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Protein

60S ribosomal protein L36a-like

Gene

RPL36AL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36a-like
Gene namesi
Name:RPL36AL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:10346. RPL36AL.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10610660S ribosomal protein L36a-likePRO_0000149118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531N6-methyllysine1 Publication

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ969Q0.
PaxDbiQ969Q0.
PRIDEiQ969Q0.

PTM databases

PhosphoSiteiQ969Q0.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ969Q0.
CleanExiHS_RPL36AL.
ExpressionAtlasiQ969Q0. baseline and differential.
GenevestigatoriQ969Q0.

Interactioni

Protein-protein interaction databases

BioGridi112085. 18 interactions.
IntActiQ969Q0. 8 interactions.
MINTiMINT-4829931.
STRINGi9606.ENSP00000346012.

Structurei

3D structure databases

ProteinModelPortaliQ969Q0.
SMRiQ969Q0. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L44e family.Curated

Phylogenomic databases

eggNOGiCOG1631.
GeneTreeiENSGT00390000018085.
HOGENOMiHOG000224989.
HOVERGENiHBG056127.
InParanoidiQ969Q0.
KOiK02929.
OMAiMTNISIF.
OrthoDBiEOG7D59R2.
PhylomeDBiQ969Q0.
TreeFamiTF300213.

Family and domain databases

Gene3Di3.10.450.80. 1 hit.
InterProiIPR000552. Ribosomal_L44e.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PANTHERiPTHR10369. PTHR10369. 1 hit.
PfamiPF00935. Ribosomal_L44. 1 hit.
[Graphical view]
ProDomiPD002841. Ribosomal_L44e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01172. RIBOSOMAL_L44E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGRRR YDRKQSGYGG
60 70 80 90 100
QTKPIFRKKA KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK

GQVIQF
Length:106
Mass (Da):12,469
Last modified:January 22, 2007 - v3
Checksum:i9C0E08264A578D31
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661I → V.
Corresponds to variant rs3088024 [ dbSNP | Ensembl ].
VAR_051809

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15661 mRNA. Translation: AAA36589.1.
AB063609 mRNA. Translation: BAC19836.1.
CR542166 mRNA. Translation: CAG46963.1.
BC000741 mRNA. Translation: AAH00741.1.
BC003145 mRNA. Translation: AAH03145.1.
BC070207 mRNA. Translation: AAH70207.1.
BC107716 mRNA. Translation: AAI07717.1.
CCDSiCCDS9689.1.
PIRiA25560. R6HU36.
RefSeqiNP_000992.1. NM_001001.4.
UniGeneiHs.444749.
Hs.745129.

Genome annotation databases

EnsembliENST00000298289; ENSP00000346012; ENSG00000165502.
GeneIDi6166.
KEGGihsa:6166.
UCSCiuc001wwq.2. human.

Polymorphism databases

DMDMi57013007.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15661 mRNA. Translation: AAA36589.1.
AB063609 mRNA. Translation: BAC19836.1.
CR542166 mRNA. Translation: CAG46963.1.
BC000741 mRNA. Translation: AAH00741.1.
BC003145 mRNA. Translation: AAH03145.1.
BC070207 mRNA. Translation: AAH70207.1.
BC107716 mRNA. Translation: AAI07717.1.
CCDSiCCDS9689.1.
PIRiA25560. R6HU36.
RefSeqiNP_000992.1. NM_001001.4.
UniGeneiHs.444749.
Hs.745129.

3D structure databases

ProteinModelPortaliQ969Q0.
SMRiQ969Q0. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112085. 18 interactions.
IntActiQ969Q0. 8 interactions.
MINTiMINT-4829931.
STRINGi9606.ENSP00000346012.

PTM databases

PhosphoSiteiQ969Q0.

Polymorphism databases

DMDMi57013007.

Proteomic databases

MaxQBiQ969Q0.
PaxDbiQ969Q0.
PRIDEiQ969Q0.

Protocols and materials databases

DNASUi6166.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298289; ENSP00000346012; ENSG00000165502.
GeneIDi6166.
KEGGihsa:6166.
UCSCiuc001wwq.2. human.

Organism-specific databases

CTDi6166.
GeneCardsiGC14M050086.
HGNCiHGNC:10346. RPL36AL.
MIMi180469. gene.
neXtProtiNX_Q969Q0.
PharmGKBiPA34732.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1631.
GeneTreeiENSGT00390000018085.
HOGENOMiHOG000224989.
HOVERGENiHBG056127.
InParanoidiQ969Q0.
KOiK02929.
OMAiMTNISIF.
OrthoDBiEOG7D59R2.
PhylomeDBiQ969Q0.
TreeFamiTF300213.

Miscellaneous databases

GenomeRNAii6166.
NextBioi23953.
PROiQ969Q0.
SOURCEiSearch...

Gene expression databases

BgeeiQ969Q0.
CleanExiHS_RPL36AL.
ExpressionAtlasiQ969Q0. baseline and differential.
GenevestigatoriQ969Q0.

Family and domain databases

Gene3Di3.10.450.80. 1 hit.
InterProiIPR000552. Ribosomal_L44e.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PANTHERiPTHR10369. PTHR10369. 1 hit.
PfamiPF00935. Ribosomal_L44. 1 hit.
[Graphical view]
ProDomiPD002841. Ribosomal_L44e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01172. RIBOSOMAL_L44E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein."
    Davies M.S., Henney A., Ward W.H.J., Craig R.K.
    Gene 45:183-191(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes."
    Uechi T., Maeda N., Tanaka T., Kenmochi N.
    Nucleic Acids Res. 30:5369-5375(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Skeletal muscle.
  5. Bienvenut W.V., Vousden K.H., Lukashchuk N.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 29-38 AND 100-106, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Lung carcinoma.
  6. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (FEB-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 45-57; 70-78 AND 100-106, METHYLATION AT LYS-53, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRL36L_HUMAN
AccessioniPrimary (citable) accession number: Q969Q0
Secondary accession number(s): Q3B7A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 3, 2005
Last sequence update: January 22, 2007
Last modified: February 3, 2015
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene has no introns in its coding regions, and therefore, was most likely produced by retrotransposition of the original X-linked gene during evolution.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.