Q969N2 (PIGT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GPI transamidase component PIG-T

Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class T protein

Gene names

Name:	PIGT
ORF Names:	CGI-06, PSEC0163, UNQ716/PRO1379

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	578 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. Ref.1
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Subunit structure	Forms a complex with PIGK/GPI8, PIGS, PIGU and GPAA1/GAA1. Has a critical role in maintaining the complex by stabilizing the expression of GPAA1 and GPI8 and linking them to PIGS. Ref.1
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein Ref.1.
Post-translational modification	The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity.
Sequence similarities	Belongs to the PIGT family.
Sequence caution	The sequence AAD27715.1 differs from that shown. Reason: Frameshift at positions 5 and 27. The sequence AAQ88951.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB57341.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	GPI-anchor biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	C-terminal protein lipidation Traceable author statement. Source: Reactome attachment of GPI anchor to protein Traceable author statement Ref.1. Source: UniProtKB neuron apoptotic process Inferred from electronic annotation. Source: Compara neuron differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	GPI-anchor transamidase complex Traceable author statement PubMed 15713669. Source: UniProtKB cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	GPI-anchor transamidase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q969N2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q969N2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     63-256: Missing.

Isoform 3 (identifier: Q969N2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-164: IDSTNTVTPTASFKPLGLAN → MWIPRGQSPRPTPDRPLSPS
     345-412: EAPPVPFLHAQRYVSGYGLQKGELSTLLYNTHPYRAFPVLLLDTVPWYLRLYVHTLTITSKGKENKPS → G

Note: No experimental confirmation available.

Isoform 4 (identifier: Q969N2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     63-164: Missing.

Isoform 5 (identifier: Q969N2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     109-164: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q969N2-6)

The sequence of this isoform differs from the canonical sequence as follows:
     345-412: EAPPVPFLHAQRYVSGYGLQKGELSTLLYNTHPYRAFPVLLLDTVPWYLRLYVHTLTITSKGKENKPS → G

