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Q969N4 (TAAR8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trace amine-associated receptor 8

Short name=TaR-8
Short name=Trace amine receptor 8
Alternative name(s):
G-protein coupled receptor 102
Trace amine receptor 5
Short name=TaR-5
Gene names
Name:TAAR8
Synonyms:GPR102, TA5, TAR5, TRAR5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in kidney and amygdala. Not expressed in other tissues or brain regions tested. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Trace amine-associated receptor 8
PRO_0000070174

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5221Helical; Name=1; Potential
Topological domain53 – 6715Cytoplasmic Potential
Transmembrane68 – 8821Helical; Name=2; Potential
Topological domain89 – 11123Extracellular Potential
Transmembrane112 – 13221Helical; Name=3; Potential
Topological domain133 – 14614Cytoplasmic Potential
Transmembrane147 – 16721Helical; Name=4; Potential
Topological domain168 – 19528Extracellular Potential
Transmembrane196 – 21621Helical; Name=5; Potential
Topological domain217 – 25842Cytoplasmic Potential
Transmembrane259 – 27921Helical; Name=6; Potential
Topological domain2801Extracellular Potential
Transmembrane281 – 30121Helical; Name=7; Potential
Topological domain302 – 34241Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Disulfide bond104 ↔ 189 By similarity

Natural variations

Natural variant1531S → N.
Corresponds to variant rs8192626 [ dbSNP | Ensembl ].
VAR_049447
Natural variant2111V → D. Ref.6
Corresponds to variant rs187426282 [ dbSNP | Ensembl ].
VAR_066638
Natural variant3281D → A.
Corresponds to variant rs8192627 [ dbSNP | Ensembl ].
VAR_049448

Sequences

Sequence LengthMass (Da)Tools
Q969N4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: AB034E68F7D60388

FASTA34238,029
        10         20         30         40         50         60 
MTSNFSQPVV QLCYEDVNGS CIETPYSPGS RVILYTAFSF GSLLAVFGNL LVMTSVLHFK 

        70         80         90        100        110        120 
QLHSPTNFLI ASLACADFLV GVTVMLFSMV RTVESCWYFG AKFCTLHSCC DVAFCYSSVL 

       130        140        150        160        170        180 
HLCFICIDRY IVVTDPLVYA TKFTVSVSGI CISVSWILPL TYSGAVFYTG VNDDGLEELV 

       190        200        210        220        230        240 
SALNCVGGCQ IIVSQGWVLI DFLLFFIPTL VMIILYSKIF LIAKQQAIKI ETTSSKVESS 

       250        260        270        280        290        300 
SESYKIRVAK RERKAAKTLG VTVLAFVISW LPYTVDILID AFMGFLTPAY IYEICCWSAY 

       310        320        330        340 
YNSAMNPLIY ALFYPWFRKA IKLILSGDVL KASSSTISLF LE 

« Hide

References

« Hide 'large scale' references
[1]"Trace amines: identification of a family of mammalian G protein-coupled receptors."
Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A., Gerald C.
Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]"Discovery and mapping of ten novel G protein-coupled receptor genes."
Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte."
Parry D.A., Logan C.V., Hayward B.E., Shires M., Landolsi H., Diggle C., Carr I., Rittore C., Touitou I., Philibert L., Fisher R.A., Fallahian M., Huntriss J.D., Picton H.M., Malik S., Taylor G.R., Johnson C.A., Bonthron D.T., Sheridan E.G.
Am. J. Hum. Genet. 89:451-458(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASP-211.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF380193 Genomic DNA. Translation: AAK71244.1.
AF411116 Genomic DNA. Translation: AAL26487.1.
AY183468 mRNA. Translation: AAO24659.1.
AL513524 Genomic DNA. Translation: CAH72098.1.
BC069166 mRNA. Translation: AAH69166.1.
RefSeqNP_444508.1. NM_053278.1.
UniGeneHs.350571.

3D structure databases

ProteinModelPortalQ969N4.
SMRQ969N4. Positions 43-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ969N4. 1 interaction.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ969N4.

Polymorphism databases

DMDM38258876.

Proteomic databases

PaxDbQ969N4.
PRIDEQ969N4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000275200; ENSP00000275200; ENSG00000146385.
GeneID83551.
KEGGhsa:83551.
UCSCuc011ecj.2. human.

Organism-specific databases

CTD83551.
GeneCardsGC06P132916.
HGNCHGNC:14964. TAAR8.
MIM606927. gene.
neXtProtNX_Q969N4.
PharmGKBPA28850.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288345.
HOGENOMHOG000239243.
HOVERGENHBG106962.
InParanoidQ969N4.
KOK05051.
OMASSTICIF.
OrthoDBEOG7966GS.
PhylomeDBQ969N4.
TreeFamTF343107.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ969N4.
CleanExHS_TAAR8.
GenevestigatorQ969N4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAAR8.
GenomeRNAi83551.
NextBio72497.
PROQ969N4.
SOURCESearch...

Entry information

Entry nameTAAR8_HUMAN
AccessionPrimary (citable) accession number: Q969N4
Secondary accession number(s): Q5VUQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries