Q969T9 (WBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WW domain-binding protein 2
Short name=WBP-2

Gene names

Name:

WBP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 By similarity. Ref.1 Ref.3
Tissue specificity	Ubiquitous.
Domain	The WW-binding 1 motif mediates interaction with NEDD4 By similarity.
Sequence similarities	Contains 1 GRAM domain.
Sequence caution	The sequence AAD10951.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
WWTR1	Q9GZV5	6	EBI-727055,EBI-747743

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	WW domain-binding protein 2		PRO_0000065950
Regions
	Domain	1 – 84	84	GRAM
	Motif	196 – 200	5	WW-binding 1
	Motif	248 – 252	5	WW-binding 2
	Compositional bias	146 – 255	110	Pro-rich
Amino acid modifications
	Modified residue	232	1	Phosphotyrosine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q969T9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 8043727A03E67C82	FASTA	261	28,087
	10 20 30 40 50 60 MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV YLTPYRVIFL 70 80 90 100 110 120 SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN YIKGTVKAEA GGGWEGSASY KLTFTAGGAI 130 140 150 160 170 180 EFGQRMLQVA SQASRGEVPS GAYGYSYMPS GAYVYPPPVA NGMYPCPPGY PYPPPPPEFY 190 200 210 220 230 240 PGPPMMDGAM GYVQPPPPPY PGPMEPPVSG PDVPSTPAAE AKAAEAAASA YYNPGNPHNV 250 260 YMPTSQPPPP PYYPPEDKKT Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands." Chen H.I., Einbond A., Kwak S.-J., Linn H., Koepf E., Peterson S., Kelly J.W., Sudol M. J. Biol. Chem. 272:17070-17077(1997) [PubMed: 9202023] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH YAP1.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Placenta.
[3]	"Identification of novel human WW domain-containing proteins by cloning of ligand targets." Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M. J. Biol. Chem. 272:14611-14616(1997) [PubMed: 9169421] [Abstract] Cited for: INTERACTION WITH WWP1 AND WWP2.
[4]	"Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry." Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J., Bodenmiller B., Watts J.D., Hood L., Aebersold R. Nat. Methods 2:591-598(2005) [PubMed: 16094384] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-232, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U79458 mRNA. Translation: AAD10951.1. Different initiation. BC007452 mRNA. Translation: AAH07452.1. BC010616 mRNA. Translation: AAH10616.1.
IPI	IPI00032050.
RefSeq	NP_036610.2. NM_012478.3.
UniGene	Hs.514489.
3D structure databases
ProteinModelPortal	Q969T9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q969T9. 6 interactions.
MINT	MINT-1431535.
STRING	Q969T9.
PTM databases
PhosphoSite	Q969T9.
Polymorphism databases
DMDM	25091539.
2D gel databases
OGP	Q969T9.
Proteomic databases
PRIDE	Q969T9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254806; ENSP00000254806; ENSG00000132471.
GeneID	23558.
KEGG	hsa:23558.
UCSC	uc002jps.1. human.
Organism-specific databases
CTD	23558.
GeneCards	GC17M073841.
H-InvDB	HIX0014192.
HGNC	HGNC:12738. WBP2.
MIM	606962. gene.
neXtProt	NX_Q969T9.
PharmGKB	PA37349.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19029.
GeneTree	ENSGT00530000063718.
HOGENOM	HBG717395.
HOVERGEN	HBG027489.
InParanoid	Q969T9.
OMA	GCEIKQP.
OrthoDB	EOG4ZGPDN.
PhylomeDB	Q969T9.
Gene expression databases
ArrayExpress	Q969T9.
Bgee	Q969T9.
CleanEx	HS_WBP2.
Genevestigator	Q969T9.
GermOnline	ENSG00000132471. Homo sapiens.
Family and domain databases
InterPro	IPR004182. GRAM. IPR018826. WW-domain-binding. [Graphical view]
Pfam	PF02893. GRAM. 1 hit. PF10349. WWbp. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	46134.
SOURCE	Search...

Entry information

Entry name

WBP2_HUMAN

Accession

Primary (citable) accession number: Q969T9
Secondary accession number(s): O95638

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.