Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q969Q6 (P2R3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Alternative name(s):
Protein phosphatase subunit G5PR
Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
Gene names
Name:PPP2R3C
Synonyms:C14orf10, G5PR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells By similarity.

Subunit structure

Interacts with MCM3AP/GANP By similarity. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Ref.7

Subcellular location

Nucleus. Cytoplasm. Note: Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. Ref.1

Tissue specificity

Ubiquitously expressed in brain and other tissues. Ref.1 Ref.7

Developmental stage

Expressed in fetal brain. Ref.1

Sequence similarities

Contains 2 EF-hand domains.

Sequence caution

The sequence AAT44532.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAT44533.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q969Q6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q969Q6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
PRO_0000277833

Regions

Domain273 – 30836EF-hand 1
Domain341 – 37636EF-hand 2
Calcium binding286 – 297121 Potential
Compositional bias226 – 2294Poly-Phe

Natural variations

Alternative sequence1 – 110110Missing in isoform 2.
VSP_023113

Experimental info

Sequence conflict1061H → R in BAA91308. Ref.2
Sequence conflict2401I → T in AAT44532. Ref.6
Sequence conflict3011Y → H in BAA91308. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9749B7188B2F7599

FASTA45353,316
        10         20         30         40         50         60 
MDWKEVLRRR LATPNTCPNK KKSEQELKDE EMDLFTKYYS EWKGGRKNTN EFYKTIPRFY 

        70         80         90        100        110        120 
YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW FLLDKHQTPP MIGEEAMINY 

       130        140        150        160        170        180 
ENFLKVGEKA GAKCKQFFTA KVFAKLLHTD SYGRISIMQF FNYVMRKVWL HQTRIGLSLY 

       190        200        210        220        230        240 
DVAGQGYLRE SDLENYILEL IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI 

       250        260        270        280        290        300 
QDILACSFLD DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR 

       310        320        330        340        350        360 
YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF KLLDIENKGY 

       370        380        390        400        410        420 
LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP KDPLKISLQD LINSNQGDTV 

       430        440        450 
TTILIDLNGF WTYENREALV ANDSENSADL DDT 

« Hide

Isoform 2 [UniParc].

Checksum: A921EE6858995288
Show »

FASTA34339,806

References

« Hide 'large scale' references
[1]"Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes."
Kamnasaran D., Chen C.-P., Devriendt K., Mehta L., Cox D.W.
Genomics 85:608-621(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Cerebellum and Gastric carcinoma.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Bone marrow, Brain and Placenta.
[5]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 (ISOFORM 1).
Tissue: Placenta.
[6]"SEREX-defined rhabdomyosarcoma antigens."
Behrends U., Gotz C., Mautner J.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-453 (ISOFORM 1).
Tissue: Embryonic rhabdomyosarcoma.
[7]"MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR."
Kono Y., Maeda K., Kuwahara K., Yamamoto H., Miyamoto E., Yonezawa K., Takagi K., Sakaguchi N.
Genes Cells 7:821-834(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PPP2CA; PPP2R1A AND PPP5C, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY157304 mRNA. Translation: AAO17045.1.
AK000651 mRNA. Translation: BAA91308.1.
AK293717 mRNA. Translation: BAG57148.1.
CH471078 Genomic DNA. Translation: EAW65886.1.
CH471078 Genomic DNA. Translation: EAW65887.1.
CH471078 Genomic DNA. Translation: EAW65889.1.
CH471078 Genomic DNA. Translation: EAW65890.1.
BC006823 mRNA. Translation: AAH06823.1.
BC010293 mRNA. Translation: AAH10293.1.
BC012563 mRNA. Translation: AAH12563.1.
BC063438 mRNA. Translation: AAH63438.1.
BX248043 mRNA. Translation: CAD62352.1.
AY518535 mRNA. Translation: AAT44532.1. Different initiation.
AY518537 mRNA. Translation: AAT44533.1. Different initiation.
CCDSCCDS9654.1. [Q969Q6-1]
RefSeqNP_060387.2. NM_017917.2. [Q969Q6-1]
XP_005267839.1. XM_005267782.1. [Q969Q6-1]
XP_005267841.1. XM_005267784.1. [Q969Q6-2]
UniGeneHs.530712.
Hs.621667.

3D structure databases

ProteinModelPortalQ969Q6.
SMRQ969Q6. Positions 188-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120344. 4 interactions.
IntActQ969Q6. 3 interactions.
STRING9606.ENSP00000261475.

PTM databases

PhosphoSiteQ969Q6.

Polymorphism databases

DMDM74762643.

Proteomic databases

MaxQBQ969Q6.
PaxDbQ969Q6.
PRIDEQ969Q6.

Protocols and materials databases

DNASU55012.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261475; ENSP00000261475; ENSG00000092020. [Q969Q6-1]
ENST00000557278; ENSP00000450815; ENSG00000092020.
GeneID55012.
KEGGhsa:55012.
UCSCuc001wss.3. human. [Q969Q6-1]

Organism-specific databases

CTD55012.
GeneCardsGC14M035554.
H-InvDBHIX0026726.
HGNCHGNC:17485. PPP2R3C.
HPAHPA040835.
neXtProtNX_Q969Q6.
PharmGKBPA162400008.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279493.
HOVERGENHBG055242.
InParanoidQ969Q6.
KOK11583.
OMAQESNWFS.
PhylomeDBQ969Q6.
TreeFamTF318412.

Gene expression databases

ArrayExpressQ969Q6.
BgeeQ969Q6.
CleanExHS_PPP2R3C.
GenevestigatorQ969Q6.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPPP2R3C.
GenomeRNAi55012.
NextBio58369.
PROQ969Q6.

Entry information

Entry nameP2R3C_HUMAN
AccessionPrimary (citable) accession number: Q969Q6
Secondary accession number(s): B4DEN7 expand/collapse secondary AC list , D3DS97, D3DS98, Q5GJ55, Q5GJ56, Q6P4G2, Q86TZ3, Q9NWR9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM