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Q969Q5

- RAB24_HUMAN

UniProt

Q969Q5 - RAB24_HUMAN

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Protein
Ras-related protein Rab-24
Gene
RAB24
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in autophagy-related processes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229GTP By similarity
Nucleotide bindingi63 – 675GTP By similarity
Nucleotide bindingi120 – 1234GTP By similarity
Nucleotide bindingi154 – 1563GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
  3. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-24
Gene namesi
Name:RAB24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:9765. RAB24.

Subcellular locationi

Cytoplasmcytosol. Membrane; Lipid-anchor By similarity
Note: Only about 20-25% is recovered in the particulate fraction.1 Publication

GO - Cellular componenti

  1. autophagic vacuole Source: Ensembl
  2. cytosol Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-SubCell
  4. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Ras-related protein Rab-24
PRO_0000121213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi200 – 2001S-geranylgeranyl cysteine By similarity
Lipidationi201 – 2011S-geranylgeranyl cysteine By similarity

Post-translational modificationi

Isoprenylation is inefficient compared to other Rab family members.

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiQ969Q5.
PaxDbiQ969Q5.
PRIDEiQ969Q5.

PTM databases

PhosphoSiteiQ969Q5.

Expressioni

Inductioni

By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).1 Publication

Gene expression databases

BgeeiQ969Q5.
CleanExiHS_RAB24.
GenevestigatoriQ969Q5.

Interactioni

Subunit structurei

Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.2 Publications

Protein-protein interaction databases

BioGridi119817. 6 interactions.
IntActiQ969Q5. 10 interactions.
STRINGi9606.ENSP00000304376.

Structurei

3D structure databases

ProteinModelPortaliQ969Q5.
SMRiQ969Q5. Positions 9-170.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ969Q5.
KOiK07912.
OMAiFWVKELQ.
OrthoDBiEOG7B8S58.
PhylomeDBiQ969Q5.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969Q5-1 [UniParc]FASTAAdd to Basket

« Hide

MSGQRVDVKV VMLGKEYVGK TSLVERYVHD RFLVGPYQNT IGAAFVAKVM    50
SVGDRTVTLG IWDTAGSERY EAMSRIYYRG AKAAIVCYDL TDSSSFERAK 100
FWVKELRSLE EGCQIYLCGT KSDLLEEDRR RRRVDFHDVQ DYADNIKAQL 150
FETSSKTGQS VDELFQKVAE DYVSVAAFQV MTEDKGVDLG QKPNPYFYSC 200
CHH 203
Length:203
Mass (Da):23,124
Last modified:December 1, 2001 - v1
Checksum:i979E1AF6F7A4E5F1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 562RT → AL in AAP97202. 1 Publication
Sequence conflicti108 – 1081S → T in AAP97202. 1 Publication
Sequence conflicti129 – 1302RR → QE in AAP97202. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087904 mRNA. Translation: AAP97202.1.
BT007268 mRNA. Translation: AAP35932.1.
BC010006 mRNA. Translation: AAH10006.1.
BC015534 mRNA. Translation: AAH15534.1.
BC021263 mRNA. Translation: AAH21263.1.
AL833898 mRNA. Translation: CAD38754.1.
CCDSiCCDS34300.1.
RefSeqiNP_001026847.1. NM_001031677.3.
NP_570137.2. NM_130781.3.
UniGeneiHs.16258.

Genome annotation databases

EnsembliENST00000303251; ENSP00000304376; ENSG00000169228.
ENST00000393611; ENSP00000377235; ENSG00000169228.
GeneIDi53917.
KEGGihsa:53917.
UCSCiuc003mfv.3. human.

Polymorphism databases

DMDMi23396831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087904 mRNA. Translation: AAP97202.1 .
BT007268 mRNA. Translation: AAP35932.1 .
BC010006 mRNA. Translation: AAH10006.1 .
BC015534 mRNA. Translation: AAH15534.1 .
BC021263 mRNA. Translation: AAH21263.1 .
AL833898 mRNA. Translation: CAD38754.1 .
CCDSi CCDS34300.1.
RefSeqi NP_001026847.1. NM_001031677.3.
NP_570137.2. NM_130781.3.
UniGenei Hs.16258.

3D structure databases

ProteinModelPortali Q969Q5.
SMRi Q969Q5. Positions 9-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119817. 6 interactions.
IntActi Q969Q5. 10 interactions.
STRINGi 9606.ENSP00000304376.

PTM databases

PhosphoSitei Q969Q5.

Polymorphism databases

DMDMi 23396831.

Proteomic databases

MaxQBi Q969Q5.
PaxDbi Q969Q5.
PRIDEi Q969Q5.

Protocols and materials databases

DNASUi 53917.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303251 ; ENSP00000304376 ; ENSG00000169228 .
ENST00000393611 ; ENSP00000377235 ; ENSG00000169228 .
GeneIDi 53917.
KEGGi hsa:53917.
UCSCi uc003mfv.3. human.

Organism-specific databases

CTDi 53917.
GeneCardsi GC05M176728.
HGNCi HGNC:9765. RAB24.
MIMi 612415. gene.
neXtProti NX_Q969Q5.
PharmGKBi PA34114.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q969Q5.
KOi K07912.
OMAi FWVKELQ.
OrthoDBi EOG7B8S58.
PhylomeDBi Q969Q5.
TreeFami TF300199.

Miscellaneous databases

GenomeRNAii 53917.
NextBioi 56226.
PROi Q969Q5.
SOURCEi Search...

Gene expression databases

Bgeei Q969Q5.
CleanExi HS_RAB24.
Genevestigatori Q969Q5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a new human cDNA homology to murine Rab24 protein mRNA."
    Zhang H.L., Yu L., Ding J.B., Zhao Y., Li M.Z., Zhao S.Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas, Skin and Uterus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-203.
    Tissue: Amygdala.
  5. "Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells."
    Erdman R.A., Shellenberger K.E., Overmeyer J.H., Maltese W.A.
    J. Biol. Chem. 275:3848-3856(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION, INEFFICIENT ISOPRENYLATION, LACK OF INTERACTION WITH ARHGDIA AND ARHGDIB.
  6. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."
    Eathiraj S., Pan X., Ritacco C., Lambright D.G.
    Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFYVE20.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRAB24_HUMAN
AccessioniPrimary (citable) accession number: Q969Q5
Secondary accession number(s): Q7Z4Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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