NP_001276339.1. NM_001289410.1.
    NP_001276340.1. NM_001289411.1.
    NP_001276341.1. NM_001289412.1.
    NP_116226.2. NM_032837.2. [Q969W3-1]
    UniGeneiHs.741276.

    Genome annotation databases

    EnsembliENST00000403627; ENSP00000384648; ENSG00000133193. [Q969W3-1]
    ENST00000405159; ENSP00000384832; ENSG00000133193. [Q969W3-2]
    GeneIDi84923.
    KEGGihsa:84923.
    UCSCiuc002jji.4. human. [Q969W3-1]
    uc002jjj.4. human. [Q969W3-2]

    Polymorphism databases

    DMDMi308153443.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027681 mRNA. Translation: BAB55292.1 . Different initiation.
    AK074755 mRNA. Translation: BAC11183.1 . Different initiation.
    AK304556 mRNA. Translation: BAG65351.1 .
    AC097641 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89116.1 .
    BC011054 mRNA. Translation: AAH11054.1 . Different initiation.
    BC025238 mRNA. Translation: AAH25238.1 . Different initiation.
    U92989 mRNA. No translation available.
    CCDSi CCDS11693.2. [Q969W3-1 ]
    CCDS45766.1. [Q969W3-2 ]
    RefSeqi NP_001092302.1. NM_001098832.1. [Q969W3-2 ]
    NP_001276339.1. NM_001289410.1.
    NP_001276340.1. NM_001289411.1.
    NP_001276341.1. NM_001289412.1.
    NP_116226.2. NM_032837.2. [Q969W3-1 ]
    UniGenei Hs.741276.

    3D structure databases

    ProteinModelPortali Q969W3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124358. 1 interaction.

    PTM databases

    PhosphoSitei Q969W3.

    Polymorphism databases

    DMDMi 308153443.

    Proteomic databases

    MaxQBi Q969W3.
    PaxDbi Q969W3.
    PRIDEi Q969W3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000403627 ; ENSP00000384648 ; ENSG00000133193 . [Q969W3-1 ]
    ENST00000405159 ; ENSP00000384832 ; ENSG00000133193 . [Q969W3-2 ]
    GeneIDi 84923.
    KEGGi hsa:84923.
    UCSCi uc002jji.4. human. [Q969W3-1 ]
    uc002jjj.4. human. [Q969W3-2 ]

    Organism-specific databases

    CTDi 84923.
    GeneCardsi GC17M071203.
    H-InvDB HIX0014136.
    HIX0019625.
    HGNCi HGNC:25918. FAM104A.
    HPAi HPA021459.
    HPA056782.
    neXtProti NX_Q969W3.
    PharmGKBi PA142671787.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47228.
    HOGENOMi HOG000231053.
    HOVERGENi HBG059882.
    OMAi KSECTEI.
    PhylomeDBi Q969W3.
    TreeFami TF335777.

    Miscellaneous databases

    ChiTaRSi FAM104A. human.
    GenomeRNAii 84923.
    NextBioi 75336.
    PROi Q969W3.

    Gene expression databases

    ArrayExpressi Q969W3.
    Bgeei Q969W3.
    CleanExi HS_FAM104A.
    Genevestigatori Q969W3.

    Family and domain databases

    InterProi IPR029222. FAM104.
    [Graphical view ]
    Pfami PF15434. FAM104. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma and Uterus.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-186 (ISOFORM 1).
      Tissue: Brain and Rhabdomyosarcoma.
    5. "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method."
      Reddy P.H., Stockburger E., Gillevet P., Tagle D.A.
      Genomics 46:174-182(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-186 (ISOFORM 2).

    Entry informationi

    Entry nameiF104A_HUMAN
    AccessioniPrimary (citable) accession number: Q969W3
    Secondary accession number(s): B4E339
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3