Q969S3 (ZN622_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 622

Alternative name(s):
Zinc finger-like protein 9

Gene names

Name:	ZNF622
Synonyms:	ZPR9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.
Subunit structure	Homo- and heterodimer. Interacts with MELK and MYBL2. Ref.1 Ref.3
Subcellular location	Cytoplasm. Nucleus Ref.1.
Tissue specificity	Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney. Ref.1
Post-translational modification	Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus. Ref.1
Sequence similarities	Contains 2 U1-type zinc fingers.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intrinsic apoptotic signaling pathway in response to oxidative stress Inferred from direct assay PubMed 21771788. Source: UniProtKB positive regulation of JNK cascade Inferred from mutant phenotype PubMed 21771788. Source: UniProtKB positive regulation of apoptotic process Inferred from direct assay PubMed 21771788. Source: UniProtKB positive regulation of kinase activity Inferred from direct assay PubMed 21771788. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAP3K5	Q99683	14	EBI-2687480,EBI-476263

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	Zinc finger protein 622		PRO_0000191815
Regions
	Zinc finger	4 – 28	25	U1-type 1
	Zinc finger	67 – 91	25	U1-type 2
	Compositional bias	195 – 242	48	Glu-rich
	Compositional bias	199 – 203	5	Poly-Glu
	Compositional bias	236 – 242	7	Poly-Glu
Amino acid modifications
	Modified residue	276	1	Phosphoserine Ref.4 Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q969S3 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 88E75FAEAB46C62B	FASTA	477	54,272
	10 20 30 40 50 60 MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER VRAQRAVAEE 70 80 90 100 110 120 ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ AVNRKVEMMN EKNLEKGLGV 130 140 150 160 170 180 DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA PAKEARNVVA VGTGGRGTHD RDPSEKPPRL 190 200 210 220 230 240 QWFEQQAKKL AKQQEEDSEE EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA 250 260 270 280 290 300 EEGPPLGAIP ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG 310 320 330 340 350 360 VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR SSYPDHKEGE 370 380 390 400 410 420 DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY KQRFGLSRAV AVAKNRKAVG 430 440 450 460 470 RVLQQYRALG WTGSTGAALM RERDMQYVQR MKSKWMLKTG MKNNATKQMH FRVQVRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)." Seong H.-A., Gil M., Kim K.-T., Kim S.-J., Ha H. Biochem. J. 361:597-604(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH MELK. Tissue: Keratinocyte.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix and Skin.
[3]	"Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein." Seong H.A., Kim K.T., Ha H. J. Biol. Chem. 278:9655-9662(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MYBL2.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY046059 mRNA. Translation: AAL02121.1. BC008752 mRNA. Translation: AAH08752.1. BC010545 mRNA. Translation: AAH10545.1.
IPI	IPI00056499.
RefSeq	NP_219482.1. NM_033414.2.
UniGene	Hs.60300.
3D structure databases
ProteinModelPortal	Q969S3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q969S3. 3 interactions.
MINT	MINT-261676.
STRING	9606.ENSP00000310042.
PTM databases
PhosphoSite	Q969S3.
Polymorphism databases
DMDM	50401777.
Proteomic databases
PaxDb	Q969S3.
PeptideAtlas	Q969S3.
PRIDE	Q969S3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308683; ENSP00000310042; ENSG00000173545.
GeneID	90441.
KEGG	hsa:90441.
UCSC	uc003jfq.3. human.
Organism-specific databases
CTD	90441.
GeneCards	GC05M016451.
HGNC	HGNC:30958. ZNF622.
HPA	HPA036515.
MIM	608694. gene.
neXtProt	NX_Q969S3.
PharmGKB	PA134992557.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253541.
HOGENOM	HOG000183078.
HOVERGEN	HBG056035.
InParanoid	Q969S3.
KO	K14816.
OMA	SATYCTV.
OrthoDB	EOG4PG611.
PhylomeDB	Q969S3.
Gene expression databases
Bgee	Q969S3.
CleanEx	HS_ZNF622.
Genevestigator	Q969S3.
GermOnline	ENSG00000173545. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR022755. Znf_C2H2_jaz. IPR003604. Znf_U1. [Graphical view]
Pfam	PF12171. zf-C2H2_jaz. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 4 hits. SM00451. ZnF_U1. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	90441.
NextBio	76766.
SOURCE	Search...

Entry information

Entry name

ZN622_HUMAN

Accession

Primary (citable) accession number: Q969S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.