UBE2F

Functionⁱ

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.1 Publication

Catalytic activityⁱ

S-NEDD8yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N₆-NEDD8yl-[acceptor protein]-L-lysine.

Pathwayⁱ: protein neddylation

This protein is involved in the pathway protein neddylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein neddylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	116	Glycyl thioester intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
NEDD8 transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19250909
ubiquitin protein ligase activity Source: GO_Central
ubiquitin protein ligase binding Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

post-translational protein modification Source: Reactome
protein neddylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19250909

Complete GO annotation...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8951664. Neddylation. R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkⁱ	Q969M7.
UniPathwayⁱ	UPA00885.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NEDD8-conjugating enzyme UBE2F (EC:2.3.2.-) Alternative name(s): NEDD8 carrier protein UBE2F NEDD8 protein ligase UBE2F NEDD8-conjugating enzyme 2 RING-type E3 NEDD8 transferase UBE2F Ubiquitin-conjugating enzyme E2 F
Gene namesⁱ	Name:UBE2F Synonyms:NCE2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12480. UBE2F.

HGNCⁱ

HGNC:12480. UBE2F.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: GO_Central
cytosol Source: Reactome

Complete GO annotation...

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000184182.
PharmGKBⁱ	PA37130.

Polymorphism and mutation databases

BioMutaⁱ	UBE2F.
DMDMⁱ	74751725.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000263077	1 – 185	NEDD8-conjugating enzyme UBE2FAdd BLAST		185

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionine1 Publication		1

Post-translational modificationⁱ

The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.1 Publication

Keywords - PTMⁱ

Acetylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q969M7.
PaxDbⁱ	Q969M7.
PeptideAtlas More...PeptideAtlasⁱ	Q969M7.
PRIDEⁱ	Q969M7.

PTM databases

iPTMnetⁱ	Q969M7.
PhosphoSitePlusⁱ	Q969M7.

Expressionⁱ

Tissue specificityⁱ

Widely expressed (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000184182.
CleanExⁱ	HS_UBE2F.
ExpressionAtlasⁱ	Q969M7. baseline and differential.
Genevisibleⁱ	Q969M7. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037444.

HPAⁱ

HPA037444.

Interactionⁱ

Subunit structureⁱ

Interacts with UBA3 and RBX2.2 Publications

GO - Molecular functionⁱ

ubiquitin protein ligase binding Source: GO_Central

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	126682. 15 interactors.
IntActⁱ	Q969M7. 8 interactors.
STRINGⁱ	9606.ENSP00000272930.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 8	Combined sources	5
Helixⁱ	32 – 44	Combined sources	13
Helixⁱ	45 – 47	Combined sources	3
Beta strandⁱ	52 – 55	Combined sources	4
Beta strandⁱ	57 – 60	Combined sources	4
Beta strandⁱ	64 – 69	Combined sources	6
Beta strandⁱ	72 – 74	Combined sources	3
Turnⁱ	75 – 78	Combined sources	4
Beta strandⁱ	81 – 86	Combined sources	6
Beta strandⁱ	97 – 100	Combined sources	4
Beta strandⁱ	107 – 109	Combined sources	3
Beta strandⁱ	111 – 113	Combined sources	3
Helixⁱ	118 – 120	Combined sources	3
Beta strandⁱ	124 – 126	Combined sources	3
Helixⁱ	136 – 145	Combined sources	10
Turnⁱ	146 – 150	Combined sources	5
Beta strandⁱ	153 – 155	Combined sources	3
Helixⁱ	159 – 167	Combined sources	9
Helixⁱ	169 – 183	Combined sources	15

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EDI	NMR	-	A	26-185	[»]
	3FN1	X-ray	2.50	B	21-185	[»]
	4GBA	X-ray	2.40	F/G	1-25	[»]
ProteinModelPortalⁱ	Q969M7.
SMRⁱ	Q969M7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q969M7.

EvolutionaryTraceⁱ

Q969M7.

