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Q969V1

- MCHR2_HUMAN

UniProt

Q969V1 - MCHR2_HUMAN

Protein

Melanin-concentrating hormone receptor 2

Gene

MCHR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanin-concentrating hormone receptor 2
    Short name:
    MCH receptor 2
    Short name:
    MCH-R2
    Short name:
    MCHR-2
    Alternative name(s):
    G-protein coupled receptor 145
    GPRv17
    MCH-2R
    Short name:
    MCH2
    Short name:
    MCH2R
    Gene namesi
    Name:MCHR2
    Synonyms:GPR145, SLT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20867. MCHR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134950856.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Melanin-concentrating hormone receptor 2PRO_0000069740Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ969V1.
    PRIDEiQ969V1.

    Expressioni

    Tissue specificityi

    Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.

    Gene expression databases

    BgeeiQ969V1.
    CleanExiHS_MCHR2.
    GenevestigatoriQ969V1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000281806.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969V1.
    SMRiQ969V1. Positions 35-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 699CytoplasmicSequence Analysis
    Topological domaini91 – 10414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 15425CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20025ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 25231CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 34031CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12925Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237628.
    HOGENOMiHOG000000704.
    HOVERGENiHBG098164.
    InParanoidiQ969V1.
    KOiK05054.
    OMAiQNKDARC.
    OrthoDBiEOG7NSB2N.
    PhylomeDBiQ969V1.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008362. MCH2_receptor.
    IPR008361. MCH_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01784. MCH2RECEPTOR.
    PR01783. MCHRECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q969V1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPFHASCWN TSAELLNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV    50
    GNILIVFTII RSRKKTVPDI YICNLAVADL VHIVGMPFLI HQWARGGEWV 100
    FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTRWRTRYKT 150
    IRINLGLWAA SFILALPVWV YSKVIKFKDG VESCAFDLTS PDDVLWYTLY 200
    LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT 250
    KMVLVLVVVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS 300
    INPFLYILLS GNFQKRLPQI QRRATEKEIN NMGNTLKSHF 340
    Length:340
    Mass (Da):38,849
    Last modified:December 1, 2001 - v1
    Checksum:i754A302BB951FAC6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631R → K No changes in receptor binding or functional signaling. 1 Publication
    VAR_026661
    Natural varianti152 – 1521R → Q No changes in receptor binding or functional signaling. 1 Publication
    Corresponds to variant rs62434070 [ dbSNP | Ensembl ].
    VAR_026662

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB060151 mRNA. Translation: BAB55677.1.
    AY029596 mRNA. Translation: AAK38157.1.
    AF399937 mRNA. Translation: AAL05528.1.
    AF347063 mRNA. Translation: AAK32193.1.
    AB058849 mRNA. Translation: BAB87842.1.
    AY562946 mRNA. Translation: AAS72374.1.
    AK123634 mRNA. Translation: BAG53926.1.
    AL590725 Genomic DNA. Translation: CAH70022.1.
    CH471051 Genomic DNA. Translation: EAW48460.1.
    BC095515 mRNA. Translation: AAH95515.1.
    CCDSiCCDS5044.1.
    PIRiJC7695.
    RefSeqiNP_001035269.1. NM_001040179.1.
    NP_115892.2. NM_032503.2.
    UniGeneiHs.591342.

    Genome annotation databases

    EnsembliENST00000281806; ENSP00000281806; ENSG00000152034.
    ENST00000369212; ENSP00000358214; ENSG00000152034.
    GeneIDi84539.
    KEGGihsa:84539.
    UCSCiuc003pqh.1. human.

    Polymorphism databases

    DMDMi34098673.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB060151 mRNA. Translation: BAB55677.1 .
    AY029596 mRNA. Translation: AAK38157.1 .
    AF399937 mRNA. Translation: AAL05528.1 .
    AF347063 mRNA. Translation: AAK32193.1 .
    AB058849 mRNA. Translation: BAB87842.1 .
    AY562946 mRNA. Translation: AAS72374.1 .
    AK123634 mRNA. Translation: BAG53926.1 .
    AL590725 Genomic DNA. Translation: CAH70022.1 .
    CH471051 Genomic DNA. Translation: EAW48460.1 .
    BC095515 mRNA. Translation: AAH95515.1 .
    CCDSi CCDS5044.1.
    PIRi JC7695.
    RefSeqi NP_001035269.1. NM_001040179.1.
    NP_115892.2. NM_032503.2.
    UniGenei Hs.591342.

    3D structure databases

    ProteinModelPortali Q969V1.
    SMRi Q969V1. Positions 35-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000281806.

    Chemistry

    BindingDBi Q969V1.
    ChEMBLi CHEMBL2111437.
    GuidetoPHARMACOLOGYi 281.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 34098673.

    Proteomic databases

    PaxDbi Q969V1.
    PRIDEi Q969V1.

    Protocols and materials databases

    DNASUi 84539.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281806 ; ENSP00000281806 ; ENSG00000152034 .
    ENST00000369212 ; ENSP00000358214 ; ENSG00000152034 .
    GeneIDi 84539.
    KEGGi hsa:84539.
    UCSCi uc003pqh.1. human.

    Organism-specific databases

    CTDi 84539.
    GeneCardsi GC06M100367.
    HGNCi HGNC:20867. MCHR2.
    MIMi 606111. gene.
    neXtProti NX_Q969V1.
    PharmGKBi PA134950856.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237628.
    HOGENOMi HOG000000704.
    HOVERGENi HBG098164.
    InParanoidi Q969V1.
    KOi K05054.
    OMAi QNKDARC.
    OrthoDBi EOG7NSB2N.
    PhylomeDBi Q969V1.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Melanin-concentrating_hormone_receptor_2.
    GenomeRNAii 84539.
    NextBioi 74387.
    PROi Q969V1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q969V1.
    CleanExi HS_MCHR2.
    Genevestigatori Q969V1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008362. MCH2_receptor.
    IPR008361. MCH_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01784. MCH2RECEPTOR.
    PR01783. MCHRECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor."
      Mori M., Harada M., Terao Y., Sugo T., Watanabe T., Shimomura Y., Abe M., Shintani Y., Onda H., Nishimura O., Fujino M.
      Biochem. Biophys. Res. Commun. 283:1013-1018(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    3. "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2."
      Wang S., Behan J., O'Neill K., Weig B., Fried S., Laz T., Bayne M., Gustafson E., Hawes B.E.
      J. Biol. Chem. 276:34664-34670(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Molecular characterization of a novel melanin-concentrating hormone receptor: evidence of its expression in lateral hypothalamus."
      Kurama T., Matsumoto S., Takasaki J., Terai K., Matsumoto M., Kamohara M., Saito T., Soga T., Saito Y., Oda T., Masuho Y., Furuichi K.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    11. "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2."
      Hawes B.E., Green B., O'Neill K., Fried S., Arreaza M.G., Qiu P., Simon J.S.
      Obes. Res. 12:1327-1334(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LYS-63 AND GLN-152, CHARACTERIZATION OF VARIANTS LYS-63 AND GLN-152.

    Entry informationi

    Entry nameiMCHR2_HUMAN
    AccessioniPrimary (citable) accession number: Q969V1
    Secondary accession number(s): B3KVW4
    , E1P5D7, Q5VTV7, Q6Q377, Q9BXA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3