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Protein

Tektin-1

Gene

TEKT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tektin-1
Gene namesi
Name:TEKT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:15534. TEKT1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: UniProtKB-KW
  • nucleus Source: UniProtKB
  • sperm flagellum Source: GO_Central

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi83659.
OpenTargetsiENSG00000167858.
PharmGKBiPA37976.

Polymorphism and mutation databases

BioMutaiTEKT1.
DMDMi25009461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001845621 – 418Tektin-1Add BLAST418

Proteomic databases

EPDiQ969V4.
PaxDbiQ969V4.
PeptideAtlasiQ969V4.
PRIDEiQ969V4.

PTM databases

iPTMnetiQ969V4.
PhosphoSitePlusiQ969V4.
SwissPalmiQ969V4.

Expressioni

Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000167858.
CleanExiHS_TEKT1.
ExpressionAtlasiQ969V4. baseline and differential.
GenevisibleiQ969V4. HS.

Organism-specific databases

HPAiHPA044444.
HPA062285.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123716. 9 interactors.
IntActiQ969V4. 26 interactors.
MINTiMINT-4990094.
STRINGi9606.ENSP00000341346.

Structurei

3D structure databases

ProteinModelPortaliQ969V4.
SMRiQ969V4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 107Sequence analysisAdd BLAST87
Coiled coili134 – 177Sequence analysisAdd BLAST44
Coiled coili266 – 308Sequence analysisAdd BLAST43
Coiled coili333 – 384Sequence analysisAdd BLAST52

Sequence similaritiesi

Belongs to the tektin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ969V4.
KOiK18628.
OMAiYHRAEAQ.
OrthoDBiEOG091G0AJL.
PhylomeDBiQ969V4.
TreeFamiTF320754.

Family and domain databases

InterProiView protein in InterPro
IPR000435. Tektin.
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.

Sequencei

Sequence statusi: Complete.

Q969V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLLQPPPK FLPSEWHIAN KNQYHRADAQ RSRSERLVAE SQRLVDEIEK
60 70 80 90 100
TTRKSQSDVN KKLEQRLEEV QFWKKELDDK LEQLVNVTDD LLIYKIRLEK
110 120 130 140 150
ALETLKEPLH ITETCLAYRE KRIGIDLVHD TVEHELIKEA EIIQGIMALL
160 170 180 190 200
TRTLEEASEQ IRMNRSAKYN LEKDLKDKFV ALTIDDICFS LNNNSPNIRY
210 220 230 240 250
SENAVRIEPN SVSLEDWLDF SSTNVEKADK QRNNSLMLKA LVDRILSQTA
260 270 280 290 300
NDLRKQCDVV DTAFKNGLKD TKDARDKLAD HLAKVMEEIA SQEKNITALE
310 320 330 340 350
KAILDQEGPA KVAHTRLETR THRPNVELCR DVAQYRLMKE VQEITHNVAR
360 370 380 390 400
LKETLAQAQA ELKGLHRRQL ALQEEIQVKE NTIYIDEVLC MQMRKSIPLR
410
DGEDHGVWAG GLRPDAVC
Length:418
Mass (Da):48,283
Last modified:December 1, 2001 - v1
Checksum:i724A9172C627BA52
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034548146I → V. Corresponds to variant dbSNP:rs34431552Ensembl.1
Natural variantiVAR_022150254R → C. Corresponds to variant dbSNP:rs3744395Ensembl.1
Natural variantiVAR_022151332V → I. Corresponds to variant dbSNP:rs2271233Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357879 mRNA. Translation: AAL27695.1.
CH471108 Genomic DNA. Translation: EAW90284.1.
CH471108 Genomic DNA. Translation: EAW90285.1.
BC014599 mRNA. Translation: AAH14599.1.
CCDSiCCDS11083.1.
RefSeqiNP_444515.1. NM_053285.1.
UniGeneiHs.462108.

Genome annotation databases

EnsembliENST00000338694; ENSP00000341346; ENSG00000167858.
GeneIDi83659.
KEGGihsa:83659.
UCSCiuc002gdt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357879 mRNA. Translation: AAL27695.1.
CH471108 Genomic DNA. Translation: EAW90284.1.
CH471108 Genomic DNA. Translation: EAW90285.1.
BC014599 mRNA. Translation: AAH14599.1.
CCDSiCCDS11083.1.
RefSeqiNP_444515.1. NM_053285.1.
UniGeneiHs.462108.

3D structure databases

ProteinModelPortaliQ969V4.
SMRiQ969V4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123716. 9 interactors.
IntActiQ969V4. 26 interactors.
MINTiMINT-4990094.
STRINGi9606.ENSP00000341346.

PTM databases

iPTMnetiQ969V4.
PhosphoSitePlusiQ969V4.
SwissPalmiQ969V4.

Polymorphism and mutation databases

BioMutaiTEKT1.
DMDMi25009461.

Proteomic databases

EPDiQ969V4.
PaxDbiQ969V4.
PeptideAtlasiQ969V4.
PRIDEiQ969V4.

Protocols and materials databases

DNASUi83659.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338694; ENSP00000341346; ENSG00000167858.
GeneIDi83659.
KEGGihsa:83659.
UCSCiuc002gdt.4. human.

Organism-specific databases

CTDi83659.
DisGeNETi83659.
GeneCardsiTEKT1.
HGNCiHGNC:15534. TEKT1.
HPAiHPA044444.
HPA062285.
MIMi609002. gene.
neXtProtiNX_Q969V4.
OpenTargetsiENSG00000167858.
PharmGKBiPA37976.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ969V4.
KOiK18628.
OMAiYHRAEAQ.
OrthoDBiEOG091G0AJL.
PhylomeDBiQ969V4.
TreeFamiTF320754.

Miscellaneous databases

GeneWikiiTEKT1.
GenomeRNAii83659.
PROiQ969V4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167858.
CleanExiHS_TEKT1.
ExpressionAtlasiQ969V4. baseline and differential.
GenevisibleiQ969V4. HS.

Family and domain databases

InterProiView protein in InterPro
IPR000435. Tektin.
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.
ProtoNetiSearch...

Entry informationi

Entry nameiTEKT1_HUMAN
AccessioniPrimary (citable) accession number: Q969V4
Secondary accession number(s): D3DTM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: March 15, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.