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 29	Interaction with UBA31 PublicationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0420. Eukaryota. ENOG410XS81. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00630000089859.
HOGENOMⁱ	HOG000233456.
HOVERGENⁱ	HBG098591.
InParanoidⁱ	Q969M7.
KEGG Orthology (KO) More...KOⁱ	K10687.
OMAⁱ	WHPNISE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N8A.
PhylomeDBⁱ	Q969M7.
TreeFamⁱ	TF101125.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195. UBCc. 1 hit.
Gene3Dⁱ	3.10.110.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179. UQ_con. 1 hit.
SUPFAMⁱ	SSF54495. SSF54495. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequences (7)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q969M7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTLASKLKR DDGLKGSRTA ATASDSTRRV SVRDKLLVKE VAELEANLPC 
        60         70         80         90        100
TCKVHFPDPN KLHCFQLTVT PDEGYYQGGK FQFETEVPDA YNMVPPKVKC 
       110        120        130        140        150
LTKIWHPNIT ETGEICLSLL REHSIDGTGW APTRTLKDVV WGLNSLFTDL 
       160        170        180 
LNFDDPLNIE AAEHHLRDKE DFRNKVDDYI KRYAR

Length:185

Mass (Da):21,077

Last modified:December 1, 2001 - v1

Checksum:ⁱB22C86238D13216E

GO

Isoform 2 (identifier: Q969M7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
170-185: EDFRNKVDDYIKRYAR → SPMLLLHRRTSGIKWMTTSNVMPDNKRGRLQAHGLCYSLSLT

« Hide

        10         20         30         40         50
MLTLASKLKR DDGLKGSRTA ATASDSTRRV SVRDKLLVKE VAELEANLPC 
        60         70         80         90        100
TCKVHFPDPN KLHCFQLTVT PDEGYYQGGK FQFETEVPDA YNMVPPKVKC 
       110        120        130        140        150
LTKIWHPNIT ETGEICLSLL REHSIDGTGW APTRTLKDVV WGLNSLFTDL 
       160        170        180        190        200
LNFDDPLNIE AAEHHLRDKS PMLLLHRRTS GIKWMTTSNV MPDNKRGRLQ 
       210 
AHGLCYSLSL T

Note: No experimental confirmation available.

Show »

Length:211

Mass (Da):23,760

Checksum:ⁱ26D6D083CACA07ED

GO

Isoform 3 (identifier: Q969M7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
40-71: Missing.

« Hide

        10         20         30         40         50
MLTLASKLKR DDGLKGSRTA ATASDSTRRV SVRDKLLVKD EGYYQGGKFQ 
        60         70         80         90        100
FETEVPDAYN MVPPKVKCLT KIWHPNITET GEICLSLLRE HSIDGTGWAP 
       110        120        130        140        150
TRTLKDVVWG LNSLFTDLLN FDDPLNIEAA EHHLRDKEDF RNKVDDYIKR 

YAR

Note: No experimental confirmation available.

Show »

Length:153

Mass (Da):17,500

Checksum:ⁱ738B62CEF923150C

GO

Isoform 4 (identifier: Q969M7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
118-120: SLL → RIF
121-185: Missing.

« Hide

        10         20         30         40         50
MLTLASKLKR DDGLKGSRTA ATASDSTRRV SVRDKLLVKE VAELEANLPC 
        60         70         80         90        100
TCKVHFPDPN KLHCFQLTVT PDEGYYQGGK FQFETEVPDA YNMVPPKVKC 
       110        120
LTKIWHPNIT ETGEICLRIF

Note: No experimental confirmation available.

Show »

Length:120

Mass (Da):13,513

Checksum:ⁱB7A58924FDDB46AF

GO

Isoform 5 (identifier: Q969M7-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
72-185: DEGYYQGGKF...VDDYIKRYAR → ASQSEMPDQDLAPQHHRDRGNMSEFIERTFN

« Hide

        10         20         30         40         50
MLTLASKLKR DDGLKGSRTA ATASDSTRRV SVRDKLLVKE VAELEANLPC 
        60         70         80         90        100
TCKVHFPDPN KLHCFQLTVT PASQSEMPDQ DLAPQHHRDR GNMSEFIERT 

FN

Note: No experimental confirmation available.

Show »

Length:102

Mass (Da):11,450

Checksum:ⁱ676F8ABBE02435AE

GO

Isoform 6 (identifier: Q969M7-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
149-169: Missing.

« Hide

        10         20         30         40         50
MLTLASKLKR DDGLKGSRTA ATASDSTRRV SVRDKLLVKE VAELEANLPC 
        60         70         80         90        100
TCKVHFPDPN KLHCFQLTVT PDEGYYQGGK FQFETEVPDA YNMVPPKVKC 
       110        120        130        140        150
LTKIWHPNIT ETGEICLSLL REHSIDGTGW APTRTLKDVV WGLNSLFTED 
       160 
FRNKVDDYIK RYAR

Note: Gene prediction based on EST data.

