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Protein

Proteasome assembly chaperone 2

Gene

PSMG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128789-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome assembly chaperone 2
Short name:
PAC-2
Alternative name(s):
Hepatocellular carcinoma-susceptibility protein 3
Tumor necrosis factor superfamily member 5-induced protein 1
Gene namesi
Name:PSMG2Imported
Synonyms:HCCA3Imported, PAC2Imported, TNFSF5IP1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:24929. PSMG2.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • cytosol Source: GO_Central
  • nucleus Source: UniProtKB
  • proteasome complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56984.
OpenTargetsiENSG00000128789.
PharmGKBiPA162400246.

Polymorphism and mutation databases

BioMutaiPSMG2.
DMDMi74731063.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003225521 – 264Proteasome assembly chaperone 2Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137PhosphothreonineCombined sources1

Post-translational modificationi

Degraded by the proteasome upon completion of 20S proteasome maturation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ969U7.
MaxQBiQ969U7.
PaxDbiQ969U7.
PeptideAtlasiQ969U7.
PRIDEiQ969U7.

PTM databases

iPTMnetiQ969U7.
PhosphoSitePlusiQ969U7.

Expressioni

Tissue specificityi

Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue.1 Publication

Gene expression databases

BgeeiENSG00000128789.
CleanExiHS_PSMG2.
ExpressionAtlasiQ969U7. baseline and differential.
GenevisibleiQ969U7. HS.

Organism-specific databases

HPAiHPA041517.
HPA046741.

Interactioni

Subunit structurei

Forms a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153233EBI-723276,EBI-948001
NOTCH2NLQ7Z3S93EBI-723276,EBI-945833
TCF4P158843EBI-723276,EBI-533224

Protein-protein interaction databases

BioGridi121301. 48 interactors.
IntActiQ969U7. 10 interactors.
MINTiMINT-6176023.
STRINGi9606.ENSP00000325919.

Structurei

3D structure databases

ProteinModelPortaliQ969U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG2 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3112. Eukaryota.
ENOG410XRHJ. LUCA.
GeneTreeiENSGT00390000018415.
HOGENOMiHOG000046033.
HOVERGENiHBG059464.
InParanoidiQ969U7.
KOiK11876.
OMAiSWKSVYG.
OrthoDBiEOG091G0OFC.
PhylomeDBiQ969U7.
TreeFamiTF105397.

Family and domain databases

InterProiIPR019151. Proteasome_assmbl_chaperone_2.
IPR016562. Proteasome_assmbl_chp_2_euk.
[Graphical view]
PfamiPF09754. PAC2. 1 hit.
[Graphical view]
PIRSFiPIRSF010044. UCP010044. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969U7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVPCGESAP DLAGFTLLMP AVSVGNVGQL AMDLIISTLN MSKIGYFYTD
60 70 80 90 100
CLVPMVGNNP YATTEGNSTE LSINAEVYSL PSRKLVALQL RSIFIKYKSK
110 120 130 140 150
PFCEKLLSWV KSSGCARVIV LSSSHSYQRN DLQLRSTPFR YLLTPSMQKS
160 170 180 190 200
VQNKIKSLNW EEMEKSRCIP EIDDSEFCIR IPGGGITKTL YDESCSKEIQ
210 220 230 240 250
MAVLLKFVSE GDNIPDALGL VEYLNEWLQI LKPLSDDPTV SASRWKIPSS
260
WRLLFGSGLP PALF
Length:264
Mass (Da):29,396
Last modified:December 1, 2001 - v1
Checksum:i7D138B81C3C20EF9
GO
Isoform 2 (identifier: Q969U7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:233
Mass (Da):26,321
Checksum:i8910F04AC6B83BEB
GO

Sequence cautioni

The sequence AAF87314 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117R → E in AAF87314 (PubMed:11920191).Curated1
Sequence conflicti164E → D in AAF87314 (PubMed:11920191).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557211 – 31Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168712 mRNA. Translation: AAF87314.1. Different initiation.
AF276707 mRNA. Translation: AAK69439.2.
EF445040 Genomic DNA. Translation: ACA06090.1.
AK057005 mRNA. Translation: BAG51841.1.
AP005482 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01540.1.
CH471113 Genomic DNA. Translation: EAX01541.1.
BC013356 mRNA. Translation: AAH13356.1.
CR457181 mRNA. Translation: CAG33462.1.
BR000237 mRNA. Translation: FAA00023.1.
CCDSiCCDS11862.1. [Q969U7-1]
CCDS67440.1. [Q969U7-2]
RefSeqiNP_064617.2. NM_020232.4. [Q969U7-1]
NP_671692.1. NM_147163.1. [Q969U7-2]
UniGeneiHs.464652.

