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Protein

60S ribosomal protein L36a-like

Gene

RPL36AL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene has no introns in its coding regions, and therefore, was most likely produced by retrotransposition of the original X-linked gene during evolution.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36a-like
Alternative name(s):
Large ribosomal subunit protein eL42-like
Gene namesi
Name:RPL36AL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165502.6
HGNCiHGNC:10346 RPL36AL
MIMi180469 gene
neXtProtiNX_Q969Q0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6166
OpenTargetsiENSG00000165502
PharmGKBiPA34732

Polymorphism and mutation databases

DMDMi57013007

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491181 – 10660S ribosomal protein L36a-likeAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-methyllysine1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ969Q0
MaxQBiQ969Q0
PeptideAtlasiQ969Q0
PRIDEiQ969Q0
TopDownProteomicsiQ969Q0

PTM databases

iPTMnetiQ969Q0
PhosphoSitePlusiQ969Q0
SwissPalmiQ969Q0

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000165502
CleanExiHS_RPL36AL
GenevisibleiQ969Q0 HS

Organism-specific databases

HPAiHPA077586

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-2877705,EBI-10172290

Protein-protein interaction databases

BioGridi112085, 77 interactors
IntActiQ969Q0, 11 interactors
MINTiQ969Q0

Structurei

3D structure databases

ProteinModelPortaliQ969Q0
SMRiQ969Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3464 Eukaryota
COG1631 LUCA
GeneTreeiENSGT00390000018085
HOGENOMiHOG000224989
HOVERGENiHBG056127
InParanoidiQ969Q0
KOiK02929
OMAiYGGFPRP
OrthoDBiEOG091G12JU
PhylomeDBiQ969Q0
TreeFamiTF300213

Family and domain databases

InterProiView protein in InterPro
IPR000552 Ribosomal_L44e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR10369 PTHR10369, 1 hit
PfamiView protein in Pfam
PF00935 Ribosomal_L44, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002841 Ribosomal_L44e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS01172 RIBOSOMAL_L44E, 1 hit

Sequencei

Sequence statusi: Complete.

Q969Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGRRR YDRKQSGYGG
60 70 80 90 100
QTKPIFRKKA KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK

GQVIQF
Length:106
Mass (Da):12,469
Last modified:January 23, 2007 - v3
Checksum:i9C0E08264A578D31
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05180966I → V. Corresponds to variant dbSNP:rs3088024Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15661 mRNA Translation: AAA36589.1
AB063609 mRNA Translation: BAC19836.1
CR542166 mRNA Translation: CAG46963.1
BC000741 mRNA Translation: AAH00741.1
BC003145 mRNA Translation: AAH03145.1
BC070207 mRNA Translation: AAH70207.1
BC107716 mRNA Translation: AAI07717.1
CCDSiCCDS9689.1
PIRiA25560 R6HU36
RefSeqiNP_000992.1, NM_001001.4
UniGeneiHs.444749
Hs.745129

Genome annotation databases

EnsembliENST00000298289; ENSP00000346012; ENSG00000165502
GeneIDi6166
KEGGihsa:6166
UCSCiuc001wwq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRL36L_HUMAN
AccessioniPrimary (citable) accession number: Q969Q0
Secondary accession number(s): Q3B7A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

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