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Q969W1

- ZDH16_HUMAN

UniProt

Q969W1 - ZDH16_HUMAN

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Protein

Probable palmitoyltransferase ZDHHC16

Gene
ZDHHC16, UNQ2570/PRO6258
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in apoptosis regulation By similarity.

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 20551DHHC-typeAdd
BLAST

GO - Molecular functioni

  1. palmitoyltransferase activity Source: UniProt
  2. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. protein palmitoylation Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC16 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 16
Short name:
DHHC-16
Gene namesi
Name:ZDHHC16
ORF Names:UNQ2570/PRO6258
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:20714. ZDHHC16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7777Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei78 – 9821Helical; Reviewed predictionAdd
BLAST
Topological domaini99 – 11618Lumenal Reviewed predictionAdd
BLAST
Transmembranei117 – 13721Helical; Reviewed predictionAdd
BLAST
Topological domaini138 – 19861Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei199 – 21921Helical; Reviewed predictionAdd
BLAST
Topological domaini220 – 26647Lumenal Reviewed predictionAdd
BLAST
Transmembranei267 – 28721Helical; Reviewed predictionAdd
BLAST
Topological domaini288 – 37790Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Probable palmitoyltransferase ZDHHC16PRO_0000212897Add
BLAST

Proteomic databases

MaxQBiQ969W1.
PaxDbiQ969W1.
PRIDEiQ969W1.

PTM databases

PhosphoSiteiQ969W1.

Expressioni

Gene expression databases

ArrayExpressiQ969W1.
BgeeiQ969W1.
CleanExiHS_ZDHHC16.
GenevestigatoriQ969W1.

Organism-specific databases

HPAiHPA039893.

Interactioni

Subunit structurei

Interacts with ABL1 By similarity.

Protein-protein interaction databases

BioGridi124014. 2 interactions.
STRINGi9606.ENSP00000359891.

Structurei

3D structure databases

ProteinModelPortaliQ969W1.

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5273.
HOVERGENiHBG054667.
InParanoidiQ969W1.
OMAiILQTYSV.
OrthoDBiEOG75QR41.
PhylomeDBiQ969W1.
TreeFamiTF320809.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969W1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRGQRSLLLG PARLCLRLLL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL    50
YNSFGGSDTA VDAAFEPVYW LVDNVIRWFG VVFVVLVIVL TGSIVAIAYL 100
CVLPLILRTY SVPRLCWHFF YSHWNLILIV FHYYQAITTP PGYPPQGRND 150
IATVSICKKC IYPKPARTHH CSICNRCVLK MDHHCPWLNN CVGHYNHRYF 200
FSFCFFMTLG CVYCSYGSWD LFREAYAAIE KMKQLDKNKL QAVANQTYHQ 250
TPPPTFSFRE RMTHKSLVYL WFLCSSVALA LGALTVWHAV LISRGETSIE 300
RHINKKERRR LQAKGRVFRN PYNYGCLDNW KVFLGVDTGR HWLTRVLLPS 350
SHLPHGNGMS WEPPPWVTAH SASVMAV 377
Length:377
Mass (Da):43,633
Last modified:December 1, 2001 - v1
Checksum:i68AC733DE498A81E
GO
Isoform 2 (identifier: Q969W1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-246: Missing.

Show »
Length:361
Mass (Da):41,794
Checksum:i37D184AD737B652E
GO
Isoform 3 (identifier: Q969W1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-214: Missing.

Show »
Length:338
Mass (Da):38,858
Checksum:i19FF4C8C0360CBF3
GO
Isoform 4 (identifier: Q969W1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-146: Missing.
     231-246: Missing.

Show »
Length:296
Mass (Da):34,275
Checksum:i5761AA22DE90EB10
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei82 – 14665Missing in isoform 4. VSP_016274Add
BLAST
Alternative sequencei176 – 21439Missing in isoform 3. VSP_016275Add
BLAST
Alternative sequencei231 – 24616Missing in isoform 2 and isoform 4. VSP_008716Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ294945 mRNA. Translation: CAC82556.1.
AY359080 mRNA. Translation: AAQ89439.1.
AF258563 mRNA. Translation: AAG23766.1.
AL355490 Genomic DNA. Translation: CAI40785.1.
AL355490 Genomic DNA. Translation: CAI40786.1.
AL355490 Genomic DNA. Translation: CAI40787.1.
AL355490 Genomic DNA. Translation: CAI40788.1.
CH471066 Genomic DNA. Translation: EAW49929.1.
CH471066 Genomic DNA. Translation: EAW49930.1.
CH471066 Genomic DNA. Translation: EAW49931.1.
CH471066 Genomic DNA. Translation: EAW49932.1.
CH471066 Genomic DNA. Translation: EAW49933.1.
CH471066 Genomic DNA. Translation: EAW49934.1.
BC004535 mRNA. Translation: AAH04535.1.
BC008074 mRNA. Translation: AAH08074.1.
BC011749 mRNA. Translation: AAH11749.1.
BC012830 mRNA. Translation: AAH12830.1.
BC033157 mRNA. Translation: AAH33157.1.
CCDSiCCDS7460.1. [Q969W1-1]
CCDS7461.1. [Q969W1-2]
CCDS7462.1. [Q969W1-3]
CCDS7463.1. [Q969W1-4]
RefSeqiNP_001274732.1. NM_001287803.1.
NP_001274733.1. NM_001287804.1.
NP_115703.2. NM_032327.3. [Q969W1-1]
NP_932160.1. NM_198043.2. [Q969W1-2]
NP_932161.1. NM_198044.2. [Q969W1-3]
NP_932162.1. NM_198045.2. [Q969W1-4]
NP_932163.1. NM_198046.2. [Q969W1-1]
UniGeneiHs.76662.

Genome annotation databases

EnsembliENST00000345745; ENSP00000304487; ENSG00000171307. [Q969W1-4]
ENST00000352634; ENSP00000345383; ENSG00000171307. [Q969W1-2]
ENST00000353979; ENSP00000323360; ENSG00000171307. [Q969W1-3]
ENST00000370842; ENSP00000359879; ENSG00000171307. [Q969W1-2]
ENST00000370854; ENSP00000359891; ENSG00000171307. [Q969W1-1]
ENST00000393760; ENSP00000377357; ENSG00000171307. [Q969W1-1]
GeneIDi84287.
KEGGihsa:84287.
UCSCiuc001knj.3. human. [Q969W1-1]
uc001knl.3. human. [Q969W1-2]
uc001knm.3. human. [Q969W1-4]
uc001knn.3. human. [Q969W1-3]

Polymorphism databases

DMDMi37999852.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ294945 mRNA. Translation: CAC82556.1 .
AY359080 mRNA. Translation: AAQ89439.1 .
AF258563 mRNA. Translation: AAG23766.1 .
AL355490 Genomic DNA. Translation: CAI40785.1 .
AL355490 Genomic DNA. Translation: CAI40786.1 .
AL355490 Genomic DNA. Translation: CAI40787.1 .
AL355490 Genomic DNA. Translation: CAI40788.1 .
CH471066 Genomic DNA. Translation: EAW49929.1 .
CH471066 Genomic DNA. Translation: EAW49930.1 .
CH471066 Genomic DNA. Translation: EAW49931.1 .
CH471066 Genomic DNA. Translation: EAW49932.1 .
CH471066 Genomic DNA. Translation: EAW49933.1 .
CH471066 Genomic DNA. Translation: EAW49934.1 .
BC004535 mRNA. Translation: AAH04535.1 .
BC008074 mRNA. Translation: AAH08074.1 .
BC011749 mRNA. Translation: AAH11749.1 .
BC012830 mRNA. Translation: AAH12830.1 .
BC033157 mRNA. Translation: AAH33157.1 .
CCDSi CCDS7460.1. [Q969W1-1 ]
CCDS7461.1. [Q969W1-2 ]
CCDS7462.1. [Q969W1-3 ]
CCDS7463.1. [Q969W1-4 ]
RefSeqi NP_001274732.1. NM_001287803.1.
NP_001274733.1. NM_001287804.1.
NP_115703.2. NM_032327.3. [Q969W1-1 ]
NP_932160.1. NM_198043.2. [Q969W1-2 ]
NP_932161.1. NM_198044.2. [Q969W1-3 ]
NP_932162.1. NM_198045.2. [Q969W1-4 ]
NP_932163.1. NM_198046.2. [Q969W1-1 ]
UniGenei Hs.76662.

3D structure databases

ProteinModelPortali Q969W1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124014. 2 interactions.
STRINGi 9606.ENSP00000359891.

PTM databases

PhosphoSitei Q969W1.

Polymorphism databases

DMDMi 37999852.

Proteomic databases

MaxQBi Q969W1.
PaxDbi Q969W1.
PRIDEi Q969W1.

Protocols and materials databases

DNASUi 84287.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345745 ; ENSP00000304487 ; ENSG00000171307 . [Q969W1-4 ]
ENST00000352634 ; ENSP00000345383 ; ENSG00000171307 . [Q969W1-2 ]
ENST00000353979 ; ENSP00000323360 ; ENSG00000171307 . [Q969W1-3 ]
ENST00000370842 ; ENSP00000359879 ; ENSG00000171307 . [Q969W1-2 ]
ENST00000370854 ; ENSP00000359891 ; ENSG00000171307 . [Q969W1-1 ]
ENST00000393760 ; ENSP00000377357 ; ENSG00000171307 . [Q969W1-1 ]
GeneIDi 84287.
KEGGi hsa:84287.
UCSCi uc001knj.3. human. [Q969W1-1 ]
uc001knl.3. human. [Q969W1-2 ]
uc001knm.3. human. [Q969W1-4 ]
uc001knn.3. human. [Q969W1-3 ]

Organism-specific databases

CTDi 84287.
GeneCardsi GC10P099195.
HGNCi HGNC:20714. ZDHHC16.
HPAi HPA039893.
neXtProti NX_Q969W1.
PharmGKBi PA134985701.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5273.
HOVERGENi HBG054667.
InParanoidi Q969W1.
OMAi ILQTYSV.
OrthoDBi EOG75QR41.
PhylomeDBi Q969W1.
TreeFami TF320809.

Miscellaneous databases

ChiTaRSi ZDHHC16. human.
GenomeRNAii 84287.
NextBioi 73905.
PROi Q969W1.

Gene expression databases

ArrayExpressi Q969W1.
Bgeei Q969W1.
CleanExi HS_ZDHHC16.
Genevestigatori Q969W1.

Family and domain databases

InterProi IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view ]
Pfami PF01529. zf-DHHC. 1 hit.
[Graphical view ]
PROSITEi PS50216. ZF_DHHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene containing the cysteine-rich zf-DHHC motif is localised at human chromosomal region 10q23.3-q24."
    Sarafidou T., Moschonas N.K.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: B-cell, Brain, Ovary and Placenta.

Entry informationi

Entry nameiZDH16_HUMAN
AccessioniPrimary (citable) accession number: Q969W1
Secondary accession number(s): D3DR52
, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q9BSV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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