Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 622

Gene

ZNF622

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2825U1-type 1Add
BLAST
Zinc fingeri67 – 9125U1-type 2Add
BLAST

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • intrinsic apoptotic signaling pathway in response to oxidative stress Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of JNK cascade Source: UniProtKB
  • positive regulation of kinase activity Source: UniProtKB
  • positive regulation of MAPK cascade Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 622
Alternative name(s):
Zinc finger-like protein 9
Gene namesi
Name:ZNF622
Synonyms:ZPR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30958. ZNF622.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992557.

Polymorphism and mutation databases

BioMutaiZNF622.
DMDMi50401777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 477476Zinc finger protein 622PRO_0000191815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei276 – 2761Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ969S3.
PaxDbiQ969S3.
PeptideAtlasiQ969S3.
PRIDEiQ969S3.

PTM databases

PhosphoSiteiQ969S3.

Expressioni

Tissue specificityi

Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.1 Publication

Gene expression databases

BgeeiQ969S3.
CleanExiHS_ZNF622.
GenevisibleiQ969S3. HS.

Organism-specific databases

HPAiHPA036514.
HPA036515.

Interactioni

Subunit structurei

Homo- and heterodimer. Interacts with MELK and MYBL2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP3K5Q9968314EBI-2687480,EBI-476263

Protein-protein interaction databases

BioGridi124717. 34 interactions.
IntActiQ969S3. 4 interactions.
MINTiMINT-261676.
STRINGi9606.ENSP00000310042.

Structurei

3D structure databases

ProteinModelPortaliQ969S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 24248Glu-richAdd
BLAST
Compositional biasi199 – 2035Poly-Glu
Compositional biasi236 – 2427Poly-Glu

Sequence similaritiesi

Contains 2 U1-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2825U1-type 1Add
BLAST
Zinc fingeri67 – 9125U1-type 2Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG253541.
GeneTreeiENSGT00390000018047.
HOGENOMiHOG000183078.
HOVERGENiHBG056035.
InParanoidiQ969S3.
KOiK14816.
OMAiSDAQRDH.
OrthoDBiEOG7ZWD1Z.
PhylomeDBiQ969S3.
TreeFamiTF313094.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER
60 70 80 90 100
VRAQRAVAEE ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ
110 120 130 140 150
AVNRKVEMMN EKNLEKGLGV DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA
160 170 180 190 200
PAKEARNVVA VGTGGRGTHD RDPSEKPPRL QWFEQQAKKL AKQQEEDSEE
210 220 230 240 250
EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA EEGPPLGAIP
260 270 280 290 300
ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG
310 320 330 340 350
VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR
360 370 380 390 400
SSYPDHKEGE DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY
410 420 430 440 450
KQRFGLSRAV AVAKNRKAVG RVLQQYRALG WTGSTGAALM RERDMQYVQR
460 470
MKSKWMLKTG MKNNATKQMH FRVQVRF
Length:477
Mass (Da):54,272
Last modified:December 1, 2001 - v1
Checksum:i88E75FAEAB46C62B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046059 mRNA. Translation: AAL02121.1.
BC008752 mRNA. Translation: AAH08752.1.
BC010545 mRNA. Translation: AAH10545.1.
CCDSiCCDS3886.1.
RefSeqiNP_219482.1. NM_033414.2.
XP_011512462.1. XM_011514160.1.
UniGeneiHs.60300.

Genome annotation databases

EnsembliENST00000308683; ENSP00000310042; ENSG00000173545.
GeneIDi90441.
KEGGihsa:90441.
UCSCiuc003jfq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046059 mRNA. Translation: AAL02121.1.
BC008752 mRNA. Translation: AAH08752.1.
BC010545 mRNA. Translation: AAH10545.1.
CCDSiCCDS3886.1.
RefSeqiNP_219482.1. NM_033414.2.
XP_011512462.1. XM_011514160.1.
UniGeneiHs.60300.

3D structure databases

ProteinModelPortaliQ969S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124717. 34 interactions.
IntActiQ969S3. 4 interactions.
MINTiMINT-261676.
STRINGi9606.ENSP00000310042.

PTM databases

PhosphoSiteiQ969S3.

Polymorphism and mutation databases

BioMutaiZNF622.
DMDMi50401777.

Proteomic databases

MaxQBiQ969S3.
PaxDbiQ969S3.
PeptideAtlasiQ969S3.
PRIDEiQ969S3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308683; ENSP00000310042; ENSG00000173545.
GeneIDi90441.
KEGGihsa:90441.
UCSCiuc003jfq.3. human.

Organism-specific databases

CTDi90441.
GeneCardsiGC05M016451.
HGNCiHGNC:30958. ZNF622.
HPAiHPA036514.
HPA036515.
MIMi608694. gene.
neXtProtiNX_Q969S3.
PharmGKBiPA134992557.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG253541.
GeneTreeiENSGT00390000018047.
HOGENOMiHOG000183078.
HOVERGENiHBG056035.
InParanoidiQ969S3.
KOiK14816.
OMAiSDAQRDH.
OrthoDBiEOG7ZWD1Z.
PhylomeDBiQ969S3.
TreeFamiTF313094.

Miscellaneous databases

ChiTaRSiZNF622. human.
GenomeRNAii90441.
NextBioi76766.
PROiQ969S3.
SOURCEiSearch...

Gene expression databases

BgeeiQ969S3.
CleanExiHS_ZNF622.
GenevisibleiQ969S3. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)."
    Seong H.-A., Gil M., Kim K.-T., Kim S.-J., Ha H.
    Biochem. J. 361:597-604(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH MELK.
    Tissue: Keratinocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix and Skin.
  3. "Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein."
    Seong H.A., Kim K.T., Ha H.
    J. Biol. Chem. 278:9655-9662(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYBL2.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN622_HUMAN
AccessioniPrimary (citable) accession number: Q969S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.