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Q969V6

- MKL1_HUMAN

UniProt

Q969V6 - MKL1_HUMAN

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Protein
MKL/myocardin-like protein 1
Gene
MKL1, KIAA1438, MAL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei3 – 42Breakpoint for translocation to form RBM15-MKL1

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. actin monomer binding Source: UniProtKB
  3. leucine zipper domain binding Source: BHF-UCL
  4. protein binding Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: Ensembl
  6. transcription coactivator activity Source: UniProtKB
  7. transcription regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. negative regulation of apoptotic signaling pathway Source: Ensembl
  2. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  3. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  4. positive regulation of transcription via serum response element binding Source: UniProtKB
  5. smooth muscle cell differentiation Source: BHF-UCL
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MKL/myocardin-like protein 1
Alternative name(s):
Megakaryoblastic leukemia 1 protein
Megakaryocytic acute leukemia protein
Myocardin-related transcription factor A
Short name:
MRTF-A
Gene namesi
Name:MKL1
Synonyms:KIAA1438, MAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:14334. MKL1.

Subcellular locationi

Nucleus. Cytoplasm By similarity
Note: Binding to globular actin is required to maintain cytoplasmic localization. Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear globular actin, promoting retention of MKL1 in the nucleus and subsequent formation of an active complex with SRF (1 Publication).2 Publications

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MKL1 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with RBM15. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA30827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931MKL/myocardin-like protein 1
PRO_0000126625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61Phosphoserine2 Publications
Modified residuei305 – 3051Phosphothreonine1 Publication
Modified residuei450 – 4501Phosphothreonine3 Publications
Modified residuei454 – 4541Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ969V6.
PaxDbiQ969V6.
PRIDEiQ969V6.

PTM databases

PhosphoSiteiQ969V6.

Expressioni

Tissue specificityi

Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.

Gene expression databases

ArrayExpressiQ969V6.
BgeeiQ969V6.
CleanExiHS_MAL.
HS_MKL1.
GenevestigatoriQ969V6.

Organism-specific databases

HPAiHPA030782.

Interactioni

Subunit structurei

Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA via SRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRFP118312EBI-493122,EBI-493034

Protein-protein interaction databases

BioGridi121642. 13 interactions.
IntActiQ969V6. 4 interactions.
MINTiMINT-4713067.
STRINGi9606.ENSP00000347847.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni345 – 3495
Helixi352 – 36110
Helixi370 – 38213
Beta strandi388 – 3903
Beta strandi392 – 3943

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KVUNMR-A336-396[»]
2KW9NMR-A336-396[»]
ProteinModelPortaliQ969V6.
SMRiQ969V6. Positions 1-91, 333-396.

Miscellaneous databases

EvolutionaryTraceiQ969V6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 4926RPEL 1
Add
BLAST
Repeati68 – 9326RPEL 2
Add
BLAST
Domaini347 – 38135SAP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 256256Mediates interaction with SCAI and ACTB By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili515 – 56349 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi264 – 28623Gln-rich
Add
BLAST
Compositional biasi564 – 811248Pro-rich
Add
BLAST

Domaini

The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity By similarity.
The RPEL repeats mediate binding to globular actin By similarity.

Sequence similaritiesi

Contains 2 RPEL repeats.
Contains 1 SAP domain.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG82832.
HOGENOMiHOG000038001.
HOVERGENiHBG036493.
InParanoidiQ969V6.
OMAiAQMDLEH.
OrthoDBiEOG7FR7G1.
PhylomeDBiQ969V6.
TreeFamiTF326024.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR004018. RPEL_repeat.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF02755. RPEL. 2 hits.
PF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00707. RPEL. 2 hits.
SM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS51073. RPEL. 2 hits.
PS50800. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969V6-1 [UniParc]FASTAAdd to Basket

