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Q969M3 (YIPF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein YIPF5
Alternative name(s):
Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5
Smooth muscle cell-associated protein 5
Short name=SMAP-5
YIP1 family member 5
YPT-interacting protein 1 A
Gene names
Name:YIPF5
Synonyms:FINGER5, YIP1A
ORF Names:PP12723, SB140, UNQ3123/PRO10275
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in transport between endoplasmic reticulum and Golgi. Ref.1 Ref.12

Subunit structure

Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B). Interacts with YIF1A. May interact with RAB1A. Ref.1 Ref.12 Ref.13

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatusGolgi stack membrane; Multi-pass membrane protein. Cytoplasmic vesicleCOPII-coated vesicle. Note: Enriched at the endoplasmic reticulum exit sites. Incorporated into COPII coated vesicles. Ref.1 Ref.13

Tissue specificity

Ubiquitously expressed. Highly expressed in coronary smooth muscles. Ref.2

Induction

By TGFB1. Ref.2

Sequence similarities

Belongs to the YIP1 family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q969M3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q969M3-2)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
Isoform 3 (identifier: Q969M3-3)

Also known as: I;

The sequence of this isoform differs from the canonical sequence as follows:
     242-257: YPCALLYGVFALISVF → LQPNITYGSNYFLFCCLPYPQQHF

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Protein YIPF5
PRO_0000234328

Regions

Topological domain1 – 124124Cytoplasmic Potential
Transmembrane125 – 14521Helical; Potential
Topological domain1461Lumenal Potential
Transmembrane147 – 16721Helical; Potential
Topological domain168 – 1736Cytoplasmic Potential
Transmembrane174 – 19421Helical; Potential
Topological domain195 – 1962Lumenal Potential
Transmembrane197 – 21721Helical; Potential
Topological domain218 – 23619Cytoplasmic Potential
Transmembrane237 – 25721Helical; Potential
Region75 – 10632Interaction with Sec23

Natural variations

Alternative sequence1 – 5454Missing in isoform 2.
VSP_018253
Alternative sequence242 – 25716YPCAL…LISVF → LQPNITYGSNYFLFCCLPYP QQHF in isoform 3.
VSP_018254

Experimental info

Sequence conflict136 – 1383AFG → DLA in AAK67644. Ref.3
Sequence conflict1551I → S in AAG48521. Ref.1
Sequence conflict1871C → W in AAK67644. Ref.3
Sequence conflict1921I → Y in AAG48521. Ref.1
Sequence conflict2441C → R in BAD97235. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: B30EACB0E514DC67

FASTA25727,989
        10         20         30         40         50         60 
MSGFENLNTD FYQTSYSIDD QSQQSYDYGG SGGPYSKQYA GYDYSQQGRF VPPDMMQPQQ 

        70         80         90        100        110        120 
PYTGQIYQPT QAYTPASPQP FYGNNFEDEP PLLEELGINF DHIWQKTLTV LHPLKVADGS 

       130        140        150        160        170        180 
IMNETDLAGP MVFCLAFGAT LLLAGKIQFG YVYGISAIGC LGMFCLLNLM SMTGVSFGCV 

       190        200        210        220        230        240 
ASVLGYCLLP MILLSSFAVI FSLQGMVGII LTAGIIGWCS FSASKIFISA LAMEGQQLLV 

       250 
AYPCALLYGV FALISVF 

« Hide

Isoform 2 (D) [UniParc].

Checksum: C29C76D8D3D7FF6F
Show »

FASTA20321,896
Isoform 3 (I) [UniParc].

Checksum: DBAD311C26DE5A05
Show »

