Reviewed, UniProtKB/Swiss-Prot Q969Q4 (ARL11_HUMAN)

Names and origin

Protein names

Recommended name:
    ADP-ribosylation factor-like protein 11
Alternative name(s):
    ADP-ribosylation factor-like tumor suppressor protein 1

Gene names

Name:	ARL11
Synonyms:	ARLTS1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in apoptosis. May act as a tumor suppressor. Ref.1
Tissue specificity	Expressed in lung and leukocytes. Ref.1
Involvement in disease	Defects in ARL11 may be a cause of susceptibility to chronic lymphocytic leukemia (CLL) [MIM:151400]. Ref.1
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate Phosphoprotein
Gene Ontology (GO)
Biological process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Potential
	Chain	2 – 196	195	ADP-ribosylation factor-like protein 11		PRO_0000207479
Regions
	Nucleotide binding	19 – 26	8	GTP By similarity
	Nucleotide binding	63 – 67	5	GTP By similarity
	Nucleotide binding	122 – 125	4	GTP By similarity
Amino acid modifications
	Modified residue	6	1	Phosphoserine Ref.5
	Lipidation	2	1	N-myristoyl glycine Potential
Natural variations
	Natural variant	22	1	S → L Ref.1		VAR_023742
	Natural variant	120	1	L → M: dbSNP rs35712316.		VAR_048318
	Natural variant	131	1	P → L Ref.1		VAR_023743
	Natural variant	148	1	C → R: dbSNP rs3803185. Ref.1		VAR_023744
	Natural variant	164	1	E → K Ref.1		VAR_023745

Sequences

	Sequence		Length	Mass (Da)
	Q969Q4-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 99389B2A2389149E	FASTA	196	21,391
	10 20 30 40 50 60 MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP LKAPGHVSLT 70 80 90 100 110 120 LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA AELTEVLNDP NMAGVPFLVL 130 140 150 160 170 180 ANKQEAPDAL PLLKIRNRLS LERFQDHCWE LRGCSALTGE GLPEALQSLW SLLKSRSCMC 190 LQARAHGAER GDSKRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Familial cancer associated with a polymorphism in ARLTS1." Calin G.A., Trapasso F., Shimizu M., Dumitru C.D., Yendamuri S., Godwin A.K., Ferracin M., Bernardi G., Chatterjee D., Baldassarre G., Rattan S., Alder H., Mabuchi H., Shiraishi T., Hansen L.L., Overgaard J., Herlea V., Mauro F.R. , Dighiero G., Movsas B., Rassenti L., Kipps T., Baffa R., Fusco A., Mori M., Russo G., Liu C.-G., Neuberg D., Bullrich F., Negrini M., Croce C.M. N. Engl. J. Med. 352:1667-1676(2005) [PubMed: 15843669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE, VARIANTS LEU-22; LEU-131; ARG-148 AND LYS-164, FUNCTION. Tissue: Bone marrow and Spleen.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[5]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF441378 mRNA. Translation: AAP19650.1. AK091249 mRNA. Translation: BAC03621.1. AL135901 Genomic DNA. Translation: CAI40715.1. BC013150 mRNA. Translation: AAH13150.1.
IPI	IPI00056495.
RefSeq	NP_612459.1.
UniGene	Hs.558599
3D structure databases
HSSP	HSSP built from PDB template 1F6B based on UniProtKB Q9QVY3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q969Q4. 1 interaction.
PTM databases
PhosphoSite	Q969Q4.
Proteomic databases
PRIDE	Q969Q4.
Genome annotation databases
Ensembl	ENSG00000152213. Homo sapiens. [Contig view]
GeneID	115761.
KEGG	hsa:115761.
Organism-specific databases
GeneCards	GC13P049100.
H-InvDB	HIX0011318.
HGNC	HGNC:24046. ARL11.
MIM	151400. phenotype. 609351. gene.
Orphanet	67038. Leukemia, B-cell lymphocytic, chronic.
PharmGKB	PA134974627.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q969Q4.
HOVERGEN	Q969Q4.
OMA	Q969Q4. WKDYLEG.
Gene expression databases
ArrayExpress	Q969Q4.
Bgee	Q969Q4.
CleanEx	HS_ARL11.
GermOnline	ENSG00000152213. Homo sapiens.
Family and domain databases
InterPro	IPR006688. ARF. IPR006689. ARF/SAR. IPR005225. Small_GTP_bd. [Graphical view]
PANTHER	PTHR11711. ARF/SAR. 1 hit.
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00328. SAR1GTPBP.
SMART	SM00177. ARF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51417. ARF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	79678.
SOURCE	Search...

Entry information

Entry name

ARL11_HUMAN

Accession

Primary (citable) accession number: Q969Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)