Genome annotation databases

EnsembliENST00000317615; ENSP00000325919; ENSG00000128789. [Q969U7-1]
ENST00000585331; ENSP00000476763; ENSG00000128789. [Q969U7-2]
GeneIDi56984.
KEGGihsa:56984.
UCSCiuc002krg.5. human. [Q969U7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168712 mRNA. Translation: AAF87314.1. Different initiation.
AF276707 mRNA. Translation: AAK69439.2.
EF445040 Genomic DNA. Translation: ACA06090.1.
AK057005 mRNA. Translation: BAG51841.1.
AP005482 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01540.1.
CH471113 Genomic DNA. Translation: EAX01541.1.
BC013356 mRNA. Translation: AAH13356.1.
CR457181 mRNA. Translation: CAG33462.1.
BR000237 mRNA. Translation: FAA00023.1.
CCDSiCCDS11862.1. [Q969U7-1]
CCDS67440.1. [Q969U7-2]
RefSeqiNP_064617.2. NM_020232.4. [Q969U7-1]
NP_671692.1. NM_147163.1. [Q969U7-2]
UniGeneiHs.464652.

3D structure databases

ProteinModelPortaliQ969U7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121301. 48 interactors.
IntActiQ969U7. 10 interactors.
MINTiMINT-6176023.
STRINGi9606.ENSP00000325919.

PTM databases

iPTMnetiQ969U7.
PhosphoSitePlusiQ969U7.

Polymorphism and mutation databases

BioMutaiPSMG2.
DMDMi74731063.

Proteomic databases

EPDiQ969U7.
MaxQBiQ969U7.
PaxDbiQ969U7.
PeptideAtlasiQ969U7.
PRIDEiQ969U7.

Protocols and materials databases

DNASUi56984.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317615; ENSP00000325919; ENSG00000128789. [Q969U7-1]
ENST00000585331; ENSP00000476763; ENSG00000128789. [Q969U7-2]
GeneIDi56984.
KEGGihsa:56984.
UCSCiuc002krg.5. human. [Q969U7-1]

Organism-specific databases

CTDi56984.
DisGeNETi56984.
GeneCardsiPSMG2.
HGNCiHGNC:24929. PSMG2.
HPAiHPA041517.
HPA046741.
MIMi609702. gene.
neXtProtiNX_Q969U7.
OpenTargetsiENSG00000128789.
PharmGKBiPA162400246.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3112. Eukaryota.
ENOG410XRHJ. LUCA.
GeneTreeiENSGT00390000018415.
HOGENOMiHOG000046033.
HOVERGENiHBG059464.
InParanoidiQ969U7.
KOiK11876.
OMAiSWKSVYG.
OrthoDBiEOG091G0OFC.
PhylomeDBiQ969U7.
TreeFamiTF105397.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128789-MONOMER.

Miscellaneous databases

ChiTaRSiPSMG2. human.
GenomeRNAii56984.
PROiQ969U7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128789.
CleanExiHS_PSMG2.
ExpressionAtlasiQ969U7. baseline and differential.
GenevisibleiQ969U7. HS.

Family and domain databases

InterProiIPR019151. Proteasome_assmbl_chaperone_2.
IPR016562. Proteasome_assmbl_chp_2_euk.
[Graphical view]
PfamiPF09754. PAC2. 1 hit.
[Graphical view]
PIRSFiPIRSF010044. UCP010044. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPSMG2_HUMAN
AccessioniPrimary (citable) accession number: Q969U7
Secondary accession number(s): B0YJB3
, Q6IAH4, Q9NRV1, V9GYH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.