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Protein

Lethal(3)malignant brain tumor-like protein 2

Gene

L3MBTL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • methylated histone binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100395-MONOMER.
ReactomeiR-HSA-4551638. SUMOylation of chromatin organization proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 2
Short name:
H-l(3)mbt-like protein 2
Short name:
L(3)mbt-like protein 2
Gene namesi
Name:L3MBTL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18594. L3MBTL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83746.
OpenTargetsiENSG00000100395.
PharmGKBiPA38356.

Polymorphism and mutation databases

BioMutaiL3MBTL2.
DMDMi27734418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844481 – 705Lethal(3)malignant brain tumor-like protein 2Add BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei76PhosphothreonineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Cross-linki675Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei683PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Cross-linki700Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki700Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ969R5.
MaxQBiQ969R5.
PaxDbiQ969R5.
PeptideAtlasiQ969R5.
PRIDEiQ969R5.

PTM databases

iPTMnetiQ969R5.
PhosphoSitePlusiQ969R5.

Expressioni

Gene expression databases

BgeeiENSG00000100395.
CleanExiHS_L3MBTL2.
ExpressionAtlasiQ969R5. baseline and differential.
GenevisibleiQ969R5. HS.

Organism-specific databases

HPAiHPA000815.

Interactioni

Subunit structurei

Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-739909,EBI-717810
HDAC3O153796EBI-739909,EBI-607682
MAXP612445EBI-739909,EBI-751711
PAICSP222343EBI-739909,EBI-712261
PHF10Q8WUB8-25EBI-739909,EBI-10276329
STAC3Q96MF23EBI-739909,EBI-745680
STAM2O758863EBI-739909,EBI-373258
TBC1D9BQ66K14-23EBI-739909,EBI-10217736
TRIM42A1L4B63EBI-739909,EBI-10172216

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123753. 58 interactors.
DIPiDIP-56748N.
IntActiQ969R5. 76 interactors.
MINTiMINT-1483852.
STRINGi9606.ENSP00000216237.

Structurei

Secondary structure

1705
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi87 – 89Combined sources3
Turni91 – 93Combined sources3
Beta strandi96 – 98Combined sources3
Turni99 – 101Combined sources3
Turni104 – 106Combined sources3
Beta strandi107 – 111Combined sources5
Helixi112 – 120Combined sources9
Helixi181 – 188Combined sources8
Helixi195 – 197Combined sources3
Helixi204 – 209Combined sources6
Beta strandi215 – 219Combined sources5
Beta strandi230 – 239Combined sources10
Beta strandi242 – 247Combined sources6
Beta strandi258 – 261Combined sources4
Helixi272 – 275Combined sources4
Turni284 – 286Combined sources3
Helixi287 – 289Combined sources3
Helixi293 – 301Combined sources9
Helixi311 – 318Combined sources8
Beta strandi328 – 332Combined sources5
Beta strandi340 – 349Combined sources10
Beta strandi352 – 357Combined sources6
Beta strandi366 – 369Combined sources4
Beta strandi375 – 377Combined sources3
Helixi380 – 384Combined sources5
Beta strandi387 – 389Combined sources3
Helixi412 – 414Combined sources3
Beta strandi420 – 422Combined sources3
Beta strandi433 – 438Combined sources6
Beta strandi441 – 453Combined sources13
Helixi455 – 457Combined sources3
Beta strandi458 – 463Combined sources6
Beta strandi475 – 478Combined sources4
Beta strandi482 – 486Combined sources5
Helixi489 – 492Combined sources4
Beta strandi505 – 507Combined sources3
Helixi510 – 517Combined sources8
Helixi524 – 526Combined sources3
Beta strandi541 – 545Combined sources5
Beta strandi553 – 562Combined sources10
Beta strandi565 – 570Combined sources6
Helixi575 – 577Combined sources3
Beta strandi579 – 582Combined sources4
Helixi593 – 597Combined sources5
Beta strandi604 – 607Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W0TNMR-A82-124[»]
3CEYX-ray2.20A/B170-625[»]
3F70X-ray2.10A/B170-625[»]
ProteinModelPortaliQ969R5.
SMRiQ969R5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ969R5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati179 – 283MBT 1Add BLAST105
Repeati291 – 391MBT 2Add BLAST101
Repeati397 – 500MBT 3Add BLAST104
Repeati508 – 604MBT 4Add BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 20Poly-Glu4
Compositional biasi620 – 624Poly-Lys5

Sequence similaritiesi

Contains 1 FCS-type zinc finger.PROSITE-ProRule annotation
Contains 4 MBT repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IMEW. Eukaryota.
ENOG410ZYE4. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000231220.
HOVERGENiHBG057974.
InParanoidiQ969R5.
OMAiDGWDNEY.
OrthoDBiEOG091G0312.
PhylomeDBiQ969R5.
TreeFamiTF316498.

