Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine palmitoyltransferase small subunit A

Gene

SPTSSA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.1 Publication

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

  • serine C-palmitoyltransferase activity Source: MGI

GO - Biological processi

  • ceramide biosynthetic process Source: MGI
  • sphingolipid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-34371.
UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine palmitoyltransferase small subunit A
Alternative name(s):
Small subunit of serine palmitoyltransferase A
Short name:
ssSPTa
Gene namesi
Name:SPTSSA
Synonyms:C14orf147, SSSPTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20361. SPTSSA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence analysisAdd
BLAST
Transmembranei13 – 2917HelicalSequence analysisAdd
BLAST
Topological domaini30 – 345LumenalSequence analysis
Transmembranei35 – 5723HelicalSequence analysisAdd
BLAST
Topological domaini58 – 7114CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • serine C-palmitoyltransferase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394765.

Polymorphism and mutation databases

BioMutaiSPTSSA.
DMDMi238054261.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7171Serine palmitoyltransferase small subunit APRO_0000089949Add
BLAST

Proteomic databases

PaxDbiQ969W0.
PRIDEiQ969W0.
TopDownProteomicsiQ969W0.

Expressioni

Gene expression databases

BgeeiENSG00000165389.
CleanExiHS_C14orf147.
GenevisibleiQ969W0. HS.

Interactioni

Subunit structurei

Interacts with SPTLC1; the interaction is direct. Component of the serine palmitoyltransferase (SPT) complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SPTSSA or SPTSSB.1 Publication

Protein-protein interaction databases

BioGridi128143. 4 interactions.
DIPiDIP-60754N.
IntActiQ969W0. 1 interaction.
MINTiMINT-1415186.
STRINGi9606.ENSP00000298130.

Structurei

3D structure databases

ProteinModelPortaliQ969W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPTSS family. SPTSSA subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J065. Eukaryota.
ENOG410Y1GV. LUCA.
GeneTreeiENSGT00390000002766.
HOGENOMiHOG000154434.
InParanoidiQ969W0.
OMAiLHYFELV.
OrthoDBiEOG091G186X.
PhylomeDBiQ969W0.
TreeFamiTF328418.

Family and domain databases

InterProiIPR024512. Ser_palmitoyltrfase_ssu-like.
[Graphical view]
PfamiPF11779. DUF3317. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGMALARAW KQMSWFYYQY LLVTALYMLE PWERTVFNSM LVSIVGMALY
60 70
TGYVFMPQHI MAILHYFEIV Q
Length:71
Mass (Da):8,466
Last modified:May 26, 2009 - v2
Checksum:iED4F188040EE703C
GO

Sequence cautioni

The sequence AAH16805 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH16808 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH21701 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH68480 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37801 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561M → V in AAH21701 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315409 mRNA. Translation: BAG37801.1. Different initiation.
CH471078 Genomic DNA. Translation: EAW65923.1.
CH471078 Genomic DNA. Translation: EAW65924.1.
BC016805 mRNA. Translation: AAH16805.1. Different initiation.
BC016808 mRNA. Translation: AAH16808.1. Different initiation.
BC021701 mRNA. Translation: AAH21701.1. Different initiation.
BC068480 mRNA. Translation: AAH68480.1. Different initiation.
CCDSiCCDS9647.2.
RefSeqiNP_612145.2. NM_138288.3.
UniGeneiHs.740577.

Genome annotation databases

EnsembliENST00000298130; ENSP00000298130; ENSG00000165389.
GeneIDi171546.
KEGGihsa:171546.
UCSCiuc001wsc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315409 mRNA. Translation: BAG37801.1. Different initiation.
CH471078 Genomic DNA. Translation: EAW65923.1.
CH471078 Genomic DNA. Translation: EAW65924.1.
BC016805 mRNA. Translation: AAH16805.1. Different initiation.
BC016808 mRNA. Translation: AAH16808.1. Different initiation.
BC021701 mRNA. Translation: AAH21701.1. Different initiation.
BC068480 mRNA. Translation: AAH68480.1. Different initiation.
CCDSiCCDS9647.2.
RefSeqiNP_612145.2. NM_138288.3.
UniGeneiHs.740577.

3D structure databases

ProteinModelPortaliQ969W0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128143. 4 interactions.
DIPiDIP-60754N.
IntActiQ969W0. 1 interaction.
MINTiMINT-1415186.
STRINGi9606.ENSP00000298130.

Polymorphism and mutation databases

BioMutaiSPTSSA.
DMDMi238054261.

Proteomic databases

PaxDbiQ969W0.
PRIDEiQ969W0.
TopDownProteomicsiQ969W0.

Protocols and materials databases

DNASUi171546.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298130; ENSP00000298130; ENSG00000165389.
GeneIDi171546.
KEGGihsa:171546.
UCSCiuc001wsc.4. human.

Organism-specific databases

CTDi171546.
GeneCardsiSPTSSA.
HGNCiHGNC:20361. SPTSSA.
MIMi613540. gene.
neXtProtiNX_Q969W0.
PharmGKBiPA128394765.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J065. Eukaryota.
ENOG410Y1GV. LUCA.
GeneTreeiENSGT00390000002766.
HOGENOMiHOG000154434.
InParanoidiQ969W0.
OMAiLHYFELV.
OrthoDBiEOG091G186X.
PhylomeDBiQ969W0.
TreeFamiTF328418.

Enzyme and pathway databases

UniPathwayiUPA00222.
BioCyciMetaCyc:MONOMER66-34371.

Miscellaneous databases

ChiTaRSiSPTSSA. human.
GenomeRNAii171546.
PROiQ969W0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165389.
CleanExiHS_C14orf147.
GenevisibleiQ969W0. HS.

Family and domain databases

InterProiIPR024512. Ser_palmitoyltrfase_ssu-like.
[Graphical view]
PfamiPF11779. DUF3317. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPTSA_HUMAN
AccessioniPrimary (citable) accession number: Q969W0
Secondary accession number(s): B2RD54, D3DS93, Q8WTZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 26, 2009
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.