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Protein

UDP-xylose and UDP-N-acetylglucosamine transporter

Gene

SLC35B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.1 Publication

GO - Molecular functioni

GO - Biological processi

  • carbohydrate transport Source: UniProtKB-KW
  • GDP-fucose transport Source: GO_Central
  • regulation of gluconeogenesis Source: Ensembl
  • UDP-N-acetylglucosamine transport Source: UniProtKB
  • UDP-xylose transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-33036-MONOMER.
ReactomeiR-HSA-727802. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.10.2. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-xylose and UDP-N-acetylglucosamine transporter
Alternative name(s):
Solute carrier family 35 member B4
YEA4 homolog
Gene namesi
Name:SLC35B4
Synonyms:YEA4
ORF Names:PSEC0055
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:20584. SLC35B4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei251 – 267HelicalSequence analysisAdd BLAST17
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: CACAO
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of endoplasmic reticulum membrane Source: GO_Central
  • integral component of Golgi membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84912.
OpenTargetsiENSG00000205060.
PharmGKBiPA134922110.

Polymorphism and mutation databases

BioMutaiSLC35B4.
DMDMi74751727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133851 – 331UDP-xylose and UDP-N-acetylglucosamine transporterAdd BLAST331

Proteomic databases

MaxQBiQ969S0.
PaxDbiQ969S0.
PeptideAtlasiQ969S0.
PRIDEiQ969S0.

Expressioni

Gene expression databases

BgeeiENSG00000205060.
CleanExiHS_SLC35B4.
ExpressionAtlasiQ969S0. baseline and differential.
GenevisibleiQ969S0. HS.

Organism-specific databases

HPAiHPA049779.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA83EBI-10281213,EBI-6942903

Protein-protein interaction databases

BioGridi124349. 3 interactors.
IntActiQ969S0. 3 interactors.
STRINGi9606.ENSP00000367770.

Structurei

3D structure databases

ProteinModelPortaliQ969S0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1583. Eukaryota.
ENOG410XQ16. LUCA.
GeneTreeiENSGT00390000002915.
HOGENOMiHOG000234632.
HOVERGENiHBG093926.
InParanoidiQ969S0.
KOiK15278.
OMAiIRYYAVM.
OrthoDBiEOG091G0DEX.
PhylomeDBiQ969S0.
TreeFamiTF312926.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969S0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF
60 70 80 90 100
EADLGRKPPA IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS
110 120 130 140 150
LIANMILGII ILKKRYSIFK YTSIALVSVG IFICTFMSAK QVTSQSSLSE
160 170 180 190 200
NDGFQAFVWW LLGIGALTFA LLMSARMGIF QETLYKRFGK HSKEALFYNH
210 220 230 240 250
ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW FYLLMNIITQ
260 270 280 290 300
YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT
310 320 330
LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N
Length:331
Mass (Da):37,424
Last modified:December 1, 2001 - v1
Checksum:i8C305DE30EFD4F82
GO
Isoform 2 (identifier: Q969S0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-231: ELYEIPV → GEFGVRQ
     232-331: Missing.

Show »
Length:231
Mass (Da):25,739
Checksum:i9FB3C66ACF052788
GO
Isoform 3 (identifier: Q969S0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-253: YVC → TPT
     254-331: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):28,357
Checksum:iB58AEBAECC3CE6FA
GO

Sequence cautioni

The sequence BAB55325 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21L → P in BAD96594 (Ref. 6) Curated1
Sequence conflicti119F → S in BAD96594 (Ref. 6) Curated1
Sequence conflicti179I → M in BAD96594 (Ref. 6) Curated1
Sequence conflicti205P → S in BAD96594 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016197225 – 231ELYEIPV → GEFGVRQ in isoform 2. 1 Publication7
Alternative sequenceiVSP_016198232 – 331Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_016199251 – 253YVC → TPT in isoform 3. 1 Publication3
Alternative sequenceiVSP_016200254 – 331Missing in isoform 3. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ971941 mRNA. Translation: CAI98963.1.
AB052892 mRNA. Translation: BAB61040.1.
AJ315497 mRNA. Translation: CAC84567.1.
AJ315498 mRNA. Translation: CAC84568.1.
AK027603 mRNA. Translation: BAB55225.1.
AK027726 mRNA. Translation: BAB55325.1. Different initiation.
AK075368 mRNA. Translation: BAC11573.1.
AK222874 mRNA. Translation: BAD96594.1.
AC008154 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24071.1.
CH471070 Genomic DNA. Translation: EAW83810.1.
BC008413 mRNA. Translation: AAH08413.1.
CCDSiCCDS34756.1. [Q969S0-1]
RefSeqiNP_116215.1. NM_032826.4. [Q969S0-1]
UniGeneiHs.490181.

