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Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Gene

PPP2R3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi286 – 2971Sequence analysisAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000092020-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Alternative name(s):
Protein phosphatase subunit G5PR
Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
Gene namesi
Name:PPP2R3C
Synonyms:C14orf10, G5PR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:17485. PPP2R3C.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.1 Publication

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • spindle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000092020.
PharmGKBiPA162400008.

Polymorphism and mutation databases

BioMutaiPPP2R3C.
DMDMi74762643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002778331 – 453Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gammaAdd BLAST453

Proteomic databases

EPDiQ969Q6.
MaxQBiQ969Q6.
PaxDbiQ969Q6.
PeptideAtlasiQ969Q6.
PRIDEiQ969Q6.

PTM databases

iPTMnetiQ969Q6.
PhosphoSitePlusiQ969Q6.

Expressioni

Tissue specificityi

Ubiquitously expressed in brain and other tissues.2 Publications

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000092020.
CleanExiHS_PPP2R3C.
ExpressionAtlasiQ969Q6. baseline and differential.
GenevisibleiQ969Q6. HS.

Organism-specific databases

HPAiHPA040835.
HPA058834.

Interactioni

Subunit structurei

Interacts with MCM3AP/GANP. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CMTM5Q96DZ93EBI-2561661,EBI-2548702
POLR1CO151605EBI-2561661,EBI-1055079
RTN3O951973EBI-2561661,EBI-740467

Protein-protein interaction databases

BioGridi120344. 29 interactors.
IntActiQ969Q6. 27 interactors.
STRINGi9606.ENSP00000261475.

Structurei

3D structure databases

ProteinModelPortaliQ969Q6.
SMRiQ969Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini273 – 308EF-hand 1Add BLAST36
Domaini341 – 376EF-hand 2Add BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi226 – 229Poly-Phe4

Sequence similaritiesi

Contains 2 EF-hand domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2562. Eukaryota.
ENOG410XRBK. LUCA.
GeneTreeiENSGT00530000063265.
HOVERGENiHBG055242.
KOiK11583.
OMAiKPKDPYK.
OrthoDBiEOG091G06I8.
PhylomeDBiQ969Q6.
TreeFamiTF318412.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969Q6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDWKEVLRRR LATPNTCPNK KKSEQELKDE EMDLFTKYYS EWKGGRKNTN
60 70 80 90 100
EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW
110 120 130 140 150
FLLDKHQTPP MIGEEAMINY ENFLKVGEKA GAKCKQFFTA KVFAKLLHTD
160 170 180 190 200
SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL
210 220 230 240 250
IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD
260 270 280 290 300
DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR
310 320 330 340 350
YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF
360 370 380 390 400
KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP
410 420 430 440 450
KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDSENSADL

DDT
Length:453
Mass (Da):53,316
Last modified:December 1, 2001 - v1
Checksum:i9749B7188B2F7599
GO
Isoform 2 (identifier: Q969Q6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:343
Mass (Da):39,806
Checksum:iA921EE6858995288
GO

Sequence cautioni

The sequence AAT44532 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAT44533 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106H → R in BAA91308 (PubMed:14702039).Curated1
Sequence conflicti240I → T in AAT44532 (Ref. 6) Curated1
Sequence conflicti301Y → H in BAA91308 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0231131 – 110Missing in isoform 2. 2 PublicationsAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157304 mRNA. Translation: AAO17045.1.
AK000651 mRNA. Translation: BAA91308.1.
AK293717 mRNA. Translation: BAG57148.1.
CH471078 Genomic DNA. Translation: EAW65886.1.
CH471078 Genomic DNA. Translation: EAW65887.1.
CH471078 Genomic DNA. Translation: EAW65889.1.
CH471078 Genomic DNA. Translation: EAW65890.1.
BC006823 mRNA. Translation: AAH06823.1.
BC010293 mRNA. Translation: AAH10293.1.
BC012563 mRNA. Translation: AAH12563.1.
BC063438 mRNA. Translation: AAH63438.1.
BX248043 mRNA. Translation: CAD62352.1.
AY518535 mRNA. Translation: AAT44532.1. Different initiation.
AY518537 mRNA. Translation: AAT44533.1. Different initiation.
CCDSiCCDS9654.1. [Q969Q6-1]
RefSeqiNP_001292084.1. NM_001305155.1. [Q969Q6-2]
NP_001292085.1. NM_001305156.1. [Q969Q6-2]
NP_060387.2. NM_017917.3. [Q969Q6-1]
XP_005267839.1. XM_005267782.3. [Q969Q6-1]
UniGeneiHs.530712.
Hs.621667.

