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Q969T9 (WBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WW domain-binding protein 2

Short name=WBP-2
Gene names
Name:WBP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 By similarity. Ref.1 Ref.3

Tissue specificity

Ubiquitous.

Domain

The WW-binding 1 motif mediates interaction with NEDD4 By similarity.

Sequence similarities

Contains 1 GRAM domain.

Sequence caution

The sequence AAD10951.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

WWTR1Q9GZV56EBI-727055,EBI-747743

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261WW domain-binding protein 2
PRO_0000065950

Regions

Domain1 – 8484GRAM
Motif196 – 2005WW-binding 1
Motif248 – 2525WW-binding 2
Compositional bias146 – 255110Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q969T9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 8043727A03E67C82

FASTA26128,087
        10         20         30         40         50         60 
MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV YLTPYRVIFL 

        70         80         90        100        110        120 
SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN YIKGTVKAEA GGGWEGSASY KLTFTAGGAI 

       130        140        150        160        170        180 
EFGQRMLQVA SQASRGEVPS GAYGYSYMPS GAYVYPPPVA NGMYPCPPGY PYPPPPPEFY 

       190        200        210        220        230        240 
PGPPMMDGAM GYVQPPPPPY PGPMEPPVSG PDVPSTPAAE AKAAEAAASA YYNPGNPHNV 

       250        260 
YMPTSQPPPP PYYPPEDKKT Q 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands."
Chen H.I., Einbond A., Kwak S.-J., Linn H., Koepf E., Peterson S., Kelly J.W., Sudol M.
J. Biol. Chem. 272:17070-17077(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH YAP1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Placenta.
[3]"Identification of novel human WW domain-containing proteins by cloning of ligand targets."
Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M.
J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WWP1 AND WWP2.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U79458 mRNA. Translation: AAD10951.1. Different initiation.
BC007452 mRNA. Translation: AAH07452.1.
BC010616 mRNA. Translation: AAH10616.1.
RefSeqNP_036610.2. NM_012478.3.
UniGeneHs.514489.

3D structure databases

ProteinModelPortalQ969T9.
SMRQ969T9. Positions 13-81.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117102. 14 interactions.
IntActQ969T9. 7 interactions.
MINTMINT-1431535.
STRING9606.ENSP00000254806.

PTM databases

PhosphoSiteQ969T9.

Polymorphism databases

DMDM25091539.

2D gel databases

OGPQ969T9.

Proteomic databases

PaxDbQ969T9.
PRIDEQ969T9.

Protocols and materials databases

DNASU23558.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254806; ENSP00000254806; ENSG00000132471.
ENST00000591399; ENSP00000467579; ENSG00000132471.
GeneID23558.
KEGGhsa:23558.
UCSCuc002jps.3. human.

Organism-specific databases

CTD23558.
GeneCardsGC17M073841.
HGNCHGNC:12738. WBP2.
MIM606962. gene.
neXtProtNX_Q969T9.
PharmGKBPA37349.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG291070.
HOGENOMHOG000231103.
HOVERGENHBG027489.
InParanoidQ969T9.
OMAYMPTNQP.
OrthoDBEOG73805Q.
PhylomeDBQ969T9.
TreeFamTF314141.

Gene expression databases

BgeeQ969T9.
CleanExHS_WBP2.
GenevestigatorQ969T9.

Family and domain databases

InterProIPR004182. GRAM.
IPR018826. WW-domain-binding.
[Graphical view]
PfamPF02893. GRAM. 1 hit.
PF10349. WWbp. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSWBP2. human.
GeneWikiWBP2.
GenomeRNAi23558.
NextBio46134.
PROQ969T9.
SOURCESearch...

Entry information

Entry nameWBP2_HUMAN
AccessionPrimary (citable) accession number: Q969T9
Secondary accession number(s): O95638
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM