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Q969P0

- IGSF8_HUMAN

UniProt

Q969P0 - IGSF8_HUMAN

Protein

Immunoglobulin superfamily member 8

Gene

IGSF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.5 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. cellular component movement Source: UniProtKB
    3. nervous system development Source: UniProtKB
    4. single fertilization Source: UniProtKB
    5. skeletal muscle tissue development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin superfamily member 8
    Short name:
    IgSF8
    Alternative name(s):
    CD81 partner 3
    Glu-Trp-Ile EWI motif-containing protein 2
    Short name:
    EWI-2
    Keratinocytes-associated transmembrane protein 4
    Short name:
    KCT-4
    LIR-D1
    Prostaglandin regulatory-like protein
    Short name:
    PGRL
    CD_antigen: CD316
    Gene namesi
    Name:IGSF8
    Synonyms:CD81P3, EWI2, KCT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17813. IGSF8.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB
    3. membrane Source: UniProtKB
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29767.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 613586Immunoglobulin superfamily member 8PRO_0000226247Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 127PROSITE-ProRule annotation
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi186 ↔ 270PROSITE-ProRule annotation
    Disulfide bondi326 ↔ 406PROSITE-ProRule annotation
    Glycosylationi327 – 3271N-linked (GlcNAc...)1 Publication
    Disulfide bondi462 ↔ 544PROSITE-ProRule annotation
    Glycosylationi463 – 4631N-linked (GlcNAc...)1 Publication
    Lipidationi604 – 6041S-palmitoyl cysteineBy similarity
    Lipidationi605 – 6051S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiQ969P0.
    PaxDbiQ969P0.
    PRIDEiQ969P0.

    2D gel databases

    UCD-2DPAGEQ969P0.

    PTM databases

    PhosphoSiteiQ969P0.

    Expressioni

    Tissue specificityi

    Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.3 Publications

    Gene expression databases

    ArrayExpressiQ969P0.
    BgeeiQ969P0.
    CleanExiHS_IGSF8.
    GenevestigatoriQ969P0.

    Organism-specific databases

    HPAiHPA011917.

    Interactioni

    Subunit structurei

    Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1.4 Publications

    Protein-protein interaction databases

    BioGridi125011. 164 interactions.
    IntActiQ969P0. 1 interaction.
    MINTiMINT-4536413.
    STRINGi9606.ENSP00000316664.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969P0.
    SMRiQ969P0. Positions 29-65, 108-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 579552ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini601 – 61313CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei580 – 60021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 149122Ig-like C2-type 1Add
    BLAST
    Domaini162 – 286125Ig-like C2-type 2Add
    BLAST
    Domaini303 – 424122Ig-like C2-type 3Add
    BLAST
    Domaini431 – 560130Ig-like C2-type 4Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi274 – 2763EWI motif

    Domaini

    The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.By similarity
    The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG28691.
    HOGENOMiHOG000113020.
    HOVERGENiHBG073047.
    InParanoidiQ969P0.
    KOiK06730.
    OMAiVTCCFMK.
    OrthoDBiEOG7H791Z.
    PhylomeDBiQ969P0.
    TreeFamiTF332702.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 4 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969P0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGALRPTLLP PSLPLLLLLM LGMGCWAREV LVPEGPLYRV AGTAVSISCN    50
    VTGYEGPAQQ NFEWFLYRPE APDTALGIVS TKDTQFSYAV FKSRVVAGEV 100
    QVQRLQGDAV VLKIARLQAQ DAGIYECHTP STDTRYLGSY SGKVELRVLP 150
    DVLQVSAAPP GPRGRQAPTS PPRMTVHEGQ ELALGCLART STQKHTHLAV 200
    SFGRSVPEAP VGRSTLQEVV GIRSDLAVEA GAPYAERLAA GELRLGKEGT 250
    DRYRMVVGGA QAGDAGTYHC TAAEWIQDPD GSWAQIAEKR AVLAHVDVQT 300
    LSSQLAVTVG PGERRIGPGE PLELLCNVSG ALPPAGRHAA YSVGWEMAPA 350
    GAPGPGRLVA QLDTEGVGSL GPGYEGRHIA MEKVASRTYR LRLEAARPGD 400
    AGTYRCLAKA YVRGSGTRLR EAASARSRPL PVHVREEGVV LEAVAWLAGG 450
    TVYRGETASL LCNISVRGGP PGLRLAASWW VERPEDGELS SVPAQLVGGV 500
    GQDGVAELGV RPGGGPVSVE LVGPRSHRLR LHSLGPEDEG VYHCAPSAWV 550
    QHADYSWYQA GSARSGPVTV YPYMHALDTL FVPLLVGTGV ALVTGATVLG 600
    TITCCFMKRL RKR 613
    Length:613
    Mass (Da):65,034
    Last modified:December 1, 2001 - v1
    Checksum:iA7255D54D42EFB88
    GO
    Isoform 2 (identifier: Q969P0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-241: Missing.
         242-315: ELRLGKEGTD...AVTVGPGERR → MRGRSWHWAA...GSFVWARKGP

    Note: No experimental confirmation available.

