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Q969U6

- FBXW5_HUMAN

UniProt

Q969U6 - FBXW5_HUMAN

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Protein

F-box/WD repeat-containing protein 5

Gene

FBXW5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.3 Publications

Pathwayi

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB

GO - Biological processi

  1. centrosome duplication Source: UniProtKB
  2. mitotic nuclear division Source: Ensembl
  3. proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
  4. protein ubiquitination Source: UniProtKB
  5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_16907. Association of TriC/CCT with target proteins during biosynthesis.
SignaLinkiQ969U6.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 5
Alternative name(s):
F-box and WD-40 domain-containing protein 5
Gene namesi
Name:FBXW5
Synonyms:FBW5
ORF Names:PP3971
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:13613. FBXW5.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi151 – 1511S → A: Impairs phosphorylation by PLK4 and enhances ubiquitination of SASS6. 1 Publication

Organism-specific databases

PharmGKBiPA134928070.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566F-box/WD repeat-containing protein 5PRO_0000050992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine; by PLK41 Publication

Post-translational modificationi

Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6.1 Publication
Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ969U6.
PaxDbiQ969U6.
PRIDEiQ969U6.

PTM databases

PhosphoSiteiQ969U6.

Expressioni

Developmental stagei

Degraded by the APC/C complex during G1 phase and reaccumulates at the G1/S phase transition.1 Publication

Gene expression databases

BgeeiQ969U6.
GenevestigatoriQ969U6.

Organism-specific databases

HPAiHPA046615.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1, RBX1 and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B), DDB1, FBXW5 and RBX1. Interacts with CDC20, EPS8, TSC1, TSC2 and SASS6. Interacts with TNFAIP8L1; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632083EBI-741068,EBI-307486

Protein-protein interaction databases

BioGridi119967. 28 interactions.
DIPiDIP-37971N.
IntActiQ969U6. 8 interactions.
MINTiMINT-276597.

Structurei

3D structure databases

ProteinModelPortaliQ969U6.
SMRiQ969U6. Positions 84-175, 442-539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 4947F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati90 – 12940WD 1Add
BLAST
Repeati467 – 50640WD 2Add
BLAST
Repeati508 – 54841WD 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi303 – 3119D-box

Domaini

The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes.Curated
The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

Sequence similaritiesi

Belongs to the FBXW5 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 3 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG81436.
GeneTreeiENSGT00730000111276.
HOVERGENiHBG051595.
InParanoidiQ969U6.
KOiK10263.
OMAiVLWLNNA.
OrthoDBiEOG7RZ5PB.
PhylomeDBiQ969U6.
TreeFamiTF324320.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF81383. SSF81383. 2 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969U6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEGGTPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWREQF
60 70 80 90 100
YRYYQVARDV PRHPAAMSWY EEFQRLYDTV PCVEVQTLRE HTDQVLHLSF
110 120 130 140 150
SHSGYQFASC SKDCTVKIWS NDLTISLLHS ADMRPYNWSY TQFSQFNKDD
160 170 180 190 200
SLLLASGVFL GPHNSSSGEI AVISLDSFAL LSRVRNKPYD VFGCWLTETS
210 220 230 240 250
LISGNLHRIG DITSCSVLWL NNAFQDVESE NVNVVKRLFK IQNLNASTVR
260 270 280 290 300
TVMVADCSRF DSPDLLLEAG DPATSPCRIF DLGSDNEEVV AGPAPAHAKE
310 320 330 340 350
GLRHFLDRVL EGRAQPQLSE RMLETKVAEL LAQGHTKPPE RSATGAKSKY
360 370 380 390 400
LIFTTGCLTY SPHQIGIKQI LPHQMTTAGP VLGEGRGSDA FFDALDHVID
410 420 430 440 450
IHGHIIGMGL SPDNRYLYVN SRAWPNGAVV ADPMQPPPIA EEIDLLVFDL
460 470 480 490 500
KTMREVRRAL RAHRAYTPND ECFFIFLDVS RDFVASGAED RHGYIWDRHY
510 520 530 540 550
NICLARLRHE DVVNSVVFSP QEQELLLTAS DDATIKAWRS PRTMRVLQAP
560
RPRPRTFFSW LASQRR
Length:566
Mass (Da):63,922
Last modified:December 1, 2001 - v1
Checksum:i7D389AB6F50193B1
GO
Isoform 2 (identifier: Q969U6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-377: IKQILPHQMTT → TPLPPCCPPRS
     378-566: Missing.

Show »
Length:377
Mass (Da):42,185
Checksum:i88369E8BB6758ACE
GO

Sequence cautioni

The sequence AAG17240.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AAG23772.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AAH00850.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI12741.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI12744.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti490 – 4901D → G in BAB15354. (PubMed:14702039)Curated
Sequence conflicti508 – 5081R → Q in BAD92963. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti340 – 3401E → K.
Corresponds to variant rs7850438 [ dbSNP | Ensembl ].
VAR_053393

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei367 – 37711IKQILPHQMTT → TPLPPCCPPRS in isoform 2. 1 PublicationVSP_009479Add
BLAST
Alternative sequencei378 – 566189Missing in isoform 2. 1 PublicationVSP_009480Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026081 mRNA. Translation: BAB15354.1.
AK315738 mRNA. Translation: BAG38093.1.
CH471090 Genomic DNA. Translation: EAW88307.1.
BC000850 mRNA. Translation: AAH00850.1. Different initiation.
BC004541 mRNA. Translation: AAH04541.2.
BC009429 mRNA. Translation: AAH09429.1.
BC014297 mRNA. Translation: AAH14297.1.
AL807752 Genomic DNA. Translation: CAI12741.1. Sequence problems.
AL807752 Genomic DNA. Translation: CAI12743.1.
AL807752 Genomic DNA. Translation: CAI12744.1. Sequence problems.
AL807752 Genomic DNA. Translation: CAI12746.1.
BC014130 mRNA. Translation: AAH14130.1.
AB209726 mRNA. Translation: BAD92963.1.
AL137631 mRNA. Translation: CAB70851.1.
AF217998 mRNA. Translation: AAG17240.1. Frameshift.
AF258569 mRNA. Translation: AAG23772.1. Frameshift.
CCDSiCCDS7014.1. [Q969U6-1]
PIRiT46483.
RefSeqiNP_061871.1. NM_018998.3. [Q969U6-1]
UniGeneiHs.522507.

