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Protein

Sorting nexin-21

Gene

SNX21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei173Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei198Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei212Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124104-MONOMER.
SignaLinkiQ969T3.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-21
Alternative name(s):
Sorting nexin L
Short name:
SNX-L1 Publication
Gene namesi
Name:SNX21
Synonyms:C20orf161, SNXL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16154. SNX21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124104.
PharmGKBiPA25703.

Polymorphism and mutation databases

BioMutaiSNX21.
DMDMi20140138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138701 – 373Sorting nexin-21Add BLAST373

Proteomic databases

EPDiQ969T3.
MaxQBiQ969T3.
PaxDbiQ969T3.
PeptideAtlasiQ969T3.
PRIDEiQ969T3.

PTM databases

iPTMnetiQ969T3.
PhosphoSitePlusiQ969T3.

Expressioni

Tissue specificityi

Highly expressed in fetus liver, but only weakly expressed in brain, skeleton muscle, smooth muscle, and cardiac muscle, kidney, and adrenal gland.1 Publication

Gene expression databases

BgeeiENSG00000124104.
CleanExiHS_SNX21.
ExpressionAtlasiQ969T3. baseline and differential.
GenevisibleiQ969T3. HS.

Organism-specific databases

HPAiHPA046359.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi124677. 33 interactors.
IntActiQ969T3. 4 interactors.
STRINGi9606.ENSP00000418593.

Structurei

3D structure databases

ProteinModelPortaliQ969T3.
SMRiQ969T3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 246PXPROSITE-ProRule annotationAdd BLAST118

Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IMHU. Eukaryota.
ENOG41114JN. LUCA.
GeneTreeiENSGT00530000063759.
HOGENOMiHOG000118087.
HOVERGENiHBG056464.
InParanoidiQ969T3.
KOiK17932.
OMAiLAVCHQE.
OrthoDBiEOG091G0S8F.
PhylomeDBiQ969T3.
TreeFamiTF326807.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969T3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHRGTQEGAM ASRLLHRLRH ALAGDGPGEA AASPEAEQFP ESSELEDDDA
60 70 80 90 100
EGLSSRLSGT LSFTSAEDDE DDEDEDDEEA GPDQLPLGDG TSGEDAERSP
110 120 130 140 150
PPDGQWGSQL LARQLQDFWK KSRNTLAPQR LLFEVTSANV VKDPPSKYVL
160 170 180 190 200
YTLAVIGPGP PDCQPAQISR RYSDFERLHR NLQRQFRGPM AAISFPRKRL
210 220 230 240 250
RRNFTAETIA RRSRAFEQFL GHLQAVPELR HAPDLQDFFV LPELRRAQSL
260 270 280 290 300
TCTGLYREAL ALWANAWQLQ AQLGTPSGPD RPLLTLAGLA VCHQELEDPG
310 320 330 340 350
EARACCEKAL QLLGDKSLHP LLAPFLEAHV RLSWRLGLDK RQSEARLQAL
360 370
QEAGLTPTPP PSLKELLIKE VLD
Length:373
Mass (Da):41,365
Last modified:December 1, 2001 - v1
Checksum:i83E4A752BAAEA7B5
GO
Isoform 2 (identifier: Q969T3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-199: RKR → QSH
     200-373: Missing.

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):21,842
Checksum:iCEDD7CD4B0C771C0
GO
Isoform 3 (identifier: Q969T3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-373: LYTLAVIGPG...KELLIKEVLD → TNLSSTPSP

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):17,020
Checksum:i248CFCF7EA1F6D38
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052482154A → T.1 PublicationCorresponds to variant rs4638862dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047115150 – 373LYTLA…KEVLD → TNLSSTPSP in isoform 3. CuratedAdd BLAST224
Alternative sequenceiVSP_045048197 – 199RKR → QSH in isoform 2. 1 Publication3
Alternative sequenceiVSP_045049200 – 373Missing in isoform 2. 1 PublicationAdd BLAST174

