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Protein

Probable palmitoyltransferase ZDHHC16

Gene

ZDHHC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in apoptosis regulation.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 20551DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • protein palmitoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.3.1.225. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC16 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 16
Short name:
DHHC-16
Gene namesi
Name:ZDHHC16
ORF Names:UNQ2570/PRO6258
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:20714. ZDHHC16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7777CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 11618LumenalSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST
Topological domaini138 – 19861CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Topological domaini220 – 26647LumenalSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Topological domaini288 – 37790CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985701.

Polymorphism and mutation databases

DMDMi37999852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Probable palmitoyltransferase ZDHHC16PRO_0000212897Add
BLAST

Proteomic databases

MaxQBiQ969W1.
PaxDbiQ969W1.
PRIDEiQ969W1.

PTM databases

PhosphoSiteiQ969W1.

Expressioni

Gene expression databases

BgeeiQ969W1.
CleanExiHS_ZDHHC16.
ExpressionAtlasiQ969W1. baseline and differential.
GenevestigatoriQ969W1.

Organism-specific databases

HPAiHPA039893.

Interactioni

Subunit structurei

Interacts with ABL1.By similarity

Protein-protein interaction databases

BioGridi124014. 1 interaction.
STRINGi9606.ENSP00000359891.

Structurei

3D structure databases

ProteinModelPortaliQ969W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 20551DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5273.
GeneTreeiENSGT00790000123037.
HOVERGENiHBG054667.
InParanoidiQ969W1.
KOiK18932.
OMAiHMNSSYA.
OrthoDBiEOG75QR41.
PhylomeDBiQ969W1.
TreeFamiTF320809.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969W1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGQRSLLLG PARLCLRLLL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL
60 70 80 90 100
YNSFGGSDTA VDAAFEPVYW LVDNVIRWFG VVFVVLVIVL TGSIVAIAYL
110 120 130 140 150
CVLPLILRTY SVPRLCWHFF YSHWNLILIV FHYYQAITTP PGYPPQGRND
160 170 180 190 200
IATVSICKKC IYPKPARTHH CSICNRCVLK MDHHCPWLNN CVGHYNHRYF
210 220 230 240 250
FSFCFFMTLG CVYCSYGSWD LFREAYAAIE KMKQLDKNKL QAVANQTYHQ
260 270 280 290 300
TPPPTFSFRE RMTHKSLVYL WFLCSSVALA LGALTVWHAV LISRGETSIE
310 320 330 340 350
RHINKKERRR LQAKGRVFRN PYNYGCLDNW KVFLGVDTGR HWLTRVLLPS
360 370
SHLPHGNGMS WEPPPWVTAH SASVMAV
Length:377
Mass (Da):43,633
Last modified:December 1, 2001 - v1
Checksum:i68AC733DE498A81E
GO
Isoform 2 (identifier: Q969W1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-246: Missing.

Show »
Length:361
Mass (Da):41,794
Checksum:i37D184AD737B652E
GO
Isoform 3 (identifier: Q969W1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-214: Missing.

Show »
Length:338
Mass (Da):38,858
Checksum:i19FF4C8C0360CBF3
GO
Isoform 4 (identifier: Q969W1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-146: Missing.
     231-246: Missing.

Show »
Length:296
Mass (Da):34,275
Checksum:i5761AA22DE90EB10
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei82 – 14665Missing in isoform 4. 1 PublicationVSP_016274Add
BLAST
Alternative sequencei176 – 21439Missing in isoform 3. 1 PublicationVSP_016275Add
BLAST
Alternative sequencei231 – 24616Missing in isoform 2 and isoform 4. 2 PublicationsVSP_008716Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ294945 mRNA. Translation: CAC82556.1.
AY359080 mRNA. Translation: AAQ89439.1.
AF258563 mRNA. Translation: AAG23766.1.
AL355490 Genomic DNA. Translation: CAI40785.1.
AL355490 Genomic DNA. Translation: CAI40786.1.
AL355490 Genomic DNA. Translation: CAI40787.1.
AL355490 Genomic DNA. Translation: CAI40788.1.
CH471066 Genomic DNA. Translation: EAW49929.1.
CH471066 Genomic DNA. Translation: EAW49930.1.
CH471066 Genomic DNA. Translation: EAW49931.1.
CH471066 Genomic DNA. Translation: EAW49932.1.
CH471066 Genomic DNA. Translation: EAW49933.1.
CH471066 Genomic DNA. Translation: EAW49934.1.
BC004535 mRNA. Translation: AAH04535.1.
BC008074 mRNA. Translation: AAH08074.1.
BC011749 mRNA. Translation: AAH11749.1.
BC012830 mRNA. Translation: AAH12830.1.
BC033157 mRNA. Translation: AAH33157.1.
CCDSiCCDS7460.1. [Q969W1-1]
CCDS7461.1. [Q969W1-2]
CCDS7462.1. [Q969W1-3]
CCDS7463.1. [Q969W1-4]
RefSeqiNP_001274732.1. NM_001287803.1.
NP_001274733.1. NM_001287804.1.
NP_115703.2. NM_032327.3. [Q969W1-1]
NP_932160.1. NM_198043.2. [Q969W1-2]
NP_932161.1. NM_198044.2. [Q969W1-3]
NP_932162.1. NM_198045.2. [Q969W1-4]
NP_932163.1. NM_198046.2. [Q969W1-1]
UniGeneiHs.76662.