Genome annotation databases

EnsembliENST00000261475; ENSP00000261475; ENSG00000092020. [Q969Q6-1]
GeneIDi55012.
KEGGihsa:55012.
UCSCiuc001wss.4. human. [Q969Q6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157304 mRNA. Translation: AAO17045.1.
AK000651 mRNA. Translation: BAA91308.1.
AK293717 mRNA. Translation: BAG57148.1.
CH471078 Genomic DNA. Translation: EAW65886.1.
CH471078 Genomic DNA. Translation: EAW65887.1.
CH471078 Genomic DNA. Translation: EAW65889.1.
CH471078 Genomic DNA. Translation: EAW65890.1.
BC006823 mRNA. Translation: AAH06823.1.
BC010293 mRNA. Translation: AAH10293.1.
BC012563 mRNA. Translation: AAH12563.1.
BC063438 mRNA. Translation: AAH63438.1.
BX248043 mRNA. Translation: CAD62352.1.
AY518535 mRNA. Translation: AAT44532.1. Different initiation.
AY518537 mRNA. Translation: AAT44533.1. Different initiation.
CCDSiCCDS9654.1. [Q969Q6-1]
RefSeqiNP_001292084.1. NM_001305155.1. [Q969Q6-2]
NP_001292085.1. NM_001305156.1. [Q969Q6-2]
NP_060387.2. NM_017917.3. [Q969Q6-1]
XP_005267839.1. XM_005267782.3. [Q969Q6-1]
UniGeneiHs.530712.
Hs.621667.

3D structure databases

ProteinModelPortaliQ969Q6.
SMRiQ969Q6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120344. 29 interactors.
IntActiQ969Q6. 27 interactors.
STRINGi9606.ENSP00000261475.

PTM databases

iPTMnetiQ969Q6.
PhosphoSitePlusiQ969Q6.

Polymorphism and mutation databases

BioMutaiPPP2R3C.
DMDMi74762643.

Proteomic databases

EPDiQ969Q6.
MaxQBiQ969Q6.
PaxDbiQ969Q6.
PeptideAtlasiQ969Q6.
PRIDEiQ969Q6.

Protocols and materials databases

DNASUi55012.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261475; ENSP00000261475; ENSG00000092020. [Q969Q6-1]
GeneIDi55012.
KEGGihsa:55012.
UCSCiuc001wss.4. human. [Q969Q6-1]

Organism-specific databases

CTDi55012.
GeneCardsiPPP2R3C.
H-InvDBHIX0026726.
HGNCiHGNC:17485. PPP2R3C.
HPAiHPA040835.
HPA058834.
MIMi615902. gene.
neXtProtiNX_Q969Q6.
OpenTargetsiENSG00000092020.
PharmGKBiPA162400008.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2562. Eukaryota.
ENOG410XRBK. LUCA.
GeneTreeiENSGT00530000063265.
HOVERGENiHBG055242.
KOiK11583.
OMAiKPKDPYK.
OrthoDBiEOG091G06I8.
PhylomeDBiQ969Q6.
TreeFamiTF318412.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000092020-MONOMER.

Miscellaneous databases

GeneWikiiPPP2R3C.
GenomeRNAii55012.
PROiQ969Q6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000092020.
CleanExiHS_PPP2R3C.
ExpressionAtlasiQ969Q6. baseline and differential.
GenevisibleiQ969Q6. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2R3C_HUMAN
AccessioniPrimary (citable) accession number: Q969Q6
Secondary accession number(s): B4DEN7
, D3DS97, D3DS98, Q5GJ55, Q5GJ56, Q6P4G2, Q86TZ3, Q9NWR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.