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Protein

ADP-ribosylation factor-like protein 11

Gene

ARL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in apoptosis. May act as a tumor suppressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi122 – 1254GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 11
Alternative name(s):
ADP-ribosylation factor-like tumor suppressor protein 1
Gene namesi
Name:ARL11
Synonyms:ARLTS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:24046. ARL11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Leukemia, chronic lymphocytic (CLL)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival.
See also OMIM:151400

Organism-specific databases

MalaCardsiARL11.
MIMi151400. phenotype.
Orphaneti67038. B-cell chronic lymphocytic leukemia.
PharmGKBiPA134974627.

Polymorphism and mutation databases

BioMutaiARL11.
DMDMi74751726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 196195ADP-ribosylation factor-like protein 11PRO_0000207479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ969Q4.
PaxDbiQ969Q4.
PRIDEiQ969Q4.

PTM databases

iPTMnetiQ969Q4.
PhosphoSiteiQ969Q4.

Expressioni

Tissue specificityi

Expressed in lung and leukocytes.1 Publication

Gene expression databases

BgeeiQ969Q4.
CleanExiHS_ARL11.
GenevisibleiQ969Q4. HS.

Organism-specific databases

HPAiHPA040855.
HPA040887.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-751892,EBI-358993

Protein-protein interaction databases

BioGridi125454. 5 interactions.
IntActiQ969Q4. 1 interaction.
MINTiMINT-1441225.
STRINGi9606.ENSP00000282026.

Structurei

3D structure databases

ProteinModelPortaliQ969Q4.
SMRiQ969Q4. Positions 14-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ969Q4.
KOiK07959.
OMAiWKDYLEG.
OrthoDBiEOG7PP583.
PhylomeDBiQ969Q4.
TreeFamiTF105471.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP
60 70 80 90 100
LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA
110 120 130 140 150
AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE
160 170 180 190
LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS
Length:196
Mass (Da):21,391
Last modified:December 1, 2001 - v1
Checksum:i99389B2A2389149E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221S → L.1 Publication
Corresponds to variant rs147389782 [ dbSNP | Ensembl ].
VAR_023742
Natural varianti120 – 1201L → M.
Corresponds to variant rs35712316 [ dbSNP | Ensembl ].
VAR_048318
Natural varianti131 – 1311P → L.1 Publication
Corresponds to variant rs147120792 [ dbSNP | Ensembl ].
VAR_023743
Natural varianti148 – 1481C → R.1 Publication
Corresponds to variant rs3803185 [ dbSNP | Ensembl ].
VAR_023744
Natural varianti164 – 1641E → K.1 Publication
VAR_023745

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441378 mRNA. Translation: AAP19650.1.
AK091249 mRNA. Translation: BAC03621.1.
AL135901 Genomic DNA. Translation: CAI40715.1.
BC013150 mRNA. Translation: AAH13150.1.
CCDSiCCDS9419.1.
RefSeqiNP_612459.1. NM_138450.5.
XP_005266310.1. XM_005266253.2.
UniGeneiHs.558599.

Genome annotation databases

EnsembliENST00000282026; ENSP00000282026; ENSG00000152213.
GeneIDi115761.
KEGGihsa:115761.
UCSCiuc001vdf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441378 mRNA. Translation: AAP19650.1.
AK091249 mRNA. Translation: BAC03621.1.
AL135901 Genomic DNA. Translation: CAI40715.1.
BC013150 mRNA. Translation: AAH13150.1.
CCDSiCCDS9419.1.
RefSeqiNP_612459.1. NM_138450.5.
XP_005266310.1. XM_005266253.2.
UniGeneiHs.558599.

3D structure databases

ProteinModelPortaliQ969Q4.
SMRiQ969Q4. Positions 14-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125454. 5 interactions.
IntActiQ969Q4. 1 interaction.
MINTiMINT-1441225.
STRINGi9606.ENSP00000282026.

PTM databases

iPTMnetiQ969Q4.
PhosphoSiteiQ969Q4.

Polymorphism and mutation databases

BioMutaiARL11.
DMDMi74751726.

Proteomic databases

EPDiQ969Q4.
PaxDbiQ969Q4.
PRIDEiQ969Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282026; ENSP00000282026; ENSG00000152213.
GeneIDi115761.
KEGGihsa:115761.
UCSCiuc001vdf.2. human.

Organism-specific databases

CTDi115761.
GeneCardsiARL11.
HGNCiHGNC:24046. ARL11.
HPAiHPA040855.
HPA040887.
MalaCardsiARL11.
MIMi151400. phenotype.
609351. gene.
neXtProtiNX_Q969Q4.
Orphaneti67038. B-cell chronic lymphocytic leukemia.
PharmGKBiPA134974627.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ969Q4.
KOiK07959.
OMAiWKDYLEG.
OrthoDBiEOG7PP583.
PhylomeDBiQ969Q4.
TreeFamiTF105471.

Miscellaneous databases

ChiTaRSiARL11. human.
GeneWikiiARL11.
GenomeRNAii115761.
NextBioi79678.
PROiQ969Q4.
SOURCEiSearch...

Gene expression databases

BgeeiQ969Q4.
CleanExiHS_ARL11.
GenevisibleiQ969Q4. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE, VARIANTS LEU-22; LEU-131; ARG-148 AND LYS-164, FUNCTION.
    Tissue: Bone marrow and Spleen.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.

Entry informationi

Entry nameiARL11_HUMAN
AccessioniPrimary (citable) accession number: Q969Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.