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Protein

Integrin-alpha FG-GAP repeat-containing protein 2

Gene

ITFG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ969R8.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin-alpha FG-GAP repeat-containing protein 2
Gene namesi
Name:ITFG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30879. ITFG2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485507.

Polymorphism and mutation databases

BioMutaiITFG2.
DMDMi74731058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Integrin-alpha FG-GAP repeat-containing protein 2PRO_0000289292Add
BLAST

Proteomic databases

EPDiQ969R8.
MaxQBiQ969R8.
PaxDbiQ969R8.
PRIDEiQ969R8.

PTM databases

PhosphoSiteiQ969R8.

Expressioni

Gene expression databases

BgeeiQ969R8.
CleanExiHS_ITFG2.
ExpressionAtlasiQ969R8. baseline and differential.
GenevisibleiQ969R8. HS.

Organism-specific databases

HPAiHPA038664.
HPA038665.

Interactioni

Protein-protein interaction databases

BioGridi120948. 13 interactions.
IntActiQ969R8. 2 interactions.
MINTiMINT-1410044.
STRINGi9606.ENSP00000228799.

Structurei

3D structure databases

ProteinModelPortaliQ969R8.
SMRiQ969R8. Positions 127-156, 275-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati19 – 4830FG-GAP 1; atypicalAdd
BLAST
Repeati126 – 15530FG-GAP 2; atypicalAdd
BLAST

Sequence similaritiesi

Contains 2 FG-GAP repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEQ3. Eukaryota.
ENOG410XPME. LUCA.
GeneTreeiENSGT00390000005378.
HOGENOMiHOG000007901.
HOVERGENiHBG004176.
InParanoidiQ969R8.
OMAiGYAILLC.
OrthoDBiEOG74N5GJ.
PhylomeDBiQ969R8.
TreeFamiTF329010.

Family and domain databases

InterProiIPR031793. Itfg2.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF15907. Itfg2. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969R8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSVSYVQRV ALEFSGSLFP HAICLGDVDN DTLNELVVGD TSGKVSVYKN
60 70 80 90 100
DDSRPWLTCS CQGMLTCVGV GDVCNKGKNL LVAVSAEGWF HLFDLTPAKV
110 120 130 140 150
LDASGHHETL IGEEQRPVFK QHIPANTKVM LISDIDGDGC RELVVGYTDR
160 170 180 190 200
VVRAFRWEEL GEGPEHLTGQ LVSLKKWMLE GQVDSLSVTL GPLGLPELMV
210 220 230 240 250
SQPGCAYAIL LCTWKKDTGS PPASEGPTDG SRETPAARDV VLHQTSGRIH
260 270 280 290 300
NKNVSTHLIG NIKQGHGTES SGSGLFALCT LDGTLKLMEE MEEADKLLWS
310 320 330 340 350
VQVDHQLFAL EKLDVTGNGH EEVVACAWDG QTYIIDHNRT VVRFQVDENI
360 370 380 390 400
RAFCAGLYAC KEGRNSPCLV YVTFNQKIYV YWEVQLERME STNLVKLLET
410 420 430 440
KPEYHSLLQE LGVDPDDLPV TRALLHQTLY HPDQPPQCAP SSLQDPT
Length:447
Mass (Da):49,313
Last modified:December 1, 2001 - v1
Checksum:i8CB025338EE04A17
GO
Isoform 2 (identifier: Q969R8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-147: DGDGCRELVVGY → GGHAYLCRQPGE
     148-447: Missing.

Show »
Length:147
Mass (Da):15,974
Checksum:iF2EF9A7497BA507A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681V → A in BAB55145 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei136 – 14712DGDGC…LVVGY → GGHAYLCRQPGE in isoform 2. 1 PublicationVSP_055985Add
BLAST
Alternative sequencei148 – 447300Missing in isoform 2. 1 PublicationVSP_055986Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY599883 mRNA. Translation: AAT09136.1.
AK027483 mRNA. Translation: BAB55145.1.
AK291110 mRNA. Translation: BAF83799.1.
AC005841 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88886.1.
CH471116 Genomic DNA. Translation: EAW88887.1.
BC006552 mRNA. Translation: AAH06552.1.
BC013399 mRNA. Translation: AAH13399.1.
CCDSiCCDS8513.1. [Q969R8-1]
RefSeqiNP_060933.3. NM_018463.3. [Q969R8-1]
UniGeneiHs.446098.
Hs.448720.

Genome annotation databases

EnsembliENST00000228799; ENSP00000228799; ENSG00000111203. [Q969R8-1]
ENST00000540929; ENSP00000443329; ENSG00000111203. [Q969R8-2]
GeneIDi55846.
KEGGihsa:55846.
UCSCiuc001qlb.3. human. [Q969R8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY599883 mRNA. Translation: AAT09136.1.
AK027483 mRNA. Translation: BAB55145.1.
AK291110 mRNA. Translation: BAF83799.1.
AC005841 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88886.1.
CH471116 Genomic DNA. Translation: EAW88887.1.
BC006552 mRNA. Translation: AAH06552.1.
BC013399 mRNA. Translation: AAH13399.1.
CCDSiCCDS8513.1. [Q969R8-1]
RefSeqiNP_060933.3. NM_018463.3. [Q969R8-1]
UniGeneiHs.446098.
Hs.448720.

3D structure databases

ProteinModelPortaliQ969R8.
SMRiQ969R8. Positions 127-156, 275-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120948. 13 interactions.
IntActiQ969R8. 2 interactions.
MINTiMINT-1410044.
STRINGi9606.ENSP00000228799.

PTM databases

PhosphoSiteiQ969R8.

Polymorphism and mutation databases

BioMutaiITFG2.
DMDMi74731058.

Proteomic databases

EPDiQ969R8.
MaxQBiQ969R8.
PaxDbiQ969R8.
PRIDEiQ969R8.

Protocols and materials databases

DNASUi55846.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228799; ENSP00000228799; ENSG00000111203. [Q969R8-1]
ENST00000540929; ENSP00000443329; ENSG00000111203. [Q969R8-2]
GeneIDi55846.
KEGGihsa:55846.
UCSCiuc001qlb.3. human. [Q969R8-1]

Organism-specific databases

CTDi55846.
GeneCardsiITFG2.
HGNCiHGNC:30879. ITFG2.
HPAiHPA038664.
HPA038665.
neXtProtiNX_Q969R8.
PharmGKBiPA143485507.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEQ3. Eukaryota.
ENOG410XPME. LUCA.
GeneTreeiENSGT00390000005378.
HOGENOMiHOG000007901.
HOVERGENiHBG004176.
InParanoidiQ969R8.
OMAiGYAILLC.
OrthoDBiEOG74N5GJ.
PhylomeDBiQ969R8.
TreeFamiTF329010.

Enzyme and pathway databases

SignaLinkiQ969R8.

Miscellaneous databases

ChiTaRSiITFG2. human.
GenomeRNAii55846.
NextBioi61095.
PROiQ969R8.

Gene expression databases

BgeeiQ969R8.
CleanExiHS_ITFG2.
ExpressionAtlasiQ969R8. baseline and differential.
GenevisibleiQ969R8. HS.

Family and domain databases

InterProiIPR031793. Itfg2.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF15907. Itfg2. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Zhou G., Zhong G., Ke R., Li H., Shen C., Lin L., Yang S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiITFG2_HUMAN
AccessioniPrimary (citable) accession number: Q969R8
Secondary accession number(s): A8K4Z5
, D3DUQ2, Q6PKU5, Q96SX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.