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Q969M3

- YIPF5_HUMAN

UniProt

Q969M3 - YIPF5_HUMAN

Protein

Protein YIPF5

Gene

YIPF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Plays a role in transport between endoplasmic reticulum and Golgi.2 Publications

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. regulation of ER to Golgi vesicle-mediated transport Source: Ensembl
    3. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein YIPF5
    Alternative name(s):
    Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5
    Smooth muscle cell-associated protein 5
    Short name:
    SMAP-5
    YIP1 family member 5
    YPT-interacting protein 1 A
    Gene namesi
    Name:YIPF5
    Synonyms:FINGER5, YIP1A
    ORF Names:PP12723, SB140, UNQ3123/PRO10275
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:24877. YIPF5.

    Subcellular locationi

    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatusGolgi stack membrane; Multi-pass membrane protein. Cytoplasmic vesicleCOPII-coated vesicle
    Note: Enriched at the endoplasmic reticulum exit sites. Incorporated into COPII coated vesicles.

    GO - Cellular componenti

    1. endoplasmic reticulum exit site Source: Ensembl
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. ER to Golgi transport vesicle Source: UniProtKB-SubCell
    4. Golgi cisterna membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670548.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Protein YIPF5PRO_0000234328Add
    BLAST

    Proteomic databases

    MaxQBiQ969M3.
    PaxDbiQ969M3.
    PRIDEiQ969M3.

    PTM databases

    PhosphoSiteiQ969M3.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Highly expressed in coronary smooth muscles.1 Publication

    Inductioni

    By TGFB1.1 Publication

    Gene expression databases

    ArrayExpressiQ969M3.
    BgeeiQ969M3.
    CleanExiHS_YIPF5.
    GenevestigatoriQ969M3.

    Interactioni

    Subunit structurei

    Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B). Interacts with YIF1A. May interact with RAB1A.3 Publications

    Protein-protein interaction databases

    BioGridi123519. 4 interactions.
    IntActiQ969M3. 6 interactions.
    MINTiMINT-5005521.
    STRINGi9606.ENSP00000274496.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969M3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 124124CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini146 – 1461LumenalSequence Analysis
    Topological domaini168 – 1736CytoplasmicSequence Analysis
    Topological domaini195 – 1962LumenalSequence Analysis
    Topological domaini218 – 23619CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni75 – 10632Interaction with Sec23Add
    BLAST

    Sequence similaritiesi

    Belongs to the YIP1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5080.
    HOVERGENiHBG055241.
    OMAiGGWWTAF.
    OrthoDBiEOG7CRTQW.
    PhylomeDBiQ969M3.
    TreeFamiTF313100.

    Family and domain databases

    InterProiIPR006977. Yip1.
    [Graphical view]
    PfamiPF04893. Yip1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969M3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGFENLNTD FYQTSYSIDD QSQQSYDYGG SGGPYSKQYA GYDYSQQGRF    50
    VPPDMMQPQQ PYTGQIYQPT QAYTPASPQP FYGNNFEDEP PLLEELGINF 100
    DHIWQKTLTV LHPLKVADGS IMNETDLAGP MVFCLAFGAT LLLAGKIQFG 150
    YVYGISAIGC LGMFCLLNLM SMTGVSFGCV ASVLGYCLLP MILLSSFAVI 200
    FSLQGMVGII LTAGIIGWCS FSASKIFISA LAMEGQQLLV AYPCALLYGV 250
    FALISVF 257
    Length:257
    Mass (Da):27,989
    Last modified:December 1, 2001 - v1
    Checksum:iB30EACB0E514DC67
    GO
    Isoform 2 (identifier: Q969M3-2) [UniParc]FASTAAdd to Basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         1-54: Missing.

