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Protein

Ribosome-releasing factor 2, mitochondrial

Gene

GFM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.UniRule annotation1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 848GTPUniRule annotation
Nucleotide bindingi141 – 1455GTPUniRule annotation
Nucleotide bindingi195 – 1984GTPUniRule annotation

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational termination Source: Reactome
  • ribosome disassembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-releasing factor 2, mitochondrialUniRule annotation
Short name:
RRF2mtUniRule annotation
Alternative name(s):
Elongation factor G 2, mitochondrialUniRule annotation
Short name:
EF-G2mtUniRule annotation
Short name:
mEF-G 2UniRule annotation
Elongation factor G2
Short name:
hEFG2
Gene namesi
Name:GFM2UniRule annotation
Synonyms:EFG2UniRule annotation
ORF Names:MSTP027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29682. GFM2.

Subcellular locationi

  • Mitochondrion UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949527.

Polymorphism and mutation databases

BioMutaiGFM2.
DMDMi28201798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 779Ribosome-releasing factor 2, mitochondrialPRO_0000007450
Transit peptidei1 – ?MitochondrionUniRule annotation

Proteomic databases

EPDiQ969S9.
MaxQBiQ969S9.
PaxDbiQ969S9.
PRIDEiQ969S9.

PTM databases

iPTMnetiQ969S9.
PhosphoSiteiQ969S9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ969S9.
CleanExiHS_GFM2.
ExpressionAtlasiQ969S9. baseline and differential.
GenevisibleiQ969S9. HS.

Organism-specific databases

HPAiHPA036863.
HPA036864.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-2371750,EBI-744695
TRIM27P143733EBI-2371750,EBI-719493
TRIM9Q9C0263EBI-2371750,EBI-720828
VPS52Q8N1B43EBI-2371750,EBI-2799833

Protein-protein interaction databases

BioGridi124062. 16 interactions.
IntActiQ969S9. 8 interactions.
STRINGi9606.ENSP00000296805.

Structurei

3D structure databases

ProteinModelPortaliQ969S9.
SMRiQ969S9. Positions 67-772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 353286tr-type GAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0465. Eukaryota.
COG0480. LUCA.
GeneTreeiENSGT00550000074890.
HOGENOMiHOG000231585.
InParanoidiQ969S9.
KOiK02355.
OMAiNCLQRED.
OrthoDBiEOG79KPF4.
PhylomeDBiQ969S9.
TreeFamiTF314848.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_03059. mEF_G_2.
InterProiIPR030851. EFG2.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969S9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTNLRIFAM SHQTIPSVYI NNICCYKIRA SLKRLKPHVP LGRNCSSLPG
60 70 80 90 100
LIGNDIKSLH SIINPPIAKI RNIGIMAHID AGKTTTTERI LYYSGYTRSL
110 120 130 140 150
GDVDDGDTVT DFMAQERERG ITIQSAAVTF DWKGYRVNLI DTPGHVDFTL
160 170 180 190 200
EVERCLRVLD GAVAVFDASA GVEAQTLTVW RQADKHNIPR ICFLNKMDKT
210 220 230 240 250
GASFKYAVES IREKLKAKPL LLQLPIGEAK TFKGVVDVVM KEKLLWNCNS
260 270 280 290 300
NDGKDFERKP LLEMNDPELL KETTEARNAL IEQVADLDDE FADLVLEEFS
310 320 330 340 350
ENFDLLPAEK LQTAIHRVTL AQTAVPVLCG SALKNKGIQP LLDAVTMYLP
360 370 380 390 400
SPEERNYEFL QWYKDDLCAL AFKVLHDKQR GPLVFMRIYS GTIKPQLAIH
410 420 430 440 450
NINGNCTERI SRLLLPFADQ HVEIPSLTAG NIALTVGLKH TATGDTIVSS
460 470 480 490 500
KSSALAAARR AEREGEKKHR QNNEAERLLL AGVEIPEPVF FCTIEPPSLS
510 520 530 540 550
KQPDLEHALK CLQREDPSLK VRLDPDSGQT VLCGMGELHI EIIHDRIKRE
560 570 580 590 600
YGLETYLGPL QVAYRETILN SVRATDTLDR TLGDKRHLVT VEVEARPIET
610 620 630 640 650
SSVMPVIEFE YAESINEGLL KVSQEAIENG IHSACLQGPL LGSPIQDVAI
660 670 680 690 700
TLHSLTIHPG TSTTMISACV SRCVQKALKK ADKQVLEPLM NLEVTVARDY
710 720 730 740 750
LSPVLADLAQ RRGNIQEIQT RQDNKVVIGF VPLAEIMGYS TVLRTLTSGS
760 770
ATFALELSTY QAMNPQDQNT LLNRRSGLT
Length:779
Mass (Da):86,601
Last modified:December 1, 2001 - v1
Checksum:i856B4E26FD9DD94E
GO
Isoform 2 (identifier: Q969S9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     361-407: Missing.