FASTA26529,107

References

« Hide 'large scale' references
[1]"A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII."
Tang B.L., Ong Y.S., Huang B., Wei S., Wong E.T., Qi R., Horstmann H., Hong W.
J. Biol. Chem. 276:40008-40017(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH SEC23 AND SEC24, SUBCELLULAR LOCATION.
[2]"Cloning, cellular localization, genomic organization, and tissue-specific expression of the TGFbeta1-inducible SMAP-5 gene."
Stolle K., Schnoor M., Fuellen G., Spitzer M., Engel T., Spener F., Cullen P., Lorkowski S.
Gene 351:119-130(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, INDUCTION.
Tissue: Coronary artery.
[3]Zhang W., Li N., Zhang M., Wan T., Cao X.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Neuroblastoma.
[6]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney epithelium.
[8]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Adipose tissue.
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Cervix, Eye and Uterus.
[11]"Molecular cloning and characterization of the human smooth muscle cell associated protein-5 (SMAP-5)."
Nishimoto S., Toyoda H., Tawara J., Aoki T., Komurasaki T.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-257 (ISOFORMS 1/2).
Tissue: Heart.
[12]"Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor."
Chen C.Z., Calero M., DeRegis C.J., Heidtman M., Barlowe C., Collins R.N.
Genetics 168:1827-1841(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RAB1A.
[13]"Human Yip1A specifies the localization of Yif1 to the Golgi apparatus."
Jin C., Zhang Y., Zhu H., Ahmed K., Fu C., Yao X.
Biochem. Biophys. Res. Commun. 334:16-22(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH YIF1A, SUBCELLULAR LOCATION.
[14]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF140225 mRNA. Translation: AAG48521.1.
AY640925 mRNA. Translation: AAV51256.1.
AY640926 mRNA. Translation: AAV51257.1.
AY640927 mRNA. Translation: AAV51258.1.
AY640928 mRNA. Translation: AAV51259.1.
AY640929 mRNA. No translation available.
AY640934 mRNA. Translation: AAV51260.1.
AY037152 mRNA. Translation: AAK67644.1.
AY358863 mRNA. Translation: AAQ89222.1.
AK054576 mRNA. Translation: BAB70763.1.
AF318329 mRNA. Translation: AAL55836.1.
AK223515 mRNA. Translation: BAD97235.1.
CR749463 mRNA. Translation: CAH18295.1.
CH471062 Genomic DNA. Translation: EAW61864.1.
CH471062 Genomic DNA. Translation: EAW61865.1.
BC007829 mRNA. Translation: AAH07829.1.
BC014253 mRNA. Translation: AAH14253.1.
BC024737 mRNA. Translation: AAH24737.1.
AB014733 mRNA. Translation: BAB20270.1.
CCDSCCDS4279.1. [Q969M3-1]
CCDS64277.1. [Q969M3-2]
RefSeqNP_001020118.1. NM_001024947.3. [Q969M3-1]
NP_001258661.1. NM_001271732.1. [Q969M3-2]
NP_110426.4. NM_030799.8. [Q969M3-1]
UniGeneHs.372050.

3D structure databases

ProteinModelPortalQ969M3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123519. 4 interactions.
IntActQ969M3. 6 interactions.
MINTMINT-5005521.
STRING9606.ENSP00000274496.

PTM databases

PhosphoSiteQ969M3.

Polymorphism databases

DMDM74760683.

Proteomic databases

MaxQBQ969M3.
PaxDbQ969M3.
PRIDEQ969M3.

Protocols and materials databases

DNASU81555.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274496; ENSP00000274496; ENSG00000145817. [Q969M3-1]
ENST00000448443; ENSP00000397704; ENSG00000145817. [Q969M3-1]
ENST00000513112; ENSP00000425422; ENSG00000145817. [Q969M3-2]
GeneID81555.
KEGGhsa:81555.
UCSCuc003lnk.5. human. [Q969M3-1]

Organism-specific databases

CTD81555.
GeneCardsGC05M143520.
H-InvDBHIX0005274.
HGNCHGNC:24877. YIPF5.
MIM611483. gene.
neXtProtNX_Q969M3.
PharmGKBPA142670548.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5080.
HOVERGENHBG055241.
OMAGGWWTAF.
OrthoDBEOG7CRTQW.
PhylomeDBQ969M3.
TreeFamTF313100.

Gene expression databases

ArrayExpressQ969M3.
BgeeQ969M3.
CleanExHS_YIPF5.
GenevestigatorQ969M3.

Family and domain databases

InterProIPR006977. Yip1.
[Graphical view]
PfamPF04893. Yip1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSYIPF5. human.
GeneWikiYIPF5.
GenomeRNAi81555.
NextBio71810.
PROQ969M3.
SOURCESearch...

Entry information

Entry nameYIPF5_HUMAN
AccessionPrimary (citable) accession number: Q969M3
Secondary accession number(s): D3DQF5 expand/collapse secondary AC list , Q4VSN6, Q53EX4, Q8NHE5, Q9H338, Q9H3U4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM