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Q969Q6

- P2R3C_HUMAN

UniProt

Q969Q6 - P2R3C_HUMAN

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Protein
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Gene
PPP2R3C, C14orf10, G5PR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi286 – 297121 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. B cell homeostasis Source: Ensembl
  2. T cell homeostasis Source: Ensembl
  3. activation of protein kinase activity Source: Ensembl
  4. positive regulation of B cell differentiation Source: Ensembl
  5. regulation of antimicrobial humoral response Source: Ensembl
  6. regulation of mitochondrial depolarization Source: Ensembl
  7. spleen development Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Alternative name(s):
Protein phosphatase subunit G5PR
Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
Gene namesi
Name:PPP2R3C
Synonyms:C14orf10, G5PR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:17485. PPP2R3C.

Subcellular locationi

Nucleus. Cytoplasm
Note: Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.1 Publication

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
PRO_0000277833Add
BLAST

Proteomic databases

MaxQBiQ969Q6.
PaxDbiQ969Q6.
PRIDEiQ969Q6.

PTM databases

PhosphoSiteiQ969Q6.

Expressioni

Tissue specificityi

Ubiquitously expressed in brain and other tissues.2 Publications

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

ArrayExpressiQ969Q6.
BgeeiQ969Q6.
CleanExiHS_PPP2R3C.
GenevestigatoriQ969Q6.

Organism-specific databases

HPAiHPA040835.

Interactioni

Subunit structurei

Interacts with MCM3AP/GANP By similarity. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A.1 Publication

Protein-protein interaction databases

BioGridi120344. 4 interactions.
IntActiQ969Q6. 3 interactions.
STRINGi9606.ENSP00000261475.

Structurei

3D structure databases

ProteinModelPortaliQ969Q6.
SMRiQ969Q6. Positions 188-411.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini273 – 30836EF-hand 1
Add
BLAST
Domaini341 – 37636EF-hand 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi226 – 2294Poly-Phe

Sequence similaritiesi

Contains 2 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG279493.
HOVERGENiHBG055242.
InParanoidiQ969Q6.
KOiK11583.
OMAiQESNWFS.
PhylomeDBiQ969Q6.
TreeFamiTF318412.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969Q6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDWKEVLRRR LATPNTCPNK KKSEQELKDE EMDLFTKYYS EWKGGRKNTN    50
EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW 100
FLLDKHQTPP MIGEEAMINY ENFLKVGEKA GAKCKQFFTA KVFAKLLHTD 150
SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL 200
IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD 250
DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR 300
YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF 350
KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP 400
KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDSENSADL 450
DDT 453
Length:453
Mass (Da):53,316
Last modified:December 1, 2001 - v1
Checksum:i9749B7188B2F7599
GO
Isoform 2 (identifier: Q969Q6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:343
Mass (Da):39,806
Checksum:iA921EE6858995288
GO

Sequence cautioni

The sequence AAT44532.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAT44533.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 110110Missing in isoform 2.
VSP_023113Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061H → R in BAA91308. 1 Publication
Sequence conflicti240 – 2401I → T in AAT44532. 1 Publication
Sequence conflicti301 – 3011Y → H in BAA91308. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY157304 mRNA. Translation: AAO17045.1.
AK000651 mRNA. Translation: BAA91308.1.
AK293717 mRNA. Translation: BAG57148.1.
CH471078 Genomic DNA. Translation: EAW65886.1.
CH471078 Genomic DNA. Translation: EAW65887.1.
CH471078 Genomic DNA. Translation: EAW65889.1.
CH471078 Genomic DNA. Translation: EAW65890.1.
BC006823 mRNA. Translation: AAH06823.1.
BC010293 mRNA. Translation: AAH10293.1.
BC012563 mRNA. Translation: AAH12563.1.
BC063438 mRNA. Translation: AAH63438.1.
BX248043 mRNA. Translation: CAD62352.1.
AY518535 mRNA. Translation: AAT44532.1. Different initiation.
AY518537 mRNA. Translation: AAT44533.1. Different initiation.
CCDSiCCDS9654.1. [Q969Q6-1]
RefSeqiNP_060387.2. NM_017917.2. [Q969Q6-1]
XP_005267839.1. XM_005267782.1. [Q969Q6-1]
XP_005267841.1. XM_005267784.1. [Q969Q6-2]
UniGeneiHs.530712.
Hs.621667.