Family and domain databases

InterProiIPR004092. Mbt.
IPR012313. Znf_FCS.
[Graphical view]
PfamiPF02820. MBT. 4 hits.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
[Graphical view]
PROSITEiPS51079. MBT. 4 hits.
PS51024. ZF_FCS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969R5-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKPRSIEET PSSEPMEEEE DDDLELFGGY DSFRSYNSSV GSESSSYLEE
60 70 80 90 100
SSEAENEDRE AGELPTSPLH LLSPGTPRSL DGSGSEPAVC EMCGIVGTRE
110 120 130 140 150
AFFSKTKRFC SVSCSRSYSS NSKKASILAR LQGKPPTKKA KVLHKAAWSA
160 170 180 190 200
KIGAFLHSQG TGQLADGTPT GQDALVLGFD WGKFLKDHSY KAAPVSCFKH
210 220 230 240 250
VPLYDQWEDV MKGMKVEVLN SDAVLPSRVY WIASVIQTAG YRVLLRYEGF
260 270 280 290 300
ENDASHDFWC NLGTVDVHPI GWCAINSKIL VPPRTIHAKF TDWKGYLMKR
310 320 330 340 350
LVGSRTLPVD FHIKMVESMK YPFRQGMRLE VVDKSQVSRT RMAVVDTVIG
360 370 380 390 400
GRLRLLYEDG DSDDDFWCHM WSPLIHPVGW SRRVGHGIKM SERRSDMAHH
410 420 430 440 450
PTFRKIYCDA VPYLFKKVRA VYTEGGWFEE GMKLEAIDPL NLGNICVATV
460 470 480 490 500
CKVLLDGYLM ICVDGGPSTD GLDWFCYHAS SHAIFPATFC QKNDIELTPP
510 520 530 540 550
KGYEAQTFNW ENYLEKTKSK AAPSRLFNMD CPNHGFKVGM KLEAVDLMEP
560 570 580 590 600
RLICVATVKR VVHRLLSIHF DGWDSEYDQW VDCESPDIYP VGWCELTGYQ
610 620 630 640 650
LQPPVAAEPA TPLKAKEATK KKKKQFGKKR KRIPPTKTRP LRQGSKKPLL
660 670 680 690 700
EDDPQGARKI SSEPVPGEII AVRVKEEHLD VASPDKASSP ELPVSVENIK

QETDD
Length:705
Mass (Da):79,110
Last modified:December 1, 2001 - v1
Checksum:i8FC86A440982FFA7
GO
Isoform 2 (identifier: Q969R5-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     608-614: EPATPLK → GKLPRSL
     615-705: Missing.

Show »
Length:614
Mass (Da):69,008
Checksum:i6098B154D7387790
GO
Isoform 3 (identifier: Q969R5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-617: EPATPLKAKE → GVGSRGPKRL
     618-705: Missing.

Show »
Length:617
Mass (Da):69,264
Checksum:i2AD8D020C5715608
GO

Sequence cautioni

The sequence BAB84917 differs from that shown. Intron retention.Curated
The sequence BAC04936 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0339987I → V.Corresponds to variant rs3804097dbSNPEnsembl.1
Natural variantiVAR_015093300R → W.Corresponds to variant rs2277846dbSNPEnsembl.1
Natural variantiVAR_061675337V → A.Corresponds to variant rs34289721dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003906608 – 617EPATPLKAKE → GVGSRGPKRL in isoform 3. 1 Publication10
Alternative sequenceiVSP_003904608 – 614EPATPLK → GKLPRSL in isoform 2. 1 Publication7
Alternative sequenceiVSP_003905615 – 705Missing in isoform 2. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_003907618 – 705Missing in isoform 3. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ305226 mRNA. Translation: CAC37794.1.
AJ305227 mRNA. Translation: CAC37795.1.
AL136564 mRNA. Translation: CAB66499.2.
AK074091 mRNA. Translation: BAB84917.1. Sequence problems.
AK097052 mRNA. Translation: BAC04936.1. Sequence problems.
CR456482 mRNA. Translation: CAG30368.1.
AL035658, AL035681 Genomic DNA. Translation: CAI23036.1.
AL035681, AL035658 Genomic DNA. Translation: CAI22654.1.
BC017191 mRNA. Translation: AAH17191.1.
CCDSiCCDS14011.1. [Q969R5-1]
RefSeqiNP_113676.2. NM_031488.4. [Q969R5-1]
UniGeneiHs.517641.

