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Protein

Ras-related protein Rab-24

Gene

RAB24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in autophagy-related processes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi120 – 1234GTPBy similarity
Nucleotide bindingi154 – 1563GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GTPase activity Source: GO_Central
  3. GTP binding Source: GO_Central

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. GTP catabolic process Source: GO_Central
  3. intracellular protein transport Source: GO_Central
  4. Rab protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-24
Gene namesi
Name:RAB24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:9765. RAB24.

Subcellular locationi

Cytoplasmcytosol 1 Publication. Membrane By similarity; Lipid-anchor By similarity
Note: Only about 20-25% is recovered in the particulate fraction.

GO - Cellular componenti

  1. autophagic vacuole Source: GO_Central
  2. cytosol Source: UniProtKB-SubCell
  3. endocytic vesicle Source: GO_Central
  4. endosome Source: GO_Central
  5. membrane Source: UniProtKB-SubCell
  6. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Ras-related protein Rab-24PRO_0000121213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity
Lipidationi201 – 2011S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Isoprenylation is inefficient compared to other Rab family members.

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiQ969Q5.
PaxDbiQ969Q5.
PRIDEiQ969Q5.

PTM databases

PhosphoSiteiQ969Q5.

Expressioni

Inductioni

By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).1 Publication

Gene expression databases

BgeeiQ969Q5.
CleanExiHS_RAB24.
ExpressionAtlasiQ969Q5. baseline.
GenevestigatoriQ969Q5.

Interactioni

Subunit structurei

Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.1 Publication

Protein-protein interaction databases

BioGridi119817. 6 interactions.
IntActiQ969Q5. 10 interactions.
STRINGi9606.ENSP00000304376.

Structurei

3D structure databases

ProteinModelPortaliQ969Q5.
SMRiQ969Q5. Positions 9-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ969Q5.
KOiK07912.
OMAiRFWVKEL.
OrthoDBiEOG7B8S58.
PhylomeDBiQ969Q5.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969Q5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGQRVDVKV VMLGKEYVGK TSLVERYVHD RFLVGPYQNT IGAAFVAKVM
60 70 80 90 100
SVGDRTVTLG IWDTAGSERY EAMSRIYYRG AKAAIVCYDL TDSSSFERAK
110 120 130 140 150
FWVKELRSLE EGCQIYLCGT KSDLLEEDRR RRRVDFHDVQ DYADNIKAQL
160 170 180 190 200
FETSSKTGQS VDELFQKVAE DYVSVAAFQV MTEDKGVDLG QKPNPYFYSC

CHH
Length:203
Mass (Da):23,124
Last modified:December 1, 2001 - v1
Checksum:i979E1AF6F7A4E5F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 562RT → AL in AAP97202. 1 PublicationCurated
Sequence conflicti108 – 1081S → T in AAP97202. 1 PublicationCurated
Sequence conflicti129 – 1302RR → QE in AAP97202. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087904 mRNA. Translation: AAP97202.1.
BT007268 mRNA. Translation: AAP35932.1.
BC010006 mRNA. Translation: AAH10006.1.
BC015534 mRNA. Translation: AAH15534.1.
BC021263 mRNA. Translation: AAH21263.1.
AL833898 mRNA. Translation: CAD38754.1.
CCDSiCCDS34300.1.
RefSeqiNP_001026847.1. NM_001031677.3.
NP_570137.2. NM_130781.3.
UniGeneiHs.16258.

Genome annotation databases

EnsembliENST00000303251; ENSP00000304376; ENSG00000169228.
ENST00000393611; ENSP00000377235; ENSG00000169228.
GeneIDi53917.
KEGGihsa:53917.
UCSCiuc003mfv.3. human.

Polymorphism databases

DMDMi23396831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087904 mRNA. Translation: AAP97202.1.
BT007268 mRNA. Translation: AAP35932.1.
BC010006 mRNA. Translation: AAH10006.1.
BC015534 mRNA. Translation: AAH15534.1.
BC021263 mRNA. Translation: AAH21263.1.
AL833898 mRNA. Translation: CAD38754.1.
CCDSiCCDS34300.1.
RefSeqiNP_001026847.1. NM_001031677.3.
NP_570137.2. NM_130781.3.
UniGeneiHs.16258.

3D structure databases

ProteinModelPortaliQ969Q5.
SMRiQ969Q5. Positions 9-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119817. 6 interactions.
IntActiQ969Q5. 10 interactions.
STRINGi9606.ENSP00000304376.

PTM databases

PhosphoSiteiQ969Q5.

Polymorphism databases

DMDMi23396831.

Proteomic databases

MaxQBiQ969Q5.
PaxDbiQ969Q5.
PRIDEiQ969Q5.

Protocols and materials databases

DNASUi53917.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303251; ENSP00000304376; ENSG00000169228.
ENST00000393611; ENSP00000377235; ENSG00000169228.
GeneIDi53917.
KEGGihsa:53917.
UCSCiuc003mfv.3. human.

Organism-specific databases

CTDi53917.
GeneCardsiGC05M176728.
HGNCiHGNC:9765. RAB24.
MIMi612415. gene.
neXtProtiNX_Q969Q5.
PharmGKBiPA34114.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ969Q5.
KOiK07912.
OMAiRFWVKEL.
OrthoDBiEOG7B8S58.
PhylomeDBiQ969Q5.
TreeFamiTF300199.

Miscellaneous databases

GenomeRNAii53917.
NextBioi56226.
PROiQ969Q5.
SOURCEiSearch...

Gene expression databases

BgeeiQ969Q5.
CleanExiHS_RAB24.
ExpressionAtlasiQ969Q5. baseline.
GenevestigatoriQ969Q5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a new human cDNA homology to murine Rab24 protein mRNA."
    Zhang H.L., Yu L., Ding J.B., Zhao Y., Li M.Z., Zhao S.Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas, Skin and Uterus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-203.
    Tissue: Amygdala.
  5. "Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells."
    Erdman R.A., Shellenberger K.E., Overmeyer J.H., Maltese W.A.
    J. Biol. Chem. 275:3848-3856(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION, INEFFICIENT ISOPRENYLATION, LACK OF INTERACTION WITH ARHGDIA AND ARHGDIB.
  6. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."
    Eathiraj S., Pan X., Ritacco C., Lambright D.G.
    Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFYVE20.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRAB24_HUMAN
AccessioniPrimary (citable) accession number: Q969Q5
Secondary accession number(s): Q7Z4Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.