Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein YIPF5

Gene

YIPF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in transport between endoplasmic reticulum and Golgi.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF5
Alternative name(s):
Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5
Smooth muscle cell-associated protein 5
Short name:
SMAP-5
YIP1 family member 5
YPT-interacting protein 1 A
Gene namesi
Name:YIPF5
Synonyms:FINGER5, YIP1A
ORF Names:PP12723, SB140, UNQ3123/PRO10275
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24877. YIPF5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 124CytoplasmicSequence analysisAdd BLAST124
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146LumenalSequence analysis1
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 173CytoplasmicSequence analysis6
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 196LumenalSequence analysis2
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 236CytoplasmicSequence analysisAdd BLAST19
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81555.
OpenTargetsiENSG00000145817.
PharmGKBiPA142670548.

Polymorphism and mutation databases

DMDMi74760683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343281 – 257Protein YIPF5Add BLAST257

Proteomic databases

EPDiQ969M3.
MaxQBiQ969M3.
PaxDbiQ969M3.
PeptideAtlasiQ969M3.
PRIDEiQ969M3.

PTM databases

iPTMnetiQ969M3.
PhosphoSitePlusiQ969M3.
SwissPalmiQ969M3.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in coronary smooth muscles.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000145817.
CleanExiHS_YIPF5.
ExpressionAtlasiQ969M3. baseline and differential.
GenevisibleiQ969M3. HS.

Organism-specific databases

HPAiCAB022462.

Interactioni

Subunit structurei

Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B). Interacts with YIF1A. May interact with RAB1A.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ERN1O754603EBI-2124787,EBI-371750
YIF1AO950704EBI-2124787,EBI-2799703

Protein-protein interaction databases

BioGridi123519. 52 interactors.
IntActiQ969M3. 56 interactors.
MINTiMINT-5005521.
STRINGi9606.ENSP00000274496.

Structurei

3D structure databases

ProteinModelPortaliQ969M3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 106Interaction with Sec23Add BLAST32

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3103. Eukaryota.
COG5080. LUCA.
GeneTreeiENSGT00510000046817.
HOVERGENiHBG055241.
InParanoidiQ969M3.
KOiK20363.
OMAiFDNLNTD.
OrthoDBiEOG091G0Y2Z.
PhylomeDBiQ969M3.
TreeFamiTF313100.

Family and domain databases

InterProiIPR006977. Yip1.
[Graphical view]
PfamiPF04893. Yip1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969M3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGFENLNTD FYQTSYSIDD QSQQSYDYGG SGGPYSKQYA GYDYSQQGRF
60 70 80 90 100
VPPDMMQPQQ PYTGQIYQPT QAYTPASPQP FYGNNFEDEP PLLEELGINF
110 120 130 140 150
DHIWQKTLTV LHPLKVADGS IMNETDLAGP MVFCLAFGAT LLLAGKIQFG
160 170 180 190 200
YVYGISAIGC LGMFCLLNLM SMTGVSFGCV ASVLGYCLLP MILLSSFAVI
210 220 230 240 250
FSLQGMVGII LTAGIIGWCS FSASKIFISA LAMEGQQLLV AYPCALLYGV

FALISVF
Length:257
Mass (Da):27,989
Last modified:December 1, 2001 - v1
Checksum:iB30EACB0E514DC67
GO
Isoform 2 (identifier: Q969M3-2) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:203
Mass (Da):21,896
Checksum:iC29C76D8D3D7FF6F
GO
Isoform 3 (identifier: Q969M3-3) [UniParc]FASTAAdd to basket
Also known as: I

The sequence of this isoform differs from the canonical sequence as follows:
     242-257: YPCALLYGVFALISVF → LQPNITYGSNYFLFCCLPYPQQHF

Show »
Length:265
Mass (Da):29,107
Checksum:iDBAD311C26DE5A05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136 – 138AFG → DLA in AAK67644 (Ref. 3) Curated3
Sequence conflicti155I → S in AAG48521 (PubMed:11489904).Curated1
Sequence conflicti187C → W in AAK67644 (Ref. 3) Curated1
Sequence conflicti192I → Y in AAG48521 (PubMed:11489904).Curated1
Sequence conflicti244C → R in BAD97235 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0182531 – 54Missing in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_018254242 – 257YPCAL…LISVF → LQPNITYGSNYFLFCCLPYP QQHF in isoform 3. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140225 mRNA. Translation: AAG48521.1.
AY640925 mRNA. Translation: AAV51256.1.
AY640926 mRNA. Translation: AAV51257.1.
AY640927 mRNA. Translation: AAV51258.1.
AY640928 mRNA. Translation: AAV51259.1.
AY640929 mRNA. No translation available.
AY640934 mRNA. Translation: AAV51260.1.
AY037152 mRNA. Translation: AAK67644.1.
AY358863 mRNA. Translation: AAQ89222.1.
AK054576 mRNA. Translation: BAB70763.1.
AF318329 mRNA. Translation: AAL55836.1.
AK223515 mRNA. Translation: BAD97235.1.
CR749463 mRNA. Translation: CAH18295.1.
CH471062 Genomic DNA. Translation: EAW61864.1.
CH471062 Genomic DNA. Translation: EAW61865.1.
BC007829 mRNA. Translation: AAH07829.1.
BC014253 mRNA. Translation: AAH14253.1.
BC024737 mRNA. Translation: AAH24737.1.
AB014733 mRNA. Translation: BAB20270.1.
CCDSiCCDS4279.1. [Q969M3-1]
CCDS64277.1. [Q969M3-2]
RefSeqiNP_001020118.1. NM_001024947.3. [Q969M3-1]
NP_001258661.1. NM_001271732.1. [Q969M3-2]
NP_110426.4. NM_030799.8. [Q969M3-1]
UniGeneiHs.372050.

