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Protein

WW domain-binding protein 2

Gene

WBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chromatin DNA binding Source: UniProtKB
  • RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • cellular response to estrogen stimulus Source: UniProtKB
  • establishment of protein localization Source: UniProtKB
  • positive regulation of gene expression, epigenetic Source: UniProtKB
  • positive regulation of histone H3-K14 acetylation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 2
Short name:
WBP-2
Gene namesi
Name:WBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:12738. WBP2.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37349.

Polymorphism and mutation databases

BioMutaiWBP2.
DMDMi25091539.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261WW domain-binding protein 2PRO_0000065950Add
BLAST

Proteomic databases

MaxQBiQ969T9.
PaxDbiQ969T9.
PRIDEiQ969T9.

2D gel databases

OGPiQ969T9.

PTM databases

PhosphoSiteiQ969T9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ969T9.
CleanExiHS_WBP2.
ExpressionAtlasiQ969T9. baseline and differential.
GenevestigatoriQ969T9.

Interactioni

Subunit structurei

Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA4Q1RN333EBI-727055,EBI-10194128
WWTR1Q9GZV56EBI-727055,EBI-747743
YAP1P469376EBI-727055,EBI-1044059

Protein-protein interaction databases

BioGridi117102. 15 interactions.
IntActiQ969T9. 9 interactions.
MINTiMINT-1431535.
STRINGi9606.ENSP00000254806.

Structurei

3D structure databases

ProteinModelPortaliQ969T9.
SMRiQ969T9. Positions 13-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8484GRAMAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi196 – 2005WW-binding 1
Motifi248 – 2525WW-binding 2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi146 – 255110Pro-richAdd
BLAST

Domaini

The WW-binding 1 motif mediates interaction with NEDD4.By similarity

Sequence similaritiesi

Contains 1 GRAM domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG291070.
GeneTreeiENSGT00530000063718.
HOGENOMiHOG000231103.
HOVERGENiHBG027489.
InParanoidiQ969T9.
OMAiYMPTNQP.
OrthoDBiEOG73805Q.
PhylomeDBiQ969T9.
TreeFamiTF314141.

Family and domain databases

InterProiIPR004182. GRAM.
IPR018826. WW-domain-binding.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF10349. WWbp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV
60 70 80 90 100
YLTPYRVIFL SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN YIKGTVKAEA
110 120 130 140 150
GGGWEGSASY KLTFTAGGAI EFGQRMLQVA SQASRGEVPS GAYGYSYMPS
160 170 180 190 200
GAYVYPPPVA NGMYPCPPGY PYPPPPPEFY PGPPMMDGAM GYVQPPPPPY
210 220 230 240 250
PGPMEPPVSG PDVPSTPAAE AKAAEAAASA YYNPGNPHNV YMPTSQPPPP
260
PYYPPEDKKT Q
Length:261
Mass (Da):28,087
Last modified:December 1, 2001 - v1
Checksum:i8043727A03E67C82
GO

Sequence cautioni

The sequence AAD10951.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79458 mRNA. Translation: AAD10951.1. Different initiation.
BC007452 mRNA. Translation: AAH07452.1.
BC010616 mRNA. Translation: AAH10616.1.
CCDSiCCDS11731.1.
RefSeqiNP_036610.2. NM_012478.3.
UniGeneiHs.514489.

Genome annotation databases

EnsembliENST00000254806; ENSP00000254806; ENSG00000132471.
ENST00000591399; ENSP00000467579; ENSG00000132471.
GeneIDi23558.
KEGGihsa:23558.
UCSCiuc002jps.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79458 mRNA. Translation: AAD10951.1. Different initiation.
BC007452 mRNA. Translation: AAH07452.1.
BC010616 mRNA. Translation: AAH10616.1.
CCDSiCCDS11731.1.
RefSeqiNP_036610.2. NM_012478.3.
UniGeneiHs.514489.

3D structure databases

ProteinModelPortaliQ969T9.
SMRiQ969T9. Positions 13-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117102. 15 interactions.
IntActiQ969T9. 9 interactions.
MINTiMINT-1431535.
STRINGi9606.ENSP00000254806.

PTM databases

PhosphoSiteiQ969T9.

Polymorphism and mutation databases

BioMutaiWBP2.
DMDMi25091539.

2D gel databases

OGPiQ969T9.

Proteomic databases

MaxQBiQ969T9.
PaxDbiQ969T9.
PRIDEiQ969T9.

Protocols and materials databases

DNASUi23558.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254806; ENSP00000254806; ENSG00000132471.
ENST00000591399; ENSP00000467579; ENSG00000132471.
GeneIDi23558.
KEGGihsa:23558.
UCSCiuc002jps.3. human.

Organism-specific databases

CTDi23558.
GeneCardsiGC17M073841.
HGNCiHGNC:12738. WBP2.
MIMi606962. gene.
neXtProtiNX_Q969T9.
PharmGKBiPA37349.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG291070.
GeneTreeiENSGT00530000063718.
HOGENOMiHOG000231103.
HOVERGENiHBG027489.
InParanoidiQ969T9.
OMAiYMPTNQP.
OrthoDBiEOG73805Q.
PhylomeDBiQ969T9.
TreeFamiTF314141.

Miscellaneous databases

ChiTaRSiWBP2. human.
GeneWikiiWBP2.
GenomeRNAii23558.
NextBioi46134.
PROiQ969T9.
SOURCEiSearch...

Gene expression databases

BgeeiQ969T9.
CleanExiHS_WBP2.
ExpressionAtlasiQ969T9. baseline and differential.
GenevestigatoriQ969T9.

Family and domain databases

InterProiIPR004182. GRAM.
IPR018826. WW-domain-binding.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF10349. WWbp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands."
    Chen H.I., Einbond A., Kwak S.-J., Linn H., Koepf E., Peterson S., Kelly J.W., Sudol M.
    J. Biol. Chem. 272:17070-17077(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH YAP1.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  3. "Identification of novel human WW domain-containing proteins by cloning of ligand targets."
    Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M.
    J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WWP1 AND WWP2.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWBP2_HUMAN
AccessioniPrimary (citable) accession number: Q969T9
Secondary accession number(s): O95638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.