    Show »
    Length:372
    Mass (Da):40,191
    Checksum:i4872C8D6CC303638
    GO
    Isoform 3 (identifier: Q969P0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         475-561: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:526
    Mass (Da):55,808
    Checksum:iC2A88D773A4F4802
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti303 – 3031S → R in AAM94901. 1 PublicationCurated
    Sequence conflicti306 – 3061A → P in AAM94901. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 241241Missing in isoform 2. 1 PublicationVSP_017429Add
    BLAST
    Alternative sequencei242 – 31574ELRLG…PGERR → MRGRSWHWAAWRGQAHRSTH TWQCPLGDLCPRHQLGGQLC RKWWESGQTWPWRLELPMLS DWLQGSFVWARKGP in isoform 2. 1 PublicationVSP_017430Add
    BLAST
    Alternative sequencei475 – 56187Missing in isoform 3. 1 PublicationVSP_017431Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF407274 mRNA. Translation: AAL01052.1.
    AY044845 mRNA. Translation: AAK92220.1.
    AY157579 mRNA. Translation: AAO13163.1.
    AF311906 mRNA. Translation: AAM94901.1.
    AK055843 mRNA. Translation: BAB71027.1.
    BC004108 mRNA. Translation: AAH04108.2.
    BC053881 mRNA. Translation: AAH53881.1.
    CCDSiCCDS1195.1. [Q969P0-1]
    RefSeqiNP_001193594.1. NM_001206665.2. [Q969P0-1]
    NP_443100.1. NM_052868.4. [Q969P0-1]
    XP_005245671.1. XM_005245614.1. [Q969P0-1]
    UniGeneiHs.332012.

    Genome annotation databases

    EnsembliENST00000314485; ENSP00000316664; ENSG00000162729. [Q969P0-1]
    ENST00000368086; ENSP00000357065; ENSG00000162729. [Q969P0-1]
    GeneIDi93185.
    KEGGihsa:93185.
    UCSCiuc001fuz.3. human. [Q969P0-1]

    Polymorphism databases

    DMDMi74762642.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF407274 mRNA. Translation: AAL01052.1 .
    AY044845 mRNA. Translation: AAK92220.1 .
    AY157579 mRNA. Translation: AAO13163.1 .
    AF311906 mRNA. Translation: AAM94901.1 .
    AK055843 mRNA. Translation: BAB71027.1 .
    BC004108 mRNA. Translation: AAH04108.2 .
    BC053881 mRNA. Translation: AAH53881.1 .
    CCDSi CCDS1195.1. [Q969P0-1 ]
    RefSeqi NP_001193594.1. NM_001206665.2. [Q969P0-1 ]
    NP_443100.1. NM_052868.4. [Q969P0-1 ]
    XP_005245671.1. XM_005245614.1. [Q969P0-1 ]
    UniGenei Hs.332012.

    3D structure databases

    ProteinModelPortali Q969P0.
    SMRi Q969P0. Positions 29-65, 108-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125011. 164 interactions.
    IntActi Q969P0. 1 interaction.
    MINTi MINT-4536413.
    STRINGi 9606.ENSP00000316664.

    PTM databases

    PhosphoSitei Q969P0.

    Polymorphism databases

    DMDMi 74762642.

    2D gel databases

    UCD-2DPAGE Q969P0.

    Proteomic databases

    MaxQBi Q969P0.
    PaxDbi Q969P0.
    PRIDEi Q969P0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314485 ; ENSP00000316664 ; ENSG00000162729 . [Q969P0-1 ]
    ENST00000368086 ; ENSP00000357065 ; ENSG00000162729 . [Q969P0-1 ]
    GeneIDi 93185.
    KEGGi hsa:93185.
    UCSCi uc001fuz.3. human. [Q969P0-1 ]

    Organism-specific databases

    CTDi 93185.
    GeneCardsi GC01M160061.
    HGNCi HGNC:17813. IGSF8.
    HPAi HPA011917.
    MIMi 606644. gene.
    neXtProti NX_Q969P0.
    PharmGKBi PA29767.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28691.
    HOGENOMi HOG000113020.
    HOVERGENi HBG073047.
    InParanoidi Q969P0.
    KOi K06730.
    OMAi VTCCFMK.
    OrthoDBi EOG7H791Z.
    PhylomeDBi Q969P0.
    TreeFami TF332702.

    Miscellaneous databases

    ChiTaRSi IGSF8. human.
    GeneWikii IGSF8.
    GenomeRNAii 93185.
    NextBioi 78023.
    PROi Q969P0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969P0.
    Bgeei Q969P0.
    CleanExi HS_IGSF8.
    Genevestigatori Q969P0.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 4 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily."
      Stipp C.S., Kolesnikova T.V., Hemler M.E.
      J. Biol. Chem. 276:40545-40554(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CD81 AND CD9.
    2. "EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells."
      Charrin S., Le Naour F., Labas V., Billard M., Le Caer J.-P., Emile J.-F., Petit M.-A., Boucheix C., Rubinstein E.
      Biochem. J. 373:409-421(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
    3. "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes."
      Bonkobara M., Das A., Takao J., Cruz P.D. Jr., Ariizumi K.
      Br. J. Dermatol. 148:654-664(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    4. "Identification of novel membrane proteins."
      Zhang W., Li N., Wan T., Cao X.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph.
    7. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
      Xu G., Shin S.B., Jaffrey S.R.
      Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 28-40.
      Tissue: Leukemic T-cell.
    8. "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells."
      Zhang X.A., Lane W.S., Charrin S., Rubinstein E., Liu L.
      Cancer Res. 63:2665-2674(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CD82, IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
    9. "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5."
      Stipp C.S., Kolesnikova T.V., Hemler M.E.
      J. Cell Biol. 163:1167-1177(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH INTEGRIN ALPHA-3 BETA-1.
    10. "EWI-2 modulates lymphocyte integrin alpha4beta1 functions."
      Kolesnikova T.V., Stipp C.S., Rao R.M., Lane W.S., Luscinskas F.W., Hemler M.E.
      Blood 103:3013-3019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH INTEGRIN ALPHA-4 BETA-1.
    11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-327 AND ASN-463.
      Tissue: Liver.

    Entry informationi

    Entry nameiIGSF8_HUMAN
    AccessioniPrimary (citable) accession number: Q969P0
    Secondary accession number(s): Q8NG09, Q96DP4, Q9BTG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3