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Q969W1

- ZDH16_HUMAN

UniProt

Q969W1 - ZDH16_HUMAN

Protein

Probable palmitoyltransferase ZDHHC16

Gene

ZDHHC16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in apoptosis regulation.By similarity

    Catalytic activityi

    Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri155 – 20551DHHC-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. palmitoyltransferase activity Source: UniProt
    2. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. protein palmitoylation Source: UniProt

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable palmitoyltransferase ZDHHC16 (EC:2.3.1.225)
    Alternative name(s):
    Zinc finger DHHC domain-containing protein 16
    Short name:
    DHHC-16
    Gene namesi
    Name:ZDHHC16
    ORF Names:UNQ2570/PRO6258
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:20714. ZDHHC16.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134985701.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Probable palmitoyltransferase ZDHHC16PRO_0000212897Add
    BLAST

    Proteomic databases

    MaxQBiQ969W1.
    PaxDbiQ969W1.
    PRIDEiQ969W1.

    PTM databases

    PhosphoSiteiQ969W1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ969W1.
    BgeeiQ969W1.
    CleanExiHS_ZDHHC16.
    GenevestigatoriQ969W1.

    Organism-specific databases

    HPAiHPA039893.

    Interactioni

    Subunit structurei

    Interacts with ABL1.By similarity

    Protein-protein interaction databases

    BioGridi124014. 2 interactions.
    STRINGi9606.ENSP00000359891.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969W1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7777CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 11618LumenalSequence AnalysisAdd
    BLAST
    Topological domaini138 – 19861CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini220 – 26647LumenalSequence AnalysisAdd
    BLAST
    Topological domaini288 – 37790CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The DHHC domain is required for palmitoyltransferase activity.By similarity

    Sequence similaritiesi

    Belongs to the DHHC palmitoyltransferase family.Curated
    Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri155 – 20551DHHC-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5273.
    HOVERGENiHBG054667.
    InParanoidiQ969W1.
    OMAiILQTYSV.
    OrthoDBiEOG75QR41.
    PhylomeDBiQ969W1.
    TreeFamiTF320809.

    Family and domain databases

    InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view]
    PfamiPF01529. zf-DHHC. 1 hit.
    [Graphical view]
    PROSITEiPS50216. ZF_DHHC. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969W1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGQRSLLLG PARLCLRLLL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL    50
    YNSFGGSDTA VDAAFEPVYW LVDNVIRWFG VVFVVLVIVL TGSIVAIAYL 100
    CVLPLILRTY SVPRLCWHFF YSHWNLILIV FHYYQAITTP PGYPPQGRND 150
    IATVSICKKC IYPKPARTHH CSICNRCVLK MDHHCPWLNN CVGHYNHRYF 200
    FSFCFFMTLG CVYCSYGSWD LFREAYAAIE KMKQLDKNKL QAVANQTYHQ 250
    TPPPTFSFRE RMTHKSLVYL WFLCSSVALA LGALTVWHAV LISRGETSIE 300
    RHINKKERRR LQAKGRVFRN PYNYGCLDNW KVFLGVDTGR HWLTRVLLPS 350
    SHLPHGNGMS WEPPPWVTAH SASVMAV 377
    Length:377
    Mass (Da):43,633
    Last modified:December 1, 2001 - v1
    Checksum:i68AC733DE498A81E
    GO
    Isoform 2 (identifier: Q969W1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         231-246: Missing.

    Show »
    Length:361
    Mass (Da):41,794
    Checksum:i37D184AD737B652E
    GO
    Isoform 3 (identifier: Q969W1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         176-214: Missing.

    Show »
    Length:338
    Mass (Da):38,858
    Checksum:i19FF4C8C0360CBF3
    GO
    Isoform 4 (identifier: Q969W1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         82-146: Missing.
         231-246: Missing.