Show »

Length:164

Mass (Da):18,619

Checksum:ⁱF8EDC983E452DE4D

GO

Isoform 7 (identifier: Q969M7-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-39: MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVK → MVLGAGPASPVSGSP

« Hide

        10         20         30         40         50
MVLGAGPASP VSGSPEVAEL EANLPCTCKV HFPDPNKLHC FQLTVTPDEG 
        60         70         80         90        100
YYQGGKFQFE TEVPDAYNMV PPKVKCLTKI WHPNITETGE ICLSLLREHS 
       110        120        130        140        150
IDGTGWAPTR TLKDVVWGLN SLFTDLLNFD DPLNIEAAEH HLRDKEDFRN 
       160 
KVDDYIKRYA R

Note: Gene prediction based on EST data.

Show »

Length:161

Mass (Da):18,158

Checksum:ⁱ44700812DFACB9CE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	181	K → E in BAF82752 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055749	1 – 39	MLTLA…KLLVK → MVLGAGPASPVSGSP in isoform 7. CuratedAdd BLAST	39
Alternative sequenceⁱVSP_037270	40 – 71	Missing in isoform 3. 1 PublicationAdd BLAST	32
Alternative sequenceⁱVSP_037271	72 – 185	DEGYY…KRYAR → ASQSEMPDQDLAPQHHRDRG NMSEFIERTFN in isoform 5. 1 PublicationAdd BLAST	114
Alternative sequenceⁱVSP_037272	118 – 120	SLL → RIF in isoform 4. 1 Publication	3
Alternative sequenceⁱVSP_037273	121 – 185	Missing in isoform 4. 1 PublicationAdd BLAST	65
Alternative sequenceⁱVSP_055750	149 – 169	Missing in isoform 6. CuratedAdd BLAST	21
Alternative sequenceⁱVSP_037274	170 – 185	EDFRN…KRYAR → SPMLLLHRRTSGIKWMTTSN VMPDNKRGRLQAHGLCYSLS LT in isoform 2. 1 PublicationAdd BLAST	16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF310723 mRNA. Translation: AAL26792.1. AK290063 mRNA. Translation: BAF82752.1. AK293334 mRNA. Translation: BAG56850.1. AK294107 mRNA. Translation: BAG57442.1. AK297502 mRNA. Translation: BAG59915.1. AK303094 mRNA. Translation: BAG64204.1. AC016776 Genomic DNA. Translation: AAY24220.1. CH471063 Genomic DNA. Translation: EAW71129.1. CH471063 Genomic DNA. Translation: EAW71132.1. BC010549 mRNA. Translation: AAH10549.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2523.1. [Q969M7-1] CCDS63175.1. [Q969M7-7] CCDS63176.1. [Q969M7-6] CCDS63177.1. [Q969M7-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001265234.1. NM_001278305.1. [Q969M7-1] NP_001265235.1. NM_001278306.1. [Q969M7-7] NP_001265236.1. NM_001278307.1. [Q969M7-3] NP_001265237.1. NM_001278308.1. [Q969M7-6] NP_542409.1. NM_080678.2. [Q969M7-1]
UniGeneⁱ	Hs.471785.

Genome annotation databases

Ensemblⁱ	ENST00000272930; ENSP00000272930; ENSG00000184182. [Q969M7-1] ENST00000409633; ENSP00000387299; ENSG00000184182. [Q969M7-6] ENST00000409953; ENSP00000386680; ENSG00000184182. [Q969M7-7] ENST00000414443; ENSP00000399183; ENSG00000184182. [Q969M7-3] ENST00000433241; ENSP00000393515; ENSG00000184182. [Q969M7-4] ENST00000441728; ENSP00000409749; ENSG00000184182. [Q969M7-5] ENST00000612130; ENSP00000478474; ENSG00000184182. [Q969M7-1]
GeneIDⁱ	140739.
KEGGⁱ	hsa:140739.
UCSC genome browser More...UCSCⁱ	uc002vxk.4. human. [Q969M7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF310723 mRNA. Translation: AAL26792.1. AK290063 mRNA. Translation: BAF82752.1. AK293334 mRNA. Translation: BAG56850.1. AK294107 mRNA. Translation: BAG57442.1. AK297502 mRNA. Translation: BAG59915.1. AK303094 mRNA. Translation: BAG64204.1. AC016776 Genomic DNA. Translation: AAY24220.1. CH471063 Genomic DNA. Translation: EAW71129.1. CH471063 Genomic DNA. Translation: EAW71132.1. BC010549 mRNA. Translation: AAH10549.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2523.1. [Q969M7-1] CCDS63175.1. [Q969M7-7] CCDS63176.1. [Q969M7-6] CCDS63177.1. [Q969M7-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001265234.1. NM_001278305.1. [Q969M7-1] NP_001265235.1. NM_001278306.1. [Q969M7-7] NP_001265236.1. NM_001278307.1. [Q969M7-3] NP_001265237.1. NM_001278308.1. [Q969M7-6] NP_542409.1. NM_080678.2. [Q969M7-1]
UniGeneⁱ	Hs.471785.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EDI	NMR	-	A	26-185	[»]
	3FN1	X-ray	2.50	B	21-185	[»]
	4GBA	X-ray	2.40	F/G	1-25	[»]
ProteinModelPortalⁱ	Q969M7.
SMRⁱ	Q969M7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126682. 15 interactors.
IntActⁱ	Q969M7. 8 interactors.
STRINGⁱ	9606.ENSP00000272930.

PTM databases

iPTMnetⁱ	Q969M7.
PhosphoSitePlusⁱ	Q969M7.

Polymorphism and mutation databases

BioMutaⁱ	UBE2F.
DMDMⁱ	74751725.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q969M7.
PaxDbⁱ	Q969M7.
PeptideAtlas More...PeptideAtlasⁱ	Q969M7.
PRIDEⁱ	Q969M7.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	140739.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000272930; ENSP00000272930; ENSG00000184182. [Q969M7-1] ENST00000409633; ENSP00000387299; ENSG00000184182. [Q969M7-6] ENST00000409953; ENSP00000386680; ENSG00000184182. [Q969M7-7] ENST00000414443; ENSP00000399183; ENSG00000184182. [Q969M7-3] ENST00000433241; ENSP00000393515; ENSG00000184182. [Q969M7-4] ENST00000441728; ENSP00000409749; ENSG00000184182. [Q969M7-5] ENST00000612130; ENSP00000478474; ENSG00000184182. [Q969M7-1]
GeneIDⁱ	140739.
KEGGⁱ	hsa:140739.
UCSC genome browser More...UCSCⁱ	uc002vxk.4. human. [Q969M7-1]

Organism-specific databases

CTDⁱ	140739.
GeneCardsⁱ	UBE2F.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12480. UBE2F.
Human Protein Atlas More...HPAⁱ	HPA037444.
neXtProtⁱ	NX_Q969M7.
Open Targets More...OpenTargetsⁱ	ENSG00000184182.
PharmGKBⁱ	PA37130.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0420. Eukaryota. ENOG410XS81. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00630000089859.
HOGENOMⁱ	HOG000233456.
HOVERGENⁱ	HBG098591.
InParanoidⁱ	Q969M7.
KEGG Orthology (KO) More...KOⁱ	K10687.
OMAⁱ	WHPNISE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N8A.
PhylomeDBⁱ	Q969M7.
TreeFamⁱ	TF101125.

Enzyme and pathway databases

UniPathwayⁱ	UPA00885.
Reactomeⁱ	R-HSA-8951664. Neddylation. R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkⁱ	Q969M7.

Miscellaneous databases

ChiTaRSⁱ	UBE2F. human.
EvolutionaryTraceⁱ	Q969M7.
GenomeRNAiⁱ	140739.
Protein Ontology More...PROⁱ	PR:Q969M7.

Gene expression databases

Bgeeⁱ	ENSG00000184182.
CleanExⁱ	HS_UBE2F.
ExpressionAtlasⁱ	Q969M7. baseline and differential.
Genevisibleⁱ	Q969M7. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195. UBCc. 1 hit.
Gene3Dⁱ	3.10.110.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179. UQ_con. 1 hit.
SUPFAMⁱ	SSF54495. SSF54495. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBE2F_HUMAN
Accessionⁱ	Q969M7Primary (citable) accession number: Q969M7 Secondary accession number(s): A8K1Z8 H9KVB9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	December 1, 2001
	Last modified:	July 5, 2017
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q969M7 (UBE2F_HUMAN)

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NEDD8-conjugating enzyme UBE2F

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein neddylation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: protein neddylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (7)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