Genome annotation databases

EnsembliENST00000345745; ENSP00000304487; ENSG00000171307. [Q969W1-4]
ENST00000352634; ENSP00000345383; ENSG00000171307. [Q969W1-2]
ENST00000353979; ENSP00000323360; ENSG00000171307. [Q969W1-3]
ENST00000370842; ENSP00000359879; ENSG00000171307. [Q969W1-2]
ENST00000370854; ENSP00000359891; ENSG00000171307. [Q969W1-1]
ENST00000393760; ENSP00000377357; ENSG00000171307. [Q969W1-1]
GeneIDi84287.
KEGGihsa:84287.
UCSCiuc001knj.3. human. [Q969W1-1]
uc001knl.3. human. [Q969W1-2]
uc001knm.3. human. [Q969W1-4]
uc001knn.3. human. [Q969W1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ294945 mRNA. Translation: CAC82556.1.
AY359080 mRNA. Translation: AAQ89439.1.
AF258563 mRNA. Translation: AAG23766.1.
AL355490 Genomic DNA. Translation: CAI40785.1.
AL355490 Genomic DNA. Translation: CAI40786.1.
AL355490 Genomic DNA. Translation: CAI40787.1.
AL355490 Genomic DNA. Translation: CAI40788.1.
CH471066 Genomic DNA. Translation: EAW49929.1.
CH471066 Genomic DNA. Translation: EAW49930.1.
CH471066 Genomic DNA. Translation: EAW49931.1.
CH471066 Genomic DNA. Translation: EAW49932.1.
CH471066 Genomic DNA. Translation: EAW49933.1.
CH471066 Genomic DNA. Translation: EAW49934.1.
BC004535 mRNA. Translation: AAH04535.1.
BC008074 mRNA. Translation: AAH08074.1.
BC011749 mRNA. Translation: AAH11749.1.
BC012830 mRNA. Translation: AAH12830.1.
BC033157 mRNA. Translation: AAH33157.1.
CCDSiCCDS7460.1. [Q969W1-1]
CCDS7461.1. [Q969W1-2]
CCDS7462.1. [Q969W1-3]
CCDS7463.1. [Q969W1-4]
RefSeqiNP_001274732.1. NM_001287803.1.
NP_001274733.1. NM_001287804.1.
NP_115703.2. NM_032327.3. [Q969W1-1]
NP_932160.1. NM_198043.2. [Q969W1-2]
NP_932161.1. NM_198044.2. [Q969W1-3]
NP_932162.1. NM_198045.2. [Q969W1-4]
NP_932163.1. NM_198046.2. [Q969W1-1]
UniGeneiHs.76662.

3D structure databases

ProteinModelPortaliQ969W1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124014. 1 interaction.
STRINGi9606.ENSP00000359891.

PTM databases

PhosphoSiteiQ969W1.

Polymorphism and mutation databases

DMDMi37999852.

Proteomic databases

MaxQBiQ969W1.
PaxDbiQ969W1.
PRIDEiQ969W1.

Protocols and materials databases

DNASUi84287.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345745; ENSP00000304487; ENSG00000171307. [Q969W1-4]
ENST00000352634; ENSP00000345383; ENSG00000171307. [Q969W1-2]
ENST00000353979; ENSP00000323360; ENSG00000171307. [Q969W1-3]
ENST00000370842; ENSP00000359879; ENSG00000171307. [Q969W1-2]
ENST00000370854; ENSP00000359891; ENSG00000171307. [Q969W1-1]
ENST00000393760; ENSP00000377357; ENSG00000171307. [Q969W1-1]
GeneIDi84287.
KEGGihsa:84287.
UCSCiuc001knj.3. human. [Q969W1-1]
uc001knl.3. human. [Q969W1-2]
uc001knm.3. human. [Q969W1-4]
uc001knn.3. human. [Q969W1-3]

Organism-specific databases

CTDi84287.
GeneCardsiGC10P099195.
HGNCiHGNC:20714. ZDHHC16.
HPAiHPA039893.
neXtProtiNX_Q969W1.
PharmGKBiPA134985701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5273.
GeneTreeiENSGT00790000123037.
HOVERGENiHBG054667.
InParanoidiQ969W1.
KOiK18932.
OMAiHMNSSYA.
OrthoDBiEOG75QR41.
PhylomeDBiQ969W1.
TreeFamiTF320809.

Enzyme and pathway databases

BRENDAi2.3.1.225. 2681.

Miscellaneous databases

ChiTaRSiZDHHC16. human.
GenomeRNAii84287.
NextBioi73905.
PROiQ969W1.

Gene expression databases

BgeeiQ969W1.
CleanExiHS_ZDHHC16.
ExpressionAtlasiQ969W1. baseline and differential.
GenevestigatoriQ969W1.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene containing the cysteine-rich zf-DHHC motif is localised at human chromosomal region 10q23.3-q24."
    Sarafidou T., Moschonas N.K.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: B-cell, Brain, Ovary and Placenta.

Entry informationi

Entry nameiZDH16_HUMAN
AccessioniPrimary (citable) accession number: Q969W1
Secondary accession number(s): D3DR52
, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q9BSV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.