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Q969S3 (ZN622_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 622
Alternative name(s):
Zinc finger-like protein 9
Gene names
Name:ZNF622
Synonyms:ZPR9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Subunit structure

Homo- and heterodimer. Interacts with MELK and MYBL2. Ref.1 Ref.3

Subcellular location

Cytoplasm. Nucleus Ref.1.

Tissue specificity

Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney. Ref.1

Post-translational modification

Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus. Ref.1

Sequence similarities

Contains 2 U1-type zinc fingers.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MAP3K5Q9968314EBI-2687480,EBI-476263

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 477476Zinc finger protein 622
PRO_0000191815

Regions

Zinc finger4 – 2825U1-type 1
Zinc finger67 – 9125U1-type 2
Compositional bias195 – 24248Glu-rich
Compositional bias199 – 2035Poly-Glu
Compositional bias236 – 2427Poly-Glu

Amino acid modifications

Modified residue21N-acetylalanine Ref.7
Modified residue2761Phosphoserine Ref.4 Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q969S3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 88E75FAEAB46C62B

FASTA47754,272
        10         20         30         40         50         60 
MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER VRAQRAVAEE 

        70         80         90        100        110        120 
ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ AVNRKVEMMN EKNLEKGLGV 

       130        140        150        160        170        180 
DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA PAKEARNVVA VGTGGRGTHD RDPSEKPPRL 

       190        200        210        220        230        240 
QWFEQQAKKL AKQQEEDSEE EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA 

       250        260        270        280        290        300 
EEGPPLGAIP ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG 

       310        320        330        340        350        360 
VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR SSYPDHKEGE 

       370        380        390        400        410        420 
DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY KQRFGLSRAV AVAKNRKAVG 

       430        440        450        460        470 
RVLQQYRALG WTGSTGAALM RERDMQYVQR MKSKWMLKTG MKNNATKQMH FRVQVRF 

« Hide

References

« Hide 'large scale' references
[1]"Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)."
Seong H.-A., Gil M., Kim K.-T., Kim S.-J., Ha H.
Biochem. J. 361:597-604(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH MELK.
Tissue: Keratinocyte.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cervix and Skin.
[3]"Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein."
Seong H.A., Kim K.T., Ha H.
J. Biol. Chem. 278:9655-9662(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MYBL2.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY046059 mRNA. Translation: AAL02121.1.
BC008752 mRNA. Translation: AAH08752.1.
BC010545 mRNA. Translation: AAH10545.1.
CCDSCCDS3886.1.
RefSeqNP_219482.1. NM_033414.2.
UniGeneHs.60300.

3D structure databases

ProteinModelPortalQ969S3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124717. 18 interactions.
IntActQ969S3. 4 interactions.
MINTMINT-261676.
STRING9606.ENSP00000310042.

PTM databases

PhosphoSiteQ969S3.

Polymorphism databases

DMDM50401777.

Proteomic databases

MaxQBQ969S3.
PaxDbQ969S3.
PeptideAtlasQ969S3.
PRIDEQ969S3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308683; ENSP00000310042; ENSG00000173545.
GeneID90441.
KEGGhsa:90441.
UCSCuc003jfq.3. human.

Organism-specific databases

CTD90441.
GeneCardsGC05M016451.
HGNCHGNC:30958. ZNF622.
HPAHPA036515.
MIM608694. gene.
neXtProtNX_Q969S3.
PharmGKBPA134992557.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG253541.
HOGENOMHOG000183078.
HOVERGENHBG056035.
InParanoidQ969S3.
KOK14816.
OMASDAQRDH.
OrthoDBEOG7ZWD1Z.
PhylomeDBQ969S3.
TreeFamTF313094.

Gene expression databases

BgeeQ969S3.
CleanExHS_ZNF622.
GenevestigatorQ969S3.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi90441.
NextBio76766.
PROQ969S3.
SOURCESearch...

Entry information

Entry nameZN622_HUMAN
AccessionPrimary (citable) accession number: Q969S3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM