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Q969S0

- S35B4_HUMAN

UniProt

Q969S0 - S35B4_HUMAN

Protein

UDP-xylose and UDP-N-acetylglucosamine transporter

Gene

SLC35B4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.1 Publication

    GO - Molecular functioni

    1. UDP-N-acetylglucosamine transmembrane transporter activity Source: UniProtKB
    2. UDP-xylose transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate transport Source: UniProtKB-KW
    2. regulation of gluconeogenesis Source: Ensembl
    3. transmembrane transport Source: Reactome
    4. UDP-N-acetylglucosamine transport Source: UniProtKB
    5. UDP-xylose transport Source: UniProtKB

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22151. Transport of nucleotide sugars.

    Protein family/group databases

    TCDBi2.A.7.10.2. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-xylose and UDP-N-acetylglucosamine transporter
    Alternative name(s):
    Solute carrier family 35 member B4
    YEA4 homolog
    Gene namesi
    Name:SLC35B4
    Synonyms:YEA4
    ORF Names:PSEC0055
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:20584. SLC35B4.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. Golgi membrane Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134922110.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331UDP-xylose and UDP-N-acetylglucosamine transporterPRO_0000213385Add
    BLAST

    Proteomic databases

    MaxQBiQ969S0.
    PaxDbiQ969S0.
    PRIDEiQ969S0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ969S0.
    BgeeiQ969S0.
    CleanExiHS_SLC35B4.
    GenevestigatoriQ969S0.

    Organism-specific databases

    HPAiHPA049779.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000367770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969S0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei30 – 5021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 26717HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG250393.
    HOGENOMiHOG000234632.
    HOVERGENiHBG093926.
    InParanoidiQ969S0.
    KOiK15278.
    OMAiPIRYYAV.
    OrthoDBiEOG7WX08P.
    PhylomeDBiQ969S0.
    TreeFamiTF312926.

    Family and domain databases

    InterProiIPR013657. UAA.
    [Graphical view]
    PfamiPF08449. UAA. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969S0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF    50
    EADLGRKPPA IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS 100
    LIANMILGII ILKKRYSIFK YTSIALVSVG IFICTFMSAK QVTSQSSLSE 150
    NDGFQAFVWW LLGIGALTFA LLMSARMGIF QETLYKRFGK HSKEALFYNH 200
    ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW FYLLMNIITQ 250
    YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT 300
    LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N 331
    Length:331
    Mass (Da):37,424
    Last modified:December 1, 2001 - v1
    Checksum:i8C305DE30EFD4F82
    GO
    Isoform 2 (identifier: Q969S0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         225-231: ELYEIPV → GEFGVRQ
         232-331: Missing.

    Show »
    Length:231
    Mass (Da):25,739
    Checksum:i9FB3C66ACF052788
    GO
    Isoform 3 (identifier: Q969S0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         251-253: YVC → TPT
         254-331: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:253
    Mass (Da):28,357
    Checksum:iB58AEBAECC3CE6FA
    GO

    Sequence cautioni

    The sequence BAB55325.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211L → P in BAD96594. 1 PublicationCurated
    Sequence conflicti119 – 1191F → S in BAD96594. 1 PublicationCurated
    Sequence conflicti179 – 1791I → M in BAD96594. 1 PublicationCurated
    Sequence conflicti205 – 2051P → S in BAD96594. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei225 – 2317ELYEIPV → GEFGVRQ in isoform 2. 1 PublicationVSP_016197
    Alternative sequencei232 – 331100Missing in isoform 2. 1 PublicationVSP_016198Add
    BLAST
    Alternative sequencei251 – 2533YVC → TPT in isoform 3. 1 PublicationVSP_016199
    Alternative sequencei254 – 33178Missing in isoform 3. 1 PublicationVSP_016200Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ971941 mRNA. Translation: CAI98963.1.
    AB052892 mRNA. Translation: BAB61040.1.
    AJ315497 mRNA. Translation: CAC84567.1.
    AJ315498 mRNA. Translation: CAC84568.1.
    AK027603 mRNA. Translation: BAB55225.1.
    AK027726 mRNA. Translation: BAB55325.1. Different initiation.
    AK075368 mRNA. Translation: BAC11573.1.
    AK222874 mRNA. Translation: BAD96594.1.
    AC008154 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24071.1.
    CH471070 Genomic DNA. Translation: EAW83810.1.
    BC008413 mRNA. Translation: AAH08413.1.
    CCDSiCCDS34756.1. [Q969S0-1]
    RefSeqiNP_116215.1. NM_032826.4. [Q969S0-1]
    UniGeneiHs.490181.

