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Protein

Melanin-concentrating hormone receptor 2

Gene

MCHR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152034-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiQ969V1.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 2
Short name:
MCH receptor 2
Short name:
MCH-R2
Short name:
MCHR-2
Alternative name(s):
G-protein coupled receptor 145
GPRv17
MCH-2R
Short name:
MCH2
Short name:
MCH2R
Gene namesi
Name:MCHR2
Synonyms:GPR145, SLT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20867. MCHR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 69CytoplasmicSequence analysis9
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 104ExtracellularSequence analysisAdd BLAST14
Transmembranei105 – 129Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini130 – 154CytoplasmicSequence analysisAdd BLAST25
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 200ExtracellularSequence analysisAdd BLAST25
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 252CytoplasmicSequence analysisAdd BLAST31
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 288ExtracellularSequence analysisAdd BLAST15
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 340CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84539.
OpenTargetsiENSG00000152034.
PharmGKBiPA134950856.

Chemistry databases

ChEMBLiCHEMBL5038.
GuidetoPHARMACOLOGYi281.

Polymorphism and mutation databases

BioMutaiMCHR2.
DMDMi34098673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697401 – 340Melanin-concentrating hormone receptor 2Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ969V1.
PeptideAtlasiQ969V1.
PRIDEiQ969V1.

Expressioni

Tissue specificityi

Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.

Gene expression databases

BgeeiENSG00000152034.
CleanExiHS_MCHR2.
GenevisibleiQ969V1. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281806.

Chemistry databases

BindingDBiQ969V1.

Structurei

3D structure databases

ProteinModelPortaliQ969V1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG098164.
InParanoidiQ969V1.
KOiK05054.
OMAiGYYLSIC.
OrthoDBiEOG091G0DIE.
PhylomeDBiQ969V1.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008362. MCH2_receptor.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01784. MCH2RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFHASCWN TSAELLNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV
60 70 80 90 100
GNILIVFTII RSRKKTVPDI YICNLAVADL VHIVGMPFLI HQWARGGEWV
110 120 130 140 150
FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTRWRTRYKT
160 170 180 190 200
IRINLGLWAA SFILALPVWV YSKVIKFKDG VESCAFDLTS PDDVLWYTLY
210 220 230 240 250
LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT
260 270 280 290 300
KMVLVLVVVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
310 320 330 340
INPFLYILLS GNFQKRLPQI QRRATEKEIN NMGNTLKSHF
Length:340
Mass (Da):38,849
Last modified:December 1, 2001 - v1
Checksum:i754A302BB951FAC6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02666163R → K No changes in receptor binding or functional signaling. 1 PublicationCorresponds to variant rs147988902dbSNPEnsembl.1
Natural variantiVAR_026662152R → Q No changes in receptor binding or functional signaling. 1 PublicationCorresponds to variant rs62434070dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060151 mRNA. Translation: BAB55677.1.
AY029596 mRNA. Translation: AAK38157.1.
AF399937 mRNA. Translation: AAL05528.1.
AF347063 mRNA. Translation: AAK32193.1.
AB058849 mRNA. Translation: BAB87842.1.
AY562946 mRNA. Translation: AAS72374.1.
AK123634 mRNA. Translation: BAG53926.1.
AL590725 Genomic DNA. Translation: CAH70022.1.
CH471051 Genomic DNA. Translation: EAW48460.1.
BC095515 mRNA. Translation: AAH95515.1.
CCDSiCCDS5044.1.
PIRiJC7695.
RefSeqiNP_001035269.1. NM_001040179.1.
NP_115892.2. NM_032503.2.
UniGeneiHs.591342.

Genome annotation databases

EnsembliENST00000281806; ENSP00000281806; ENSG00000152034.
ENST00000369212; ENSP00000358214; ENSG00000152034.
GeneIDi84539.
KEGGihsa:84539.
UCSCiuc003pqh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060151 mRNA. Translation: BAB55677.1.
AY029596 mRNA. Translation: AAK38157.1.
AF399937 mRNA. Translation: AAL05528.1.
AF347063 mRNA. Translation: AAK32193.1.
AB058849 mRNA. Translation: BAB87842.1.
AY562946 mRNA. Translation: AAS72374.1.
AK123634 mRNA. Translation: BAG53926.1.
AL590725 Genomic DNA. Translation: CAH70022.1.
CH471051 Genomic DNA. Translation: EAW48460.1.
BC095515 mRNA. Translation: AAH95515.1.
CCDSiCCDS5044.1.
PIRiJC7695.
RefSeqiNP_001035269.1. NM_001040179.1.
NP_115892.2. NM_032503.2.
UniGeneiHs.591342.

3D structure databases

ProteinModelPortaliQ969V1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281806.

Chemistry databases

BindingDBiQ969V1.
ChEMBLiCHEMBL5038.
GuidetoPHARMACOLOGYi281.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMCHR2.
DMDMi34098673.

Proteomic databases

PaxDbiQ969V1.
PeptideAtlasiQ969V1.
PRIDEiQ969V1.

Protocols and materials databases

DNASUi84539.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281806; ENSP00000281806; ENSG00000152034.
ENST00000369212; ENSP00000358214; ENSG00000152034.
GeneIDi84539.
KEGGihsa:84539.
UCSCiuc003pqh.1. human.

Organism-specific databases

CTDi84539.
DisGeNETi84539.
GeneCardsiMCHR2.
HGNCiHGNC:20867. MCHR2.
MIMi606111. gene.
neXtProtiNX_Q969V1.
OpenTargetsiENSG00000152034.
PharmGKBiPA134950856.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG098164.
InParanoidiQ969V1.
KOiK05054.
OMAiGYYLSIC.
OrthoDBiEOG091G0DIE.
PhylomeDBiQ969V1.
TreeFamiTF315737.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152034-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiQ969V1.

Miscellaneous databases

GeneWikiiMelanin-concentrating_hormone_receptor_2.
GenomeRNAii84539.
PROiQ969V1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152034.
CleanExiHS_MCHR2.
GenevisibleiQ969V1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008362. MCH2_receptor.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01784. MCH2RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCHR2_HUMAN
AccessioniPrimary (citable) accession number: Q969V1
Secondary accession number(s): B3KVW4
, E1P5D7, Q5VTV7, Q6Q377, Q9BXA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.