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Q969U6

- FBXW5_HUMAN

UniProt

Q969U6 - FBXW5_HUMAN

Protein

F-box/WD repeat-containing protein 5

Gene

FBXW5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.3 Publications

    Pathwayi

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. centrosome duplication Source: UniProtKB
    2. mitotic nuclear division Source: Ensembl
    3. proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
    4. protein ubiquitination Source: UniProtKB
    5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_16907. Association of TriC/CCT with target proteins during biosynthesis.
    SignaLinkiQ969U6.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/WD repeat-containing protein 5
    Alternative name(s):
    F-box and WD-40 domain-containing protein 5
    Gene namesi
    Name:FBXW5
    Synonyms:FBW5
    ORF Names:PP3971
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:13613. FBXW5.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. SCF ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi151 – 1511S → A: Impairs phosphorylation by PLK4 and enhances ubiquitination of SASS6. 1 Publication

    Organism-specific databases

    PharmGKBiPA134928070.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566F-box/WD repeat-containing protein 5PRO_0000050992Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Phosphoserine; by PLK41 Publication

    Post-translational modificationi

    Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6.1 Publication
    Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ969U6.
    PaxDbiQ969U6.
    PRIDEiQ969U6.

    PTM databases

    PhosphoSiteiQ969U6.

    Expressioni

    Developmental stagei

    Degraded by the APC/C complex during G1 phase and reaccumulates at the G1/S phase transition.1 Publication

    Gene expression databases

    BgeeiQ969U6.
    GenevestigatoriQ969U6.

    Organism-specific databases

    HPAiHPA046615.

    Interactioni

    Subunit structurei

    Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1, RBX1 and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B), DDB1, FBXW5 and RBX1. Interacts with CDC20, EPS8, TSC1, TSC2 and SASS6.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SKP1P632083EBI-741068,EBI-307486

    Protein-protein interaction databases

    BioGridi119967. 23 interactions.
    DIPiDIP-37971N.
    IntActiQ969U6. 8 interactions.
    MINTiMINT-276597.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969U6.
    SMRiQ969U6. Positions 513-538.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 4947F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati90 – 12940WD 1Add
    BLAST
    Repeati467 – 50640WD 2Add
    BLAST
    Repeati508 – 54841WD 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi303 – 3119D-box

    Domaini

    The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes.Curated
    The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

    Sequence similaritiesi

    Belongs to the FBXW5 family.Curated
    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 3 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG81436.
    HOVERGENiHBG051595.
    InParanoidiQ969U6.
    KOiK10263.
    OMAiVLWLNNA.
    OrthoDBiEOG7RZ5PB.
    PhylomeDBiQ969U6.
    TreeFamiTF324320.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR001810. F-box_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    SM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    SSF81383. SSF81383. 2 hits.
    PROSITEiPS50181. FBOX. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969U6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDEGGTPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWREQF    50
    YRYYQVARDV PRHPAAMSWY EEFQRLYDTV PCVEVQTLRE HTDQVLHLSF 100
    SHSGYQFASC SKDCTVKIWS NDLTISLLHS ADMRPYNWSY TQFSQFNKDD 150
    SLLLASGVFL GPHNSSSGEI AVISLDSFAL LSRVRNKPYD VFGCWLTETS 200
    LISGNLHRIG DITSCSVLWL NNAFQDVESE NVNVVKRLFK IQNLNASTVR 250
    TVMVADCSRF DSPDLLLEAG DPATSPCRIF DLGSDNEEVV AGPAPAHAKE 300
    GLRHFLDRVL EGRAQPQLSE RMLETKVAEL LAQGHTKPPE RSATGAKSKY 350
    LIFTTGCLTY SPHQIGIKQI LPHQMTTAGP VLGEGRGSDA FFDALDHVID 400
    IHGHIIGMGL SPDNRYLYVN SRAWPNGAVV ADPMQPPPIA EEIDLLVFDL 450
    KTMREVRRAL RAHRAYTPND ECFFIFLDVS RDFVASGAED RHGYIWDRHY 500
    NICLARLRHE DVVNSVVFSP QEQELLLTAS DDATIKAWRS PRTMRVLQAP 550
    RPRPRTFFSW LASQRR 566
    Length:566
    Mass (Da):63,922
    Last modified:December 1, 2001 - v1
    Checksum:i7D389AB6F50193B1
    GO
    Isoform 2 (identifier: Q969U6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         367-377: IKQILPHQMTT → TPLPPCCPPRS
         378-566: Missing.