    Show »
    Length:203
    Mass (Da):21,896
    Checksum:iC29C76D8D3D7FF6F
    GO
    Isoform 3 (identifier: Q969M3-3) [UniParc]FASTAAdd to Basket

    Also known as: I

    The sequence of this isoform differs from the canonical sequence as follows:
         242-257: YPCALLYGVFALISVF → LQPNITYGSNYFLFCCLPYPQQHF

    Show »
    Length:265
    Mass (Da):29,107
    Checksum:iDBAD311C26DE5A05
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti136 – 1383AFG → DLA in AAK67644. 1 PublicationCurated
    Sequence conflicti155 – 1551I → S in AAG48521. (PubMed:11489904)Curated
    Sequence conflicti187 – 1871C → W in AAK67644. 1 PublicationCurated
    Sequence conflicti192 – 1921I → Y in AAG48521. (PubMed:11489904)Curated
    Sequence conflicti244 – 2441C → R in BAD97235. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5454Missing in isoform 2. 1 PublicationVSP_018253Add
    BLAST
    Alternative sequencei242 – 25716YPCAL…LISVF → LQPNITYGSNYFLFCCLPYP QQHF in isoform 3. 1 PublicationVSP_018254Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140225 mRNA. Translation: AAG48521.1.
    AY640925 mRNA. Translation: AAV51256.1.
    AY640926 mRNA. Translation: AAV51257.1.
    AY640927 mRNA. Translation: AAV51258.1.
    AY640928 mRNA. Translation: AAV51259.1.
    AY640929 mRNA. No translation available.
    AY640934 mRNA. Translation: AAV51260.1.
    AY037152 mRNA. Translation: AAK67644.1.
    AY358863 mRNA. Translation: AAQ89222.1.
    AK054576 mRNA. Translation: BAB70763.1.
    AF318329 mRNA. Translation: AAL55836.1.
    AK223515 mRNA. Translation: BAD97235.1.
    CR749463 mRNA. Translation: CAH18295.1.
    CH471062 Genomic DNA. Translation: EAW61864.1.
    CH471062 Genomic DNA. Translation: EAW61865.1.
    BC007829 mRNA. Translation: AAH07829.1.
    BC014253 mRNA. Translation: AAH14253.1.
    BC024737 mRNA. Translation: AAH24737.1.
    AB014733 mRNA. Translation: BAB20270.1.
    CCDSiCCDS4279.1. [Q969M3-1]
    CCDS64277.1. [Q969M3-2]
    RefSeqiNP_001020118.1. NM_001024947.3. [Q969M3-1]
    NP_001258661.1. NM_001271732.1. [Q969M3-2]
    NP_110426.4. NM_030799.8. [Q969M3-1]
    UniGeneiHs.372050.

    Genome annotation databases

    EnsembliENST00000274496; ENSP00000274496; ENSG00000145817. [Q969M3-1]
    ENST00000448443; ENSP00000397704; ENSG00000145817. [Q969M3-1]
    ENST00000513112; ENSP00000425422; ENSG00000145817. [Q969M3-2]
    GeneIDi81555.
    KEGGihsa:81555.
    UCSCiuc003lnk.5. human. [Q969M3-1]

    Polymorphism databases

    DMDMi74760683.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140225 mRNA. Translation: AAG48521.1 .
    AY640925 mRNA. Translation: AAV51256.1 .
    AY640926 mRNA. Translation: AAV51257.1 .
    AY640927 mRNA. Translation: AAV51258.1 .
    AY640928 mRNA. Translation: AAV51259.1 .
    AY640929 mRNA. No translation available.
    AY640934 mRNA. Translation: AAV51260.1 .
    AY037152 mRNA. Translation: AAK67644.1 .
    AY358863 mRNA. Translation: AAQ89222.1 .
    AK054576 mRNA. Translation: BAB70763.1 .
    AF318329 mRNA. Translation: AAL55836.1 .
    AK223515 mRNA. Translation: BAD97235.1 .
    CR749463 mRNA. Translation: CAH18295.1 .
    CH471062 Genomic DNA. Translation: EAW61864.1 .
    CH471062 Genomic DNA. Translation: EAW61865.1 .
    BC007829 mRNA. Translation: AAH07829.1 .
    BC014253 mRNA. Translation: AAH14253.1 .
    BC024737 mRNA. Translation: AAH24737.1 .
    AB014733 mRNA. Translation: BAB20270.1 .
    CCDSi CCDS4279.1. [Q969M3-1 ]
    CCDS64277.1. [Q969M3-2 ]
    RefSeqi NP_001020118.1. NM_001024947.3. [Q969M3-1 ]
    NP_001258661.1. NM_001271732.1. [Q969M3-2 ]
    NP_110426.4. NM_030799.8. [Q969M3-1 ]
    UniGenei Hs.372050.

    3D structure databases

    ProteinModelPortali Q969M3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123519. 4 interactions.
    IntActi Q969M3. 6 interactions.
    MINTi MINT-5005521.
    STRINGi 9606.ENSP00000274496.

    PTM databases

    PhosphoSitei Q969M3.

    Polymorphism databases

    DMDMi 74760683.

    Proteomic databases

    MaxQBi Q969M3.
    PaxDbi Q969M3.
    PRIDEi Q969M3.

    Protocols and materials databases

    DNASUi 81555.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274496 ; ENSP00000274496 ; ENSG00000145817 . [Q969M3-1 ]
    ENST00000448443 ; ENSP00000397704 ; ENSG00000145817 . [Q969M3-1 ]
    ENST00000513112 ; ENSP00000425422 ; ENSG00000145817 . [Q969M3-2 ]
    GeneIDi 81555.
    KEGGi hsa:81555.
    UCSCi uc003lnk.5. human. [Q969M3-1 ]

    Organism-specific databases

    CTDi 81555.
    GeneCardsi GC05M143520.
    H-InvDB HIX0005274.
    HGNCi HGNC:24877. YIPF5.
    MIMi 611483. gene.
    neXtProti NX_Q969M3.
    PharmGKBi PA142670548.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5080.
    HOVERGENi HBG055241.
    OMAi GGWWTAF.
    OrthoDBi EOG7CRTQW.
    PhylomeDBi Q969M3.
    TreeFami TF313100.

    Miscellaneous databases

    ChiTaRSi YIPF5. human.
    GeneWikii YIPF5.
    GenomeRNAii 81555.
    NextBioi 71810.
    PROi Q969M3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969M3.
    Bgeei Q969M3.
    CleanExi HS_YIPF5.
    Genevestigatori Q969M3.

    Family and domain databases

    InterProi IPR006977. Yip1.
    [Graphical view ]
    Pfami PF04893. Yip1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII."
      Tang B.L., Ong Y.S., Huang B., Wei S., Wong E.T., Qi R., Horstmann H., Hong W.
      J. Biol. Chem. 276:40008-40017(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH SEC23 AND SEC24, SUBCELLULAR LOCATION.
    2. "Cloning, cellular localization, genomic organization, and tissue-specific expression of the TGFbeta1-inducible SMAP-5 gene."
      Stolle K., Schnoor M., Fuellen G., Spitzer M., Engel T., Spener F., Cullen P., Lorkowski S.
      Gene 351:119-130(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, INDUCTION.
      Tissue: Coronary artery.
    3. Zhang W., Li N., Zhang M., Wan T., Cao X.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Neuroblastoma.
    6. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney epithelium.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Adipose tissue.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix, Eye and Uterus.
    11. "Molecular cloning and characterization of the human smooth muscle cell associated protein-5 (SMAP-5)."
      Nishimoto S., Toyoda H., Tawara J., Aoki T., Komurasaki T.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-257 (ISOFORMS 1/2).
      Tissue: Heart.
    12. "Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor."
      Chen C.Z., Calero M., DeRegis C.J., Heidtman M., Barlowe C., Collins R.N.
      Genetics 168:1827-1841(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RAB1A.
    13. "Human Yip1A specifies the localization of Yif1 to the Golgi apparatus."
      Jin C., Zhang Y., Zhu H., Ahmed K., Fu C., Yao X.
      Biochem. Biophys. Res. Commun. 334:16-22(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH YIF1A, SUBCELLULAR LOCATION.
    14. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYIPF5_HUMAN
    AccessioniPrimary (citable) accession number: Q969M3
    Secondary accession number(s): D3DQF5
    , Q4VSN6, Q53EX4, Q8NHE5, Q9H338, Q9H3U4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3