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Protein

Protein FAM104A

Gene

FAM104A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM104A
Gene namesi
Name:FAM104A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25918. FAM104A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Protein FAM104APRO_0000236182Add
BLAST

Proteomic databases

MaxQBiQ969W3.
PaxDbiQ969W3.
PRIDEiQ969W3.

PTM databases

PhosphoSiteiQ969W3.

Expressioni

Gene expression databases

BgeeiQ969W3.
CleanExiHS_FAM104A.
ExpressionAtlasiQ969W3. baseline and differential.
GenevestigatoriQ969W3.

Organism-specific databases

HPAiHPA021459.
HPA056782.

Interactioni

Protein-protein interaction databases

BioGridi124358. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ969W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi94 – 14552Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM104 family.Curated

Phylogenomic databases

eggNOGiNOG47228.
GeneTreeiENSGT00390000001055.
HOGENOMiHOG000231053.
HOVERGENiHBG059882.
InParanoidiQ969W3.
OMAiNKVFCAS.
PhylomeDBiQ969W3.
TreeFamiTF335777.

Family and domain databases

InterProiIPR029222. FAM104.
[Graphical view]
PfamiPF15434. FAM104. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969W3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV
60 70 80 90 100
PSLRGAAPRS FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF
110 120 130 140 150
QDSWDTESSG SDSGGSSSSS SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ
160 170 180
PVPEQSALCQ GLYFHINQTL REAHFHSLQH RGRPLT
Length:186
Mass (Da):19,484
Last modified:October 5, 2010 - v2
Checksum:iBE96E7F6BC18DEB4
GO
Isoform 2 (identifier: Q969W3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: E → ETVPVMRNSKENRLRGNKAFCA

Show »
Length:207
Mass (Da):21,858
Checksum:i76275AFA9982B1B6
GO

Sequence cautioni

The sequence AAH11054.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH25238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11183.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei107 – 1071E → ETVPVMRNSKENRLRGNKAF CA in isoform 2. 1 PublicationVSP_039868

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027681 mRNA. Translation: BAB55292.1. Different initiation.
AK074755 mRNA. Translation: BAC11183.1. Different initiation.
AK304556 mRNA. Translation: BAG65351.1.
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89116.1.
BC011054 mRNA. Translation: AAH11054.1. Different initiation.
BC025238 mRNA. Translation: AAH25238.1. Different initiation.
U92989 mRNA. No translation available.
CCDSiCCDS11693.2. [Q969W3-1]
CCDS45766.1. [Q969W3-2]
RefSeqiNP_001092302.1. NM_001098832.1. [Q969W3-2]
NP_001276339.1. NM_001289410.1.
NP_001276340.1. NM_001289411.1.
NP_001276341.1. NM_001289412.1.
NP_116226.2. NM_032837.2. [Q969W3-1]
UniGeneiHs.741276.

Genome annotation databases

EnsembliENST00000403627; ENSP00000384648; ENSG00000133193. [Q969W3-1]
ENST00000405159; ENSP00000384832; ENSG00000133193. [Q969W3-2]
GeneIDi84923.
KEGGihsa:84923.
UCSCiuc002jji.4. human. [Q969W3-1]
uc002jjj.4. human. [Q969W3-2]

Polymorphism databases

DMDMi308153443.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027681 mRNA. Translation: BAB55292.1. Different initiation.
AK074755 mRNA. Translation: BAC11183.1. Different initiation.
AK304556 mRNA. Translation: BAG65351.1.
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89116.1.
BC011054 mRNA. Translation: AAH11054.1. Different initiation.
BC025238 mRNA. Translation: AAH25238.1. Different initiation.
U92989 mRNA. No translation available.
CCDSiCCDS11693.2. [Q969W3-1]
CCDS45766.1. [Q969W3-2]
RefSeqiNP_001092302.1. NM_001098832.1. [Q969W3-2]
NP_001276339.1. NM_001289410.1.
NP_001276340.1. NM_001289411.1.
NP_001276341.1. NM_001289412.1.
NP_116226.2. NM_032837.2. [Q969W3-1]
UniGeneiHs.741276.

3D structure databases

ProteinModelPortaliQ969W3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124358. 5 interactions.

PTM databases

PhosphoSiteiQ969W3.

Polymorphism databases

DMDMi308153443.

Proteomic databases

MaxQBiQ969W3.
PaxDbiQ969W3.
PRIDEiQ969W3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403627; ENSP00000384648; ENSG00000133193. [Q969W3-1]
ENST00000405159; ENSP00000384832; ENSG00000133193. [Q969W3-2]
GeneIDi84923.
KEGGihsa:84923.
UCSCiuc002jji.4. human. [Q969W3-1]
uc002jjj.4. human. [Q969W3-2]

Organism-specific databases

CTDi84923.
GeneCardsiGC17M071203.
H-InvDBHIX0014136.
HIX0019625.
HGNCiHGNC:25918. FAM104A.
HPAiHPA021459.
HPA056782.
neXtProtiNX_Q969W3.
PharmGKBiPA142671787.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47228.
GeneTreeiENSGT00390000001055.
HOGENOMiHOG000231053.
HOVERGENiHBG059882.
InParanoidiQ969W3.
OMAiNKVFCAS.
PhylomeDBiQ969W3.
TreeFamiTF335777.

Miscellaneous databases

ChiTaRSiFAM104A. human.
GenomeRNAii84923.
NextBioi75336.
PROiQ969W3.

Gene expression databases

BgeeiQ969W3.
CleanExiHS_FAM104A.
ExpressionAtlasiQ969W3. baseline and differential.
GenevestigatoriQ969W3.

Family and domain databases

InterProiIPR029222. FAM104.
[Graphical view]
PfamiPF15434. FAM104. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma and Uterus.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-186 (ISOFORM 1).
    Tissue: Brain and Rhabdomyosarcoma.
  5. "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method."
    Reddy P.H., Stockburger E., Gillevet P., Tagle D.A.
    Genomics 46:174-182(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-186 (ISOFORM 2).

Entry informationi

Entry nameiF104A_HUMAN
AccessioniPrimary (citable) accession number: Q969W3
Secondary accession number(s): B4E339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 5, 2010
Last modified: March 4, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.