Genome annotation databases

EnsembliENST00000261475; ENSP00000261475; ENSG00000092020. [Q969Q6-1]
ENST00000557278; ENSP00000450815; ENSG00000092020.
GeneIDi55012.
KEGGihsa:55012.
UCSCiuc001wss.3. human. [Q969Q6-1]

Polymorphism databases

DMDMi74762643.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY157304 mRNA. Translation: AAO17045.1 .
AK000651 mRNA. Translation: BAA91308.1 .
AK293717 mRNA. Translation: BAG57148.1 .
CH471078 Genomic DNA. Translation: EAW65886.1 .
CH471078 Genomic DNA. Translation: EAW65887.1 .
CH471078 Genomic DNA. Translation: EAW65889.1 .
CH471078 Genomic DNA. Translation: EAW65890.1 .
BC006823 mRNA. Translation: AAH06823.1 .
BC010293 mRNA. Translation: AAH10293.1 .
BC012563 mRNA. Translation: AAH12563.1 .
BC063438 mRNA. Translation: AAH63438.1 .
BX248043 mRNA. Translation: CAD62352.1 .
AY518535 mRNA. Translation: AAT44532.1 . Different initiation.
AY518537 mRNA. Translation: AAT44533.1 . Different initiation.
CCDSi CCDS9654.1. [Q969Q6-1 ]
RefSeqi NP_060387.2. NM_017917.2. [Q969Q6-1 ]
XP_005267839.1. XM_005267782.1. [Q969Q6-1 ]
XP_005267841.1. XM_005267784.1. [Q969Q6-2 ]
UniGenei Hs.530712.
Hs.621667.

3D structure databases

ProteinModelPortali Q969Q6.
SMRi Q969Q6. Positions 188-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120344. 4 interactions.
IntActi Q969Q6. 3 interactions.
STRINGi 9606.ENSP00000261475.

PTM databases

PhosphoSitei Q969Q6.

Polymorphism databases

DMDMi 74762643.

Proteomic databases

MaxQBi Q969Q6.
PaxDbi Q969Q6.
PRIDEi Q969Q6.

Protocols and materials databases

DNASUi 55012.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261475 ; ENSP00000261475 ; ENSG00000092020 . [Q969Q6-1 ]
ENST00000557278 ; ENSP00000450815 ; ENSG00000092020 .
GeneIDi 55012.
KEGGi hsa:55012.
UCSCi uc001wss.3. human. [Q969Q6-1 ]

Organism-specific databases

CTDi 55012.
GeneCardsi GC14M035554.
H-InvDB HIX0026726.
HGNCi HGNC:17485. PPP2R3C.
HPAi HPA040835.
neXtProti NX_Q969Q6.
PharmGKBi PA162400008.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279493.
HOVERGENi HBG055242.
InParanoidi Q969Q6.
KOi K11583.
OMAi QESNWFS.
PhylomeDBi Q969Q6.
TreeFami TF318412.

Miscellaneous databases

GeneWikii PPP2R3C.
GenomeRNAii 55012.
NextBioi 58369.
PROi Q969Q6.

Gene expression databases

ArrayExpressi Q969Q6.
Bgeei Q969Q6.
CleanExi HS_PPP2R3C.
Genevestigatori Q969Q6.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes."
    Kamnasaran D., Chen C.-P., Devriendt K., Mehta L., Cox D.W.
    Genomics 85:608-621(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum and Gastric carcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Bone marrow, Brain and Placenta.
  5. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 (ISOFORM 1).
    Tissue: Placenta.
  6. "SEREX-defined rhabdomyosarcoma antigens."
    Behrends U., Gotz C., Mautner J.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-453 (ISOFORM 1).
    Tissue: Embryonic rhabdomyosarcoma.
  7. "MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR."
    Kono Y., Maeda K., Kuwahara K., Yamamoto H., Miyamoto E., Yonezawa K., Takagi K., Sakaguchi N.
    Genes Cells 7:821-834(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPP2CA; PPP2R1A AND PPP5C, TISSUE SPECIFICITY.

Entry informationi

Entry nameiP2R3C_HUMAN
AccessioniPrimary (citable) accession number: Q969Q6
Secondary accession number(s): B4DEN7
, D3DS97, D3DS98, Q5GJ55, Q5GJ56, Q6P4G2, Q86TZ3, Q9NWR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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