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Q969Q5

- RAB24_HUMAN

UniProt

Q969Q5 - RAB24_HUMAN

Protein

Ras-related protein Rab-24

Gene

RAB24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in autophagy-related processes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 229GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi120 – 1234GTPBy similarity
    Nucleotide bindingi154 – 1563GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW
    3. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-24
    Gene namesi
    Name:RAB24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:9765. RAB24.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication. Membrane By similarity; Lipid-anchor By similarity
    Note: Only about 20-25% is recovered in the particulate fraction.

    GO - Cellular componenti

    1. autophagic vacuole Source: Ensembl
    2. cytosol Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34114.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Ras-related protein Rab-24PRO_0000121213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity
    Lipidationi201 – 2011S-geranylgeranyl cysteineBy similarity

    Post-translational modificationi

    Isoprenylation is inefficient compared to other Rab family members.

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    MaxQBiQ969Q5.
    PaxDbiQ969Q5.
    PRIDEiQ969Q5.

    PTM databases

    PhosphoSiteiQ969Q5.

    Expressioni

    Inductioni

    By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).1 Publication

    Gene expression databases

    BgeeiQ969Q5.
    CleanExiHS_RAB24.
    GenevestigatoriQ969Q5.

    Interactioni

    Subunit structurei

    Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.1 Publication

    Protein-protein interaction databases

    BioGridi119817. 6 interactions.
    IntActiQ969Q5. 10 interactions.
    STRINGi9606.ENSP00000304376.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969Q5.
    SMRiQ969Q5. Positions 9-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi37 – 459Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ969Q5.
    KOiK07912.
    OMAiFWVKELQ.
    OrthoDBiEOG7B8S58.
    PhylomeDBiQ969Q5.
    TreeFamiTF300199.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q969Q5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGQRVDVKV VMLGKEYVGK TSLVERYVHD RFLVGPYQNT IGAAFVAKVM    50
    SVGDRTVTLG IWDTAGSERY EAMSRIYYRG AKAAIVCYDL TDSSSFERAK 100
    FWVKELRSLE EGCQIYLCGT KSDLLEEDRR RRRVDFHDVQ DYADNIKAQL 150
    FETSSKTGQS VDELFQKVAE DYVSVAAFQV MTEDKGVDLG QKPNPYFYSC 200
    CHH 203
    Length:203
    Mass (Da):23,124
    Last modified:December 1, 2001 - v1
    Checksum:i979E1AF6F7A4E5F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 562RT → AL in AAP97202. 1 PublicationCurated
    Sequence conflicti108 – 1081S → T in AAP97202. 1 PublicationCurated
    Sequence conflicti129 – 1302RR → QE in AAP97202. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087904 mRNA. Translation: AAP97202.1.
    BT007268 mRNA. Translation: AAP35932.1.
    BC010006 mRNA. Translation: AAH10006.1.
    BC015534 mRNA. Translation: AAH15534.1.
    BC021263 mRNA. Translation: AAH21263.1.
    AL833898 mRNA. Translation: CAD38754.1.
    CCDSiCCDS34300.1.
    RefSeqiNP_001026847.1. NM_001031677.3.
    NP_570137.2. NM_130781.3.
    UniGeneiHs.16258.

    Genome annotation databases

    EnsembliENST00000303251; ENSP00000304376; ENSG00000169228.
    ENST00000393611; ENSP00000377235; ENSG00000169228.
    GeneIDi53917.
    KEGGihsa:53917.
    UCSCiuc003mfv.3. human.

    Polymorphism databases

    DMDMi23396831.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087904 mRNA. Translation: AAP97202.1 .
    BT007268 mRNA. Translation: AAP35932.1 .
    BC010006 mRNA. Translation: AAH10006.1 .
    BC015534 mRNA. Translation: AAH15534.1 .
    BC021263 mRNA. Translation: AAH21263.1 .
    AL833898 mRNA. Translation: CAD38754.1 .
    CCDSi CCDS34300.1.
    RefSeqi NP_001026847.1. NM_001031677.3.
    NP_570137.2. NM_130781.3.
    UniGenei Hs.16258.

    3D structure databases

    ProteinModelPortali Q969Q5.
    SMRi Q969Q5. Positions 9-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119817. 6 interactions.
    IntActi Q969Q5. 10 interactions.
    STRINGi 9606.ENSP00000304376.

    PTM databases

    PhosphoSitei Q969Q5.

    Polymorphism databases

    DMDMi 23396831.

    Proteomic databases

    MaxQBi Q969Q5.
    PaxDbi Q969Q5.
    PRIDEi Q969Q5.

    Protocols and materials databases

    DNASUi 53917.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303251 ; ENSP00000304376 ; ENSG00000169228 .
    ENST00000393611 ; ENSP00000377235 ; ENSG00000169228 .
    GeneIDi 53917.
    KEGGi hsa:53917.
    UCSCi uc003mfv.3. human.

    Organism-specific databases

    CTDi 53917.
    GeneCardsi GC05M176728.
    HGNCi HGNC:9765. RAB24.
    MIMi 612415. gene.
    neXtProti NX_Q969Q5.
    PharmGKBi PA34114.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q969Q5.
    KOi K07912.
    OMAi FWVKELQ.
    OrthoDBi EOG7B8S58.
    PhylomeDBi Q969Q5.
    TreeFami TF300199.

    Miscellaneous databases

    GenomeRNAii 53917.
    NextBioi 56226.
    PROi Q969Q5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q969Q5.
    CleanExi HS_RAB24.
    Genevestigatori Q969Q5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a new human cDNA homology to murine Rab24 protein mRNA."
      Zhang H.L., Yu L., Ding J.B., Zhao Y., Li M.Z., Zhao S.Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas, Skin and Uterus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-203.
      Tissue: Amygdala.
    5. "Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells."
      Erdman R.A., Shellenberger K.E., Overmeyer J.H., Maltese W.A.
      J. Biol. Chem. 275:3848-3856(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INDUCTION, INEFFICIENT ISOPRENYLATION, LACK OF INTERACTION WITH ARHGDIA AND ARHGDIB.
    6. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."
      Eathiraj S., Pan X., Ritacco C., Lambright D.G.
      Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZFYVE20.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRAB24_HUMAN
    AccessioniPrimary (citable) accession number: Q969Q5
    Secondary accession number(s): Q7Z4Z7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3