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Q969V1

- MCHR2_HUMAN

UniProt

Q969V1 - MCHR2_HUMAN

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Protein

Melanin-concentrating hormone receptor 2

Gene

MCHR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 2
Short name:
MCH receptor 2
Short name:
MCH-R2
Short name:
MCHR-2
Alternative name(s):
G-protein coupled receptor 145
GPRv17
MCH-2R
Short name:
MCH2
Short name:
MCH2R
Gene namesi
Name:MCHR2
Synonyms:GPR145, SLT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20867. MCHR2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Melanin-concentrating hormone receptor 2PRO_0000069740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ969V1.
PRIDEiQ969V1.

Expressioni

Tissue specificityi

Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.

Gene expression databases

BgeeiQ969V1.
CleanExiHS_MCHR2.
GenevestigatoriQ969V1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281806.

Structurei

3D structure databases

ProteinModelPortaliQ969V1.
SMRiQ969V1. Positions 13-314.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Topological domaini61 – 699CytoplasmicSequence Analysis
Topological domaini91 – 10414ExtracellularSequence AnalysisAdd
BLAST
Topological domaini130 – 15425CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini176 – 20025ExtracellularSequence AnalysisAdd
BLAST
Topological domaini222 – 25231CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini274 – 28815ExtracellularSequence AnalysisAdd
BLAST
Topological domaini310 – 34031CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei105 – 12925Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237628.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG098164.
InParanoidiQ969V1.
KOiK05054.
OMAiQNKDARC.
OrthoDBiEOG7NSB2N.
PhylomeDBiQ969V1.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008362. MCH2_receptor.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01784. MCH2RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969V1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPFHASCWN TSAELLNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV
60 70 80 90 100
GNILIVFTII RSRKKTVPDI YICNLAVADL VHIVGMPFLI HQWARGGEWV
110 120 130 140 150
FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTRWRTRYKT
160 170 180 190 200
IRINLGLWAA SFILALPVWV YSKVIKFKDG VESCAFDLTS PDDVLWYTLY
210 220 230 240 250
LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT
260 270 280 290 300
KMVLVLVVVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
310 320 330 340
INPFLYILLS GNFQKRLPQI QRRATEKEIN NMGNTLKSHF
Length:340
Mass (Da):38,849
Last modified:December 1, 2001 - v1
Checksum:i754A302BB951FAC6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631R → K No changes in receptor binding or functional signaling. 1 Publication
VAR_026661
Natural varianti152 – 1521R → Q No changes in receptor binding or functional signaling. 1 Publication
Corresponds to variant rs62434070 [ dbSNP | Ensembl ].
VAR_026662

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060151 mRNA. Translation: BAB55677.1.
AY029596 mRNA. Translation: AAK38157.1.
AF399937 mRNA. Translation: AAL05528.1.
AF347063 mRNA. Translation: AAK32193.1.
AB058849 mRNA. Translation: BAB87842.1.
AY562946 mRNA. Translation: AAS72374.1.
AK123634 mRNA. Translation: BAG53926.1.
AL590725 Genomic DNA. Translation: CAH70022.1.
CH471051 Genomic DNA. Translation: EAW48460.1.
BC095515 mRNA. Translation: AAH95515.1.
CCDSiCCDS5044.1.
PIRiJC7695.
RefSeqiNP_001035269.1. NM_001040179.1.
NP_115892.2. NM_032503.2.
UniGeneiHs.591342.

Genome annotation databases

EnsembliENST00000281806; ENSP00000281806; ENSG00000152034.
ENST00000369212; ENSP00000358214; ENSG00000152034.
GeneIDi84539.
KEGGihsa:84539.
UCSCiuc003pqh.1. human.

Polymorphism databases

DMDMi34098673.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060151 mRNA. Translation: BAB55677.1 .
AY029596 mRNA. Translation: AAK38157.1 .
AF399937 mRNA. Translation: AAL05528.1 .
AF347063 mRNA. Translation: AAK32193.1 .
AB058849 mRNA. Translation: BAB87842.1 .
AY562946 mRNA. Translation: AAS72374.1 .
AK123634 mRNA. Translation: BAG53926.1 .
AL590725 Genomic DNA. Translation: CAH70022.1 .
CH471051 Genomic DNA. Translation: EAW48460.1 .
BC095515 mRNA. Translation: AAH95515.1 .
CCDSi CCDS5044.1.
PIRi JC7695.
RefSeqi NP_001035269.1. NM_001040179.1.
NP_115892.2. NM_032503.2.
UniGenei Hs.591342.

3D structure databases

ProteinModelPortali Q969V1.
SMRi Q969V1. Positions 13-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000281806.

Chemistry

BindingDBi Q969V1.
ChEMBLi CHEMBL2111437.
GuidetoPHARMACOLOGYi 281.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 34098673.

Proteomic databases

PaxDbi Q969V1.
PRIDEi Q969V1.

Protocols and materials databases

DNASUi 84539.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281806 ; ENSP00000281806 ; ENSG00000152034 .
ENST00000369212 ; ENSP00000358214 ; ENSG00000152034 .
GeneIDi 84539.
KEGGi hsa:84539.
UCSCi uc003pqh.1. human.

Organism-specific databases

CTDi 84539.
GeneCardsi GC06M100367.
HGNCi HGNC:20867. MCHR2.
MIMi 606111. gene.
neXtProti NX_Q969V1.
PharmGKBi PA134950856.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237628.
GeneTreei ENSGT00760000118797.
HOGENOMi HOG000000704.
HOVERGENi HBG098164.
InParanoidi Q969V1.
KOi K05054.
OMAi QNKDARC.
OrthoDBi EOG7NSB2N.
PhylomeDBi Q969V1.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Melanin-concentrating_hormone_receptor_2.
GenomeRNAii 84539.
NextBioi 74387.
PROi Q969V1.
SOURCEi Search...

Gene expression databases

Bgeei Q969V1.
CleanExi HS_MCHR2.
Genevestigatori Q969V1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008362. MCH2_receptor.
IPR008361. MCH_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01784. MCH2RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor."
    Mori M., Harada M., Terao Y., Sugo T., Watanabe T., Shimomura Y., Abe M., Shintani Y., Onda H., Nishimura O., Fujino M.
    Biochem. Biophys. Res. Commun. 283:1013-1018(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2."
    Wang S., Behan J., O'Neill K., Weig B., Fried S., Laz T., Bayne M., Gustafson E., Hawes B.E.
    J. Biol. Chem. 276:34664-34670(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Molecular characterization of a novel melanin-concentrating hormone receptor: evidence of its expression in lateral hypothalamus."
    Kurama T., Matsumoto S., Takasaki J., Terai K., Matsumoto M., Kamohara M., Saito T., Soga T., Saito Y., Oda T., Masuho Y., Furuichi K.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  11. "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2."
    Hawes B.E., Green B., O'Neill K., Fried S., Arreaza M.G., Qiu P., Simon J.S.
    Obes. Res. 12:1327-1334(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-63 AND GLN-152, CHARACTERIZATION OF VARIANTS LYS-63 AND GLN-152.

Entry informationi

Entry nameiMCHR2_HUMAN
AccessioniPrimary (citable) accession number: Q969V1
Secondary accession number(s): B3KVW4
, E1P5D7, Q5VTV7, Q6Q377, Q9BXA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3