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Q969S0

- S35B4_HUMAN

UniProt

Q969S0 - S35B4_HUMAN

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Protein
UDP-xylose and UDP-N-acetylglucosamine transporter
Gene
SLC35B4, YEA4, PSEC0055
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.1 Publication

GO - Molecular functioni

  1. UDP-N-acetylglucosamine transmembrane transporter activity Source: UniProtKB
  2. UDP-xylose transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. UDP-N-acetylglucosamine transport Source: UniProtKB
  2. UDP-xylose transport Source: UniProtKB
  3. carbohydrate transport Source: UniProtKB-KW
  4. regulation of gluconeogenesis Source: Ensembl
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_22151. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.10.2. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-xylose and UDP-N-acetylglucosamine transporter
Alternative name(s):
Solute carrier family 35 member B4
YEA4 homolog
Gene namesi
Name:SLC35B4
Synonyms:YEA4
ORF Names:PSEC0055
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:20584. SLC35B4.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Transmembranei30 – 5021Helical; Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Transmembranei92 – 11221Helical; Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Transmembranei153 – 17321Helical; Reviewed prediction
Add
BLAST
Transmembranei201 – 22121Helical; Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Reviewed prediction
Add
BLAST
Transmembranei251 – 26717Helical; Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei291 – 31121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331UDP-xylose and UDP-N-acetylglucosamine transporter
PRO_0000213385Add
BLAST

Proteomic databases

MaxQBiQ969S0.
PaxDbiQ969S0.
PRIDEiQ969S0.

Expressioni

Gene expression databases

ArrayExpressiQ969S0.
BgeeiQ969S0.
CleanExiHS_SLC35B4.
GenevestigatoriQ969S0.

Organism-specific databases

HPAiHPA049779.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367770.

Structurei

3D structure databases

ProteinModelPortaliQ969S0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250393.
HOGENOMiHOG000234632.
HOVERGENiHBG093926.
InParanoidiQ969S0.
KOiK15278.
OMAiPIRYYAV.
OrthoDBiEOG7WX08P.
PhylomeDBiQ969S0.
TreeFamiTF312926.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969S0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF    50
EADLGRKPPA IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS 100
LIANMILGII ILKKRYSIFK YTSIALVSVG IFICTFMSAK QVTSQSSLSE 150
NDGFQAFVWW LLGIGALTFA LLMSARMGIF QETLYKRFGK HSKEALFYNH 200
ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW FYLLMNIITQ 250
YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT 300
LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N 331
Length:331
Mass (Da):37,424
Last modified:December 1, 2001 - v1
Checksum:i8C305DE30EFD4F82
GO
Isoform 2 (identifier: Q969S0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-231: ELYEIPV → GEFGVRQ
     232-331: Missing.

Show »
Length:231
Mass (Da):25,739
Checksum:i9FB3C66ACF052788
GO
Isoform 3 (identifier: Q969S0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-253: YVC → TPT
     254-331: Missing.

Note: No experimental confirmation available.

Show »
Length:253
Mass (Da):28,357
Checksum:iB58AEBAECC3CE6FA
GO

Sequence cautioni

The sequence BAB55325.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 2317ELYEIPV → GEFGVRQ in isoform 2.
VSP_016197
Alternative sequencei232 – 331100Missing in isoform 2.
VSP_016198Add
BLAST
Alternative sequencei251 – 2533YVC → TPT in isoform 3.
VSP_016199
Alternative sequencei254 – 33178Missing in isoform 3.
VSP_016200Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211L → P in BAD96594. 1 Publication
Sequence conflicti119 – 1191F → S in BAD96594. 1 Publication
Sequence conflicti179 – 1791I → M in BAD96594. 1 Publication
Sequence conflicti205 – 2051P → S in BAD96594. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ971941 mRNA. Translation: CAI98963.1.
AB052892 mRNA. Translation: BAB61040.1.
AJ315497 mRNA. Translation: CAC84567.1.
AJ315498 mRNA. Translation: CAC84568.1.
AK027603 mRNA. Translation: BAB55225.1.
AK027726 mRNA. Translation: BAB55325.1. Different initiation.
AK075368 mRNA. Translation: BAC11573.1.
AK222874 mRNA. Translation: BAD96594.1.
AC008154 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24071.1.
CH471070 Genomic DNA. Translation: EAW83810.1.
BC008413 mRNA. Translation: AAH08413.1.
CCDSiCCDS34756.1. [Q969S0-1]
RefSeqiNP_116215.1. NM_032826.4. [Q969S0-1]
UniGeneiHs.490181.