Note: No experimental confirmation available.
Show »
Length:732
Mass (Da):81,200
Checksum:i15869E090CB0848A
GO
Isoform 3 (identifier: Q969S9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-609: Missing.

Note: No experimental confirmation available.
Show »
Length:777
Mass (Da):86,324
Checksum:i539970B070FB4904
GO
Isoform 4 (identifier: Q969S9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-531: TV → IP
     532-709: Missing.

Note: No experimental confirmation available.
Show »
Length:601
Mass (Da):67,068
Checksum:iC712D5773F21E83E
GO
Isoform 5 (identifier: Q969S9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-513: DLEHALKCLQ → GINGLSVSTN
     514-779: Missing.

Note: No experimental confirmation available.
Show »
Length:513
Mass (Da):57,060
Checksum:i81B3AF2019E9D71F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591L → I in AAH30612 (PubMed:15489334).Curated
Sequence conflicti201 – 2011G → V in AAS49035 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641N → S.
Corresponds to variant rs957680 [ dbSNP | Ensembl ].
VAR_053983
Natural varianti300 – 3001S → C.
Corresponds to variant rs16872235 [ dbSNP | Ensembl ].
VAR_053984
Natural varianti425 – 4251P → H.1 Publication
Corresponds to variant rs17852780 [ dbSNP | Ensembl ].
VAR_060200
Natural varianti594 – 5941E → G.1 Publication
Corresponds to variant rs17856872 [ dbSNP | Ensembl ].
VAR_060201
Natural varianti735 – 7351E → G.1 Publication
Corresponds to variant rs17856871 [ dbSNP | Ensembl ].
VAR_060202
Natural varianti774 – 7741R → Q.
Corresponds to variant rs1048167 [ dbSNP | Ensembl ].
VAR_053985

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei361 – 40747Missing in isoform 2. 1 PublicationVSP_001363Add
BLAST
Alternative sequencei504 – 51310DLEHALKCLQ → GINGLSVSTN in isoform 5. 1 PublicationVSP_038190
Alternative sequencei514 – 779266Missing in isoform 5. 1 PublicationVSP_038191Add
BLAST
Alternative sequencei530 – 5312TV → IP in isoform 4. 1 PublicationVSP_038192
Alternative sequencei532 – 709178Missing in isoform 4. 1 PublicationVSP_038193Add
BLAST
Alternative sequencei608 – 6092Missing in isoform 3. 1 PublicationVSP_038194

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367997 mRNA. Translation: AAK53401.1.
AY453587 mRNA. Translation: AAS49035.1.
AK025314 mRNA. Translation: BAB15109.1.
AF111808 mRNA. Translation: AAL39010.1.
CH471084 Genomic DNA. Translation: EAW95744.1.
BC015712 mRNA. Translation: AAH15712.1.
BC030612 mRNA. Translation: AAH30612.1.
CCDSiCCDS4023.1. [Q969S9-1]
CCDS4024.1. [Q969S9-2]
CCDS47232.1. [Q969S9-5]
RefSeqiNP_001268231.1. NM_001281302.1.
NP_115756.2. NM_032380.4. [Q969S9-1]
NP_733781.1. NM_170681.2. [Q969S9-5]
NP_733792.1. NM_170691.2. [Q969S9-2]
XP_011541992.1. XM_011543690.1. [Q969S9-1]
UniGeneiHs.277154.
Hs.656975.

Genome annotation databases

EnsembliENST00000296805; ENSP00000296805; ENSG00000164347. [Q969S9-1]
ENST00000345239; ENSP00000296804; ENSG00000164347. [Q969S9-2]
ENST00000427854; ENSP00000405808; ENSG00000164347. [Q969S9-5]
ENST00000509430; ENSP00000427004; ENSG00000164347. [Q969S9-1]
GeneIDi84340.
KEGGihsa:84340.
UCSCiuc003kdh.2. human. [Q969S9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367997 mRNA. Translation: AAK53401.1.
AY453587 mRNA. Translation: AAS49035.1.
AK025314 mRNA. Translation: BAB15109.1.
AF111808 mRNA. Translation: AAL39010.1.
CH471084 Genomic DNA. Translation: EAW95744.1.
BC015712 mRNA. Translation: AAH15712.1.
BC030612 mRNA. Translation: AAH30612.1.
CCDSiCCDS4023.1. [Q969S9-1]
CCDS4024.1. [Q969S9-2]
CCDS47232.1. [Q969S9-5]
RefSeqiNP_001268231.1. NM_001281302.1.
NP_115756.2. NM_032380.4. [Q969S9-1]
NP_733781.1. NM_170681.2. [Q969S9-5]
NP_733792.1. NM_170691.2. [Q969S9-2]
XP_011541992.1. XM_011543690.1. [Q969S9-1]
UniGeneiHs.277154.
Hs.656975.

3D structure databases

ProteinModelPortaliQ969S9.
SMRiQ969S9. Positions 67-772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124062. 16 interactions.
IntActiQ969S9. 8 interactions.
STRINGi9606.ENSP00000296805.

PTM databases

iPTMnetiQ969S9.
PhosphoSiteiQ969S9.

Polymorphism and mutation databases

BioMutaiGFM2.
DMDMi28201798.

Proteomic databases

EPDiQ969S9.
MaxQBiQ969S9.
PaxDbiQ969S9.
PRIDEiQ969S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296805; ENSP00000296805; ENSG00000164347. [Q969S9-1]
ENST00000345239; ENSP00000296804; ENSG00000164347. [Q969S9-2]
ENST00000427854; ENSP00000405808; ENSG00000164347. [Q969S9-5]
ENST00000509430; ENSP00000427004; ENSG00000164347. [Q969S9-1]
GeneIDi84340.
KEGGihsa:84340.
UCSCiuc003kdh.2. human. [Q969S9-1]

Organism-specific databases

CTDi84340.
GeneCardsiGFM2.
HGNCiHGNC:29682. GFM2.
HPAiHPA036863.
HPA036864.
MIMi606544. gene.
neXtProtiNX_Q969S9.
PharmGKBiPA134949527.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0465. Eukaryota.
COG0480. LUCA.
GeneTreeiENSGT00550000074890.
HOGENOMiHOG000231585.
InParanoidiQ969S9.
KOiK02355.
OMAiNCLQRED.
OrthoDBiEOG79KPF4.
PhylomeDBiQ969S9.
TreeFamiTF314848.

Enzyme and pathway databases

ReactomeiR-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiGFM2. human.
GenomeRNAii84340.
PROiQ969S9.
SOURCEiSearch...

Gene expression databases

BgeeiQ969S9.
CleanExiHS_GFM2.
ExpressionAtlasiQ969S9. baseline and differential.
GenevisibleiQ969S9. HS.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_03059. mEF_G_2.
InterProiIPR030851. EFG2.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution."
    Hammarsund M., Wilson W., Corcoran M., Merup M., Einhorn S., Grander D., Sangfelt O.
    Hum. Genet. 109:542-550(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Cloning of elongation factor G isoform."
    Zheng M., Xie Y., Mao Y.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Colon.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Aorta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS HIS-425; GLY-594 AND GLY-735.
    Tissue: Brain and Skin.
  7. "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis."
    Tsuboi M., Morita H., Nozaki Y., Akama K., Ueda T., Ito K., Nierhaus K.H., Takeuchi N.
    Mol. Cell 35:502-510(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRRF2M_HUMAN
AccessioniPrimary (citable) accession number: Q969S9
Secondary accession number(s): A0AR28
, Q8N6D8, Q8WYI0, Q9H6Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.