Reviewed,
UniProtKB/Swiss-Prot Q969T7 (5NT3L_HUMAN)
Last modified
February 9, 2010.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytosolic 5'-nucleotidase III-like protein Short name=cN-III-like protein EC=3.1.3.5 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 292 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Can act both as nucleotidase and as phosphotransferase By similarity. |
| Catalytic activity | A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. |
| Subcellular location | Cytoplasm Potential. |
| Sequence similarities | Belongs to the pyrimidine 5'-nucleotidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Ligand | Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Hydrolase Transferase |
| PTM | Acetylation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 5'-nucleotidase activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW nucleotide bindingInferred from electronic annotation. Source: UniProtKB-KW transferase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 292 | 292 | Cytosolic 5'-nucleotidase III-like protein | PRO_0000328948 | |||||
Regions | |||||||||
| Region | 148 – 149 | 2 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 33 | 1 | Nucleophile By similarity | ||||||
| Active site | 35 | 1 | Proton donor By similarity | ||||||
| Metal binding | 33 | 1 | Magnesium By similarity | ||||||
| Metal binding | 35 | 1 | Magnesium; via carbonyl oxygen By similarity | ||||||
| Metal binding | 222 | 1 | Magnesium By similarity | ||||||
| Binding site | 197 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 248 | 1 | N6-acetyllysine Ref.5 | ||||||
Natural variations | |||||||||
| Natural variant | 201 | 1 | V → A: dbSNP rs1046403. | VAR_042582 | |||||
| Natural variant | 205 | 1 | C → S: dbSNP rs1046404. | VAR_042583 | |||||
Sequences
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References
| [1] | "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. Nusbaum C.Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver, Lung and Testis. |
| [4] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [5] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-248, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC091172 Genomic DNA. No translation available. CH471152 Genomic DNA. Translation: EAW60771.1. BC013742 mRNA. Translation: AAH13742.2. BC014132 mRNA. Translation: AAH14132.2. BC016971 mRNA. Translation: AAH16971.2. BC067788 mRNA. Translation: AAH67788.1. |
| IPI | IPI00056505. |
| RefSeq | NP_443167.3. |
| UniGene | Hs.237536 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2CN1 based on UniProtKB Q9UC45. |
| SMR | Q969T7. Positions 1-281. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000269534; ENSP00000269534; ENSG00000141698; Homo sapiens. [Genome view] ENST00000393911; ENSP00000377488; ENSG00000141698; Homo sapiens. [Genome view] |
| GeneID | 115024. |
| KEGG | hsa:115024. |
| UCSC | uc002hxx.2. human. |
Organism-specific databases | |
| CTD | 115024. |
| GeneCards | GC17M037235. |
| HGNC | HGNC:28300. NT5C3L. |
| PharmGKB | PA142671245. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG06021. |
| HOGENOM | HBG382723. |
| HOVERGEN | Q969T7. |
| InParanoid | Q969T7. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.5. 247. |
Gene expression databases | |
| ArrayExpress | Q969T7. |
| Bgee | Q969T7. |
| CleanEx | HS_NT5C3L. |
| Genevestigator | Q969T7. |
Family and domain databases | |
| InterPro | IPR006434. HAD-SF_hydro_IE. IPR018012. HAD-SF_hydro_IE_pln. [Graphical view] |
| PANTHER | PTHR13045. HAD-SF_hydro_IE. 1 hit. |
| TIGRFAMs | TIGR01544. HAD-SF-IE. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 79498. |
Entry information
| Entry name | 5NT3L_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q969T7 Secondary accession number(s): A8MWB9, Q7L3B7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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