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Q969Q0

- RL36L_HUMAN

UniProt

Q969Q0 - RL36L_HUMAN

Protein

60S ribosomal protein L36a-like

Gene

RPL36AL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L36a-like
    Gene namesi
    Name:RPL36AL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:10346. RPL36AL.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34732.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10610660S ribosomal protein L36a-likePRO_0000149118Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 531N6-methyllysine1 Publication

    Keywords - PTMi

    Methylation

    Proteomic databases

    MaxQBiQ969Q0.
    PaxDbiQ969Q0.
    PRIDEiQ969Q0.

    PTM databases

    PhosphoSiteiQ969Q0.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    BgeeiQ969Q0.
    CleanExiHS_RPL36AL.
    GenevestigatoriQ969Q0.

    Interactioni

    Protein-protein interaction databases

    BioGridi112085. 7 interactions.
    IntActiQ969Q0. 8 interactions.
    MINTiMINT-4829931.
    STRINGi9606.ENSP00000346012.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969Q0.
    SMRiQ969Q0. Positions 2-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L44e family.Curated

    Phylogenomic databases

    eggNOGiCOG1631.
    HOGENOMiHOG000224989.
    HOVERGENiHBG056127.
    InParanoidiQ969Q0.
    KOiK02929.
    OMAiYKGGKRR.
    OrthoDBiEOG7D59R2.
    PhylomeDBiQ969Q0.
    TreeFamiTF300213.

    Family and domain databases

    Gene3Di3.10.450.80. 1 hit.
    InterProiIPR000552. Ribosomal_L44e.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view]
    PANTHERiPTHR10369. PTHR10369. 1 hit.
    PfamiPF00935. Ribosomal_L44. 1 hit.
    [Graphical view]
    ProDomiPD002841. Ribosomal_L44e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57829. SSF57829. 1 hit.
    PROSITEiPS01172. RIBOSOMAL_L44E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q969Q0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGRRR YDRKQSGYGG    50
    QTKPIFRKKA KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK 100
    GQVIQF 106
    Length:106
    Mass (Da):12,469
    Last modified:January 23, 2007 - v3
    Checksum:i9C0E08264A578D31
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661I → V.
    Corresponds to variant rs3088024 [ dbSNP | Ensembl ].
    VAR_051809

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15661 mRNA. Translation: AAA36589.1.
    AB063609 mRNA. Translation: BAC19836.1.
    CR542166 mRNA. Translation: CAG46963.1.
    BC000741 mRNA. Translation: AAH00741.1.
    BC003145 mRNA. Translation: AAH03145.1.
    BC070207 mRNA. Translation: AAH70207.1.
    BC107716 mRNA. Translation: AAI07717.1.
    CCDSiCCDS9689.1.
    PIRiA25560. R6HU36.
    RefSeqiNP_000992.1. NM_001001.4.
    UniGeneiHs.444749.
    Hs.745129.

    Genome annotation databases

    EnsembliENST00000298289; ENSP00000346012; ENSG00000165502.
    GeneIDi6166.
    KEGGihsa:6166.
    UCSCiuc001wwq.2. human.

    Polymorphism databases

    DMDMi57013007.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15661 mRNA. Translation: AAA36589.1 .
    AB063609 mRNA. Translation: BAC19836.1 .
    CR542166 mRNA. Translation: CAG46963.1 .
    BC000741 mRNA. Translation: AAH00741.1 .
    BC003145 mRNA. Translation: AAH03145.1 .
    BC070207 mRNA. Translation: AAH70207.1 .
    BC107716 mRNA. Translation: AAI07717.1 .
    CCDSi CCDS9689.1.
    PIRi A25560. R6HU36.
    RefSeqi NP_000992.1. NM_001001.4.
    UniGenei Hs.444749.
    Hs.745129.

    3D structure databases

    ProteinModelPortali Q969Q0.
    SMRi Q969Q0. Positions 2-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112085. 7 interactions.
    IntActi Q969Q0. 8 interactions.
    MINTi MINT-4829931.
    STRINGi 9606.ENSP00000346012.

    PTM databases

    PhosphoSitei Q969Q0.

    Polymorphism databases

    DMDMi 57013007.

    Proteomic databases

    MaxQBi Q969Q0.
    PaxDbi Q969Q0.
    PRIDEi Q969Q0.

    Protocols and materials databases

    DNASUi 6166.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298289 ; ENSP00000346012 ; ENSG00000165502 .
    GeneIDi 6166.
    KEGGi hsa:6166.
    UCSCi uc001wwq.2. human.

    Organism-specific databases

    CTDi 6166.
    GeneCardsi GC14M050086.
    HGNCi HGNC:10346. RPL36AL.
    MIMi 180469. gene.
    neXtProti NX_Q969Q0.
    PharmGKBi PA34732.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1631.
    HOGENOMi HOG000224989.
    HOVERGENi HBG056127.
    InParanoidi Q969Q0.
    KOi K02929.
    OMAi YKGGKRR.
    OrthoDBi EOG7D59R2.
    PhylomeDBi Q969Q0.
    TreeFami TF300213.

    Miscellaneous databases

    GenomeRNAii 6166.
    NextBioi 23953.
    PROi Q969Q0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q969Q0.
    CleanExi HS_RPL36AL.
    Genevestigatori Q969Q0.

    Family and domain databases

    Gene3Di 3.10.450.80. 1 hit.
    InterProi IPR000552. Ribosomal_L44e.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view ]
    PANTHERi PTHR10369. PTHR10369. 1 hit.
    Pfami PF00935. Ribosomal_L44. 1 hit.
    [Graphical view ]
    ProDomi PD002841. Ribosomal_L44e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57829. SSF57829. 1 hit.
    PROSITEi PS01172. RIBOSOMAL_L44E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein."
      Davies M.S., Henney A., Ward W.H.J., Craig R.K.
      Gene 45:183-191(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes."
      Uechi T., Maeda N., Tanaka T., Kenmochi N.
      Nucleic Acids Res. 30:5369-5375(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Skeletal muscle.
    5. Bienvenut W.V., Vousden K.H., Lukashchuk N.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 29-38 AND 100-106, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Lung carcinoma.
    6. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 45-57; 70-78 AND 100-106, METHYLATION AT LYS-53, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRL36L_HUMAN
    AccessioniPrimary (citable) accession number: Q969Q0
    Secondary accession number(s): Q3B7A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene has no introns in its coding regions, and therefore, was most likely produced by retrotransposition of the original X-linked gene during evolution.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3