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Protein

Transmembrane protein 203

Gene

TMEM203

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).1 Publication

GO - Biological processi

  • cellular calcium ion homeostasis Source: UniProtKB
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • spermatogenesis Source: UniProtKB
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Protein family/group databases

TCDBi8.A.76.1.1. the tmem203 or pf14967 (tmem203) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 203
Gene namesi
Name:TMEM203
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28217. TMEM203.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Transmembranei50 – 7223HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406377.

Polymorphism and mutation databases

BioMutaiTMEM203.
DMDMi74731059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Transmembrane protein 203PRO_0000317203Add
BLAST

Proteomic databases

PaxDbiQ969S6.
PRIDEiQ969S6.

Expressioni

Gene expression databases

BgeeiENSG00000187713.
CleanExiHS_TMEM203.
GenevisibleiQ969S6. HS.

Organism-specific databases

HPAiHPA043250.

Interactioni

Subunit structurei

Interacts with ATP2A2, ITPR3 and STIM1.1 Publication

Protein-protein interaction databases

BioGridi125117. 2 interactions.
STRINGi9606.ENSP00000375053.

Structurei

3D structure databases

ProteinModelPortaliQ969S6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY4R. Eukaryota.
ENOG4111SGD. LUCA.
GeneTreeiENSGT00510000049510.
HOGENOMiHOG000007895.
HOVERGENiHBG059488.
InParanoidiQ969S6.
OMAiFEIWINL.
OrthoDBiEOG091G0UU5.
PhylomeDBiQ969S6.
TreeFamiTF323514.

Family and domain databases

InterProiIPR019396. TM_Fragile-X-F-assoc.
[Graphical view]
PfamiPF10269. Tmemb_185A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFSLRELVQ WLGFATFEIF VHLLALLVFS VLLALRVDGL VPGLSWWNVF
60 70 80 90 100
VPFFAADGLS TYFTTIVSVR LFQDGEKRLA VLRLFWVLTV LSLKFVFEML
110 120 130
LCQKLAEQTR ELWFGLITSP LFILLQLLMI RACRVN
Length:136
Mass (Da):15,760
Last modified:December 1, 2001 - v1
Checksum:i87CA7D87F00B16FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961V → F in AAH67786 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471090 Genomic DNA. Translation: EAW88365.1.
BC009283 mRNA. Translation: AAH09283.1.
BC009461 mRNA. Translation: AAH09461.1.
BC067786 mRNA. Translation: AAH67786.1.
CCDSiCCDS35185.1.
RefSeqiNP_444273.1. NM_053045.1.
UniGeneiHs.231029.

Genome annotation databases

EnsembliENST00000343666; ENSP00000375053; ENSG00000187713.
GeneIDi94107.
KEGGihsa:94107.
UCSCiuc004clv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471090 Genomic DNA. Translation: EAW88365.1.
BC009283 mRNA. Translation: AAH09283.1.
BC009461 mRNA. Translation: AAH09461.1.
BC067786 mRNA. Translation: AAH67786.1.
CCDSiCCDS35185.1.
RefSeqiNP_444273.1. NM_053045.1.
UniGeneiHs.231029.

3D structure databases

ProteinModelPortaliQ969S6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125117. 2 interactions.
STRINGi9606.ENSP00000375053.

Protein family/group databases

TCDBi8.A.76.1.1. the tmem203 or pf14967 (tmem203) family.

Polymorphism and mutation databases

BioMutaiTMEM203.
DMDMi74731059.

Proteomic databases

PaxDbiQ969S6.
PRIDEiQ969S6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343666; ENSP00000375053; ENSG00000187713.
GeneIDi94107.
KEGGihsa:94107.
UCSCiuc004clv.4. human.

Organism-specific databases

CTDi94107.
GeneCardsiTMEM203.
HGNCiHGNC:28217. TMEM203.
HPAiHPA043250.
MIMi616499. gene.
neXtProtiNX_Q969S6.
PharmGKBiPA162406377.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY4R. Eukaryota.
ENOG4111SGD. LUCA.
GeneTreeiENSGT00510000049510.
HOGENOMiHOG000007895.
HOVERGENiHBG059488.
InParanoidiQ969S6.
OMAiFEIWINL.
OrthoDBiEOG091G0UU5.
PhylomeDBiQ969S6.
TreeFamiTF323514.

Miscellaneous databases

GenomeRNAii94107.
PROiQ969S6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187713.
CleanExiHS_TMEM203.
GenevisibleiQ969S6. HS.

Family and domain databases

InterProiIPR019396. TM_Fragile-X-F-assoc.
[Graphical view]
PfamiPF10269. Tmemb_185A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM203_HUMAN
AccessioniPrimary (citable) accession number: Q969S6
Secondary accession number(s): Q6NW08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.