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Protein

Trace amine-associated receptor 8

Gene

TAAR8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB
  • trace-amine receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16983. Amine ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 8
Short name:
TaR-8
Short name:
Trace amine receptor 8
Alternative name(s):
G-protein coupled receptor 102
Trace amine receptor 5
Short name:
TaR-5
Gene namesi
Name:TAAR8
Synonyms:GPR102, TA5, TAR5, TRAR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14964. TAAR8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 6715CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini89 – 11123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini133 – 14614CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini168 – 19528ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 25842CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei259 – 27921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini280 – 2801ExtracellularSequence Analysis
Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini302 – 34241CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28850.

Polymorphism and mutation databases

BioMutaiTAAR8.
DMDMi38258876.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Trace amine-associated receptor 8PRO_0000070174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ969N4.
PRIDEiQ969N4.

PTM databases

PhosphoSiteiQ969N4.

Expressioni

Tissue specificityi

Expressed in kidney and amygdala. Not expressed in other tissues or brain regions tested.1 Publication

Gene expression databases

BgeeiQ969N4.
CleanExiHS_TAAR8.
GenevisibleiQ969N4. HS.

Interactioni

Protein-protein interaction databases

IntActiQ969N4. 1 interaction.
STRINGi9606.ENSP00000275200.

Structurei

3D structure databases

ProteinModelPortaliQ969N4.
SMRiQ969N4. Positions 43-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288345.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ969N4.
KOiK05051.
OMAiSSTICIF.
OrthoDBiEOG7966GS.
PhylomeDBiQ969N4.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNFSQPVV QLCYEDVNGS CIETPYSPGS RVILYTAFSF GSLLAVFGNL
60 70 80 90 100
LVMTSVLHFK QLHSPTNFLI ASLACADFLV GVTVMLFSMV RTVESCWYFG
110 120 130 140 150
AKFCTLHSCC DVAFCYSSVL HLCFICIDRY IVVTDPLVYA TKFTVSVSGI
160 170 180 190 200
CISVSWILPL TYSGAVFYTG VNDDGLEELV SALNCVGGCQ IIVSQGWVLI
210 220 230 240 250
DFLLFFIPTL VMIILYSKIF LIAKQQAIKI ETTSSKVESS SESYKIRVAK
260 270 280 290 300
RERKAAKTLG VTVLAFVISW LPYTVDILID AFMGFLTPAY IYEICCWSAY
310 320 330 340
YNSAMNPLIY ALFYPWFRKA IKLILSGDVL KASSSTISLF LE
Length:342
Mass (Da):38,029
Last modified:December 1, 2001 - v1
Checksum:iAB034E68F7D60388
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531S → N.
Corresponds to variant rs8192626 [ dbSNP | Ensembl ].
VAR_049447
Natural varianti211 – 2111V → D.1 Publication
Corresponds to variant rs187426282 [ dbSNP | Ensembl ].
VAR_066638
Natural varianti328 – 3281D → A.
Corresponds to variant rs8192627 [ dbSNP | Ensembl ].
VAR_049448

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380193 Genomic DNA. Translation: AAK71244.1.
AF411116 Genomic DNA. Translation: AAL26487.1.
AY183468 mRNA. Translation: AAO24659.1.
AL513524 Genomic DNA. Translation: CAH72098.1.
BC069166 mRNA. Translation: AAH69166.1.
CCDSiCCDS5154.1.
RefSeqiNP_444508.1. NM_053278.1.
UniGeneiHs.350571.

Genome annotation databases

EnsembliENST00000275200; ENSP00000275200; ENSG00000146385.
GeneIDi83551.
KEGGihsa:83551.
UCSCiuc011ecj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380193 Genomic DNA. Translation: AAK71244.1.
AF411116 Genomic DNA. Translation: AAL26487.1.
AY183468 mRNA. Translation: AAO24659.1.
AL513524 Genomic DNA. Translation: CAH72098.1.
BC069166 mRNA. Translation: AAH69166.1.
CCDSiCCDS5154.1.
RefSeqiNP_444508.1. NM_053278.1.
UniGeneiHs.350571.

3D structure databases

ProteinModelPortaliQ969N4.
SMRiQ969N4. Positions 43-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ969N4. 1 interaction.
STRINGi9606.ENSP00000275200.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ969N4.

Polymorphism and mutation databases

BioMutaiTAAR8.
DMDMi38258876.

Proteomic databases

PaxDbiQ969N4.
PRIDEiQ969N4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275200; ENSP00000275200; ENSG00000146385.
GeneIDi83551.
KEGGihsa:83551.
UCSCiuc011ecj.2. human.

Organism-specific databases

CTDi83551.
GeneCardsiGC06P132916.
HGNCiHGNC:14964. TAAR8.
MIMi606927. gene.
neXtProtiNX_Q969N4.
PharmGKBiPA28850.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG288345.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ969N4.
KOiK05051.
OMAiSSTICIF.
OrthoDBiEOG7966GS.
PhylomeDBiQ969N4.
TreeFamiTF343107.

Enzyme and pathway databases

ReactomeiREACT_16983. Amine ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiTAAR8.
GenomeRNAii83551.
NextBioi72497.
PROiQ969N4.
SOURCEiSearch...

Gene expression databases

BgeeiQ969N4.
CleanExiHS_TAAR8.
GenevisibleiQ969N4. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte."
    Parry D.A., Logan C.V., Hayward B.E., Shires M., Landolsi H., Diggle C., Carr I., Rittore C., Touitou I., Philibert L., Fisher R.A., Fallahian M., Huntriss J.D., Picton H.M., Malik S., Taylor G.R., Johnson C.A., Bonthron D.T., Sheridan E.G.
    Am. J. Hum. Genet. 89:451-458(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASP-211.

Entry informationi

Entry nameiTAAR8_HUMAN
AccessioniPrimary (citable) accession number: Q969N4
Secondary accession number(s): Q5VUQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.