    Show »
    Length:377
    Mass (Da):42,185
    Checksum:i88369E8BB6758ACE
    GO

    Sequence cautioni

    The sequence AAG17240.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence AAG23772.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence AAH00850.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI12741.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI12744.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti490 – 4901D → G in BAB15354. (PubMed:14702039)Curated
    Sequence conflicti508 – 5081R → Q in BAD92963. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti340 – 3401E → K.
    Corresponds to variant rs7850438 [ dbSNP | Ensembl ].
    VAR_053393

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei367 – 37711IKQILPHQMTT → TPLPPCCPPRS in isoform 2. 1 PublicationVSP_009479Add
    BLAST
    Alternative sequencei378 – 566189Missing in isoform 2. 1 PublicationVSP_009480Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026081 mRNA. Translation: BAB15354.1.
    AK315738 mRNA. Translation: BAG38093.1.
    CH471090 Genomic DNA. Translation: EAW88307.1.
    BC000850 mRNA. Translation: AAH00850.1. Different initiation.
    BC004541 mRNA. Translation: AAH04541.2.
    BC009429 mRNA. Translation: AAH09429.1.
    BC014297 mRNA. Translation: AAH14297.1.
    AL807752 Genomic DNA. Translation: CAI12741.1. Sequence problems.
    AL807752 Genomic DNA. Translation: CAI12743.1.
    AL807752 Genomic DNA. Translation: CAI12744.1. Sequence problems.
    AL807752 Genomic DNA. Translation: CAI12746.1.
    BC014130 mRNA. Translation: AAH14130.1.
    AB209726 mRNA. Translation: BAD92963.1.
    AL137631 mRNA. Translation: CAB70851.1.
    AF217998 mRNA. Translation: AAG17240.1. Frameshift.
    AF258569 mRNA. Translation: AAG23772.1. Frameshift.
    CCDSiCCDS7014.1. [Q969U6-1]
    PIRiT46483.
    RefSeqiNP_061871.1. NM_018998.3. [Q969U6-1]
    UniGeneiHs.522507.

    Genome annotation databases

    EnsembliENST00000325285; ENSP00000313034; ENSG00000159069. [Q969U6-1]
    GeneIDi54461.
    KEGGihsa:54461.
    UCSCiuc004cjx.3. human. [Q969U6-1]

    Polymorphism databases

    DMDMi44887886.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026081 mRNA. Translation: BAB15354.1 .
    AK315738 mRNA. Translation: BAG38093.1 .
    CH471090 Genomic DNA. Translation: EAW88307.1 .
    BC000850 mRNA. Translation: AAH00850.1 . Different initiation.
    BC004541 mRNA. Translation: AAH04541.2 .
    BC009429 mRNA. Translation: AAH09429.1 .
    BC014297 mRNA. Translation: AAH14297.1 .
    AL807752 Genomic DNA. Translation: CAI12741.1 . Sequence problems.
    AL807752 Genomic DNA. Translation: CAI12743.1 .
    AL807752 Genomic DNA. Translation: CAI12744.1 . Sequence problems.
    AL807752 Genomic DNA. Translation: CAI12746.1 .
    BC014130 mRNA. Translation: AAH14130.1 .
    AB209726 mRNA. Translation: BAD92963.1 .
    AL137631 mRNA. Translation: CAB70851.1 .
    AF217998 mRNA. Translation: AAG17240.1 . Frameshift.
    AF258569 mRNA. Translation: AAG23772.1 . Frameshift.
    CCDSi CCDS7014.1. [Q969U6-1 ]
    PIRi T46483.
    RefSeqi NP_061871.1. NM_018998.3. [Q969U6-1 ]
    UniGenei Hs.522507.

