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Q969Q6

- P2R3C_HUMAN

UniProt

Q969Q6 - P2R3C_HUMAN

Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Gene

PPP2R3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi286 – 297121Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. activation of protein kinase activity Source: Ensembl
    2. B cell homeostasis Source: Ensembl
    3. positive regulation of B cell differentiation Source: Ensembl
    4. regulation of antimicrobial humoral response Source: Ensembl
    5. regulation of mitochondrial depolarization Source: Ensembl
    6. spleen development Source: Ensembl
    7. T cell homeostasis Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
    Alternative name(s):
    Protein phosphatase subunit G5PR
    Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
    Gene namesi
    Name:PPP2R3C
    Synonyms:C14orf10, G5PR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:17485. PPP2R3C.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400008.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gammaPRO_0000277833Add
    BLAST

    Proteomic databases

    MaxQBiQ969Q6.
    PaxDbiQ969Q6.
    PRIDEiQ969Q6.

    PTM databases

    PhosphoSiteiQ969Q6.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in brain and other tissues.2 Publications

    Developmental stagei

    Expressed in fetal brain.1 Publication

    Gene expression databases

    ArrayExpressiQ969Q6.
    BgeeiQ969Q6.
    CleanExiHS_PPP2R3C.
    GenevestigatoriQ969Q6.

    Organism-specific databases

    HPAiHPA040835.

    Interactioni

    Subunit structurei

    Interacts with MCM3AP/GANP By similarity. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi120344. 4 interactions.
    IntActiQ969Q6. 3 interactions.
    STRINGi9606.ENSP00000261475.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969Q6.
    SMRiQ969Q6. Positions 188-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini273 – 30836EF-hand 1Add
    BLAST
    Domaini341 – 37636EF-hand 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi226 – 2294Poly-Phe

    Sequence similaritiesi

    Contains 2 EF-hand domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG279493.
    HOVERGENiHBG055242.
    InParanoidiQ969Q6.
    KOiK11583.
    OMAiQESNWFS.
    PhylomeDBiQ969Q6.
    TreeFamiTF318412.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969Q6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDWKEVLRRR LATPNTCPNK KKSEQELKDE EMDLFTKYYS EWKGGRKNTN    50
    EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW 100
    FLLDKHQTPP MIGEEAMINY ENFLKVGEKA GAKCKQFFTA KVFAKLLHTD 150
    SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL 200
    IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD 250
    DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR 300
    YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF 350
    KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP 400
    KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDSENSADL 450
    DDT 453
    Length:453
    Mass (Da):53,316
    Last modified:December 1, 2001 - v1
    Checksum:i9749B7188B2F7599
    GO
    Isoform 2 (identifier: Q969Q6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-110: Missing.

    Show »
    Length:343
    Mass (Da):39,806
    Checksum:iA921EE6858995288
    GO

    Sequence cautioni

    The sequence AAT44532.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAT44533.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061H → R in BAA91308. (PubMed:14702039)Curated
    Sequence conflicti240 – 2401I → T in AAT44532. 1 PublicationCurated
    Sequence conflicti301 – 3011Y → H in BAA91308. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 110110Missing in isoform 2. 2 PublicationsVSP_023113Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157304 mRNA. Translation: AAO17045.1.
    AK000651 mRNA. Translation: BAA91308.1.
    AK293717 mRNA. Translation: BAG57148.1.
    CH471078 Genomic DNA. Translation: EAW65886.1.
    CH471078 Genomic DNA. Translation: EAW65887.1.
    CH471078 Genomic DNA. Translation: EAW65889.1.
    CH471078 Genomic DNA. Translation: EAW65890.1.
    BC006823 mRNA. Translation: AAH06823.1.
    BC010293 mRNA. Translation: AAH10293.1.
    BC012563 mRNA. Translation: AAH12563.1.
    BC063438 mRNA. Translation: AAH63438.1.
    BX248043 mRNA. Translation: CAD62352.1.
    AY518535 mRNA. Translation: AAT44532.1. Different initiation.
    AY518537 mRNA. Translation: AAT44533.1. Different initiation.
    CCDSiCCDS9654.1. [Q969Q6-1]
    RefSeqiNP_060387.2. NM_017917.2. [Q969Q6-1]
    XP_005267839.1. XM_005267782.1. [Q969Q6-1]
    XP_005267841.1. XM_005267784.1. [Q969Q6-2]
    UniGeneiHs.530712.
    Hs.621667.

