Q969Q5 (RAB24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-24

Gene names

Name:

RAB24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in autophagy-related processes By similarity.
Subunit structure	Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20. Ref.5 Ref.6
Subcellular location	Cytoplasm › cytosol. Membrane; Lipid-anchor By similarity. Note: Only about 20-25% is recovered in the particulate fraction. Ref.5
Induction	By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level). Ref.5
Post-translational modification	Isoprenylation is inefficient compared to other Rab family members.
Miscellaneous	The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	autophagic vacuole Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Ras-related protein Rab-24		PRO_0000121213
Regions
	Nucleotide binding	14 – 22	9	GTP By similarity
	Nucleotide binding	63 – 67	5	GTP By similarity
	Nucleotide binding	120 – 123	4	GTP By similarity
	Nucleotide binding	154 – 156	3	GTP By similarity
	Motif	37 – 45	9	Effector region By similarity
Amino acid modifications
	Lipidation	200	1	S-geranylgeranyl cysteine By similarity
	Lipidation	201	1	S-geranylgeranyl cysteine By similarity
Experimental info
	Sequence conflict	55 – 56	2	RT → AL in AAP97202. Ref.1
	Sequence conflict	108	1	S → T in AAP97202. Ref.1
	Sequence conflict	129 – 130	2	RR → QE in AAP97202. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q969Q5 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 979E1AF6F7A4E5F1	FASTA	203	23,124
	10 20 30 40 50 60 MSGQRVDVKV VMLGKEYVGK TSLVERYVHD RFLVGPYQNT IGAAFVAKVM SVGDRTVTLG 70 80 90 100 110 120 IWDTAGSERY EAMSRIYYRG AKAAIVCYDL TDSSSFERAK FWVKELRSLE EGCQIYLCGT 130 140 150 160 170 180 KSDLLEEDRR RRRVDFHDVQ DYADNIKAQL FETSSKTGQS VDELFQKVAE DYVSVAAFQV 190 200 MTEDKGVDLG QKPNPYFYSC CHH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a new human cDNA homology to murine Rab24 protein mRNA." Zhang H.L., Yu L., Ding J.B., Zhao Y., Li M.Z., Zhao S.Y. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas, Skin and Uterus.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-203. Tissue: Amygdala.
[5]	"Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells." Erdman R.A., Shellenberger K.E., Overmeyer J.H., Maltese W.A. J. Biol. Chem. 275:3848-3856(2000) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INDUCTION, INEFFICIENT ISOPRENYLATION, LACK OF INTERACTION WITH ARHGDIA AND ARHGDIB.
[6]	"Structural basis of family-wide Rab GTPase recognition by rabenosyn-5." Eathiraj S., Pan X., Ritacco C., Lambright D.G. Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ZFYVE20.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF087904 mRNA. Translation: AAP97202.1. BT007268 mRNA. Translation: AAP35932.1. BC010006 mRNA. Translation: AAH10006.1. BC015534 mRNA. Translation: AAH15534.1. BC021263 mRNA. Translation: AAH21263.1. AL833898 mRNA. Translation: CAD38754.1.
IPI	IPI00056496.
RefSeq	NP_001026847.1. NM_001031677.2. NP_570137.2. NM_130781.2.
UniGene	Hs.16258.
3D structure databases
ProteinModelPortal	Q969Q5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q969Q5. 10 interactions.
STRING	9606.ENSP00000304376.
PTM databases
PhosphoSite	Q969Q5.
Polymorphism databases
DMDM	23396831.
Proteomic databases
PaxDb	Q969Q5.
PRIDE	Q969Q5.
Protocols and materials databases
DNASU	53917.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000303251; ENSP00000304376; ENSG00000169228. ENST00000393611; ENSP00000377235; ENSG00000169228.
GeneID	53917.
KEGG	hsa:53917.
UCSC	uc003mfv.3. human.
Organism-specific databases
CTD	53917.
GeneCards	GC05M176728.
HGNC	HGNC:9765. RAB24.
MIM	612415. gene.
neXtProt	NX_Q969Q5.
PharmGKB	PA34114.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	Q969Q5.
KO	K07912.
OMA	FWVKELQ.
OrthoDB	EOG469QVS.
PhylomeDB	Q969Q5.
Gene expression databases
ArrayExpress	Q969Q5.
Bgee	Q969Q5.
CleanEx	HS_RAB24.
Genevestigator	Q969Q5.
GermOnline	ENSG00000169228. Homo sapiens.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	53917.
NextBio	56226.
SOURCE	Search...

Entry information

Entry name

RAB24_HUMAN

Accession

Primary (citable) accession number: Q969Q5
Secondary accession number(s): Q7Z4Z7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.