    Genome annotation databases

    EnsembliENST00000378509; ENSP00000367770; ENSG00000205060. [Q969S0-1]
    GeneIDi84912.
    KEGGihsa:84912.
    UCSCiuc003vrn.3. human. [Q969S0-1]
    uc003vro.4. human. [Q969S0-2]

    Polymorphism databases

    DMDMi74751727.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ971941 mRNA. Translation: CAI98963.1 .
    AB052892 mRNA. Translation: BAB61040.1 .
    AJ315497 mRNA. Translation: CAC84567.1 .
    AJ315498 mRNA. Translation: CAC84568.1 .
    AK027603 mRNA. Translation: BAB55225.1 .
    AK027726 mRNA. Translation: BAB55325.1 . Different initiation.
    AK075368 mRNA. Translation: BAC11573.1 .
    AK222874 mRNA. Translation: BAD96594.1 .
    AC008154 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24071.1 .
    CH471070 Genomic DNA. Translation: EAW83810.1 .
    BC008413 mRNA. Translation: AAH08413.1 .
    CCDSi CCDS34756.1. [Q969S0-1 ]
    RefSeqi NP_116215.1. NM_032826.4. [Q969S0-1 ]
    UniGenei Hs.490181.

    3D structure databases

    ProteinModelPortali Q969S0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000367770.

    Protein family/group databases

    TCDBi 2.A.7.10.2. the drug/metabolite transporter (dmt) superfamily.

    Polymorphism databases

    DMDMi 74751727.

    Proteomic databases

    MaxQBi Q969S0.
    PaxDbi Q969S0.
    PRIDEi Q969S0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378509 ; ENSP00000367770 ; ENSG00000205060 . [Q969S0-1 ]
    GeneIDi 84912.
    KEGGi hsa:84912.
    UCSCi uc003vrn.3. human. [Q969S0-1 ]
    uc003vro.4. human. [Q969S0-2 ]

    Organism-specific databases

    CTDi 84912.
    GeneCardsi GC07M133974.
    HGNCi HGNC:20584. SLC35B4.
    HPAi HPA049779.
    MIMi 610923. gene.
    neXtProti NX_Q969S0.
    PharmGKBi PA134922110.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG250393.
    HOGENOMi HOG000234632.
    HOVERGENi HBG093926.
    InParanoidi Q969S0.
    KOi K15278.
    OMAi PIRYYAV.
    OrthoDBi EOG7WX08P.
    PhylomeDBi Q969S0.
    TreeFami TF312926.

    Enzyme and pathway databases

    Reactomei REACT_22151. Transport of nucleotide sugars.

    Miscellaneous databases

    ChiTaRSi SLC35B4. human.
    GeneWikii SLC35B4.
    GenomeRNAii 84912.
    NextBioi 75300.
    PROi Q969S0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969S0.
    Bgeei Q969S0.
    CleanExi HS_SLC35B4.
    Genevestigatori Q969S0.

    Family and domain databases

    InterProi IPR013657. UAA.
    [Graphical view ]
    Pfami PF08449. UAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine."
      Ashikov A., Routier F., Fuhlrott J., Helmus Y., Wild M., Gerardy-Schahn R., Bakker H.
      J. Biol. Chem. 280:27230-27235(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
    2. "Molecular cloning of full-length cDNA similar to Yeast Yea4p from human liver cDNA library."
      Moriya Y., Ito K., Aburatani H., Suzuki H., Sugiyama Y.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Liver.
    3. "Molecular cloning and characterisation of human yea4p."
      Kobayashi T., Burchell B.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-331 (ISOFORM 3).
    5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver.
    7. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.

    Entry informationi

    Entry nameiS35B4_HUMAN
    AccessioniPrimary (citable) accession number: Q969S0
    Secondary accession number(s): A4D1P3
    , A6NNS4, Q53GQ7, Q8TCU7, Q96K33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3