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Protein

Ras-related protein Rab-24

Gene

RAB24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in autophagy-related processes.By similarity

Miscellaneous

The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi120 – 123GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-24
Gene namesi
Name:RAB24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169228.13
HGNCiHGNC:9765 RAB24
MIMi612415 gene
neXtProtiNX_Q969Q5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53917
OpenTargetsiENSG00000169228
PharmGKBiPA34114

Polymorphism and mutation databases

DMDMi23396831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212131 – 203Ras-related protein Rab-24Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Isoprenylation is inefficient compared to other Rab family members.1 Publication

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiQ969Q5
MaxQBiQ969Q5
PaxDbiQ969Q5
PeptideAtlasiQ969Q5
PRIDEiQ969Q5
ProteomicsDBi75816

PTM databases

iPTMnetiQ969Q5
PhosphoSitePlusiQ969Q5

Expressioni

Inductioni

By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000169228
CleanExiHS_RAB24
ExpressionAtlasiQ969Q5 baseline and differential
GenevisibleiQ969Q5 HS

Organism-specific databases

HPAiHPA034945

Interactioni

Subunit structurei

Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.1 Publication

Protein-protein interaction databases

BioGridi119817, 7 interactors
IntActiQ969Q5, 10 interactors
STRINGi9606.ENSP00000304376

Structurei

3D structure databases

ProteinModelPortaliQ969Q5
SMRiQ969Q5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00910000144316
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ969Q5
KOiK07912
OMAiVERYVHH
OrthoDBiEOG091G0NNJ
PhylomeDBiQ969Q5
TreeFamiTF300199

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q969Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQRVDVKV VMLGKEYVGK TSLVERYVHD RFLVGPYQNT IGAAFVAKVM
60 70 80 90 100
SVGDRTVTLG IWDTAGSERY EAMSRIYYRG AKAAIVCYDL TDSSSFERAK
110 120 130 140 150
FWVKELRSLE EGCQIYLCGT KSDLLEEDRR RRRVDFHDVQ DYADNIKAQL
160 170 180 190 200
FETSSKTGQS VDELFQKVAE DYVSVAAFQV MTEDKGVDLG QKPNPYFYSC

CHH
Length:203
Mass (Da):23,124
Last modified:December 1, 2001 - v1
Checksum:i979E1AF6F7A4E5F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55 – 56RT → AL in AAP97202 (Ref. 1) Curated2
Sequence conflicti108S → T in AAP97202 (Ref. 1) Curated1
Sequence conflicti129 – 130RR → QE in AAP97202 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087904 mRNA Translation: AAP97202.1
BT007268 mRNA Translation: AAP35932.1
CH471195 Genomic DNA Translation: EAW85025.1
CH471195 Genomic DNA Translation: EAW85028.1
CH471195 Genomic DNA Translation: EAW85029.1
BC010006 mRNA Translation: AAH10006.1
BC015534 mRNA Translation: AAH15534.1
BC021263 mRNA Translation: AAH21263.1
AL833898 mRNA Translation: CAD38754.1
CCDSiCCDS34300.1
RefSeqiNP_001026847.1, NM_001031677.3
NP_570137.2, NM_130781.3
UniGeneiHs.16258

Genome annotation databases

EnsembliENST00000303251; ENSP00000304376; ENSG00000169228
ENST00000393611; ENSP00000377235; ENSG00000169228
GeneIDi53917
KEGGihsa:53917
UCSCiuc003mfv.5 human

Similar proteinsi

Entry informationi

Entry nameiRAB24_HUMAN
AccessioniPrimary (citable) accession number: Q969Q5
Secondary accession number(s): A0A024R7N9, Q7Z4Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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