Q969W3 (F104A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM104A

Gene names

Name:

FAM104A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM104 family.

Sequence caution

The sequence AAH11054.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH25238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB55292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC11183.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q969W3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q969W3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: E → ETVPVMRNSKENRLRGNKAFCA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Protein FAM104A		PRO_0000236182
Regions
	Compositional bias	94 – 145	52	Ser-rich
Natural variations
	Alternative sequence	107	1	E → ETVPVMRNSKENRLRGNKAF CA in isoform 2.		VSP_039868

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: BE96E7F6BC18DEB4	FASTA	186	19,484
	10 20 30 40 50 60 MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV PSLRGAAPRS 70 80 90 100 110 120 FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF QDSWDTESSG SDSGGSSSSS 130 140 150 160 170 180 SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ PVPEQSALCQ GLYFHINQTL REAHFHSLQH RGRPLT
	Isoform 2 [UniParc]. Checksum: 76275AFA9982B1B6	FASTA	207	21,858
	10 20 30 40 50 60 MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV PSLRGAAPRS 70 80 90 100 110 120 FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF QDSWDTETVP VMRNSKENRL 130 140 150 160 170 180 RGNKAFCASS GSDSGGSSSS SSSSINSPDR ASGPEGSLSQ TMAGSSPNTP QPVPEQSALC 190 200 QGLYFHINQT LREAHFHSLQ HRGRPLT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Teratocarcinoma and Uterus.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-186 (ISOFORM 1). Tissue: Brain and Rhabdomyosarcoma.
[5]	"Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method." Reddy P.H., Stockburger E., Gillevet P., Tagle D.A. Genomics 46:174-182(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-186 (ISOFORM 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK027681 mRNA. Translation: BAB55292.1. Different initiation. AK074755 mRNA. Translation: BAC11183.1. Different initiation. AK304556 mRNA. Translation: BAG65351.1. AC097641 Genomic DNA. No translation available. CH471099 Genomic DNA. Translation: EAW89116.1. BC011054 mRNA. Translation: AAH11054.1. Different initiation. BC025238 mRNA. Translation: AAH25238.1. Different initiation. U92989 mRNA. No translation available.
IPI	IPI00792344. IPI00879757.
RefSeq	NP_001092302.1. NM_001098832.1. NP_116226.2. NM_032837.2.
UniGene	Hs.741276.
3D structure databases
ProteinModelPortal	Q969W3.
ModBase	Search...
PTM databases
PhosphoSite	Q969W3.
Polymorphism databases
DMDM	308153443.
Proteomic databases
PaxDb	Q969W3.
PRIDE	Q969W3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000403627; ENSP00000384648; ENSG00000133193. ENST00000405159; ENSP00000384832; ENSG00000133193.
GeneID	84923.
KEGG	hsa:84923.
UCSC	uc002jji.4. human. uc002jjj.4. human.
Organism-specific databases
CTD	84923.
GeneCards	GC17M071203.
H-InvDB	HIX0014136. HIX0019625.
HGNC	HGNC:25918. FAM104A.
HPA	HPA021459.
neXtProt	NX_Q969W3.
PharmGKB	PA142671787.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47228.
HOGENOM	HOG000231053.
HOVERGEN	HBG059882.
OMA	WDTETVP.
Gene expression databases
Bgee	Q969W3.
CleanEx	HS_FAM104A.
Genevestigator	Q969W3.
GermOnline	ENSG00000133193. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	FAM104A. human.
GenomeRNAi	84923.
NextBio	75336.

Entry information

Entry name

F104A_HUMAN

Accession

Primary (citable) accession number: Q969W3
Secondary accession number(s): B4E339

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	October 5, 2010
Last modified:	April 3, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.