Genome annotation databases

EnsembliENST00000378509; ENSP00000367770; ENSG00000205060. [Q969S0-1]
GeneIDi84912.
KEGGihsa:84912.
UCSCiuc003vrn.3. human. [Q969S0-1]
uc003vro.4. human. [Q969S0-2]

Polymorphism databases

DMDMi74751727.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ971941 mRNA. Translation: CAI98963.1 .
AB052892 mRNA. Translation: BAB61040.1 .
AJ315497 mRNA. Translation: CAC84567.1 .
AJ315498 mRNA. Translation: CAC84568.1 .
AK027603 mRNA. Translation: BAB55225.1 .
AK027726 mRNA. Translation: BAB55325.1 . Different initiation.
AK075368 mRNA. Translation: BAC11573.1 .
AK222874 mRNA. Translation: BAD96594.1 .
AC008154 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24071.1 .
CH471070 Genomic DNA. Translation: EAW83810.1 .
BC008413 mRNA. Translation: AAH08413.1 .
CCDSi CCDS34756.1. [Q969S0-1 ]
RefSeqi NP_116215.1. NM_032826.4. [Q969S0-1 ]
UniGenei Hs.490181.

3D structure databases

ProteinModelPortali Q969S0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000367770.

Protein family/group databases

TCDBi 2.A.7.10.2. the drug/metabolite transporter (dmt) superfamily.

Polymorphism databases

DMDMi 74751727.

Proteomic databases

MaxQBi Q969S0.
PaxDbi Q969S0.
PRIDEi Q969S0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378509 ; ENSP00000367770 ; ENSG00000205060 . [Q969S0-1 ]
GeneIDi 84912.
KEGGi hsa:84912.
UCSCi uc003vrn.3. human. [Q969S0-1 ]
uc003vro.4. human. [Q969S0-2 ]

Organism-specific databases

CTDi 84912.
GeneCardsi GC07M133974.
HGNCi HGNC:20584. SLC35B4.
HPAi HPA049779.
MIMi 610923. gene.
neXtProti NX_Q969S0.
PharmGKBi PA134922110.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG250393.
HOGENOMi HOG000234632.
HOVERGENi HBG093926.
InParanoidi Q969S0.
KOi K15278.
OMAi PIRYYAV.
OrthoDBi EOG7WX08P.
PhylomeDBi Q969S0.
TreeFami TF312926.

Enzyme and pathway databases

Reactomei REACT_22151. Transport of nucleotide sugars.

Miscellaneous databases

ChiTaRSi SLC35B4. human.
GeneWikii SLC35B4.
GenomeRNAii 84912.
NextBioi 75300.
PROi Q969S0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q969S0.
Bgeei Q969S0.
CleanExi HS_SLC35B4.
Genevestigatori Q969S0.

Family and domain databases

InterProi IPR013657. UAA.
[Graphical view ]
Pfami PF08449. UAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine."
    Ashikov A., Routier F., Fuhlrott J., Helmus Y., Wild M., Gerardy-Schahn R., Bakker H.
    J. Biol. Chem. 280:27230-27235(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
  2. "Molecular cloning of full-length cDNA similar to Yeast Yea4p from human liver cDNA library."
    Moriya Y., Ito K., Aburatani H., Suzuki H., Sugiyama Y.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver.
  3. "Molecular cloning and characterisation of human yea4p."
    Kobayashi T., Burchell B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-331 (ISOFORM 3).
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.

Entry informationi

Entry nameiS35B4_HUMAN
AccessioniPrimary (citable) accession number: Q969S0
Secondary accession number(s): A4D1P3
, A6NNS4, Q53GQ7, Q8TCU7, Q96K33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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