    3D structure databases

    ProteinModelPortali Q969U6.
    SMRi Q969U6. Positions 513-538.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119967. 23 interactions.
    DIPi DIP-37971N.
    IntActi Q969U6. 8 interactions.
    MINTi MINT-276597.

    PTM databases

    PhosphoSitei Q969U6.

    Polymorphism databases

    DMDMi 44887886.

    Proteomic databases

    MaxQBi Q969U6.
    PaxDbi Q969U6.
    PRIDEi Q969U6.

    Protocols and materials databases

    DNASUi 54461.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325285 ; ENSP00000313034 ; ENSG00000159069 . [Q969U6-1 ]
    GeneIDi 54461.
    KEGGi hsa:54461.
    UCSCi uc004cjx.3. human. [Q969U6-1 ]

    Organism-specific databases

    CTDi 54461.
    GeneCardsi GC09M139834.
    HGNCi HGNC:13613. FBXW5.
    HPAi HPA046615.
    MIMi 609072. gene.
    neXtProti NX_Q969U6.
    PharmGKBi PA134928070.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81436.
    HOVERGENi HBG051595.
    InParanoidi Q969U6.
    KOi K10263.
    OMAi VLWLNNA.
    OrthoDBi EOG7RZ5PB.
    PhylomeDBi Q969U6.
    TreeFami TF324320.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_16907. Association of TriC/CCT with target proteins during biosynthesis.
    SignaLinki Q969U6.

    Miscellaneous databases

    ChiTaRSi FBXW5. human.
    GeneWikii FBXW5.
    GenomeRNAii 54461.
    NextBioi 56717.
    PROi Q969U6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q969U6.
    Genevestigatori Q969U6.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR001810. F-box_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    SSF81383. SSF81383. 2 hits.
    PROSITEi PS50181. FBOX. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix, Colon, Ovary, Placenta and Skin.
    5. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-566 (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-566 (ISOFORM 2).
      Tissue: Testis.
    7. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-566 (ISOFORM 1).
    8. "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase."
      Hu J., Zacharek S., He Y.J., Lee H., Shumway S., Duronio R.J., Xiong Y.
      Genes Dev. 22:866-871(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TSC1 AND TSC2, IDENTIFICATION IN A DCX PROTEIN LIGASE COMPLEX.
    9. "An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway."
      Minoda Y., Sakurai H., Kobayashi T., Yoshimura A., Takaesu G.
      Biochem. Biophys. Res. Commun. 381:412-417(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication."
      Puklowski A., Homsi Y., Keller D., May M., Chauhan S., Kossatz U., Grunwald V., Kubicka S., Pich A., Manns M.P., Hoffmann I., Gonczy P., Malek N.P.
      Nat. Cell Biol. 13:1004-1009(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SASS6 AND CDC20, IDENTIFICATION IN A SCF PROTEIN LIGASE COMPLEX, DEVELOPMENTAL STAGE, UBIQUITINATION, PHOSPHORYLATION AT SER-151, MUTAGENESIS OF SER-151.

    Entry informationi

    Entry nameiFBXW5_HUMAN
    AccessioniPrimary (citable) accession number: Q969U6
    Secondary accession number(s): B2RDZ6
    , Q59ET5, Q5SPZ8, Q5SPZ9, Q5SQ00, Q5SQ02, Q5SQ03, Q5SQ04, Q8WY79, Q96GJ6, Q9BSU8, Q9H6A8, Q9HBQ6, Q9NSZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3