Genome annotation databases

EnsembliENST00000325285; ENSP00000313034; ENSG00000159069. [Q969U6-1]
GeneIDi54461.
KEGGihsa:54461.
UCSCiuc004cjx.3. human. [Q969U6-1]

Polymorphism databases

DMDMi44887886.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026081 mRNA. Translation: BAB15354.1 .
AK315738 mRNA. Translation: BAG38093.1 .
CH471090 Genomic DNA. Translation: EAW88307.1 .
BC000850 mRNA. Translation: AAH00850.1 . Different initiation.
BC004541 mRNA. Translation: AAH04541.2 .
BC009429 mRNA. Translation: AAH09429.1 .
BC014297 mRNA. Translation: AAH14297.1 .
AL807752 Genomic DNA. Translation: CAI12741.1 . Sequence problems.
AL807752 Genomic DNA. Translation: CAI12743.1 .
AL807752 Genomic DNA. Translation: CAI12744.1 . Sequence problems.
AL807752 Genomic DNA. Translation: CAI12746.1 .
BC014130 mRNA. Translation: AAH14130.1 .
AB209726 mRNA. Translation: BAD92963.1 .
AL137631 mRNA. Translation: CAB70851.1 .
AF217998 mRNA. Translation: AAG17240.1 . Frameshift.
AF258569 mRNA. Translation: AAG23772.1 . Frameshift.
CCDSi CCDS7014.1. [Q969U6-1 ]
PIRi T46483.
RefSeqi NP_061871.1. NM_018998.3. [Q969U6-1 ]
UniGenei Hs.522507.

3D structure databases

ProteinModelPortali Q969U6.
SMRi Q969U6. Positions 84-175, 442-539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119967. 28 interactions.
DIPi DIP-37971N.
IntActi Q969U6. 8 interactions.
MINTi MINT-276597.

PTM databases

PhosphoSitei Q969U6.

Polymorphism databases

DMDMi 44887886.

Proteomic databases

MaxQBi Q969U6.
PaxDbi Q969U6.
PRIDEi Q969U6.

Protocols and materials databases

DNASUi 54461.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325285 ; ENSP00000313034 ; ENSG00000159069 . [Q969U6-1 ]
GeneIDi 54461.
KEGGi hsa:54461.
UCSCi uc004cjx.3. human. [Q969U6-1 ]

Organism-specific databases

CTDi 54461.
GeneCardsi GC09M139834.
HGNCi HGNC:13613. FBXW5.
HPAi HPA046615.
MIMi 609072. gene.
neXtProti NX_Q969U6.
PharmGKBi PA134928070.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81436.
GeneTreei ENSGT00730000111276.
HOVERGENi HBG051595.
InParanoidi Q969U6.
KOi K10263.
OMAi VLWLNNA.
OrthoDBi EOG7RZ5PB.
PhylomeDBi Q969U6.
TreeFami TF324320.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_16907. Association of TriC/CCT with target proteins during biosynthesis.
SignaLinki Q969U6.

Miscellaneous databases

ChiTaRSi FBXW5. human.
GeneWikii FBXW5.
GenomeRNAii 54461.
NextBioi 56717.
PROi Q969U6.
SOURCEi Search...

Gene expression databases

Bgeei Q969U6.
Genevestigatori Q969U6.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR001810. F-box_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
SSF81383. SSF81383. 2 hits.
PROSITEi PS50181. FBOX. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix, Colon, Ovary, Placenta and Skin.
  5. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-566 (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-566 (ISOFORM 2).
    Tissue: Testis.
  7. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-566 (ISOFORM 1).
  8. "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase."
    Hu J., Zacharek S., He Y.J., Lee H., Shumway S., Duronio R.J., Xiong Y.
    Genes Dev. 22:866-871(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TSC1 AND TSC2, IDENTIFICATION IN A DCX PROTEIN LIGASE COMPLEX.
  9. "An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway."
    Minoda Y., Sakurai H., Kobayashi T., Yoshimura A., Takaesu G.
    Biochem. Biophys. Res. Commun. 381:412-417(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication."
    Puklowski A., Homsi Y., Keller D., May M., Chauhan S., Kossatz U., Grunwald V., Kubicka S., Pich A., Manns M.P., Hoffmann I., Gonczy P., Malek N.P.
    Nat. Cell Biol. 13:1004-1009(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SASS6 AND CDC20, IDENTIFICATION IN A SCF PROTEIN LIGASE COMPLEX, DEVELOPMENTAL STAGE, UBIQUITINATION, PHOSPHORYLATION AT SER-151, MUTAGENESIS OF SER-151.

Entry informationi

Entry nameiFBXW5_HUMAN
AccessioniPrimary (citable) accession number: Q969U6
Secondary accession number(s): B2RDZ6
, Q59ET5, Q5SPZ8, Q5SPZ9, Q5SQ00, Q5SQ02, Q5SQ03, Q5SQ04, Q8WY79, Q96GJ6, Q9BSU8, Q9H6A8, Q9HBQ6, Q9NSZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3