    Show »
    Length:296
    Mass (Da):34,275
    Checksum:i5761AA22DE90EB10
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei82 – 14665Missing in isoform 4. 1 PublicationVSP_016274Add
    BLAST
    Alternative sequencei176 – 21439Missing in isoform 3. 1 PublicationVSP_016275Add
    BLAST
    Alternative sequencei231 – 24616Missing in isoform 2 and isoform 4. 2 PublicationsVSP_008716Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ294945 mRNA. Translation: CAC82556.1.
    AY359080 mRNA. Translation: AAQ89439.1.
    AF258563 mRNA. Translation: AAG23766.1.
    AL355490 Genomic DNA. Translation: CAI40785.1.
    AL355490 Genomic DNA. Translation: CAI40786.1.
    AL355490 Genomic DNA. Translation: CAI40787.1.
    AL355490 Genomic DNA. Translation: CAI40788.1.
    CH471066 Genomic DNA. Translation: EAW49929.1.
    CH471066 Genomic DNA. Translation: EAW49930.1.
    CH471066 Genomic DNA. Translation: EAW49931.1.
    CH471066 Genomic DNA. Translation: EAW49932.1.
    CH471066 Genomic DNA. Translation: EAW49933.1.
    CH471066 Genomic DNA. Translation: EAW49934.1.
    BC004535 mRNA. Translation: AAH04535.1.
    BC008074 mRNA. Translation: AAH08074.1.
    BC011749 mRNA. Translation: AAH11749.1.
    BC012830 mRNA. Translation: AAH12830.1.
    BC033157 mRNA. Translation: AAH33157.1.
    CCDSiCCDS7460.1. [Q969W1-1]
    CCDS7461.1. [Q969W1-2]
    CCDS7462.1. [Q969W1-3]
    CCDS7463.1. [Q969W1-4]
    RefSeqiNP_001274732.1. NM_001287803.1.
    NP_001274733.1. NM_001287804.1.
    NP_115703.2. NM_032327.3. [Q969W1-1]
    NP_932160.1. NM_198043.2. [Q969W1-2]
    NP_932161.1. NM_198044.2. [Q969W1-3]
    NP_932162.1. NM_198045.2. [Q969W1-4]
    NP_932163.1. NM_198046.2. [Q969W1-1]
    UniGeneiHs.76662.

    Genome annotation databases

    EnsembliENST00000345745; ENSP00000304487; ENSG00000171307. [Q969W1-4]
    ENST00000352634; ENSP00000345383; ENSG00000171307. [Q969W1-2]
    ENST00000353979; ENSP00000323360; ENSG00000171307. [Q969W1-3]
    ENST00000370842; ENSP00000359879; ENSG00000171307. [Q969W1-2]
    ENST00000370854; ENSP00000359891; ENSG00000171307. [Q969W1-1]
    ENST00000393760; ENSP00000377357; ENSG00000171307. [Q969W1-1]
    GeneIDi84287.
    KEGGihsa:84287.
    UCSCiuc001knj.3. human. [Q969W1-1]
    uc001knl.3. human. [Q969W1-2]
    uc001knm.3. human. [Q969W1-4]
    uc001knn.3. human. [Q969W1-3]