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.1
	Chain	22 – 578	557	GPI transamidase component PIG-T		PRO_0000024107
Regions
	Topological domain	22 – 527	506	Lumenal Potential
	Transmembrane	528 – 548	21	Helical; Potential
	Topological domain	549 – 578	30	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	164	1	N-linked (GlcNAc...) Ref.12
	Glycosylation	291	1	N-linked (GlcNAc...) Potential
	Glycosylation	327	1	N-linked (GlcNAc...) Potential
	Disulfide bond	182		Interchain (with C-92 in PIGK/GPI8) Ref.11
Natural variations
	Alternative sequence	1 – 144	144	Missing in isoform 3.		VSP_009536
	Alternative sequence	63 – 256	194	Missing in isoform 2.		VSP_009537
	Alternative sequence	63 – 164	102	Missing in isoform 4.		VSP_009538
	Alternative sequence	109 – 164	56	Missing in isoform 5.		VSP_043167
	Alternative sequence	145 – 164	20	IDSTN…LGLAN → MWIPRGQSPRPTPDRPLSPS in isoform 3.		VSP_009539
	Alternative sequence	345 – 412	68	EAPPV…ENKPS → G in isoform 3 and isoform 6.		VSP_009540
	Natural variant	473	1	A → T. Corresponds to variant rs36056071 [ dbSNP | Ensembl ].		VAR_053583
Experimental info
	Mutagenesis	182	1	C → S: Decrease in activity. Ref.11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: AC7865160CFBCBBA	FASTA	578	65,700
	10 20 30 40 50 60 MAAAMPLALL VLLLLGPGGW CLAEPPRDSL REELVITPLP SGDVAATFQF RTRWDSELQR 70 80 90 100 110 120 EGVSHYRLFP KALGQLISKY SLRELHLSFT QGFWRTRYWG PPFLQAPSGA ELWVWFQDTV 130 140 150 160 170 180 TDVDKSWKEL SNVLSGIFCA SLNFIDSTNT VTPTASFKPL GLANDTDHYF LRYAVLPREV 190 200 210 220 230 240 VCTENLTPWK KLLPCSSKAG LSVLLKADRL FHTSYHSQAV HIRPVCRNAR CTSISWELRQ 250 260 270 280 290 300 TLSVVFDAFI TGQGKKDWSL FRMFSRTLTE PCPLASESRV YVDITTYNQD NETLEVHPPP 310 320 330 340 350 360 TTTYQDVILG TRKTYAIYDL LDTAMINNSR NLNIQLKWKR PPENEAPPVP FLHAQRYVSG 370 380 390 400 410 420 YGLQKGELST LLYNTHPYRA FPVLLLDTVP WYLRLYVHTL TITSKGKENK PSYIHYQPAQ 430 440 450 460 470 480 DRLQPHLLEM LIQLPANSVT KVSIQFERAL LKWTEYTPDP NHGFYVSPSV LSALVPSMVA 490 500 510 520 530 540 AKPVDWEESP LFNSLFPVSD GSNYFVRLYT EPLLVNLPTP DFSMPYNVIC LTCTVVAVCY 550 560 570 GSFYNLLTRT FHIEEPRTGG LAKRLANLIR RARGVPPL
	Isoform 2 [UniParc]. Checksum: AC75FF3BD9DCB0C2	FASTA	384	43,616
	10 20 30 40 50 60 MAAAMPLALL VLLLLGPGGW CLAEPPRDSL REELVITPLP SGDVAATFQF RTRWDSELQR 70 80 90 100 110 120 EGDWSLFRMF SRTLTEPCPL ASESRVYVDI TTYNQDNETL EVHPPPTTTY QDVILGTRKT 130 140 150 160 170 180 YAIYDLLDTA MINNSRNLNI QLKWKRPPEN EAPPVPFLHA QRYVSGYGLQ KGELSTLLYN 190 200 210 220 230 240 THPYRAFPVL LLDTVPWYLR LYVHTLTITS KGKENKPSYI HYQPAQDRLQ PHLLEMLIQL 250 260 270 280 290 300 PANSVTKVSI QFERALLKWT EYTPDPNHGF YVSPSVLSAL VPSMVAAKPV DWEESPLFNS 310 320 330 340 350 360 LFPVSDGSNY FVRLYTEPLL VNLPTPDFSM PYNVICLTCT VVAVCYGSFY NLLTRTFHIE 370 380 EPRTGGLAKR LANLIRRARG VPPL
	Isoform 3 [UniParc]. Checksum: D31A0D75D51AB651	FASTA	367	41,905
	10 20 30 40 50 60 MWIPRGQSPR PTPDRPLSPS DTDHYFLRYA VLPREVVCTE NLTPWKKLLP CSSKAGLSVL 70 80 90 100 110 120 LKADRLFHTS YHSQAVHIRP VCRNARCTSI SWELRQTLSV VFDAFITGQG KKDWSLFRMF 130 140 150 160 170 180 SRTLTEPCPL ASESRVYVDI TTYNQDNETL EVHPPPTTTY QDVILGTRKT YAIYDLLDTA 190 200 210 220 230 240 MINNSRNLNI QLKWKRPPEN GYIHYQPAQD RLQPHLLEML IQLPANSVTK VSIQFERALL 250 260 270 280 290 300 KWTEYTPDPN HGFYVSPSVL SALVPSMVAA KPVDWEESPL FNSLFPVSDG SNYFVRLYTE 310 320 330 340 350 360 PLLVNLPTPD FSMPYNVICL TCTVVAVCYG SFYNLLTRTF HIEEPRTGGL AKRLANLIRR ARGVPPL
