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Q969M3

- YIPF5_HUMAN

UniProt

Q969M3 - YIPF5_HUMAN

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Protein

Protein YIPF5

Gene

YIPF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in transport between endoplasmic reticulum and Golgi.2 Publications

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. regulation of ER to Golgi vesicle-mediated transport Source: Ensembl
  3. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF5
Alternative name(s):
Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5
Smooth muscle cell-associated protein 5
Short name:
SMAP-5
YIP1 family member 5
YPT-interacting protein 1 A
Gene namesi
Name:YIPF5
Synonyms:FINGER5, YIP1A
ORF Names:PP12723, SB140, UNQ3123/PRO10275
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:24877. YIPF5.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatusGolgi stack membrane; Multi-pass membrane protein. Cytoplasmic vesicleCOPII-coated vesicle
Note: Enriched at the endoplasmic reticulum exit sites. Incorporated into COPII coated vesicles.

GO - Cellular componenti

  1. endoplasmic reticulum exit site Source: Ensembl
  2. ER to Golgi transport vesicle Source: Ensembl
  3. Golgi apparatus Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. nuclear outer membrane-endoplasmic reticulum membrane network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Protein YIPF5PRO_0000234328Add
BLAST

Proteomic databases

MaxQBiQ969M3.
PaxDbiQ969M3.
PRIDEiQ969M3.

PTM databases

PhosphoSiteiQ969M3.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in coronary smooth muscles.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiQ969M3.
CleanExiHS_YIPF5.
ExpressionAtlasiQ969M3. baseline and differential.
GenevestigatoriQ969M3.

Interactioni

Subunit structurei

Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B). Interacts with YIF1A. May interact with RAB1A.3 Publications

Protein-protein interaction databases

BioGridi123519. 4 interactions.
IntActiQ969M3. 6 interactions.
MINTiMINT-5005521.
STRINGi9606.ENSP00000274496.

Structurei

3D structure databases

ProteinModelPortaliQ969M3.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 124124CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini146 – 1461LumenalSequence Analysis
Topological domaini168 – 1736CytoplasmicSequence Analysis
Topological domaini195 – 1962LumenalSequence Analysis
Topological domaini218 – 23619CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 10632Interaction with Sec23Add
BLAST

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5080.
GeneTreeiENSGT00510000046817.
HOVERGENiHBG055241.
InParanoidiQ969M3.
OMAiGGWWTAF.
OrthoDBiEOG7CRTQW.
PhylomeDBiQ969M3.
TreeFamiTF313100.

Family and domain databases

InterProiIPR006977. Yip1.
[Graphical view]
PfamiPF04893. Yip1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969M3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGFENLNTD FYQTSYSIDD QSQQSYDYGG SGGPYSKQYA GYDYSQQGRF
60 70 80 90 100
VPPDMMQPQQ PYTGQIYQPT QAYTPASPQP FYGNNFEDEP PLLEELGINF
110 120 130 140 150
DHIWQKTLTV LHPLKVADGS IMNETDLAGP MVFCLAFGAT LLLAGKIQFG
160 170 180 190 200
YVYGISAIGC LGMFCLLNLM SMTGVSFGCV ASVLGYCLLP MILLSSFAVI
210 220 230 240 250
FSLQGMVGII LTAGIIGWCS FSASKIFISA LAMEGQQLLV AYPCALLYGV

FALISVF
Length:257
Mass (Da):27,989
Last modified:December 1, 2001 - v1
Checksum:iB30EACB0E514DC67
GO
Isoform 2 (identifier: Q969M3-2) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:203
Mass (Da):21,896
Checksum:iC29C76D8D3D7FF6F
GO
Isoform 3 (identifier: Q969M3-3) [UniParc]FASTAAdd to Basket

Also known as: I

The sequence of this isoform differs from the canonical sequence as follows:
     242-257: YPCALLYGVFALISVF → LQPNITYGSNYFLFCCLPYPQQHF