Genome annotation databases

EnsembliENST00000274496; ENSP00000274496; ENSG00000145817. [Q969M3-1]
ENST00000448443; ENSP00000397704; ENSG00000145817. [Q969M3-1]
ENST00000513112; ENSP00000425422; ENSG00000145817. [Q969M3-2]
GeneIDi81555.
KEGGihsa:81555.
UCSCiuc003lnk.6. human. [Q969M3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140225 mRNA. Translation: AAG48521.1.
AY640925 mRNA. Translation: AAV51256.1.
AY640926 mRNA. Translation: AAV51257.1.
AY640927 mRNA. Translation: AAV51258.1.
AY640928 mRNA. Translation: AAV51259.1.
AY640929 mRNA. No translation available.
AY640934 mRNA. Translation: AAV51260.1.
AY037152 mRNA. Translation: AAK67644.1.
AY358863 mRNA. Translation: AAQ89222.1.
AK054576 mRNA. Translation: BAB70763.1.
AF318329 mRNA. Translation: AAL55836.1.
AK223515 mRNA. Translation: BAD97235.1.
CR749463 mRNA. Translation: CAH18295.1.
CH471062 Genomic DNA. Translation: EAW61864.1.
CH471062 Genomic DNA. Translation: EAW61865.1.
BC007829 mRNA. Translation: AAH07829.1.
BC014253 mRNA. Translation: AAH14253.1.
BC024737 mRNA. Translation: AAH24737.1.
AB014733 mRNA. Translation: BAB20270.1.
CCDSiCCDS4279.1. [Q969M3-1]
CCDS64277.1. [Q969M3-2]
RefSeqiNP_001020118.1. NM_001024947.3. [Q969M3-1]
NP_001258661.1. NM_001271732.1. [Q969M3-2]
NP_110426.4. NM_030799.8. [Q969M3-1]
UniGeneiHs.372050.

3D structure databases

ProteinModelPortaliQ969M3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123519. 52 interactors.
IntActiQ969M3. 56 interactors.
MINTiMINT-5005521.
STRINGi9606.ENSP00000274496.

PTM databases

iPTMnetiQ969M3.
PhosphoSitePlusiQ969M3.
SwissPalmiQ969M3.

Polymorphism and mutation databases

DMDMi74760683.

Proteomic databases

EPDiQ969M3.
MaxQBiQ969M3.
PaxDbiQ969M3.
PeptideAtlasiQ969M3.
PRIDEiQ969M3.

Protocols and materials databases

DNASUi81555.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274496; ENSP00000274496; ENSG00000145817. [Q969M3-1]
ENST00000448443; ENSP00000397704; ENSG00000145817. [Q969M3-1]
ENST00000513112; ENSP00000425422; ENSG00000145817. [Q969M3-2]
GeneIDi81555.
KEGGihsa:81555.
UCSCiuc003lnk.6. human. [Q969M3-1]

Organism-specific databases

CTDi81555.
DisGeNETi81555.
GeneCardsiYIPF5.
H-InvDBHIX0005274.
HGNCiHGNC:24877. YIPF5.
HPAiCAB022462.
MIMi611483. gene.
neXtProtiNX_Q969M3.
OpenTargetsiENSG00000145817.
PharmGKBiPA142670548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3103. Eukaryota.
COG5080. LUCA.
GeneTreeiENSGT00510000046817.
HOVERGENiHBG055241.
InParanoidiQ969M3.
KOiK20363.
OMAiFDNLNTD.
OrthoDBiEOG091G0Y2Z.
PhylomeDBiQ969M3.
TreeFamiTF313100.

Miscellaneous databases

ChiTaRSiYIPF5. human.
GeneWikiiYIPF5.
GenomeRNAii81555.
PROiQ969M3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145817.
CleanExiHS_YIPF5.
ExpressionAtlasiQ969M3. baseline and differential.
GenevisibleiQ969M3. HS.

Family and domain databases

InterProiIPR006977. Yip1.
[Graphical view]
PfamiPF04893. Yip1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYIPF5_HUMAN
AccessioniPrimary (citable) accession number: Q969M3
Secondary accession number(s): D3DQF5
, Q4VSN6, Q53EX4, Q8NHE5, Q9H338, Q9H3U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.