Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

KICSTOR complex protein ITFG2

Gene

ITFG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.1 Publication

GO - Biological processi

  • cellular response to amino acid starvation Source: UniProtKB
  • cellular response to glucose starvation Source: UniProtKB
  • germinal center B cell differentiation Source: Ensembl
  • negative regulation of TORC1 signaling Source: UniProtKB

Enzyme and pathway databases

SignaLinkiQ969R8.

Names & Taxonomyi

Protein namesi
Recommended name:
KICSTOR complex protein ITFG2Curated
Alternative name(s):
Integrin-alpha FG-GAP repeat-containing protein 2Imported
Gene namesi
Name:ITFG2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111203.11.
HGNCiHGNC:30879. ITFG2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111203.
PharmGKBiPA143485507.

Polymorphism and mutation databases

BioMutaiITFG2.
DMDMi74731058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892921 – 447KICSTOR complex protein ITFG2Add BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ969R8.
MaxQBiQ969R8.
PaxDbiQ969R8.
PeptideAtlasiQ969R8.
PRIDEiQ969R8.

PTM databases

iPTMnetiQ969R8.
PhosphoSitePlusiQ969R8.

Expressioni

Gene expression databases

BgeeiENSG00000111203.
CleanExiHS_ITFG2.
ExpressionAtlasiQ969R8. baseline and differential.
GenevisibleiQ969R8. HS.

Organism-specific databases

HPAiHPA038664.
HPA038665.

Interactioni

Subunit structurei

Part of the KICSTOR complex composed of KPTN, ITFG2, C12orf66 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and may mediate the direct interaction with the GATOR complex via GATOR1. The KICSTOR complex interacts directly with the GATOR1 complex and most probably indirectly with the GATOR2 complexe in an amino acid-independent manner.1 Publication

Protein-protein interaction databases

BioGridi120948. 14 interactors.
CORUMiQ969R8.
IntActiQ969R8. 2 interactors.
MINTiMINT-1410044.
STRINGi9606.ENSP00000228799.

Structurei

3D structure databases

ProteinModelPortaliQ969R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 48FG-GAP 1; atypicalAdd BLAST30
Repeati126 – 155FG-GAP 2; atypicalAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEQ3. Eukaryota.
ENOG410XPME. LUCA.
GeneTreeiENSGT00390000005378.
HOGENOMiHOG000007901.
HOVERGENiHBG004176.
InParanoidiQ969R8.
OMAiQKIYIYW.
OrthoDBiEOG091G06ZJ.
PhylomeDBiQ969R8.
TreeFamiTF329010.

Family and domain databases

InterProiView protein in InterPro
IPR031793. KICSTOR_ITFG2.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF15907. Itfg2. 1 hit.
SUPFAMiSSF50978. SSF50978. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969R8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSVSYVQRV ALEFSGSLFP HAICLGDVDN DTLNELVVGD TSGKVSVYKN
60 70 80 90 100
DDSRPWLTCS CQGMLTCVGV GDVCNKGKNL LVAVSAEGWF HLFDLTPAKV
110 120 130 140 150
LDASGHHETL IGEEQRPVFK QHIPANTKVM LISDIDGDGC RELVVGYTDR
160 170 180 190 200
VVRAFRWEEL GEGPEHLTGQ LVSLKKWMLE GQVDSLSVTL GPLGLPELMV
210 220 230 240 250
SQPGCAYAIL LCTWKKDTGS PPASEGPTDG SRETPAARDV VLHQTSGRIH
260 270 280 290 300
NKNVSTHLIG NIKQGHGTES SGSGLFALCT LDGTLKLMEE MEEADKLLWS
310 320 330 340 350
VQVDHQLFAL EKLDVTGNGH EEVVACAWDG QTYIIDHNRT VVRFQVDENI
360 370 380 390 400
RAFCAGLYAC KEGRNSPCLV YVTFNQKIYV YWEVQLERME STNLVKLLET
410 420 430 440
KPEYHSLLQE LGVDPDDLPV TRALLHQTLY HPDQPPQCAP SSLQDPT
Length:447
Mass (Da):49,313
Last modified:December 1, 2001 - v1
Checksum:i8CB025338EE04A17
GO
Isoform 2 (identifier: Q969R8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-147: DGDGCRELVVGY → GGHAYLCRQPGE
     148-447: Missing.

Show »
Length:147
Mass (Da):15,974
Checksum:iF2EF9A7497BA507A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68V → A in BAB55145 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055985136 – 147DGDGC…LVVGY → GGHAYLCRQPGE in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_055986148 – 447Missing in isoform 2. 1 PublicationAdd BLAST300

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY599883 mRNA. Translation: AAT09136.1.
AK027483 mRNA. Translation: BAB55145.1.
AK291110 mRNA. Translation: BAF83799.1.
AC005841 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88886.1.
CH471116 Genomic DNA. Translation: EAW88887.1.
BC006552 mRNA. Translation: AAH06552.1.
BC013399 mRNA. Translation: AAH13399.1.
CCDSiCCDS8513.1. [Q969R8-1]
RefSeqiNP_060933.3. NM_018463.3. [Q969R8-1]
UniGeneiHs.239.
Hs.446098.
Hs.448720.
Hs.709471.

Genome annotation databases

EnsembliENST00000228799; ENSP00000228799; ENSG00000111203. [Q969R8-1]
ENST00000540929; ENSP00000443329; ENSG00000111203. [Q969R8-2]
GeneIDi55846.
KEGGihsa:55846.
UCSCiuc001qlb.3. human. [Q969R8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiITFG2_HUMAN
AccessioniPrimary (citable) accession number: Q969R8
Secondary accession number(s): A8K4Z5
, D3DUQ2, Q6PKU5, Q96SX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot