Q969N4 (TAAR8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 8
Short name=TaR-8
Short name=Trace amine receptor 8

Alternative name(s):
G-protein coupled receptor 102
Trace amine receptor 5
Short name=TaR-5

Gene names

Name:	TAAR8
Synonyms:	GPR102, TA5, TAR5, TRAR5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in kidney and amygdala. Not expressed in other tissues or brain regions tested. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred by curator PubMed 15718104. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15718104. Source: GDB trace-amine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Trace amine-associated receptor 8		PRO_0000070174
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 52	21	Helical; Name=1; Potential
	Topological domain	53 – 67	15	Cytoplasmic Potential
	Transmembrane	68 – 88	21	Helical; Name=2; Potential
	Topological domain	89 – 111	23	Extracellular Potential
	Transmembrane	112 – 132	21	Helical; Name=3; Potential
	Topological domain	133 – 146	14	Cytoplasmic Potential
	Transmembrane	147 – 167	21	Helical; Name=4; Potential
	Topological domain	168 – 195	28	Extracellular Potential
	Transmembrane	196 – 216	21	Helical; Name=5; Potential
	Topological domain	217 – 258	42	Cytoplasmic Potential
	Transmembrane	259 – 279	21	Helical; Name=6; Potential
	Topological domain	280	1	Extracellular Potential
	Transmembrane	281 – 301	21	Helical; Name=7; Potential
	Topological domain	302 – 342	41	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Disulfide bond	104 ↔ 189		By similarity
Natural variations
	Natural variant	153	1	S → N. Corresponds to variant rs8192626 [ dbSNP | Ensembl ].		VAR_049447
	Natural variant	211	1	V → D. Ref.6 Corresponds to variant rs187426282 [ dbSNP | Ensembl ].		VAR_066638
	Natural variant	328	1	D → A. Corresponds to variant rs8192627 [ dbSNP | Ensembl ].		VAR_049448

Sequences

	Sequence		Length	Mass (Da)
	Q969N4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: AB034E68F7D60388	FASTA	342	38,029
	10 20 30 40 50 60 MTSNFSQPVV QLCYEDVNGS CIETPYSPGS RVILYTAFSF GSLLAVFGNL LVMTSVLHFK 70 80 90 100 110 120 QLHSPTNFLI ASLACADFLV GVTVMLFSMV RTVESCWYFG AKFCTLHSCC DVAFCYSSVL 130 140 150 160 170 180 HLCFICIDRY IVVTDPLVYA TKFTVSVSGI CISVSWILPL TYSGAVFYTG VNDDGLEELV 190 200 210 220 230 240 SALNCVGGCQ IIVSQGWVLI DFLLFFIPTL VMIILYSKIF LIAKQQAIKI ETTSSKVESS 250 260 270 280 290 300 SESYKIRVAK RERKAAKTLG VTVLAFVISW LPYTVDILID AFMGFLTPAY IYEICCWSAY 310 320 330 340 YNSAMNPLIY ALFYPWFRKA IKLILSGDVL KASSSTISLF LE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Trace amines: identification of a family of mammalian G protein-coupled receptors." Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A., Gerald C. Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]	"Discovery and mapping of ten novel G protein-coupled receptor genes." Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F. Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte." Parry D.A., Logan C.V., Hayward B.E., Shires M., Landolsi H., Diggle C., Carr I., Rittore C., Touitou I., Philibert L., Fisher R.A., Fallahian M., Huntriss J.D., Picton H.M., Malik S., Taylor G.R., Johnson C.A., Bonthron D.T., Sheridan E.G. Am. J. Hum. Genet. 89:451-458(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ASP-211.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF380193 Genomic DNA. Translation: AAK71244.1. AF411116 Genomic DNA. Translation: AAL26487.1. AY183468 mRNA. Translation: AAO24659.1. AL513524 Genomic DNA. Translation: CAH72098.1. BC069166 mRNA. Translation: AAH69166.1.
IPI	IPI00056444.
RefSeq	NP_444508.1. NM_053278.1.
UniGene	Hs.350571.
3D structure databases
ProteinModelPortal	Q969N4.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q969N4.
Polymorphism databases
DMDM	38258876.
Proteomic databases
PaxDb	Q969N4.
PRIDE	Q969N4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000275200; ENSP00000275200; ENSG00000146385.
GeneID	83551.
KEGG	hsa:83551.
UCSC	uc011ecj.2. human.
Organism-specific databases
CTD	83551.
GeneCards	GC06P132916.
HGNC	HGNC:14964. TAAR8.
MIM	606927. gene.
neXtProt	NX_Q969N4.
PharmGKB	PA28850.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288345.
HOGENOM	HOG000239243.
HOVERGEN	HBG106962.
InParanoid	Q969N4.
KO	K05051.
OMA	GMCIGIS.
OrthoDB	EOG41JZCJ.
PhylomeDB	Q969N4.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q969N4.
CleanEx	HS_TAAR8.
Genevestigator	Q969N4.
GermOnline	ENSG00000146385. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR009132. Trace_amine_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83551.
NextBio	72497.
SOURCE	Search...

Entry information

Entry name

TAAR8_HUMAN

Accession

Primary (citable) accession number: Q969N4
Secondary accession number(s): Q5VUQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.