    Genome annotation databases

    EnsembliENST00000261475; ENSP00000261475; ENSG00000092020. [Q969Q6-1]
    ENST00000557278; ENSP00000450815; ENSG00000092020.
    GeneIDi55012.
    KEGGihsa:55012.
    UCSCiuc001wss.3. human. [Q969Q6-1]

    Polymorphism databases

    DMDMi74762643.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157304 mRNA. Translation: AAO17045.1 .
    AK000651 mRNA. Translation: BAA91308.1 .
    AK293717 mRNA. Translation: BAG57148.1 .
    CH471078 Genomic DNA. Translation: EAW65886.1 .
    CH471078 Genomic DNA. Translation: EAW65887.1 .
    CH471078 Genomic DNA. Translation: EAW65889.1 .
    CH471078 Genomic DNA. Translation: EAW65890.1 .
    BC006823 mRNA. Translation: AAH06823.1 .
    BC010293 mRNA. Translation: AAH10293.1 .
    BC012563 mRNA. Translation: AAH12563.1 .
    BC063438 mRNA. Translation: AAH63438.1 .
    BX248043 mRNA. Translation: CAD62352.1 .
    AY518535 mRNA. Translation: AAT44532.1 . Different initiation.
    AY518537 mRNA. Translation: AAT44533.1 . Different initiation.
    CCDSi CCDS9654.1. [Q969Q6-1 ]
    RefSeqi NP_060387.2. NM_017917.2. [Q969Q6-1 ]
    XP_005267839.1. XM_005267782.1. [Q969Q6-1 ]
    XP_005267841.1. XM_005267784.1. [Q969Q6-2 ]
    UniGenei Hs.530712.
    Hs.621667.

    3D structure databases

    ProteinModelPortali Q969Q6.
    SMRi Q969Q6. Positions 188-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120344. 4 interactions.
    IntActi Q969Q6. 3 interactions.
    STRINGi 9606.ENSP00000261475.

    PTM databases

    PhosphoSitei Q969Q6.

    Polymorphism databases

    DMDMi 74762643.

    Proteomic databases

    MaxQBi Q969Q6.
    PaxDbi Q969Q6.
    PRIDEi Q969Q6.

    Protocols and materials databases

    DNASUi 55012.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261475 ; ENSP00000261475 ; ENSG00000092020 . [Q969Q6-1 ]
    ENST00000557278 ; ENSP00000450815 ; ENSG00000092020 .
    GeneIDi 55012.
    KEGGi hsa:55012.
    UCSCi uc001wss.3. human. [Q969Q6-1 ]

    Organism-specific databases

    CTDi 55012.
    GeneCardsi GC14M035554.
    H-InvDB HIX0026726.
    HGNCi HGNC:17485. PPP2R3C.
    HPAi HPA040835.
    neXtProti NX_Q969Q6.
    PharmGKBi PA162400008.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279493.
    HOVERGENi HBG055242.
    InParanoidi Q969Q6.
    KOi K11583.
    OMAi QESNWFS.
    PhylomeDBi Q969Q6.
    TreeFami TF318412.

    Miscellaneous databases

    GeneWikii PPP2R3C.
    GenomeRNAii 55012.
    NextBioi 58369.
    PROi Q969Q6.

    Gene expression databases

    ArrayExpressi Q969Q6.
    Bgeei Q969Q6.
    CleanExi HS_PPP2R3C.
    Genevestigatori Q969Q6.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes."
      Kamnasaran D., Chen C.-P., Devriendt K., Mehta L., Cox D.W.
      Genomics 85:608-621(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cerebellum and Gastric carcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Bone marrow, Brain and Placenta.
    5. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 (ISOFORM 1).
      Tissue: Placenta.
    6. "SEREX-defined rhabdomyosarcoma antigens."
      Behrends U., Gotz C., Mautner J.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-453 (ISOFORM 1).
      Tissue: Embryonic rhabdomyosarcoma.
    7. "MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR."
      Kono Y., Maeda K., Kuwahara K., Yamamoto H., Miyamoto E., Yonezawa K., Takagi K., Sakaguchi N.
      Genes Cells 7:821-834(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPP2CA; PPP2R1A AND PPP5C, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiP2R3C_HUMAN
    AccessioniPrimary (citable) accession number: Q969Q6
    Secondary accession number(s): B4DEN7
    , D3DS97, D3DS98, Q5GJ55, Q5GJ56, Q6P4G2, Q86TZ3, Q9NWR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3