Genome annotation databases

EnsembliENST00000216237; ENSP00000216237; ENSG00000100395. [Q969R5-1]
ENST00000452106; ENSP00000414423; ENSG00000100395. [Q969R5-2]
GeneIDi83746.
KEGGihsa:83746.
UCSCiuc003azo.4. human. [Q969R5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ305226 mRNA. Translation: CAC37794.1.
AJ305227 mRNA. Translation: CAC37795.1.
AL136564 mRNA. Translation: CAB66499.2.
AK074091 mRNA. Translation: BAB84917.1. Sequence problems.
AK097052 mRNA. Translation: BAC04936.1. Sequence problems.
CR456482 mRNA. Translation: CAG30368.1.
AL035658, AL035681 Genomic DNA. Translation: CAI23036.1.
AL035681, AL035658 Genomic DNA. Translation: CAI22654.1.
BC017191 mRNA. Translation: AAH17191.1.
CCDSiCCDS14011.1. [Q969R5-1]
RefSeqiNP_113676.2. NM_031488.4. [Q969R5-1]
UniGeneiHs.517641.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W0TNMR-A82-124[»]
3CEYX-ray2.20A/B170-625[»]
3F70X-ray2.10A/B170-625[»]
ProteinModelPortaliQ969R5.
SMRiQ969R5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123753. 58 interactors.
DIPiDIP-56748N.
IntActiQ969R5. 76 interactors.
MINTiMINT-1483852.
STRINGi9606.ENSP00000216237.

PTM databases

iPTMnetiQ969R5.
PhosphoSitePlusiQ969R5.

Polymorphism and mutation databases

BioMutaiL3MBTL2.
DMDMi27734418.

Proteomic databases

EPDiQ969R5.
MaxQBiQ969R5.
PaxDbiQ969R5.
PeptideAtlasiQ969R5.
PRIDEiQ969R5.

Protocols and materials databases

DNASUi83746.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216237; ENSP00000216237; ENSG00000100395. [Q969R5-1]
ENST00000452106; ENSP00000414423; ENSG00000100395. [Q969R5-2]
GeneIDi83746.
KEGGihsa:83746.
UCSCiuc003azo.4. human. [Q969R5-1]

Organism-specific databases

CTDi83746.
DisGeNETi83746.
GeneCardsiL3MBTL2.
HGNCiHGNC:18594. L3MBTL2.
HPAiHPA000815.
MIMi611865. gene.
neXtProtiNX_Q969R5.
OpenTargetsiENSG00000100395.
PharmGKBiPA38356.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMEW. Eukaryota.
ENOG410ZYE4. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000231220.
HOVERGENiHBG057974.
InParanoidiQ969R5.
OMAiDGWDNEY.
OrthoDBiEOG091G0312.
PhylomeDBiQ969R5.
TreeFamiTF316498.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100395-MONOMER.
ReactomeiR-HSA-4551638. SUMOylation of chromatin organization proteins.

Miscellaneous databases

ChiTaRSiL3MBTL2. human.
EvolutionaryTraceiQ969R5.
GeneWikiiL3MBTL2.
GenomeRNAii83746.
PROiQ969R5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100395.
CleanExiHS_L3MBTL2.
ExpressionAtlasiQ969R5. baseline and differential.
GenevisibleiQ969R5. HS.

Family and domain databases

InterProiIPR004092. Mbt.
IPR012313. Znf_FCS.
[Graphical view]
PfamiPF02820. MBT. 4 hits.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
[Graphical view]
PROSITEiPS51079. MBT. 4 hits.
PS51024. ZF_FCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMBL2_HUMAN
AccessioniPrimary (citable) accession number: Q969R5
Secondary accession number(s): Q8TEN1
, Q96SC4, Q9BQI2, Q9UGS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.