Show »
Length:265
Mass (Da):29,107
Checksum:iDBAD311C26DE5A05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1383AFG → DLA in AAK67644. 1 PublicationCurated
Sequence conflicti155 – 1551I → S in AAG48521. (PubMed:11489904)Curated
Sequence conflicti187 – 1871C → W in AAK67644. 1 PublicationCurated
Sequence conflicti192 – 1921I → Y in AAG48521. (PubMed:11489904)Curated
Sequence conflicti244 – 2441C → R in BAD97235. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 2. 1 PublicationVSP_018253Add
BLAST
Alternative sequencei242 – 25716YPCAL…LISVF → LQPNITYGSNYFLFCCLPYP QQHF in isoform 3. 1 PublicationVSP_018254Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140225 mRNA. Translation: AAG48521.1.
AY640925 mRNA. Translation: AAV51256.1.
AY640926 mRNA. Translation: AAV51257.1.
AY640927 mRNA. Translation: AAV51258.1.
AY640928 mRNA. Translation: AAV51259.1.
AY640929 mRNA. No translation available.
AY640934 mRNA. Translation: AAV51260.1.
AY037152 mRNA. Translation: AAK67644.1.
AY358863 mRNA. Translation: AAQ89222.1.
AK054576 mRNA. Translation: BAB70763.1.
AF318329 mRNA. Translation: AAL55836.1.
AK223515 mRNA. Translation: BAD97235.1.
CR749463 mRNA. Translation: CAH18295.1.
CH471062 Genomic DNA. Translation: EAW61864.1.
CH471062 Genomic DNA. Translation: EAW61865.1.
BC007829 mRNA. Translation: AAH07829.1.
BC014253 mRNA. Translation: AAH14253.1.
BC024737 mRNA. Translation: AAH24737.1.
AB014733 mRNA. Translation: BAB20270.1.
CCDSiCCDS4279.1. [Q969M3-1]
CCDS64277.1. [Q969M3-2]
RefSeqiNP_001020118.1. NM_001024947.3. [Q969M3-1]
NP_001258661.1. NM_001271732.1. [Q969M3-2]
NP_110426.4. NM_030799.8. [Q969M3-1]
UniGeneiHs.372050.

Genome annotation databases

EnsembliENST00000274496; ENSP00000274496; ENSG00000145817. [Q969M3-1]
ENST00000448443; ENSP00000397704; ENSG00000145817. [Q969M3-1]
ENST00000513112; ENSP00000425422; ENSG00000145817. [Q969M3-2]
GeneIDi81555.
KEGGihsa:81555.
UCSCiuc003lnk.5. human. [Q969M3-1]

Polymorphism databases

DMDMi74760683.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140225 mRNA. Translation: AAG48521.1 .
AY640925 mRNA. Translation: AAV51256.1 .
AY640926 mRNA. Translation: AAV51257.1 .
AY640927 mRNA. Translation: AAV51258.1 .
AY640928 mRNA. Translation: AAV51259.1 .
AY640929 mRNA. No translation available.
AY640934 mRNA. Translation: AAV51260.1 .
AY037152 mRNA. Translation: AAK67644.1 .
AY358863 mRNA. Translation: AAQ89222.1 .
AK054576 mRNA. Translation: BAB70763.1 .
AF318329 mRNA. Translation: AAL55836.1 .
AK223515 mRNA. Translation: BAD97235.1 .
CR749463 mRNA. Translation: CAH18295.1 .
CH471062 Genomic DNA. Translation: EAW61864.1 .
CH471062 Genomic DNA. Translation: EAW61865.1 .
BC007829 mRNA. Translation: AAH07829.1 .
BC014253 mRNA. Translation: AAH14253.1 .
BC024737 mRNA. Translation: AAH24737.1 .
AB014733 mRNA. Translation: BAB20270.1 .
CCDSi CCDS4279.1. [Q969M3-1 ]
CCDS64277.1. [Q969M3-2 ]
RefSeqi NP_001020118.1. NM_001024947.3. [Q969M3-1 ]
NP_001258661.1. NM_001271732.1. [Q969M3-2 ]
NP_110426.4. NM_030799.8. [Q969M3-1 ]
UniGenei Hs.372050.

