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Protein

ADP-ribosylation factor-like protein 11

Gene

ARL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in apoptosis. May act as a tumor suppressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 11
Alternative name(s):
ADP-ribosylation factor-like tumor suppressor protein 1
Gene namesi
Name:ARL11
Synonyms:ARLTS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000152213.3.
HGNCiHGNC:24046. ARL11.

Subcellular locationi

Pathology & Biotechi

Involvement in diseasei

Leukemia, chronic lymphocytic (CLL)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival.
See also OMIM:151400

Organism-specific databases

DisGeNETi115761.
MalaCardsiARL11.
MIMi151400. phenotype.
OpenTargetsiENSG00000152213.
Orphaneti67038. B-cell chronic lymphocytic leukemia.
PharmGKBiPA134974627.

Polymorphism and mutation databases

BioMutaiARL11.
DMDMi74751726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074792 – 196ADP-ribosylation factor-like protein 11Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ969Q4.
PaxDbiQ969Q4.
PeptideAtlasiQ969Q4.
PRIDEiQ969Q4.

PTM databases

iPTMnetiQ969Q4.
PhosphoSitePlusiQ969Q4.

Expressioni

Tissue specificityi

Expressed in lung and leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000152213.
CleanExiHS_ARL11.
GenevisibleiQ969Q4. HS.

Organism-specific databases

HPAiHPA040855.
HPA040887.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-751892,EBI-358993

Protein-protein interaction databases

BioGridi125454. 6 interactors.
IntActiQ969Q4. 1 interactor.
MINTiMINT-1441225.
STRINGi9606.ENSP00000282026.

Structurei

3D structure databases

ProteinModelPortaliQ969Q4.
SMRiQ969Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00890000139352.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ969Q4.
KOiK07959.
OMAiWKDYLEG.
OrthoDBiEOG091G0O0X.
PhylomeDBiQ969Q4.
TreeFamiTF105471.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP
60 70 80 90 100
LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA
110 120 130 140 150
AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE
160 170 180 190
LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS
Length:196
Mass (Da):21,391
Last modified:December 1, 2001 - v1
Checksum:i99389B2A2389149E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02374222S → L1 PublicationCorresponds to variant dbSNP:rs147389782Ensembl.1
Natural variantiVAR_048318120L → M. Corresponds to variant dbSNP:rs35712316Ensembl.1
Natural variantiVAR_023743131P → L1 PublicationCorresponds to variant dbSNP:rs147120792Ensembl.1
Natural variantiVAR_023744148C → R1 PublicationCorresponds to variant dbSNP:rs3803185Ensembl.1
Natural variantiVAR_023745164E → K1 PublicationCorresponds to variant dbSNP:rs146850453Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441378 mRNA. Translation: AAP19650.1.
AK091249 mRNA. Translation: BAC03621.1.
AL135901 Genomic DNA. No translation available.
BC013150 mRNA. Translation: AAH13150.1.
CCDSiCCDS9419.1.
RefSeqiNP_612459.1. NM_138450.5.
XP_005266310.1. XM_005266253.3.
UniGeneiHs.558599.

Genome annotation databases

EnsembliENST00000282026; ENSP00000282026; ENSG00000152213.
GeneIDi115761.
KEGGihsa:115761.
UCSCiuc001vdf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARL11_HUMAN
AccessioniPrimary (citable) accession number: Q969Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families