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Protein

Tektin-1

Gene

TEKT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.

Names & Taxonomyi

Protein namesi
Recommended name:
Tektin-1
Gene namesi
Name:TEKT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:15534. TEKT1.

Subcellular locationi

GO - Cellular componenti

  • cilium Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37976.

Polymorphism and mutation databases

BioMutaiTEKT1.
DMDMi25009461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Tektin-1PRO_0000184562Add
BLAST

Proteomic databases

EPDiQ969V4.
PaxDbiQ969V4.
PRIDEiQ969V4.

PTM databases

PhosphoSiteiQ969V4.
SwissPalmiQ969V4.

Expressioni

Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

BgeeiQ969V4.
CleanExiHS_TEKT1.
ExpressionAtlasiQ969V4. baseline and differential.
GenevisibleiQ969V4. HS.

Organism-specific databases

HPAiHPA044444.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BYSLQ138955EBI-10180409,EBI-358049
CCHCR1Q8TD31-33EBI-10180409,EBI-10175300
CHD2O146473EBI-10180409,EBI-1210503
HNRNPH2P557953EBI-10180409,EBI-352823
NCAPD3Q96FA63EBI-10180409,EBI-10285636
PRKAG1P546193EBI-10180409,EBI-1181439
SDCBPO005603EBI-10180409,EBI-727004
VCLP182063EBI-10180409,EBI-716775

Protein-protein interaction databases

BioGridi123716. 8 interactions.
IntActiQ969V4. 8 interactions.
MINTiMINT-4990094.
STRINGi9606.ENSP00000341346.

Structurei

3D structure databases

ProteinModelPortaliQ969V4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili21 – 10787Sequence analysisAdd
BLAST
Coiled coili134 – 17744Sequence analysisAdd
BLAST
Coiled coili266 – 30843Sequence analysisAdd
BLAST
Coiled coili333 – 38452Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the tektin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ969V4.
KOiK18628.
OMAiYHRAEAQ.
PhylomeDBiQ969V4.
TreeFamiTF320754.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.

Sequencei

Sequence statusi: Complete.

Q969V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLLQPPPK FLPSEWHIAN KNQYHRADAQ RSRSERLVAE SQRLVDEIEK
60 70 80 90 100
TTRKSQSDVN KKLEQRLEEV QFWKKELDDK LEQLVNVTDD LLIYKIRLEK
110 120 130 140 150
ALETLKEPLH ITETCLAYRE KRIGIDLVHD TVEHELIKEA EIIQGIMALL
160 170 180 190 200
TRTLEEASEQ IRMNRSAKYN LEKDLKDKFV ALTIDDICFS LNNNSPNIRY
210 220 230 240 250
SENAVRIEPN SVSLEDWLDF SSTNVEKADK QRNNSLMLKA LVDRILSQTA
260 270 280 290 300
NDLRKQCDVV DTAFKNGLKD TKDARDKLAD HLAKVMEEIA SQEKNITALE
310 320 330 340 350
KAILDQEGPA KVAHTRLETR THRPNVELCR DVAQYRLMKE VQEITHNVAR
360 370 380 390 400
LKETLAQAQA ELKGLHRRQL ALQEEIQVKE NTIYIDEVLC MQMRKSIPLR
410
DGEDHGVWAG GLRPDAVC
Length:418
Mass (Da):48,283
Last modified:December 1, 2001 - v1
Checksum:i724A9172C627BA52
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461I → V.
Corresponds to variant rs34431552 [ dbSNP | Ensembl ].
VAR_034548
Natural varianti254 – 2541R → C.
Corresponds to variant rs3744395 [ dbSNP | Ensembl ].
VAR_022150
Natural varianti332 – 3321V → I.
Corresponds to variant rs2271233 [ dbSNP | Ensembl ].
VAR_022151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357879 mRNA. Translation: AAL27695.1.
CH471108 Genomic DNA. Translation: EAW90284.1.
CH471108 Genomic DNA. Translation: EAW90285.1.
BC014599 mRNA. Translation: AAH14599.1.
CCDSiCCDS11083.1.
RefSeqiNP_444515.1. NM_053285.1.
UniGeneiHs.462108.

Genome annotation databases

EnsembliENST00000338694; ENSP00000341346; ENSG00000167858.
GeneIDi83659.
KEGGihsa:83659.
UCSCiuc002gdt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357879 mRNA. Translation: AAL27695.1.
CH471108 Genomic DNA. Translation: EAW90284.1.
CH471108 Genomic DNA. Translation: EAW90285.1.
BC014599 mRNA. Translation: AAH14599.1.
CCDSiCCDS11083.1.
RefSeqiNP_444515.1. NM_053285.1.
UniGeneiHs.462108.

3D structure databases

ProteinModelPortaliQ969V4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123716. 8 interactions.
IntActiQ969V4. 8 interactions.
MINTiMINT-4990094.
STRINGi9606.ENSP00000341346.

PTM databases

PhosphoSiteiQ969V4.
SwissPalmiQ969V4.

Polymorphism and mutation databases

BioMutaiTEKT1.
DMDMi25009461.

Proteomic databases

EPDiQ969V4.
PaxDbiQ969V4.
PRIDEiQ969V4.

Protocols and materials databases

DNASUi83659.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338694; ENSP00000341346; ENSG00000167858.
GeneIDi83659.
KEGGihsa:83659.
UCSCiuc002gdt.4. human.

Organism-specific databases

CTDi83659.
GeneCardsiTEKT1.
HGNCiHGNC:15534. TEKT1.
HPAiHPA044444.
MIMi609002. gene.
neXtProtiNX_Q969V4.
PharmGKBiPA37976.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ969V4.
KOiK18628.
OMAiYHRAEAQ.
PhylomeDBiQ969V4.
TreeFamiTF320754.

Miscellaneous databases

GeneWikiiTEKT1.
GenomeRNAii83659.
NextBioi72627.
PROiQ969V4.
SOURCEiSearch...

Gene expression databases

BgeeiQ969V4.
CleanExiHS_TEKT1.
ExpressionAtlasiQ969V4. baseline and differential.
GenevisibleiQ969V4. HS.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTEKT1_HUMAN
AccessioniPrimary (citable) accession number: Q969V4
Secondary accession number(s): D3DTM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.