Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM104A

Gene

FAM104A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133193-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM104A
Gene namesi
Name:FAM104A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25918. FAM104A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133193.
PharmGKBiPA142671787.

Polymorphism and mutation databases

BioMutaiFAM104A.
DMDMi308153443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002361821 – 186Protein FAM104AAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ969W3.
MaxQBiQ969W3.
PeptideAtlasiQ969W3.
PRIDEiQ969W3.

PTM databases

iPTMnetiQ969W3.
PhosphoSitePlusiQ969W3.

Expressioni

Gene expression databases

BgeeiENSG00000133193.
CleanExiHS_FAM104A.
ExpressionAtlasiQ969W3. baseline and differential.
GenevisibleiQ969W3. HS.

Organism-specific databases

HPAiHPA021459.
HPA056782.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HEL-S-70V9HW803EBI-10281506,EBI-10175326

Protein-protein interaction databases

BioGridi124358. 6 interactors.
IntActiQ969W3. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ969W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi94 – 145Ser-richAdd BLAST52

Sequence similaritiesi

Belongs to the FAM104 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001055.
HOGENOMiHOG000231053.
HOVERGENiHBG059882.
InParanoidiQ969W3.
OMAiNKVFCAS.
OrthoDBiEOG091G11TE.
PhylomeDBiQ969W3.
TreeFamiTF335777.

Family and domain databases

InterProiIPR029222. FAM104.
[Graphical view]
PfamiPF15434. FAM104. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969W3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV
60 70 80 90 100
PSLRGAAPRS FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF
110 120 130 140 150
QDSWDTESSG SDSGGSSSSS SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ
160 170 180
PVPEQSALCQ GLYFHINQTL REAHFHSLQH RGRPLT
Length:186
Mass (Da):19,484
Last modified:October 5, 2010 - v2
Checksum:iBE96E7F6BC18DEB4
GO
Isoform 2 (identifier: Q969W3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: E → ETVPVMRNSKENRLRGNKAFCA

Show »
Length:207
Mass (Da):21,858
Checksum:i76275AFA9982B1B6
GO

Sequence cautioni

The sequence AAH11054 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH25238 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55292 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11183 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039868107E → ETVPVMRNSKENRLRGNKAF CA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027681 mRNA. Translation: BAB55292.1. Different initiation.
AK074755 mRNA. Translation: BAC11183.1. Different initiation.
AK304556 mRNA. Translation: BAG65351.1.
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89116.1.
BC011054 mRNA. Translation: AAH11054.1. Different initiation.
BC025238 mRNA. Translation: AAH25238.1. Different initiation.
U92989 mRNA. No translation available.
CCDSiCCDS11693.2. [Q969W3-1]
CCDS45766.1. [Q969W3-2]
RefSeqiNP_001092302.1. NM_001098832.1. [Q969W3-2]
NP_001276339.1. NM_001289410.1.
NP_001276340.1. NM_001289411.1.
NP_001276341.1. NM_001289412.1.
NP_116226.2. NM_032837.2. [Q969W3-1]
UniGeneiHs.741276.

Genome annotation databases

EnsembliENST00000403627; ENSP00000384648; ENSG00000133193. [Q969W3-1]
ENST00000405159; ENSP00000384832; ENSG00000133193. [Q969W3-2]
GeneIDi84923.
KEGGihsa:84923.
UCSCiuc002jji.5. human. [Q969W3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027681 mRNA. Translation: BAB55292.1. Different initiation.
AK074755 mRNA. Translation: BAC11183.1. Different initiation.
AK304556 mRNA. Translation: BAG65351.1.
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89116.1.
BC011054 mRNA. Translation: AAH11054.1. Different initiation.
BC025238 mRNA. Translation: AAH25238.1. Different initiation.
U92989 mRNA. No translation available.
CCDSiCCDS11693.2. [Q969W3-1]
CCDS45766.1. [Q969W3-2]
RefSeqiNP_001092302.1. NM_001098832.1. [Q969W3-2]
NP_001276339.1. NM_001289410.1.
NP_001276340.1. NM_001289411.1.
NP_001276341.1. NM_001289412.1.
NP_116226.2. NM_032837.2. [Q969W3-1]
UniGeneiHs.741276.

3D structure databases

ProteinModelPortaliQ969W3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124358. 6 interactors.
IntActiQ969W3. 2 interactors.

PTM databases

iPTMnetiQ969W3.
PhosphoSitePlusiQ969W3.

Polymorphism and mutation databases

BioMutaiFAM104A.
DMDMi308153443.

Proteomic databases

EPDiQ969W3.
MaxQBiQ969W3.
PeptideAtlasiQ969W3.
PRIDEiQ969W3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403627; ENSP00000384648; ENSG00000133193. [Q969W3-1]
ENST00000405159; ENSP00000384832; ENSG00000133193. [Q969W3-2]
GeneIDi84923.
KEGGihsa:84923.
UCSCiuc002jji.5. human. [Q969W3-1]

Organism-specific databases

CTDi84923.
GeneCardsiFAM104A.
H-InvDBHIX0014136.
HIX0019625.
HGNCiHGNC:25918. FAM104A.
HPAiHPA021459.
HPA056782.
neXtProtiNX_Q969W3.
OpenTargetsiENSG00000133193.
PharmGKBiPA142671787.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000001055.
HOGENOMiHOG000231053.
HOVERGENiHBG059882.
InParanoidiQ969W3.
OMAiNKVFCAS.
OrthoDBiEOG091G11TE.
PhylomeDBiQ969W3.
TreeFamiTF335777.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133193-MONOMER.

Miscellaneous databases

ChiTaRSiFAM104A. human.
GenomeRNAii84923.
PROiQ969W3.

Gene expression databases

BgeeiENSG00000133193.
CleanExiHS_FAM104A.
ExpressionAtlasiQ969W3. baseline and differential.
GenevisibleiQ969W3. HS.

Family and domain databases

InterProiIPR029222. FAM104.
[Graphical view]
PfamiPF15434. FAM104. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF104A_HUMAN
AccessioniPrimary (citable) accession number: Q969W3
Secondary accession number(s): B4E339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.