Genome annotation databases

EnsembliENST00000378509; ENSP00000367770; ENSG00000205060. [Q969S0-1]
ENST00000470969; ENSP00000485857; ENSG00000205060. [Q969S0-2]
GeneIDi84912.
KEGGihsa:84912.
UCSCiuc003vrn.4. human. [Q969S0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ971941 mRNA. Translation: CAI98963.1.
AB052892 mRNA. Translation: BAB61040.1.
AJ315497 mRNA. Translation: CAC84567.1.
AJ315498 mRNA. Translation: CAC84568.1.
AK027603 mRNA. Translation: BAB55225.1.
AK027726 mRNA. Translation: BAB55325.1. Different initiation.
AK075368 mRNA. Translation: BAC11573.1.
AK222874 mRNA. Translation: BAD96594.1.
AC008154 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24071.1.
CH471070 Genomic DNA. Translation: EAW83810.1.
BC008413 mRNA. Translation: AAH08413.1.
CCDSiCCDS34756.1. [Q969S0-1]
RefSeqiNP_116215.1. NM_032826.4. [Q969S0-1]
UniGeneiHs.490181.

3D structure databases

ProteinModelPortaliQ969S0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124349. 3 interactors.
IntActiQ969S0. 3 interactors.
STRINGi9606.ENSP00000367770.

Protein family/group databases

TCDBi2.A.7.10.2. the drug/metabolite transporter (dmt) superfamily.

Polymorphism and mutation databases

BioMutaiSLC35B4.
DMDMi74751727.

Proteomic databases

MaxQBiQ969S0.
PaxDbiQ969S0.
PeptideAtlasiQ969S0.
PRIDEiQ969S0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378509; ENSP00000367770; ENSG00000205060. [Q969S0-1]
ENST00000470969; ENSP00000485857; ENSG00000205060. [Q969S0-2]
GeneIDi84912.
KEGGihsa:84912.
UCSCiuc003vrn.4. human. [Q969S0-1]

Organism-specific databases

CTDi84912.
DisGeNETi84912.
GeneCardsiSLC35B4.
HGNCiHGNC:20584. SLC35B4.
HPAiHPA049779.
MIMi610923. gene.
neXtProtiNX_Q969S0.
OpenTargetsiENSG00000205060.
PharmGKBiPA134922110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1583. Eukaryota.
ENOG410XQ16. LUCA.
GeneTreeiENSGT00390000002915.
HOGENOMiHOG000234632.
HOVERGENiHBG093926.
InParanoidiQ969S0.
KOiK15278.
OMAiIRYYAVM.
OrthoDBiEOG091G0DEX.
PhylomeDBiQ969S0.
TreeFamiTF312926.

Enzyme and pathway databases

BioCyciZFISH:G66-33036-MONOMER.
ReactomeiR-HSA-727802. Transport of nucleotide sugars.

Miscellaneous databases

ChiTaRSiSLC35B4. human.
GeneWikiiSLC35B4.
GenomeRNAii84912.
PROiQ969S0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205060.
CleanExiHS_SLC35B4.
ExpressionAtlasiQ969S0. baseline and differential.
GenevisibleiQ969S0. HS.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35B4_HUMAN
AccessioniPrimary (citable) accession number: Q969S0
Secondary accession number(s): A4D1P3
, A6NNS4, Q53GQ7, Q8TCU7, Q96K33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.