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Q969W1 (ZDH16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable palmitoyltransferase ZDHHC16

EC=2.3.1.225
Alternative name(s):
Zinc finger DHHC domain-containing protein 16
Short name=DHHC-16
Gene names
Name:ZDHHC16
ORF Names:UNQ2570/PRO6258
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in apoptosis regulation By similarity.

Catalytic activity

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Subunit structure

Interacts with ABL1 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Domain

The DHHC domain is required for palmitoyltransferase activity By similarity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family.

Contains 1 DHHC-type zinc finger.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q969W1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q969W1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     231-246: Missing.
Isoform 3 (identifier: Q969W1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     176-214: Missing.
Isoform 4 (identifier: Q969W1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     82-146: Missing.
     231-246: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Probable palmitoyltransferase ZDHHC16
PRO_0000212897

Regions

Topological domain1 – 7777Cytoplasmic Potential
Transmembrane78 – 9821Helical; Potential
Topological domain99 – 11618Lumenal Potential
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 19861Cytoplasmic Potential
Transmembrane199 – 21921Helical; Potential
Topological domain220 – 26647Lumenal Potential
Transmembrane267 – 28721Helical; Potential
Topological domain288 – 37790Cytoplasmic Potential
Zinc finger155 – 20551DHHC-type

Natural variations

Alternative sequence82 – 14665Missing in isoform 4.
VSP_016274
Alternative sequence176 – 21439Missing in isoform 3.
VSP_016275
Alternative sequence231 – 24616Missing in isoform 2 and isoform 4.
VSP_008716

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 68AC733DE498A81E

FASTA37743,633
        10         20         30         40         50         60 
MRGQRSLLLG PARLCLRLLL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL YNSFGGSDTA 

        70         80         90        100        110        120 
VDAAFEPVYW LVDNVIRWFG VVFVVLVIVL TGSIVAIAYL CVLPLILRTY SVPRLCWHFF 

       130        140        150        160        170        180 
YSHWNLILIV FHYYQAITTP PGYPPQGRND IATVSICKKC IYPKPARTHH CSICNRCVLK 

       190        200        210        220        230        240 
MDHHCPWLNN CVGHYNHRYF FSFCFFMTLG CVYCSYGSWD LFREAYAAIE KMKQLDKNKL 

       250        260        270        280        290        300 
QAVANQTYHQ TPPPTFSFRE RMTHKSLVYL WFLCSSVALA LGALTVWHAV LISRGETSIE 

       310        320        330        340        350        360 
RHINKKERRR LQAKGRVFRN PYNYGCLDNW KVFLGVDTGR HWLTRVLLPS SHLPHGNGMS 

       370 
WEPPPWVTAH SASVMAV 

« Hide

Isoform 2 [UniParc].

Checksum: 37D184AD737B652E
Show »

FASTA36141,794
Isoform 3 [UniParc].

Checksum: 19FF4C8C0360CBF3
Show »

FASTA33838,858
Isoform 4 [UniParc].

Checksum: 5761AA22DE90EB10
Show »

FASTA29634,275

References

« Hide 'large scale' references
[1]"A novel gene containing the cysteine-rich zf-DHHC motif is localised at human chromosomal region 10q23.3-q24."
Sarafidou T., Moschonas N.K.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
Tissue: B-cell, Brain, Ovary and Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ294945 mRNA. Translation: CAC82556.1.
AY359080 mRNA. Translation: AAQ89439.1.
AF258563 mRNA. Translation: AAG23766.1.
AL355490 Genomic DNA. Translation: CAI40785.1.
AL355490 Genomic DNA. Translation: CAI40786.1.
AL355490 Genomic DNA. Translation: CAI40787.1.
AL355490 Genomic DNA. Translation: CAI40788.1.
CH471066 Genomic DNA. Translation: EAW49929.1.
CH471066 Genomic DNA. Translation: EAW49930.1.
CH471066 Genomic DNA. Translation: EAW49931.1.
CH471066 Genomic DNA. Translation: EAW49932.1.
CH471066 Genomic DNA. Translation: EAW49933.1.
CH471066 Genomic DNA. Translation: EAW49934.1.
BC004535 mRNA. Translation: AAH04535.1.
BC008074 mRNA. Translation: AAH08074.1.
BC011749 mRNA. Translation: AAH11749.1.
BC012830 mRNA. Translation: AAH12830.1.
BC033157 mRNA. Translation: AAH33157.1.
CCDSCCDS7460.1. [Q969W1-1]
CCDS7461.1. [Q969W1-2]
CCDS7462.1. [Q969W1-3]
CCDS7463.1. [Q969W1-4]
RefSeqNP_001274732.1. NM_001287803.1.
NP_001274733.1. NM_001287804.1.
NP_115703.2. NM_032327.3. [Q969W1-1]
NP_932160.1. NM_198043.2. [Q969W1-2]
NP_932161.1. NM_198044.2. [Q969W1-3]
NP_932162.1. NM_198045.2. [Q969W1-4]
NP_932163.1. NM_198046.2. [Q969W1-1]
UniGeneHs.76662.

3D structure databases

ProteinModelPortalQ969W1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124014. 2 interactions.
STRING9606.ENSP00000359891.

PTM databases

PhosphoSiteQ969W1.

Polymorphism databases

DMDM37999852.

Proteomic databases

MaxQBQ969W1.
PaxDbQ969W1.
PRIDEQ969W1.

Protocols and materials databases

DNASU84287.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000345745; ENSP00000304487; ENSG00000171307. [Q969W1-4]
ENST00000352634; ENSP00000345383; ENSG00000171307. [Q969W1-2]
ENST00000353979; ENSP00000323360; ENSG00000171307. [Q969W1-3]
ENST00000370842; ENSP00000359879; ENSG00000171307. [Q969W1-2]
ENST00000370854; ENSP00000359891; ENSG00000171307. [Q969W1-1]
ENST00000393760; ENSP00000377357; ENSG00000171307. [Q969W1-1]
GeneID84287.
KEGGhsa:84287.
UCSCuc001knj.3. human. [Q969W1-1]
uc001knl.3. human. [Q969W1-2]
uc001knm.3. human. [Q969W1-4]
uc001knn.3. human. [Q969W1-3]

Organism-specific databases

CTD84287.
GeneCardsGC10P099195.
HGNCHGNC:20714. ZDHHC16.
HPAHPA039893.
neXtProtNX_Q969W1.
PharmGKBPA134985701.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5273.
HOVERGENHBG054667.
InParanoidQ969W1.
OMAILQTYSV.
OrthoDBEOG75QR41.
PhylomeDBQ969W1.
TreeFamTF320809.

Gene expression databases

ArrayExpressQ969W1.
BgeeQ969W1.
CleanExHS_ZDHHC16.
GenevestigatorQ969W1.

Family and domain databases

InterProIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZDHHC16. human.
GenomeRNAi84287.
NextBio73905.
PROQ969W1.

Entry information

Entry nameZDH16_HUMAN
AccessionPrimary (citable) accession number: Q969W1
Secondary accession number(s): D3DR52 expand/collapse secondary AC list , D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q9BSV3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM