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Protein

Zinc finger protein 622

Gene

ZNF622

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 28U1-type 1Add BLAST25
Zinc fingeri67 – 91U1-type 2Add BLAST25

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • intrinsic apoptotic signaling pathway in response to oxidative stress Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of JNK cascade Source: UniProtKB
  • positive regulation of kinase activity Source: UniProtKB
  • positive regulation of MAPK cascade Source: UniProtKB
  • ribosomal large subunit biogenesis Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173545-MONOMER.
SIGNORiQ969S3.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 622
Alternative name(s):
Zinc finger-like protein 9
Gene namesi
Name:ZNF622
Synonyms:ZPR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30958. ZNF622.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173545.
PharmGKBiPA134992557.

Polymorphism and mutation databases

BioMutaiZNF622.
DMDMi50401777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001918152 – 477Zinc finger protein 622Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei276PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ969S3.
MaxQBiQ969S3.
PaxDbiQ969S3.
PeptideAtlasiQ969S3.
PRIDEiQ969S3.

PTM databases

iPTMnetiQ969S3.
PhosphoSitePlusiQ969S3.

Expressioni

Tissue specificityi

Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.1 Publication

Gene expression databases

BgeeiENSG00000173545.
CleanExiHS_ZNF622.
GenevisibleiQ969S3. HS.

Organism-specific databases

HPAiHPA036514.
HPA036515.

Interactioni

Subunit structurei

Homo- and heterodimer. Interacts with MELK and MYBL2 (PubMed:11802789, PubMed:12645566). Interacts with DNAJC21 (PubMed:27346687).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP3K5Q9968314EBI-2687480,EBI-476263

Protein-protein interaction databases

BioGridi124717. 51 interactors.
IntActiQ969S3. 19 interactors.
MINTiMINT-261676.
STRINGi9606.ENSP00000310042.

Structurei

3D structure databases

ProteinModelPortaliQ969S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 242Glu-richAdd BLAST48
Compositional biasi199 – 203Poly-Glu5
Compositional biasi236 – 242Poly-Glu7

Sequence similaritiesi

Contains 2 U1-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 28U1-type 1Add BLAST25
Zinc fingeri67 – 91U1-type 2Add BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2785. Eukaryota.
ENOG410XPH0. LUCA.
GeneTreeiENSGT00390000018047.
HOGENOMiHOG000183078.
HOVERGENiHBG056035.
InParanoidiQ969S3.
KOiK14816.
OMAiSDAQRDH.
OrthoDBiEOG091G0BCO.
PhylomeDBiQ969S3.
TreeFamiTF313094.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12756. zf-C2H2_2. 1 hit.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER
60 70 80 90 100
VRAQRAVAEE ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ
110 120 130 140 150
AVNRKVEMMN EKNLEKGLGV DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA
160 170 180 190 200
PAKEARNVVA VGTGGRGTHD RDPSEKPPRL QWFEQQAKKL AKQQEEDSEE
210 220 230 240 250
EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA EEGPPLGAIP
260 270 280 290 300
ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG
310 320 330 340 350
VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR
360 370 380 390 400
SSYPDHKEGE DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY
410 420 430 440 450
KQRFGLSRAV AVAKNRKAVG RVLQQYRALG WTGSTGAALM RERDMQYVQR
460 470
MKSKWMLKTG MKNNATKQMH FRVQVRF
Length:477
Mass (Da):54,272
Last modified:December 1, 2001 - v1
Checksum:i88E75FAEAB46C62B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046059 mRNA. Translation: AAL02121.1.
BC008752 mRNA. Translation: AAH08752.1.
BC010545 mRNA. Translation: AAH10545.1.
CCDSiCCDS3886.1.
RefSeqiNP_219482.1. NM_033414.2.
UniGeneiHs.60300.

Genome annotation databases

EnsembliENST00000308683; ENSP00000310042; ENSG00000173545.
GeneIDi90441.
KEGGihsa:90441.
UCSCiuc003jfq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046059 mRNA. Translation: AAL02121.1.
BC008752 mRNA. Translation: AAH08752.1.
BC010545 mRNA. Translation: AAH10545.1.
CCDSiCCDS3886.1.
RefSeqiNP_219482.1. NM_033414.2.
UniGeneiHs.60300.

3D structure databases

ProteinModelPortaliQ969S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124717. 51 interactors.
IntActiQ969S3. 19 interactors.
MINTiMINT-261676.
STRINGi9606.ENSP00000310042.

PTM databases

iPTMnetiQ969S3.
PhosphoSitePlusiQ969S3.

Polymorphism and mutation databases

BioMutaiZNF622.
DMDMi50401777.

Proteomic databases

EPDiQ969S3.
MaxQBiQ969S3.
PaxDbiQ969S3.
PeptideAtlasiQ969S3.
PRIDEiQ969S3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308683; ENSP00000310042; ENSG00000173545.
GeneIDi90441.
KEGGihsa:90441.
UCSCiuc003jfq.4. human.

Organism-specific databases

CTDi90441.
GeneCardsiZNF622.
HGNCiHGNC:30958. ZNF622.
HPAiHPA036514.
HPA036515.
MIMi608694. gene.
neXtProtiNX_Q969S3.
OpenTargetsiENSG00000173545.
PharmGKBiPA134992557.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2785. Eukaryota.
ENOG410XPH0. LUCA.
GeneTreeiENSGT00390000018047.
HOGENOMiHOG000183078.
HOVERGENiHBG056035.
InParanoidiQ969S3.
KOiK14816.
OMAiSDAQRDH.
OrthoDBiEOG091G0BCO.
PhylomeDBiQ969S3.
TreeFamiTF313094.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173545-MONOMER.
SIGNORiQ969S3.

Miscellaneous databases

ChiTaRSiZNF622. human.
GenomeRNAii90441.
PROiQ969S3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173545.
CleanExiHS_ZNF622.
GenevisibleiQ969S3. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12756. zf-C2H2_2. 1 hit.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN622_HUMAN
AccessioniPrimary (citable) accession number: Q969S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.