3D structure databases

ProteinModelPortali Q969M3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123519. 4 interactions.
IntActi Q969M3. 6 interactions.
MINTi MINT-5005521.
STRINGi 9606.ENSP00000274496.

PTM databases

PhosphoSitei Q969M3.

Polymorphism databases

DMDMi 74760683.

Proteomic databases

MaxQBi Q969M3.
PaxDbi Q969M3.
PRIDEi Q969M3.

Protocols and materials databases

DNASUi 81555.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274496 ; ENSP00000274496 ; ENSG00000145817 . [Q969M3-1 ]
ENST00000448443 ; ENSP00000397704 ; ENSG00000145817 . [Q969M3-1 ]
ENST00000513112 ; ENSP00000425422 ; ENSG00000145817 . [Q969M3-2 ]
GeneIDi 81555.
KEGGi hsa:81555.
UCSCi uc003lnk.5. human. [Q969M3-1 ]

Organism-specific databases

CTDi 81555.
GeneCardsi GC05M143520.
H-InvDB HIX0005274.
HGNCi HGNC:24877. YIPF5.
MIMi 611483. gene.
neXtProti NX_Q969M3.
PharmGKBi PA142670548.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5080.
GeneTreei ENSGT00510000046817.
HOVERGENi HBG055241.
InParanoidi Q969M3.
OMAi GGWWTAF.
OrthoDBi EOG7CRTQW.
PhylomeDBi Q969M3.
TreeFami TF313100.

Miscellaneous databases

ChiTaRSi YIPF5. human.
GeneWikii YIPF5.
GenomeRNAii 81555.
NextBioi 71810.
PROi Q969M3.
SOURCEi Search...

Gene expression databases

Bgeei Q969M3.
CleanExi HS_YIPF5.
ExpressionAtlasi Q969M3. baseline and differential.
Genevestigatori Q969M3.

Family and domain databases

InterProi IPR006977. Yip1.
[Graphical view ]
Pfami PF04893. Yip1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII."
    Tang B.L., Ong Y.S., Huang B., Wei S., Wong E.T., Qi R., Horstmann H., Hong W.
    J. Biol. Chem. 276:40008-40017(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH SEC23 AND SEC24, SUBCELLULAR LOCATION.
  2. "Cloning, cellular localization, genomic organization, and tissue-specific expression of the TGFbeta1-inducible SMAP-5 gene."
    Stolle K., Schnoor M., Fuellen G., Spitzer M., Engel T., Spener F., Cullen P., Lorkowski S.
    Gene 351:119-130(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, INDUCTION.
    Tissue: Coronary artery.
  3. Zhang W., Li N., Zhang M., Wan T., Cao X.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Neuroblastoma.
  6. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney epithelium.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adipose tissue.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix, Eye and Uterus.
  11. "Molecular cloning and characterization of the human smooth muscle cell associated protein-5 (SMAP-5)."
    Nishimoto S., Toyoda H., Tawara J., Aoki T., Komurasaki T.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-257 (ISOFORMS 1/2).
    Tissue: Heart.
  12. "Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor."
    Chen C.Z., Calero M., DeRegis C.J., Heidtman M., Barlowe C., Collins R.N.
    Genetics 168:1827-1841(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAB1A.
  13. "Human Yip1A specifies the localization of Yif1 to the Golgi apparatus."
    Jin C., Zhang Y., Zhu H., Ahmed K., Fu C., Yao X.
    Biochem. Biophys. Res. Commun. 334:16-22(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YIF1A, SUBCELLULAR LOCATION.
  14. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYIPF5_HUMAN
AccessioniPrimary (citable) accession number: Q969M3
Secondary accession number(s): D3DQF5
, Q4VSN6, Q53EX4, Q8NHE5, Q9H338, Q9H3U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3