Q969T3 (SNX21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorting nexin-21

Alternative name(s):
Sorting nexin L
Short name=SNX-L

Gene names

Name:	SNX21
Synonyms:	C20orf161, SNXL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in several stages of intracellular trafficking By similarity.
Subcellular location	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Tissue specificity	Highly expressed in fetus liver, but only weakly expressed in brain, skeleton muscle, smooth muscle, and cardiac muscle, kidney, and adrenal gland. Ref.2
Domain	The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) By similarity.
Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Lipid-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q969T3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q969T3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     197-199: RKR → QSH
     200-373: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Sorting nexin-21		PRO_0000213870
Regions
	Domain	129 – 246	118	PX
Sites
	Binding site	171	1	Phosphatidylinositol 3-phosphate By similarity
	Binding site	173	1	Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	198	1	Phosphatidylinositol 3-phosphate By similarity
	Binding site	212	1	Phosphatidylinositol 3-phosphate By similarity
Natural variations
	Alternative sequence	197 – 199	3	RKR → QSH in isoform 2.		VSP_045048
	Alternative sequence	200 – 373	174	Missing in isoform 2.		VSP_045049
	Natural variant	154	1	A → T. Ref.5 Corresponds to variant rs4638862 [ dbSNP | Ensembl ].		VAR_052482

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 83E4A752BAAEA7B5	FASTA	373	41,365
	10 20 30 40 50 60 MHRGTQEGAM ASRLLHRLRH ALAGDGPGEA AASPEAEQFP ESSELEDDDA EGLSSRLSGT 70 80 90 100 110 120 LSFTSAEDDE DDEDEDDEEA GPDQLPLGDG TSGEDAERSP PPDGQWGSQL LARQLQDFWK 130 140 150 160 170 180 KSRNTLAPQR LLFEVTSANV VKDPPSKYVL YTLAVIGPGP PDCQPAQISR RYSDFERLHR 190 200 210 220 230 240 NLQRQFRGPM AAISFPRKRL RRNFTAETIA RRSRAFEQFL GHLQAVPELR HAPDLQDFFV 250 260 270 280 290 300 LPELRRAQSL TCTGLYREAL ALWANAWQLQ AQLGTPSGPD RPLLTLAGLA VCHQELEDPG 310 320 330 340 350 360 EARACCEKAL QLLGDKSLHP LLAPFLEAHV RLSWRLGLDK RQSEARLQAL QEAGLTPTPP 370 PSLKELLIKE VLD
	Isoform 2 [UniParc]. Checksum: CEDD7CD4B0C771C0	FASTA	199	21,842
	10 20 30 40 50 60 MHRGTQEGAM ASRLLHRLRH ALAGDGPGEA AASPEAEQFP ESSELEDDDA EGLSSRLSGT 70 80 90 100 110 120 LSFTSAEDDE DDEDEDDEEA GPDQLPLGDG TSGEDAERSP PPDGQWGSQL LARQLQDFWK 130 140 150 160 170 180 KSRNTLAPQR LLFEVTSANV VKDPPSKYVL YTLAVIGPGP PDCQPAQISR RYSDFERLHR 190 NLQRQFRGPM AAISFPQSH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new member (SNX21) of the sorting nexin protein family." Hong W. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development." Zeng W., Yuan W., Wang Y., Jiao W., Zhu Y., Huang C., Li D., Li Y., Zhu C., Wu X., Liu M. Biochem. Biophys. Res. Commun. 299:542-548(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	Stavrides G.S., Huckle E.J., Deloukas P. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-154. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF395845 mRNA. Translation: AAK73126.1. AF523834 mRNA. Translation: AAM77915.1. AL591562 mRNA. Translation: CAC39140.1. AL008726 Genomic DNA. Translation: CAI20243.1. AL008726 Genomic DNA. Translation: CAI20244.1. BC019823 mRNA. Translation: AAH19823.1.
IPI	IPI00056503. IPI00335868.
RefSeq	NP_219489.1. NM_033421.2. NP_690857.1. NM_152897.1.
UniGene	Hs.472854.
3D structure databases
ProteinModelPortal	Q969T3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q969T3. 1 interaction.
STRING	9606.ENSP00000418593.
PTM databases
PhosphoSite	Q969T3.
Polymorphism databases
DMDM	20140138.
Proteomic databases
PaxDb	Q969T3.
PRIDE	Q969T3.
Protocols and materials databases
DNASU	90203.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342644; ENSP00000344586; ENSG00000124104. ENST00000491381; ENSP00000418593; ENSG00000124104.
GeneID	90203.
KEGG	hsa:90203.
UCSC	uc002xps.1. human. uc002xpv.1. human.
Organism-specific databases
CTD	90203.
GeneCards	GC20P044462.
HGNC	HGNC:16154. SNX21.
HPA	HPA046359.
neXtProt	NX_Q969T3.
PharmGKB	PA25703.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG299779.
HOGENOM	HOG000118351.
HOVERGEN	HBG056464.
InParanoid	Q969T3.
OMA	RRNFTAE.
PhylomeDB	Q969T3.
Enzyme and pathway databases
SignaLink	Q969T3.
Gene expression databases
ArrayExpress	Q969T3.
Bgee	Q969T3.
CleanEx	HS_SNX21.
Genevestigator	Q969T3.
GermOnline	ENSG00000124104. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.10. 1 hit. 3.30.1520.10. 1 hit.
InterPro	IPR001683. Phox. IPR011990. TPR-like_helical. [Graphical view]
Pfam	PF00787. PX. 1 hit. [Graphical view]
SMART	SM00312. PX. 1 hit. [Graphical view]
SUPFAM	SSF64268. PX. 1 hit.
PROSITE	PS50195. PX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	90203.
NextBio	76589.

Entry information

Entry name

SNX21_HUMAN

Accession

Primary (citable) accession number: Q969T3
Secondary accession number(s): Q5JZH5 , Q5JZH6, Q8WUR6, Q9BR16

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.