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Protein

Histone deacetylase 10

Gene

HDAC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei135By similarity1

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • histone deacetylase activity Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  • protein deacetylase activity Source: UniProtKB

GO - Biological processi

  • chromatin organization Source: UniProtKB
  • histone deacetylation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • oligodendrocyte development Source: Ensembl
  • protein deacetylation Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BRENDAi3.5.1.98 2681
ReactomeiR-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
SABIO-RKiQ969S8
SIGNORiQ969S8

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 10 (EC:3.5.1.98)
Short name:
HD10
Gene namesi
Name:HDAC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100429.17
HGNCiHGNC:18128 HDAC10
MIMi608544 gene
neXtProtiNX_Q969S8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi135H → A: Abolishes deacetylase activity. Does not affect interaction with HDAC3. 2 Publications1

Organism-specific databases

DisGeNETi83933
OpenTargetsiENSG00000100429
PharmGKBiPA38297

Chemistry databases

ChEMBLiCHEMBL5103
DrugBankiDB05015 Belinostat
DB06603 Panobinostat
GuidetoPHARMACOLOGYi2614

Polymorphism and mutation databases

BioMutaiHDAC10
DMDMi27734403

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147121 – 669Histone deacetylase 10Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei393PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ969S8
PaxDbiQ969S8
PeptideAtlasiQ969S8
PRIDEiQ969S8

PTM databases

iPTMnetiQ969S8
PhosphoSitePlusiQ969S8

Expressioni

Tissue specificityi

Ubiquitous. High expression in liver, spleen, pancreas and kidney.

Gene expression databases

BgeeiENSG00000100429
CleanExiHS_HDAC10
ExpressionAtlasiQ969S8 baseline and differential
GenevisibleiQ969S8 HS

Organism-specific databases

HPAiCAB045977
HPA056514

Interactioni

Subunit structurei

Interacts with HDAC2, HDAC3 and NCOR2.2 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123818, 36 interactors
CORUMiQ969S8
IntActiQ969S8, 11 interactors
STRINGi9606.ENSP00000216271

Chemistry databases

BindingDBiQ969S8

Structurei

3D structure databases

ProteinModelPortaliQ969S8
SMRiQ969S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 323Histone deacetylaseAdd BLAST323

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00530000062809
HOVERGENiHBG051892
InParanoidiQ969S8
KOiK18671
OMAiGLEQRCL
OrthoDBiEOG091G0210
PhylomeDBiQ969S8
TreeFamiTF106173

Family and domain databases

Gene3Di3.40.800.20, 2 hits
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 2 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969S8-1) [UniParc]FASTAAdd to basket
Also known as: B, Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIERPER LTAALDRLRQ RGLEQRCLRL
60 70 80 90 100
SAREASEEEL GLVHSPEYVS LVRETQVLGK EELQALSGQF DAIYFHPSTF
110 120 130 140 150
HCARLAAGAG LQLVDAVLTG AVQNGLALVR PPGHHGQRAA ANGFCVFNNV
160 170 180 190 200
AIAAAHAKQK HGLHRILVVD WDVHHGQGIQ YLFEDDPSVL YFSWHRYEHG
210 220 230 240 250
RFWPFLRESD ADAVGRGQGL GFTVNLPWNQ VGMGNADYVA AFLHLLLPLA
260 270 280 290 300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRVCAV
310 320 330 340 350
LEGGYHLESL AESVCMTVQT LLGDPAPPLS GPMAPCQSAL ESIQSARAAQ
360 370 380 390 400
APHWKSLQQQ DVTAVPMSPS SHSPEGRPPP LLPGGPVCKA AASAPSSLLD
410 420 430 440 450
QPCLCPAPSV RTAVALTTPD ITLVLPPDVI QQEASALREE TEAWARPHES
460 470 480 490 500
LAREEALTAL GKLLYLLDGM LDGQVNSGIA ATPASAAAAT LDVAVRRGLS
510 520 530 540 550
HGAQRLLCVA LGQLDRPPDL AHDGRSLWLN IRGKEAAALS MFHVSTPLPV
560 570 580 590 600
MTGGFLSCIL GLVLPLAYGF QPDLVLVALG PGHGLQGPHA ALLAAMLRGL
610 620 630 640 650
AGGRVLALLE ENSTPQLAGI LARVLNGEAP PSLGPSSVAS PEDVQALMYL
660
RGQLEPQWKM LQCHPHLVA
Length:669
Mass (Da):71,445
Last modified:December 1, 2001 - v1
Checksum:i872D9427E6893A18
GO
Isoform 2 (identifier: Q969S8-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     252-271: Missing.

Show »
Length:649
Mass (Da):69,385
Checksum:i7756351E6BC838FB
GO
Isoform 4 (identifier: Q969S8-4) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     612-669: NSTPQLAGIL...MLQCHPHLVA → VSWAGWRCCG...GPGAEWRGTS

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:658
Mass (Da):70,033
Checksum:i0EABDDA886585928
GO
Isoform 5 (identifier: Q969S8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-301: Missing.
     447-669: Missing.

Show »
Length:396
Mass (Da):43,016
Checksum:i22DE1D205E5856A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92A → T in AAS48345 (Ref. 6) Curated1
Sequence conflicti177Q → R in AAS48345 (Ref. 6) Curated1
Sequence conflicti337Q → QRC in CAC21653 (PubMed:17974005).Curated1
Sequence conflicti594A → T in AAK92205 (PubMed:11677242).Curated1
Sequence conflicti594A → T in AAK92206 (PubMed:11677242).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049356429V → I. Corresponds to variant dbSNP:rs34402301Ensembl.1
Natural variantiVAR_015067584G → C1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014698252 – 301Missing in isoform 5. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_002089252 – 271Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_014699447 – 669Missing in isoform 5. 1 PublicationAdd BLAST223
Alternative sequenceiVSP_002090612 – 669NSTPQ…PHLVA → VSWAGWRCCGVGRGKGPVTA SVFAPGPELHTPASRDPGPG AEWRGTS in isoform 4. 2 PublicationsAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426160 mRNA Translation: AAL30513.1
AF393962 mRNA Translation: AAK84023.1
AF407272 mRNA Translation: AAK92205.1
AF407273 mRNA Translation: AAK92206.1
CR456465 mRNA Translation: CAG30351.1
AY450395 mRNA Translation: AAS48345.1
AL022328 Genomic DNA No translation available.
BC125083 mRNA Translation: AAI25084.1
AL512711 mRNA Translation: CAC21653.2
CCDSiCCDS14088.1 [Q969S8-1]
CCDS54545.1 [Q969S8-2]
RefSeqiNP_001152758.1, NM_001159286.1 [Q969S8-2]
NP_114408.3, NM_032019.5 [Q969S8-1]
UniGeneiHs.26593

Genome annotation databases

EnsembliENST00000216271; ENSP00000216271; ENSG00000100429 [Q969S8-1]
ENST00000349505; ENSP00000343540; ENSG00000100429 [Q969S8-2]
ENST00000454936; ENSP00000406150; ENSG00000100429 [Q969S8-5]
GeneIDi83933
KEGGihsa:83933
UCSCiuc003bkg.4 human [Q969S8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHDA10_HUMAN
AccessioniPrimary (citable) accession number: Q969S8
Secondary accession number(s): Q08AP4
, Q6STF9, Q96P77, Q96P78, Q9H028, Q9UGX1, Q9UGX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health