	Isoform 4 [UniParc]. Checksum: 18A9624936EB7553	FASTA	476	54,118
	10 20 30 40 50 60 MAAAMPLALL VLLLLGPGGW CLAEPPRDSL REELVITPLP SGDVAATFQF RTRWDSELQR 70 80 90 100 110 120 EGDTDHYFLR YAVLPREVVC TENLTPWKKL LPCSSKAGLS VLLKADRLFH TSYHSQAVHI 130 140 150 160 170 180 RPVCRNARCT SISWELRQTL SVVFDAFITG QGKKDWSLFR MFSRTLTEPC PLASESRVYV 190 200 210 220 230 240 DITTYNQDNE TLEVHPPPTT TYQDVILGTR KTYAIYDLLD TAMINNSRNL NIQLKWKRPP 250 260 270 280 290 300 ENEAPPVPFL HAQRYVSGYG LQKGELSTLL YNTHPYRAFP VLLLDTVPWY LRLYVHTLTI 310 320 330 340 350 360 TSKGKENKPS YIHYQPAQDR LQPHLLEMLI QLPANSVTKV SIQFERALLK WTEYTPDPNH 370 380 390 400 410 420 GFYVSPSVLS ALVPSMVAAK PVDWEESPLF NSLFPVSDGS NYFVRLYTEP LLVNLPTPDF 430 440 450 460 470 SMPYNVICLT CTVVAVCYGS FYNLLTRTFH IEEPRTGGLA KRLANLIRRA RGVPPL
	Isoform 5 [UniParc]. Checksum: 5085BEC6CC7D5B88	FASTA	522	59,582
	10 20 30 40 50 60 MAAAMPLALL VLLLLGPGGW CLAEPPRDSL REELVITPLP SGDVAATFQF RTRWDSELQR 70 80 90 100 110 120 EGVSHYRLFP KALGQLISKY SLRELHLSFT QGFWRTRYWG PPFLQAPSDT DHYFLRYAVL 130 140 150 160 170 180 PREVVCTENL TPWKKLLPCS SKAGLSVLLK ADRLFHTSYH SQAVHIRPVC RNARCTSISW 190 200 210 220 230 240 ELRQTLSVVF DAFITGQGKK DWSLFRMFSR TLTEPCPLAS ESRVYVDITT YNQDNETLEV 250 260 270 280 290 300 HPPPTTTYQD VILGTRKTYA IYDLLDTAMI NNSRNLNIQL KWKRPPENEA PPVPFLHAQR 310 320 330 340 350 360 YVSGYGLQKG ELSTLLYNTH PYRAFPVLLL DTVPWYLRLY VHTLTITSKG KENKPSYIHY 370 380 390 400 410 420 QPAQDRLQPH LLEMLIQLPA NSVTKVSIQF ERALLKWTEY TPDPNHGFYV SPSVLSALVP 430 440 450 460 470 480 SMVAAKPVDW EESPLFNSLF PVSDGSNYFV RLYTEPLLVN LPTPDFSMPY NVICLTCTVV 490 500 510 520 AVCYGSFYNL LTRTFHIEEP RTGGLAKRLA NLIRRARGVP PL
	Isoform 6 [UniParc]. Checksum: EC1AB6BA095A9D23	FASTA	511	57,988
	10 20 30 40 50 60 MAAAMPLALL VLLLLGPGGW CLAEPPRDSL REELVITPLP SGDVAATFQF RTRWDSELQR 70 80 90 100 110 120 EGVSHYRLFP KALGQLISKY SLRELHLSFT QGFWRTRYWG PPFLQAPSGA ELWVWFQDTV 130 140 150 160 170 180 TDVDKSWKEL SNVLSGIFCA SLNFIDSTNT VTPTASFKPL GLANDTDHYF LRYAVLPREV 190 200 210 220 230 240 VCTENLTPWK KLLPCSSKAG LSVLLKADRL FHTSYHSQAV HIRPVCRNAR CTSISWELRQ 250 260 270 280 290 300 TLSVVFDAFI TGQGKKDWSL FRMFSRTLTE PCPLASESRV YVDITTYNQD NETLEVHPPP 310 320 330 340 350 360 TTTYQDVILG TRKTYAIYDL LDTAMINNSR NLNIQLKWKR PPENGYIHYQ PAQDRLQPHL 370 380 390 400 410 420 LEMLIQLPAN SVTKVSIQFE RALLKWTEYT PDPNHGFYVS PSVLSALVPS MVAAKPVDWE 430 440 450 460 470 480 ESPLFNSLFP VSDGSNYFVR LYTEPLLVNL PTPDFSMPYN VICLTCTVVA VCYGSFYNLL 490 500 510 TRTFHIEEPR TGGLAKRLAN LIRRARGVPP L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8." Ohishi K., Inoue N., Kinoshita T. EMBO J. 20:4088-4098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-41, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5). Tissue: Testis and Thalamus.
[3]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[4]	"Homo sapiens protein coding cDNA." Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Signet-ring cell carcinoma.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Amygdala.
[6]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain, Leukocyte, Skin and Testis.
[9]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-578 (ISOFORM 1).
[10]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-578 (ISOFORM 1).
