Q969V4 (TEKT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tektin-1

Gene names

Name:

TEKT1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme. Cytoplasm › cytoskeleton › flagellum axoneme.
Tissue specificity	Predominantly expressed in testis. Ref.1
Sequence similarities	Belongs to the tektin family.

Ontologies

Keywords
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	microtubule cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular component	cilium axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell flagellar axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Tektin-1		PRO_0000184562
Regions
	Coiled coil	21 – 107	87	Potential
	Coiled coil	134 – 177	44	Potential
	Coiled coil	266 – 308	43	Potential
	Coiled coil	333 – 384	52	Potential
Natural variations
	Natural variant	146	1	I → V. Corresponds to variant rs34431552 [ dbSNP | Ensembl ].		VAR_034548
	Natural variant	254	1	R → C. Corresponds to variant rs3744395 [ dbSNP | Ensembl ].		VAR_022150
	Natural variant	332	1	V → I. Corresponds to variant rs2271233 [ dbSNP | Ensembl ].		VAR_022151

Sequences

	Sequence		Length	Mass (Da)
	Q969V4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 724A9172C627BA52	FASTA	418	48,283
	10 20 30 40 50 60 MAKLLQPPPK FLPSEWHIAN KNQYHRADAQ RSRSERLVAE SQRLVDEIEK TTRKSQSDVN 70 80 90 100 110 120 KKLEQRLEEV QFWKKELDDK LEQLVNVTDD LLIYKIRLEK ALETLKEPLH ITETCLAYRE 130 140 150 160 170 180 KRIGIDLVHD TVEHELIKEA EIIQGIMALL TRTLEEASEQ IRMNRSAKYN LEKDLKDKFV 190 200 210 220 230 240 ALTIDDICFS LNNNSPNIRY SENAVRIEPN SVSLEDWLDF SSTNVEKADK QRNNSLMLKA 250 260 270 280 290 300 LVDRILSQTA NDLRKQCDVV DTAFKNGLKD TKDARDKLAD HLAKVMEEIA SQEKNITALE 310 320 330 340 350 360 KAILDQEGPA KVAHTRLETR THRPNVELCR DVAQYRLMKE VQEITHNVAR LKETLAQAQA 370 380 390 400 410 ELKGLHRRQL ALQEEIQVKE NTIYIDEVLC MQMRKSIPLR DGEDHGVWAG GLRPDAVC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel human TEKTIN1 gene." Xu M., Zhou Z., Cheng C., Zhao W., Tang R., Huang Y., Wang W., Xu J., Zeng L., Xie Y., Mao Y. Int. J. Biochem. Cell Biol. 33:1172-1182(2001) [PubMed: 11606253] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF357879 mRNA. Translation: AAL27695.1. CH471108 Genomic DNA. Translation: EAW90284.1. CH471108 Genomic DNA. Translation: EAW90285.1. BC014599 mRNA. Translation: AAH14599.1.
IPI	IPI00056511.
RefSeq	NP_444515.1. NM_053285.1.
UniGene	Hs.462108.
3D structure databases
ProteinModelPortal	Q969V4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q969V4.
Polymorphism databases
DMDM	25009461.
Proteomic databases
PRIDE	Q969V4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338694; ENSP00000341346; ENSG00000167858.
GeneID	83659.
KEGG	hsa:83659.
UCSC	uc002gdt.1. human.
Organism-specific databases
CTD	83659.
GeneCards	GC17M006644.
H-InvDB	HIX0013482.
HGNC	HGNC:15534. TEKT1.
HPA	HPA044444.
MIM	609002. gene.
neXtProt	NX_Q969V4.
PharmGKB	PA37976.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09008.
GeneTree	ENSGT00390000016344.
HOGENOM	HBG714086.
HOVERGEN	HBG056503.
InParanoid	Q969V4.
OMA	KTTRKSQ.
OrthoDB	EOG4T4CVV.
PhylomeDB	Q969V4.
Gene expression databases
ArrayExpress	Q969V4.
Bgee	Q969V4.
CleanEx	HS_TEKT1.
Genevestigator	Q969V4.
GermOnline	ENSG00000167858. Homo sapiens.
Family and domain databases
InterPro	IPR000435. Tektin. [Graphical view]
Pfam	PF03148. Tektin. 1 hit. [Graphical view]
PRINTS	PR00511. TEKTIN.
ProtoNet	Search...
Other
NextBio	72627.
SOURCE	Search...

Entry information

Entry name

TEKT1_HUMAN

Accession

Primary (citable) accession number: Q969V4
Secondary accession number(s): D3DTM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.