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395845 mRNA. Translation: AAK73126.1.
AF523834 mRNA. Translation: AAM77915.1.
AL591562 mRNA. Translation: CAC39140.1.
AL008726 Genomic DNA. Translation: CAI20243.1.
AL008726 Genomic DNA. Translation: CAI20244.1.
BC019823 mRNA. Translation: AAH19823.1.
CCDSiCCDS13376.1. [Q969T3-2]
CCDS13377.1. [Q969T3-1]
CCDS42883.1. [Q969T3-3]
RefSeqiNP_219489.1. NM_033421.3. [Q969T3-1]
NP_690857.1. NM_152897.2. [Q969T3-2]
UniGeneiHs.472854.

Genome annotation databases

EnsembliENST00000342644; ENSP00000344586; ENSG00000124104. [Q969T3-2]
ENST00000462307; ENSP00000420169; ENSG00000124104. [Q969T3-3]
ENST00000491381; ENSP00000418593; ENSG00000124104. [Q969T3-1]
GeneIDi90203.
KEGGihsa:90203.
UCSCiuc002xps.2. human. [Q969T3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395845 mRNA. Translation: AAK73126.1.
AF523834 mRNA. Translation: AAM77915.1.
AL591562 mRNA. Translation: CAC39140.1.
AL008726 Genomic DNA. Translation: CAI20243.1.
AL008726 Genomic DNA. Translation: CAI20244.1.
BC019823 mRNA. Translation: AAH19823.1.
CCDSiCCDS13376.1. [Q969T3-2]
CCDS13377.1. [Q969T3-1]
CCDS42883.1. [Q969T3-3]
RefSeqiNP_219489.1. NM_033421.3. [Q969T3-1]
NP_690857.1. NM_152897.2. [Q969T3-2]
UniGeneiHs.472854.

3D structure databases

ProteinModelPortaliQ969T3.
SMRiQ969T3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124677. 33 interactors.
IntActiQ969T3. 4 interactors.
STRINGi9606.ENSP00000418593.

PTM databases

iPTMnetiQ969T3.
PhosphoSitePlusiQ969T3.

Polymorphism and mutation databases

BioMutaiSNX21.
DMDMi20140138.

Proteomic databases

EPDiQ969T3.
MaxQBiQ969T3.
PaxDbiQ969T3.
PeptideAtlasiQ969T3.
PRIDEiQ969T3.

Protocols and materials databases

DNASUi90203.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342644; ENSP00000344586; ENSG00000124104. [Q969T3-2]
ENST00000462307; ENSP00000420169; ENSG00000124104. [Q969T3-3]
ENST00000491381; ENSP00000418593; ENSG00000124104. [Q969T3-1]
GeneIDi90203.
KEGGihsa:90203.
UCSCiuc002xps.2. human. [Q969T3-1]

Organism-specific databases

CTDi90203.
GeneCardsiSNX21.
HGNCiHGNC:16154. SNX21.
HPAiHPA046359.
neXtProtiNX_Q969T3.
OpenTargetsiENSG00000124104.
PharmGKBiPA25703.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMHU. Eukaryota.
ENOG41114JN. LUCA.
GeneTreeiENSGT00530000063759.
HOGENOMiHOG000118087.
HOVERGENiHBG056464.
InParanoidiQ969T3.
KOiK17932.
OMAiLAVCHQE.
OrthoDBiEOG091G0S8F.
PhylomeDBiQ969T3.
TreeFamiTF326807.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124104-MONOMER.
SignaLinkiQ969T3.

Miscellaneous databases

ChiTaRSiSNX21. human.
GeneWikiiSNX21.
GenomeRNAii90203.
PROiQ969T3.

Gene expression databases

BgeeiENSG00000124104.
CleanExiHS_SNX21.
ExpressionAtlasiQ969T3. baseline and differential.
GenevisibleiQ969T3. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX21_HUMAN
AccessioniPrimary (citable) accession number: Q969T3
Secondary accession number(s): Q5JZH5
, Q5JZH6, Q5JZH7, Q8WUR6, Q9BR16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.