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Protein

WW domain-binding protein 2

Gene

WBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).HMP:1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 2
Short name:
WBP-2
Gene namesi
Name:WBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000132471.11.
HGNCiHGNC:12738. WBP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 107 (DFNB107)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:617639
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079500160A → T in DFNB107. 1 Publication1
Natural variantiVAR_079501163M → L in DFNB107; unknown pathological significance. 1 Publication1
Natural variantiVAR_079502224A → V in DFNB107; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi51Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi55Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi75Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi143Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi145Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi153Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi164Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi170Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi172Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi180Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi192Y → F: Strongly decreases phosphorylation induced by EGF. Abolishes phosphorylation in response to EGF, estrogen and progesterone; when associated with F-231. 1 Publication1
Mutagenesisi200Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi231Y → F: Strongly decreases phosphorylation induced by EGF. Abolishes phosphorylation in response to EGF, estrogen and progesterone; when associated with F-231. 1 Publication1
Mutagenesisi232Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi248 – 252PPPPY → AAAPA: Loss of coactivator activity in presence of estrogen. 1 Publication5
Mutagenesisi252Y → F: No effect on phosphorylation induced by EGF. 1 Publication1
Mutagenesisi253Y → F: No effect on phosphorylation induced by EGF. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi23558.
MIMi617639. phenotype.
OpenTargetsiENSG00000132471.
PharmGKBiPA37349.

Polymorphism and mutation databases

BioMutaiWBP2.
DMDMi25091539.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659501 – 261WW domain-binding protein 2Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192Phosphotyrosine; by YES and SRC1 Publication1
Modified residuei231Phosphotyrosine; by YES and SRC1 Publication1

Post-translational modificationi

Phosphorylated in repsonse to EGF as well as estrogen and progesterone hormones (PubMed:21642474). Tyr-192 and Tyr-231 are phosphorylated by YES and SRC inducing nuclear translocation (PubMed:21642474).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ969T9.
MaxQBiQ969T9.
PaxDbiQ969T9.
PeptideAtlasiQ969T9.
PRIDEiQ969T9.

2D gel databases

OGPiQ969T9.

PTM databases

iPTMnetiQ969T9.
PhosphoSitePlusiQ969T9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000132471.
CleanExiHS_WBP2.
ExpressionAtlasiQ969T9. baseline and differential.
GenevisibleiQ969T9. HS.

Organism-specific databases

HPAiHPA065682.
HPA068819.

Interactioni

Subunit structurei

Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity). Interacts with ESR1 and UBE3A (PubMed:16772533, PubMed:21642474).HMP:2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117102. 19 interactors.
DIPiDIP-42509N.
IntActiQ969T9. 10 interactors.
MINTiMINT-1431535.
STRINGi9606.ENSP00000254806.

Structurei

3D structure databases

ProteinModelPortaliQ969T9.
SMRiQ969T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 84GRAMAdd BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi196 – 200PPxY motif 15
Motifi248 – 252PPxY motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 255Pro-richAdd BLAST110

Domaini

The PPxY motif 1 mediates interaction with NEDD4 (By similarity). The PPxY motif 2 is required for the coactivation function (PubMed:16772533).HMP:1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3294. Eukaryota.
ENOG4111FQW. LUCA.
GeneTreeiENSGT00530000063718.
HOGENOMiHOG000231103.
HOVERGENiHBG027489.
InParanoidiQ969T9.
OMAiYLMKGCE.
OrthoDBiEOG091G0ICX.
PhylomeDBiQ969T9.
TreeFamiTF314141.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR004182. GRAM.
IPR011993. PH-like_dom_sf.
IPR033598. WBP2.
PANTHERiPTHR31606:SF4. PTHR31606:SF4. 1 hit.
PfamiView protein in Pfam
PF02893. GRAM. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969T9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV
60 70 80 90 100
YLTPYRVIFL SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN YIKGTVKAEA
110 120 130 140 150
GGGWEGSASY KLTFTAGGAI EFGQRMLQVA SQASRGEVPS GAYGYSYMPS
160 170 180 190 200
GAYVYPPPVA NGMYPCPPGY PYPPPPPEFY PGPPMMDGAM GYVQPPPPPY
210 220 230 240 250
PGPMEPPVSG PDVPSTPAAE AKAAEAAASA YYNPGNPHNV YMPTSQPPPP
260
PYYPPEDKKT Q
Length:261
Mass (Da):28,087
Last modified:December 1, 2001 - v1
Checksum:i8043727A03E67C82
GO
Isoform 2 (identifier: Q969T9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-177: Missing.

Show »
Length:216
Mass (Da):23,385
Checksum:i630A8D972FA1A8CD
GO

Sequence cautioni

The sequence AAD10951 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.IKR:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079500160A → T in DFNB107. 1 Publication1
Natural variantiVAR_079501163M → L in DFNB107; unknown pathological significance. 1 Publication1
Natural variantiVAR_079502224A → V in DFNB107; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059233133 – 177Missing in isoform 2. Add BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79458 mRNA. Translation: AAD10951.1. Different initiation.
AK294082 mRNA. Translation: BAG57423.1.
AC087289 Genomic DNA. No translation available.
BC007452 mRNA. Translation: AAH07452.1.
BC010616 mRNA. Translation: AAH10616.1.
CCDSiCCDS11731.1.
RefSeqiNP_001317428.1. NM_001330499.1.
NP_001335099.1. NM_001348170.1.
NP_036610.2. NM_012478.3.
UniGeneiHs.514489.

Genome annotation databases

EnsembliENST00000254806; ENSP00000254806; ENSG00000132471.
ENST00000591399; ENSP00000467579; ENSG00000132471.
GeneIDi23558.
KEGGihsa:23558.
UCSCiuc002jps.3. human.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiWBP2_HUMAN
AccessioniPrimary (citable) accession number: Q969T9
Secondary accession number(s): B4DFG2, O95638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot