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Q969N4

- TAAR8_HUMAN

UniProt

Q969N4 - TAAR8_HUMAN

Protein

Trace amine-associated receptor 8

Gene

TAAR8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB
    2. trace-amine receptor activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16983. Amine ligand-binding receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trace amine-associated receptor 8
    Short name:
    TaR-8
    Short name:
    Trace amine receptor 8
    Alternative name(s):
    G-protein coupled receptor 102
    Trace amine receptor 5
    Short name:
    TaR-5
    Gene namesi
    Name:TAAR8
    Synonyms:GPR102, TA5, TAR5, TRAR5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14964. TAAR8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28850.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Trace amine-associated receptor 8PRO_0000070174Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ969N4.
    PRIDEiQ969N4.

    PTM databases

    PhosphoSiteiQ969N4.

    Expressioni

    Tissue specificityi

    Expressed in kidney and amygdala. Not expressed in other tissues or brain regions tested.1 Publication

    Gene expression databases

    BgeeiQ969N4.
    CleanExiHS_TAAR8.
    GenevestigatoriQ969N4.

    Interactioni

    Protein-protein interaction databases

    IntActiQ969N4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969N4.
    SMRiQ969N4. Positions 43-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 6715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini89 – 11123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini133 – 14614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini168 – 19528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 25842CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini280 – 2801ExtracellularSequence Analysis
    Topological domaini302 – 34241CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288345.
    HOGENOMiHOG000239243.
    HOVERGENiHBG106962.
    InParanoidiQ969N4.
    KOiK05051.
    OMAiSSTICIF.
    OrthoDBiEOG7966GS.
    PhylomeDBiQ969N4.
    TreeFamiTF343107.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR009132. TAAR_fam.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01830. TRACEAMINER.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q969N4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSNFSQPVV QLCYEDVNGS CIETPYSPGS RVILYTAFSF GSLLAVFGNL    50
    LVMTSVLHFK QLHSPTNFLI ASLACADFLV GVTVMLFSMV RTVESCWYFG 100
    AKFCTLHSCC DVAFCYSSVL HLCFICIDRY IVVTDPLVYA TKFTVSVSGI 150
    CISVSWILPL TYSGAVFYTG VNDDGLEELV SALNCVGGCQ IIVSQGWVLI 200
    DFLLFFIPTL VMIILYSKIF LIAKQQAIKI ETTSSKVESS SESYKIRVAK 250
    RERKAAKTLG VTVLAFVISW LPYTVDILID AFMGFLTPAY IYEICCWSAY 300
    YNSAMNPLIY ALFYPWFRKA IKLILSGDVL KASSSTISLF LE 342
    Length:342
    Mass (Da):38,029
    Last modified:December 1, 2001 - v1
    Checksum:iAB034E68F7D60388
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti153 – 1531S → N.
    Corresponds to variant rs8192626 [ dbSNP | Ensembl ].
    VAR_049447
    Natural varianti211 – 2111V → D.1 Publication
    Corresponds to variant rs187426282 [ dbSNP | Ensembl ].
    VAR_066638
    Natural varianti328 – 3281D → A.
    Corresponds to variant rs8192627 [ dbSNP | Ensembl ].
    VAR_049448

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF380193 Genomic DNA. Translation: AAK71244.1.
    AF411116 Genomic DNA. Translation: AAL26487.1.
    AY183468 mRNA. Translation: AAO24659.1.
    AL513524 Genomic DNA. Translation: CAH72098.1.
    BC069166 mRNA. Translation: AAH69166.1.
    CCDSiCCDS5154.1.
    RefSeqiNP_444508.1. NM_053278.1.
    UniGeneiHs.350571.

    Genome annotation databases

    EnsembliENST00000275200; ENSP00000275200; ENSG00000146385.
    GeneIDi83551.
    KEGGihsa:83551.
    UCSCiuc011ecj.2. human.

    Polymorphism databases

    DMDMi38258876.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF380193 Genomic DNA. Translation: AAK71244.1 .
    AF411116 Genomic DNA. Translation: AAL26487.1 .
    AY183468 mRNA. Translation: AAO24659.1 .
    AL513524 Genomic DNA. Translation: CAH72098.1 .
    BC069166 mRNA. Translation: AAH69166.1 .
    CCDSi CCDS5154.1.
    RefSeqi NP_444508.1. NM_053278.1.
    UniGenei Hs.350571.

    3D structure databases

    ProteinModelPortali Q969N4.
    SMRi Q969N4. Positions 43-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q969N4. 1 interaction.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q969N4.

    Polymorphism databases

    DMDMi 38258876.

    Proteomic databases

    PaxDbi Q969N4.
    PRIDEi Q969N4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275200 ; ENSP00000275200 ; ENSG00000146385 .
    GeneIDi 83551.
    KEGGi hsa:83551.
    UCSCi uc011ecj.2. human.

    Organism-specific databases

    CTDi 83551.
    GeneCardsi GC06P132916.
    HGNCi HGNC:14964. TAAR8.
    MIMi 606927. gene.
    neXtProti NX_Q969N4.
    PharmGKBi PA28850.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288345.
    HOGENOMi HOG000239243.
    HOVERGENi HBG106962.
    InParanoidi Q969N4.
    KOi K05051.
    OMAi SSTICIF.
    OrthoDBi EOG7966GS.
    PhylomeDBi Q969N4.
    TreeFami TF343107.

    Enzyme and pathway databases

    Reactomei REACT_16983. Amine ligand-binding receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii TAAR8.
    GenomeRNAii 83551.
    NextBioi 72497.
    PROi Q969N4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q969N4.
    CleanExi HS_TAAR8.
    Genevestigatori Q969N4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR009132. TAAR_fam.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01830. TRACEAMINER.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    2. "Discovery and mapping of ten novel G protein-coupled receptor genes."
      Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
      Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte."
      Parry D.A., Logan C.V., Hayward B.E., Shires M., Landolsi H., Diggle C., Carr I., Rittore C., Touitou I., Philibert L., Fisher R.A., Fallahian M., Huntriss J.D., Picton H.M., Malik S., Taylor G.R., Johnson C.A., Bonthron D.T., Sheridan E.G.
      Am. J. Hum. Genet. 89:451-458(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ASP-211.

    Entry informationi

    Entry nameiTAAR8_HUMAN
    AccessioniPrimary (citable) accession number: Q969N4
    Secondary accession number(s): Q5VUQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3