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Protein

Melanin-concentrating hormone receptor 2

Gene

MCHR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 2
Short name:
MCH receptor 2
Short name:
MCH-R2
Short name:
MCHR-2
Alternative name(s):
G-protein coupled receptor 145
GPRv17
MCH-2R
Short name:
MCH2
Short name:
MCH2R
Gene namesi
Name:MCHR2
Synonyms:GPR145, SLT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20867. MCHR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 699CytoplasmicSequence Analysis
Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini91 – 10414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei105 – 12925Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 15425CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 20025ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini222 – 25231CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 28815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 34031CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950856.

Polymorphism and mutation databases

BioMutaiMCHR2.
DMDMi34098673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Melanin-concentrating hormone receptor 2PRO_0000069740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ969V1.
PRIDEiQ969V1.

Expressioni

Tissue specificityi

Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.

Gene expression databases

BgeeiQ969V1.
CleanExiHS_MCHR2.
GenevisibleiQ969V1. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281806.

Structurei

3D structure databases

ProteinModelPortaliQ969V1.
SMRiQ969V1. Positions 25-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237628.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG098164.
InParanoidiQ969V1.
KOiK05054.
OMAiQNKDARC.
OrthoDBiEOG7NSB2N.
PhylomeDBiQ969V1.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008362. MCH2_receptor.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01784. MCH2RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFHASCWN TSAELLNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV
60 70 80 90 100
GNILIVFTII RSRKKTVPDI YICNLAVADL VHIVGMPFLI HQWARGGEWV
110 120 130 140 150
FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTRWRTRYKT
160 170 180 190 200
IRINLGLWAA SFILALPVWV YSKVIKFKDG VESCAFDLTS PDDVLWYTLY
210 220 230 240 250
LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT
260 270 280 290 300
KMVLVLVVVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
310 320 330 340
INPFLYILLS GNFQKRLPQI QRRATEKEIN NMGNTLKSHF
Length:340
Mass (Da):38,849
Last modified:December 1, 2001 - v1
Checksum:i754A302BB951FAC6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631R → K No changes in receptor binding or functional signaling. 1 Publication
VAR_026661
Natural varianti152 – 1521R → Q No changes in receptor binding or functional signaling. 1 Publication
Corresponds to variant rs62434070 [ dbSNP | Ensembl ].
VAR_026662

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060151 mRNA. Translation: BAB55677.1.
AY029596 mRNA. Translation: AAK38157.1.
AF399937 mRNA. Translation: AAL05528.1.
AF347063 mRNA. Translation: AAK32193.1.
AB058849 mRNA. Translation: BAB87842.1.
AY562946 mRNA. Translation: AAS72374.1.
AK123634 mRNA. Translation: BAG53926.1.
AL590725 Genomic DNA. Translation: CAH70022.1.
CH471051 Genomic DNA. Translation: EAW48460.1.
BC095515 mRNA. Translation: AAH95515.1.
CCDSiCCDS5044.1.
PIRiJC7695.
RefSeqiNP_001035269.1. NM_001040179.1.
NP_115892.2. NM_032503.2.
UniGeneiHs.591342.

Genome annotation databases

EnsembliENST00000281806; ENSP00000281806; ENSG00000152034.
ENST00000369212; ENSP00000358214; ENSG00000152034.
GeneIDi84539.
KEGGihsa:84539.
UCSCiuc003pqh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060151 mRNA. Translation: BAB55677.1.
AY029596 mRNA. Translation: AAK38157.1.
AF399937 mRNA. Translation: AAL05528.1.
AF347063 mRNA. Translation: AAK32193.1.
AB058849 mRNA. Translation: BAB87842.1.
AY562946 mRNA. Translation: AAS72374.1.
AK123634 mRNA. Translation: BAG53926.1.
AL590725 Genomic DNA. Translation: CAH70022.1.
CH471051 Genomic DNA. Translation: EAW48460.1.
BC095515 mRNA. Translation: AAH95515.1.
CCDSiCCDS5044.1.
PIRiJC7695.
RefSeqiNP_001035269.1. NM_001040179.1.
NP_115892.2. NM_032503.2.
UniGeneiHs.591342.

3D structure databases

ProteinModelPortaliQ969V1.
SMRiQ969V1. Positions 25-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281806.

Chemistry

BindingDBiQ969V1.
ChEMBLiCHEMBL2111437.
GuidetoPHARMACOLOGYi281.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMCHR2.
DMDMi34098673.

Proteomic databases

PaxDbiQ969V1.
PRIDEiQ969V1.

Protocols and materials databases

DNASUi84539.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281806; ENSP00000281806; ENSG00000152034.
ENST00000369212; ENSP00000358214; ENSG00000152034.
GeneIDi84539.
KEGGihsa:84539.
UCSCiuc003pqh.1. human.

Organism-specific databases

CTDi84539.
GeneCardsiGC06M100367.
HGNCiHGNC:20867. MCHR2.
MIMi606111. gene.
neXtProtiNX_Q969V1.
PharmGKBiPA134950856.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG237628.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG098164.
InParanoidiQ969V1.
KOiK05054.
OMAiQNKDARC.
OrthoDBiEOG7NSB2N.
PhylomeDBiQ969V1.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiMelanin-concentrating_hormone_receptor_2.
GenomeRNAii84539.
NextBioi74387.
PROiQ969V1.
SOURCEiSearch...

Gene expression databases

BgeeiQ969V1.
CleanExiHS_MCHR2.
GenevisibleiQ969V1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008362. MCH2_receptor.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01784. MCH2RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor."
    Mori M., Harada M., Terao Y., Sugo T., Watanabe T., Shimomura Y., Abe M., Shintani Y., Onda H., Nishimura O., Fujino M.
    Biochem. Biophys. Res. Commun. 283:1013-1018(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2."
    Wang S., Behan J., O'Neill K., Weig B., Fried S., Laz T., Bayne M., Gustafson E., Hawes B.E.
    J. Biol. Chem. 276:34664-34670(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Molecular characterization of a novel melanin-concentrating hormone receptor: evidence of its expression in lateral hypothalamus."
    Kurama T., Matsumoto S., Takasaki J., Terai K., Matsumoto M., Kamohara M., Saito T., Soga T., Saito Y., Oda T., Masuho Y., Furuichi K.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  11. "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2."
    Hawes B.E., Green B., O'Neill K., Fried S., Arreaza M.G., Qiu P., Simon J.S.
    Obes. Res. 12:1327-1334(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-63 AND GLN-152, CHARACTERIZATION OF VARIANTS LYS-63 AND GLN-152.

Entry informationi

Entry nameiMCHR2_HUMAN
AccessioniPrimary (citable) accession number: Q969V1
Secondary accession number(s): B3KVW4
, E1P5D7, Q5VTV7, Q6Q377, Q9BXA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.