Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q969S3

- ZN622_HUMAN

UniProt

Q969S3 - ZN622_HUMAN

Protein

Zinc finger protein 622

Gene

ZNF622

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2825U1-type 1Add
    BLAST
    Zinc fingeri67 – 9125U1-type 2Add
    BLAST

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. intrinsic apoptotic signaling pathway in response to oxidative stress Source: UniProtKB
    2. positive regulation of apoptotic process Source: UniProtKB
    3. positive regulation of JNK cascade Source: UniProtKB
    4. positive regulation of kinase activity Source: UniProtKB
    5. positive regulation of MAPK cascade Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 622
    Alternative name(s):
    Zinc finger-like protein 9
    Gene namesi
    Name:ZNF622
    Synonyms:ZPR9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30958. ZNF622.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. Golgi apparatus Source: HPA
    3. nucleolus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134992557.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 477476Zinc finger protein 622PRO_0000191815Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei276 – 2761Phosphoserine3 Publications

    Post-translational modificationi

    Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ969S3.
    PaxDbiQ969S3.
    PeptideAtlasiQ969S3.
    PRIDEiQ969S3.

    PTM databases

    PhosphoSiteiQ969S3.

    Expressioni

    Tissue specificityi

    Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.1 Publication

    Gene expression databases

    BgeeiQ969S3.
    CleanExiHS_ZNF622.
    GenevestigatoriQ969S3.

    Organism-specific databases

    HPAiHPA036515.

    Interactioni

    Subunit structurei

    Homo- and heterodimer. Interacts with MELK and MYBL2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAP3K5Q9968314EBI-2687480,EBI-476263

    Protein-protein interaction databases

    BioGridi124717. 33 interactions.
    IntActiQ969S3. 4 interactions.
    MINTiMINT-261676.
    STRINGi9606.ENSP00000310042.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969S3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi195 – 24248Glu-richAdd
    BLAST
    Compositional biasi199 – 2035Poly-Glu
    Compositional biasi236 – 2427Poly-Glu

    Sequence similaritiesi

    Contains 2 U1-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2825U1-type 1Add
    BLAST
    Zinc fingeri67 – 9125U1-type 2Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG253541.
    HOGENOMiHOG000183078.
    HOVERGENiHBG056035.
    InParanoidiQ969S3.
    KOiK14816.
    OMAiSDAQRDH.
    OrthoDBiEOG7ZWD1Z.
    PhylomeDBiQ969S3.
    TreeFamiTF313094.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    IPR003604. Znf_U1.
    [Graphical view]
    PfamiPF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    SM00451. ZnF_U1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q969S3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER    50
    VRAQRAVAEE ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ 100
    AVNRKVEMMN EKNLEKGLGV DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA 150
    PAKEARNVVA VGTGGRGTHD RDPSEKPPRL QWFEQQAKKL AKQQEEDSEE 200
    EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA EEGPPLGAIP 250
    ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG 300
    VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR 350
    SSYPDHKEGE DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY 400
    KQRFGLSRAV AVAKNRKAVG RVLQQYRALG WTGSTGAALM RERDMQYVQR 450
    MKSKWMLKTG MKNNATKQMH FRVQVRF 477
    Length:477
    Mass (Da):54,272
    Last modified:December 1, 2001 - v1
    Checksum:i88E75FAEAB46C62B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY046059 mRNA. Translation: AAL02121.1.
    BC008752 mRNA. Translation: AAH08752.1.
    BC010545 mRNA. Translation: AAH10545.1.
    CCDSiCCDS3886.1.
    RefSeqiNP_219482.1. NM_033414.2.
    UniGeneiHs.60300.

    Genome annotation databases

    EnsembliENST00000308683; ENSP00000310042; ENSG00000173545.
    GeneIDi90441.
    KEGGihsa:90441.
    UCSCiuc003jfq.3. human.

    Polymorphism databases

    DMDMi50401777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY046059 mRNA. Translation: AAL02121.1 .
    BC008752 mRNA. Translation: AAH08752.1 .
    BC010545 mRNA. Translation: AAH10545.1 .
    CCDSi CCDS3886.1.
    RefSeqi NP_219482.1. NM_033414.2.
    UniGenei Hs.60300.

    3D structure databases

    ProteinModelPortali Q969S3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124717. 33 interactions.
    IntActi Q969S3. 4 interactions.
    MINTi MINT-261676.
    STRINGi 9606.ENSP00000310042.

    PTM databases

    PhosphoSitei Q969S3.

    Polymorphism databases

    DMDMi 50401777.

    Proteomic databases

    MaxQBi Q969S3.
    PaxDbi Q969S3.
    PeptideAtlasi Q969S3.
    PRIDEi Q969S3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308683 ; ENSP00000310042 ; ENSG00000173545 .
    GeneIDi 90441.
    KEGGi hsa:90441.
    UCSCi uc003jfq.3. human.

    Organism-specific databases

    CTDi 90441.
    GeneCardsi GC05M016451.
    HGNCi HGNC:30958. ZNF622.
    HPAi HPA036515.
    MIMi 608694. gene.
    neXtProti NX_Q969S3.
    PharmGKBi PA134992557.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253541.
    HOGENOMi HOG000183078.
    HOVERGENi HBG056035.
    InParanoidi Q969S3.
    KOi K14816.
    OMAi SDAQRDH.
    OrthoDBi EOG7ZWD1Z.
    PhylomeDBi Q969S3.
    TreeFami TF313094.

    Miscellaneous databases

    GenomeRNAii 90441.
    NextBioi 76766.
    PROi Q969S3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q969S3.
    CleanExi HS_ZNF622.
    Genevestigatori Q969S3.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    IPR003604. Znf_U1.
    [Graphical view ]
    Pfami PF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    SM00451. ZnF_U1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)."
      Seong H.-A., Gil M., Kim K.-T., Kim S.-J., Ha H.
      Biochem. J. 361:597-604(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH MELK.
      Tissue: Keratinocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix and Skin.
    3. "Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein."
      Seong H.A., Kim K.T., Ha H.
      J. Biol. Chem. 278:9655-9662(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYBL2.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN622_HUMAN
    AccessioniPrimary (citable) accession number: Q969S3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3