[11]	"Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge." Ohishi K., Nagamune K., Maeda Y., Kinoshita T. J. Biol. Chem. 278:13959-13967(2003) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BOND FORMATION WITH PIGK/GPI8, MUTAGENESIS OF CYS-182.
[12]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-164, MASS SPECTROMETRY. Tissue: Liver.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB057724 mRNA. Translation: BAB60854.1. AK296139 mRNA. Translation: BAH12267.1. AK302093 mRNA. Translation: BAH13624.1. AK075469 mRNA. Translation: BAC11639.1. AK225517 mRNA. No translation available. BX537612 mRNA. Translation: CAD97799.1. AL121742 mRNA. Translation: CAB57341.1. Different initiation. AL021578 Genomic DNA. Translation: CAC18110.2. AL021578 Genomic DNA. Translation: CAC36338.2. AL021578 Genomic DNA. Translation: CAC36339.2. CH471077 Genomic DNA. Translation: EAW75844.1. CH471077 Genomic DNA. Translation: EAW75845.1. CH471077 Genomic DNA. Translation: EAW75846.1. BC015022 mRNA. Translation: AAH15022.3. BC110892 mRNA. Translation: AAI10893.1. BC136827 mRNA. Translation: AAI36828.1. BC136828 mRNA. Translation: AAI36829.1. AY358588 mRNA. Translation: AAQ88951.1. Different initiation. AF132940 mRNA. Translation: AAD27715.1. Frameshift.
IPI	IPI00100030. IPI00385011. IPI00401041. IPI00401043. IPI00922696.
RefSeq	NP_001171657.1. NM_001184728.2. NP_001171658.1. NM_001184729.2. NP_001171659.1. NM_001184730.2. NP_057021.2. NM_015937.5.
UniGene	Hs.437388.
3D structure databases
ProteinModelPortal	Q969N2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q969N2. 2 interactions.
MINT	MINT-1417476.
PTM databases
PhosphoSite	Q969N2.
Polymorphism databases
DMDM	44888284.
Proteomic databases
PaxDb	Q969N2.
PRIDE	Q969N2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000279035; ENSP00000279035; ENSG00000124155. ENST00000279036; ENSP00000279036; ENSG00000124155. ENST00000341555; ENSP00000343783; ENSG00000124155. ENST00000372689; ENSP00000361774; ENSG00000124155. ENST00000455050; ENSP00000407574; ENSG00000124155. ENST00000543458; ENSP00000441577; ENSG00000124155.
GeneID	51604.
KEGG	hsa:51604.
UCSC	uc002xoh.2. human. uc002xol.1. human. uc010zwy.2. human.
Organism-specific databases
CTD	51604.
GeneCards	GC20P044044.
HGNC	HGNC:14938. PIGT.
MIM	610272. gene.
neXtProt	NX_Q969N2.
PharmGKB	PA33302.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG331717.
HOVERGEN	HBG049395.
InParanoid	Q969N2.
KO	K05292.
OMA	LQLKWKR.
OrthoDB	EOG4R7V9J.
PhylomeDB	Q969N2.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
UniPathway	UPA00196.
Gene expression databases
ArrayExpress	Q969N2.
Bgee	Q969N2.
CleanEx	HS_PIGT.
Genevestigator	Q969N2.
GermOnline	ENSG00000124155. Homo sapiens.
Family and domain databases
InterPro	IPR007245. PIG-T. [Graphical view]
PANTHER	PTHR12959. PTHR12959. 1 hit.
Pfam	PF04113. Gpi16. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PIGT. human.
GenomeRNAi	51604.
NextBio	55490.
SOURCE	Search...

Entry information

Entry name

PIGT_HUMAN

Accession

Primary (citable) accession number: Q969N2
Secondary accession number(s): B2RND5 , B7Z3N1, B7Z7I8, E1P622, G8JLF5, Q2NL69, Q7Z3N7, Q9BQY7, Q9BQY8, Q9UJG6, Q9Y2Z5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.