    Polymorphism databases

    DMDMi37999852.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ294945 mRNA. Translation: CAC82556.1 .
    AY359080 mRNA. Translation: AAQ89439.1 .
    AF258563 mRNA. Translation: AAG23766.1 .
    AL355490 Genomic DNA. Translation: CAI40785.1 .
    AL355490 Genomic DNA. Translation: CAI40786.1 .
    AL355490 Genomic DNA. Translation: CAI40787.1 .
    AL355490 Genomic DNA. Translation: CAI40788.1 .
    CH471066 Genomic DNA. Translation: EAW49929.1 .
    CH471066 Genomic DNA. Translation: EAW49930.1 .
    CH471066 Genomic DNA. Translation: EAW49931.1 .
    CH471066 Genomic DNA. Translation: EAW49932.1 .
    CH471066 Genomic DNA. Translation: EAW49933.1 .
    CH471066 Genomic DNA. Translation: EAW49934.1 .
    BC004535 mRNA. Translation: AAH04535.1 .
    BC008074 mRNA. Translation: AAH08074.1 .
    BC011749 mRNA. Translation: AAH11749.1 .
    BC012830 mRNA. Translation: AAH12830.1 .
    BC033157 mRNA. Translation: AAH33157.1 .
    CCDSi CCDS7460.1. [Q969W1-1 ]
    CCDS7461.1. [Q969W1-2 ]
    CCDS7462.1. [Q969W1-3 ]
    CCDS7463.1. [Q969W1-4 ]
    RefSeqi NP_001274732.1. NM_001287803.1.
    NP_001274733.1. NM_001287804.1.
    NP_115703.2. NM_032327.3. [Q969W1-1 ]
    NP_932160.1. NM_198043.2. [Q969W1-2 ]
    NP_932161.1. NM_198044.2. [Q969W1-3 ]
    NP_932162.1. NM_198045.2. [Q969W1-4 ]
    NP_932163.1. NM_198046.2. [Q969W1-1 ]
    UniGenei Hs.76662.

    3D structure databases

    ProteinModelPortali Q969W1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124014. 2 interactions.
    STRINGi 9606.ENSP00000359891.

    PTM databases

    PhosphoSitei Q969W1.

    Polymorphism databases

    DMDMi 37999852.

    Proteomic databases

    MaxQBi Q969W1.
    PaxDbi Q969W1.
    PRIDEi Q969W1.

    Protocols and materials databases

    DNASUi 84287.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345745 ; ENSP00000304487 ; ENSG00000171307 . [Q969W1-4 ]
    ENST00000352634 ; ENSP00000345383 ; ENSG00000171307 . [Q969W1-2 ]
    ENST00000353979 ; ENSP00000323360 ; ENSG00000171307 . [Q969W1-3 ]
    ENST00000370842 ; ENSP00000359879 ; ENSG00000171307 . [Q969W1-2 ]
    ENST00000370854 ; ENSP00000359891 ; ENSG00000171307 . [Q969W1-1 ]
    ENST00000393760 ; ENSP00000377357 ; ENSG00000171307 . [Q969W1-1 ]
    GeneIDi 84287.
    KEGGi hsa:84287.
    UCSCi uc001knj.3. human. [Q969W1-1 ]
    uc001knl.3. human. [Q969W1-2 ]
    uc001knm.3. human. [Q969W1-4 ]
    uc001knn.3. human. [Q969W1-3 ]

    Organism-specific databases

    CTDi 84287.
    GeneCardsi GC10P099195.
    HGNCi HGNC:20714. ZDHHC16.
    HPAi HPA039893.
    neXtProti NX_Q969W1.
    PharmGKBi PA134985701.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5273.
    HOVERGENi HBG054667.
    InParanoidi Q969W1.
    OMAi ILQTYSV.
    OrthoDBi EOG75QR41.
    PhylomeDBi Q969W1.
    TreeFami TF320809.

    Miscellaneous databases

    ChiTaRSi ZDHHC16. human.
    GenomeRNAii 84287.
    NextBioi 73905.
    PROi Q969W1.

    Gene expression databases

    ArrayExpressi Q969W1.
    Bgeei Q969W1.
    CleanExi HS_ZDHHC16.
    Genevestigatori Q969W1.

    Family and domain databases

    InterProi IPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view ]
    Pfami PF01529. zf-DHHC. 1 hit.
    [Graphical view ]
    PROSITEi PS50216. ZF_DHHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene containing the cysteine-rich zf-DHHC motif is localised at human chromosomal region 10q23.3-q24."
      Sarafidou T., Moschonas N.K.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: B-cell, Brain, Ovary and Placenta.

    Entry informationi

    Entry nameiZDH16_HUMAN
    AccessioniPrimary (citable) accession number: Q969W1
    Secondary accession number(s): D3DR52
    , D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q9BSV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3