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Q969W3

- F104A_HUMAN

UniProt

Q969W3 - F104A_HUMAN

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Protein
Protein FAM104A
Gene
FAM104A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM104A
Gene namesi
Name:FAM104A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25918. FAM104A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Protein FAM104A
PRO_0000236182Add
BLAST

Proteomic databases

MaxQBiQ969W3.
PaxDbiQ969W3.
PRIDEiQ969W3.

PTM databases

PhosphoSiteiQ969W3.

Expressioni

Gene expression databases

ArrayExpressiQ969W3.
BgeeiQ969W3.
CleanExiHS_FAM104A.
GenevestigatoriQ969W3.

Organism-specific databases

HPAiHPA021459.
HPA056782.

Interactioni

Protein-protein interaction databases

BioGridi124358. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ969W3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi94 – 14552Ser-rich
Add
BLAST

Sequence similaritiesi

Belongs to the FAM104 family.

Phylogenomic databases

eggNOGiNOG47228.
HOGENOMiHOG000231053.
HOVERGENiHBG059882.
OMAiKSECTEI.
PhylomeDBiQ969W3.
TreeFamiTF335777.

Family and domain databases

InterProiIPR029222. FAM104.
[Graphical view]
PfamiPF15434. FAM104. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969W3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV    50
PSLRGAAPRS FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF 100
QDSWDTESSG SDSGGSSSSS SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ 150
PVPEQSALCQ GLYFHINQTL REAHFHSLQH RGRPLT 186
Length:186
Mass (Da):19,484
Last modified:October 5, 2010 - v2
Checksum:iBE96E7F6BC18DEB4
GO
Isoform 2 (identifier: Q969W3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: E → ETVPVMRNSKENRLRGNKAFCA

Show »
Length:207
Mass (Da):21,858
Checksum:i76275AFA9982B1B6
GO

Sequence cautioni

The sequence AAH11054.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH25238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB55292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC11183.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei107 – 1071E → ETVPVMRNSKENRLRGNKAF CA in isoform 2.
VSP_039868

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027681 mRNA. Translation: BAB55292.1. Different initiation.
AK074755 mRNA. Translation: BAC11183.1. Different initiation.
AK304556 mRNA. Translation: BAG65351.1.
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89116.1.
BC011054 mRNA. Translation: AAH11054.1. Different initiation.
BC025238 mRNA. Translation: AAH25238.1. Different initiation.
U92989 mRNA. No translation available.
CCDSiCCDS11693.2. [Q969W3-1]
CCDS45766.1. [Q969W3-2]
RefSeqiNP_001092302.1. NM_001098832.1. [Q969W3-2]
NP_001276339.1. NM_001289410.1.
NP_001276340.1. NM_001289411.1.
NP_001276341.1. NM_001289412.1.
NP_116226.2. NM_032837.2. [Q969W3-1]
UniGeneiHs.741276.

Genome annotation databases

EnsembliENST00000403627; ENSP00000384648; ENSG00000133193. [Q969W3-1]
ENST00000405159; ENSP00000384832; ENSG00000133193. [Q969W3-2]
GeneIDi84923.
KEGGihsa:84923.
UCSCiuc002jji.4. human. [Q969W3-1]
uc002jjj.4. human. [Q969W3-2]

Polymorphism databases

DMDMi308153443.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027681 mRNA. Translation: BAB55292.1 . Different initiation.
AK074755 mRNA. Translation: BAC11183.1 . Different initiation.
AK304556 mRNA. Translation: BAG65351.1 .
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89116.1 .
BC011054 mRNA. Translation: AAH11054.1 . Different initiation.
BC025238 mRNA. Translation: AAH25238.1 . Different initiation.
U92989 mRNA. No translation available.
CCDSi CCDS11693.2. [Q969W3-1 ]
CCDS45766.1. [Q969W3-2 ]
RefSeqi NP_001092302.1. NM_001098832.1. [Q969W3-2 ]
NP_001276339.1. NM_001289410.1.
NP_001276340.1. NM_001289411.1.
NP_001276341.1. NM_001289412.1.
NP_116226.2. NM_032837.2. [Q969W3-1 ]
UniGenei Hs.741276.

3D structure databases

ProteinModelPortali Q969W3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124358. 1 interaction.

PTM databases

PhosphoSitei Q969W3.

Polymorphism databases

DMDMi 308153443.

Proteomic databases

MaxQBi Q969W3.
PaxDbi Q969W3.
PRIDEi Q969W3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000403627 ; ENSP00000384648 ; ENSG00000133193 . [Q969W3-1 ]
ENST00000405159 ; ENSP00000384832 ; ENSG00000133193 . [Q969W3-2 ]
GeneIDi 84923.
KEGGi hsa:84923.
UCSCi uc002jji.4. human. [Q969W3-1 ]
uc002jjj.4. human. [Q969W3-2 ]

Organism-specific databases

CTDi 84923.
GeneCardsi GC17M071203.
H-InvDB HIX0014136.
HIX0019625.
HGNCi HGNC:25918. FAM104A.
HPAi HPA021459.
HPA056782.
neXtProti NX_Q969W3.
PharmGKBi PA142671787.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47228.
HOGENOMi HOG000231053.
HOVERGENi HBG059882.
OMAi KSECTEI.
PhylomeDBi Q969W3.
TreeFami TF335777.

Miscellaneous databases

ChiTaRSi FAM104A. human.
GenomeRNAii 84923.
NextBioi 75336.
PROi Q969W3.

Gene expression databases

ArrayExpressi Q969W3.
Bgeei Q969W3.
CleanExi HS_FAM104A.
Genevestigatori Q969W3.

Family and domain databases

InterProi IPR029222. FAM104.
[Graphical view ]
Pfami PF15434. FAM104. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma and Uterus.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-186 (ISOFORM 1).
    Tissue: Brain and Rhabdomyosarcoma.
  5. "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method."
    Reddy P.H., Stockburger E., Gillevet P., Tagle D.A.
    Genomics 46:174-182(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-186 (ISOFORM 2).

Entry informationi

Entry nameiF104A_HUMAN
AccessioniPrimary (citable) accession number: Q969W3
Secondary accession number(s): B4E339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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