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Q969S3

- ZN622_HUMAN

UniProt

Q969S3 - ZN622_HUMAN

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Protein

Zinc finger protein 622

Gene

ZNF622

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2825U1-type 1Add
BLAST
Zinc fingeri67 – 9125U1-type 2Add
BLAST

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. intrinsic apoptotic signaling pathway in response to oxidative stress Source: UniProtKB
  2. positive regulation of apoptotic process Source: UniProtKB
  3. positive regulation of JNK cascade Source: UniProtKB
  4. positive regulation of kinase activity Source: UniProtKB
  5. positive regulation of MAPK cascade Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 622
Alternative name(s):
Zinc finger-like protein 9
Gene namesi
Name:ZNF622
Synonyms:ZPR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:30958. ZNF622.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. Golgi apparatus Source: HPA
  3. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 477476Zinc finger protein 622PRO_0000191815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei276 – 2761Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ969S3.
PaxDbiQ969S3.
PeptideAtlasiQ969S3.
PRIDEiQ969S3.

PTM databases

PhosphoSiteiQ969S3.

Expressioni

Tissue specificityi

Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.1 Publication

Gene expression databases

BgeeiQ969S3.
CleanExiHS_ZNF622.
GenevestigatoriQ969S3.

Organism-specific databases

HPAiHPA036515.

Interactioni

Subunit structurei

Homo- and heterodimer. Interacts with MELK and MYBL2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP3K5Q9968314EBI-2687480,EBI-476263

Protein-protein interaction databases

BioGridi124717. 33 interactions.
IntActiQ969S3. 4 interactions.
MINTiMINT-261676.
STRINGi9606.ENSP00000310042.

Structurei

3D structure databases

ProteinModelPortaliQ969S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 24248Glu-richAdd
BLAST
Compositional biasi199 – 2035Poly-Glu
Compositional biasi236 – 2427Poly-Glu

Sequence similaritiesi

Contains 2 U1-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2825U1-type 1Add
BLAST
Zinc fingeri67 – 9125U1-type 2Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG253541.
GeneTreeiENSGT00390000018047.
HOGENOMiHOG000183078.
HOVERGENiHBG056035.
InParanoidiQ969S3.
KOiK14816.
OMAiSDAQRDH.
OrthoDBiEOG7ZWD1Z.
PhylomeDBiQ969S3.
TreeFamiTF313094.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969S3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER
60 70 80 90 100
VRAQRAVAEE ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ
110 120 130 140 150
AVNRKVEMMN EKNLEKGLGV DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA
160 170 180 190 200
PAKEARNVVA VGTGGRGTHD RDPSEKPPRL QWFEQQAKKL AKQQEEDSEE
210 220 230 240 250
EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA EEGPPLGAIP
260 270 280 290 300
ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG
310 320 330 340 350
VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR
360 370 380 390 400
SSYPDHKEGE DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY
410 420 430 440 450
KQRFGLSRAV AVAKNRKAVG RVLQQYRALG WTGSTGAALM RERDMQYVQR
460 470
MKSKWMLKTG MKNNATKQMH FRVQVRF
Length:477
Mass (Da):54,272
Last modified:December 1, 2001 - v1
Checksum:i88E75FAEAB46C62B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046059 mRNA. Translation: AAL02121.1.
BC008752 mRNA. Translation: AAH08752.1.
BC010545 mRNA. Translation: AAH10545.1.
CCDSiCCDS3886.1.
RefSeqiNP_219482.1. NM_033414.2.
UniGeneiHs.60300.

Genome annotation databases

EnsembliENST00000308683; ENSP00000310042; ENSG00000173545.
GeneIDi90441.
KEGGihsa:90441.
UCSCiuc003jfq.3. human.

Polymorphism databases

DMDMi50401777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046059 mRNA. Translation: AAL02121.1 .
BC008752 mRNA. Translation: AAH08752.1 .
BC010545 mRNA. Translation: AAH10545.1 .
CCDSi CCDS3886.1.
RefSeqi NP_219482.1. NM_033414.2.
UniGenei Hs.60300.

3D structure databases

ProteinModelPortali Q969S3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124717. 33 interactions.
IntActi Q969S3. 4 interactions.
MINTi MINT-261676.
STRINGi 9606.ENSP00000310042.

PTM databases

PhosphoSitei Q969S3.

Polymorphism databases

DMDMi 50401777.

Proteomic databases

MaxQBi Q969S3.
PaxDbi Q969S3.
PeptideAtlasi Q969S3.
PRIDEi Q969S3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308683 ; ENSP00000310042 ; ENSG00000173545 .
GeneIDi 90441.
KEGGi hsa:90441.
UCSCi uc003jfq.3. human.

Organism-specific databases

CTDi 90441.
GeneCardsi GC05M016451.
HGNCi HGNC:30958. ZNF622.
HPAi HPA036515.
MIMi 608694. gene.
neXtProti NX_Q969S3.
PharmGKBi PA134992557.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253541.
GeneTreei ENSGT00390000018047.
HOGENOMi HOG000183078.
HOVERGENi HBG056035.
InParanoidi Q969S3.
KOi K14816.
OMAi SDAQRDH.
OrthoDBi EOG7ZWD1Z.
PhylomeDBi Q969S3.
TreeFami TF313094.

Miscellaneous databases

ChiTaRSi ZNF622. human.
GenomeRNAii 90441.
NextBioi 76766.
PROi Q969S3.
SOURCEi Search...

Gene expression databases

Bgeei Q969S3.
CleanExi HS_ZNF622.
Genevestigatori Q969S3.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view ]
Pfami PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)."
    Seong H.-A., Gil M., Kim K.-T., Kim S.-J., Ha H.
    Biochem. J. 361:597-604(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH MELK.
    Tissue: Keratinocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix and Skin.
  3. "Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein."
    Seong H.A., Kim K.T., Ha H.
    J. Biol. Chem. 278:9655-9662(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYBL2.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN622_HUMAN
AccessioniPrimary (citable) accession number: Q969S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3