« Hide

MPPLKSPAAF HEQRRSLERA RTEDYLKRKI RSRPERSELV RMHILEETSA    50
EPSLQAKQLK LKRARLADDL NEKIAQRPGP MELVEKNILP VESSLKEAII 100
VGQVNYPKVA DSSSFDEDSS DALSPEQPAS HESQGSVPSP LEARVSEPLL 150
SATSASPTQV VSQLPMGRDS REMLFLAEQP PLPPPPLLPP SLTNGTTIPT 200
AKSTPTLIKQ SQPKSASEKS QRSKKAKELK PKVKKLKYHQ YIPPDQKQDR 250
GAPPMDSSYA KILQQQQLFL QLQILNQQQQ QHHNYQAILP APPKSAGEAL 300
GSSGTPPVRS LSTTNSSSSS GAPGPCGLAR QNSTSLTGKP GALPANLDDM 350
KVAELKQELK LRSLPVSGTK TELIERLRAY QDQISPVPGA PKAPAATSIL 400
HKAGEVVVAF PAARLSTGPA LVAAGLAPAE VVVATVASSG VVKFGSTGST 450
PPVSPTPSER SLLSTGDENS TPGDTFGEMV TSPLTQLTLQ ASPLQILVKE 500
EGPRAGSCCL SPGGRAELEG RDKDQMLQEK DKQIEALTRM LRQKQQLVER 550
LKLQLEQEKR AQQPAPAPAP LGTPVKQENS FSSCQLSQQP LGPAHPFNPS 600
LAAPATNHID PCAVAPGPPS VVVKQEALQP EPEPVPAPQL LLGPQGPSLI 650
KGVAPPTLIT DSTGTHLVLT VTNKNADSPG LSSGSPQQPS SQPGSPAPAP 700
SAQMDLEHPL QPLFGTPTSL LKKEPPGYEE AMSQQPKQQE NGSSSQQMDD 750
LFDILIQSGE ISADFKEPPS LPGKEKPSPK TVCGSPLAAQ PSPSAELPQA 800
APPPPGSPSL PGRLEDFLES STGLPLLTSG HDGPEPLSLI DDLHSQMLSS 850
TAILDHPPSP MDTSELHFVP EPSSTMGLDL ADGHLDSMDW LELSSGGPVL 900
SLAPLSTTAP SLFSTDFLDG HDLQLHWDSC L 931
Length:931
Mass (Da):98,919
Last modified:December 1, 2001 - v1
Checksum:i6EDE5E2C56D89609
GO

Sequence cautioni

The sequence AAK56920.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA92676.2 differs from that shown. Reason: Erroneous initiation.
The sequence CAC38828.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAC38829.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti648 – 6481S → G.2 Publications
Corresponds to variant rs878756 [ dbSNP | Ensembl ].
VAR_021409

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ297257 mRNA. Translation: CAC38826.1.
AF364035 mRNA. Translation: AAK56920.1. Different initiation.
CR456522 mRNA. Translation: CAG30408.1.
AJ297258 mRNA. Translation: CAC38827.1.
AF368061 mRNA. Translation: AAK54721.1.
AJ303089 mRNA. Translation: CAC38828.1. Different initiation.
AJ303090 mRNA. Translation: CAC38829.1. Different initiation.
AB037859 mRNA. Translation: BAA92676.2. Different initiation.
AL022238 Genomic DNA. Translation: CAI18985.1.
AL713710 mRNA. Translation: CAD28507.2.
CCDSiCCDS14003.1.
RefSeqiNP_001269589.1. NM_001282660.1.
NP_001269590.1. NM_001282661.1.
NP_065882.1. NM_020831.4.
XP_005261751.1. XM_005261694.1.
UniGeneiHs.654688.

Genome annotation databases

EnsembliENST00000355630; ENSP00000347847; ENSG00000196588.
ENST00000407029; ENSP00000385835; ENSG00000196588.
GeneIDi57591.
KEGGihsa:57591.
UCSCiuc003ayv.1. human.

Polymorphism databases

DMDMi32363202.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ297257 mRNA. Translation: CAC38826.1 .
AF364035 mRNA. Translation: AAK56920.1 . Different initiation.
CR456522 mRNA. Translation: CAG30408.1 .
AJ297258 mRNA. Translation: CAC38827.1 .
AF368061 mRNA. Translation: AAK54721.1 .
AJ303089 mRNA. Translation: CAC38828.1 . Different initiation.
AJ303090 mRNA. Translation: CAC38829.1 . Different initiation.
AB037859 mRNA. Translation: BAA92676.2 . Different initiation.
AL022238 Genomic DNA. Translation: CAI18985.1 .
AL713710 mRNA. Translation: CAD28507.2 .
CCDSi CCDS14003.1.
RefSeqi NP_001269589.1. NM_001282660.1.
NP_001269590.1. NM_001282661.1.
NP_065882.1. NM_020831.4.
XP_005261751.1. XM_005261694.1.
UniGenei Hs.654688.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KVU NMR - A 336-396 [» ]
2KW9 NMR - A 336-396 [» ]
ProteinModelPortali Q969V6.
SMRi Q969V6. Positions 1-91, 333-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121642. 13 interactions.
IntActi Q969V6. 4 interactions.
MINTi MINT-4713067.
STRINGi 9606.ENSP00000347847.

PTM databases

PhosphoSitei Q969V6.

Polymorphism databases

DMDMi 32363202.

Proteomic databases

MaxQBi Q969V6.
PaxDbi Q969V6.
PRIDEi Q969V6.

Protocols and materials databases

DNASUi 57591.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355630 ; ENSP00000347847 ; ENSG00000196588 .
ENST00000407029 ; ENSP00000385835 ; ENSG00000196588 .
GeneIDi 57591.
KEGGi hsa:57591.
UCSCi uc003ayv.1. human.

Organism-specific databases

CTDi 57591.
GeneCardsi GC22M040807.
HGNCi HGNC:14334. MKL1.
HPAi HPA030782.
MIMi 606078. gene.
neXtProti NX_Q969V6.
PharmGKBi PA30827.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82832.
HOGENOMi HOG000038001.
HOVERGENi HBG036493.
InParanoidi Q969V6.
OMAi AQMDLEH.
OrthoDBi EOG7FR7G1.
PhylomeDBi Q969V6.
TreeFami TF326024.

Miscellaneous databases

ChiTaRSi MKL1. human.
EvolutionaryTracei Q969V6.
GeneWikii MKL1.
GenomeRNAii 57591.
NextBioi 64178.
PROi Q969V6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q969V6.
Bgeei Q969V6.
CleanExi HS_MAL.
HS_MKL1.
Genevestigatori Q969V6.

Family and domain databases

Gene3Di 1.10.720.30. 1 hit.
InterProi IPR004018. RPEL_repeat.
IPR003034. SAP_dom.
[Graphical view ]
Pfami PF02755. RPEL. 2 hits.
PF02037. SAP. 1 hit.
[Graphical view ]
SMARTi SM00707. RPEL. 2 hits.
SM00513. SAP. 1 hit.
[Graphical view ]
PROSITEi PS51073. RPEL. 2 hits.
PS50800. SAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia."
    Ma Z., Morris S.W., Valentine V., Li M., Herbrick J.-A., Cui X., Bouman D., Li Y., Mehta P.K., Nizetic D., Kaneko Y., Chan G.C.F., Chan L.C., Squire J., Scherer S.W., Hitzler J.K.
    Nat. Genet. 28:220-221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH RBM15.
  2. "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia."
    Mercher T., Coniat M.B.-L., Monni R., Mauchauffe M., Khac F.N., Gressin L., Mugneret F., Leblanc T., Dastugue N., Berger R., Bernard O.A.
    Proc. Natl. Acad. Sci. U.S.A. 98:5776-5779(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH RBM15.
    Tissue: Blood.
  3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-648.
  6. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-931, VARIANT GLY-648.
    Tissue: Testis.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-305 AND THR-450, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin."
    Brandt D.T., Baarlink C., Kitzing T.M., Kremmer E., Ivaska J., Nollau P., Grosse R.
    Nat. Cell Biol. 11:557-568(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCAI AND SRF, SUBCELLULAR LOCATION.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-450 AND SER-454, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; THR-450 AND SER-454, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Redox modification of nuclear actin by MICAL-2 regulates SRF signaling."
    Lundquist M.R., Storaska A.J., Liu T.C., Larsen S.D., Evans T., Neubig R.R., Jaffrey S.R.
    Cell 156:563-576(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  16. "Northeast structural genomics consortium target HR4547E."
    Northeast structural genomics consortium (NESG)
    Submitted (JUN-2010) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 336-396.

Entry informationi

Entry nameiMKL1_HUMAN
AccessioniPrimary (citable) accession number: Q969V6
Secondary accession number(s): Q8TCL1
, Q96SC5, Q96SC6, Q9P2B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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