Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction alpha-10 protein

Gene

GJA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-112303. Electric Transmission Across Gap Junctions.
R-HSA-190861. Gap junction assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-10 protein
Alternative name(s):
Connexin-62
Short name:
Cx62
Gene namesi
Name:GJA10
Synonyms:CX62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:16995. GJA10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence analysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Topological domaini38 – 7639ExtracellularSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Topological domaini98 – 16568CytoplasmicSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST
Topological domaini187 – 20923ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Topological domaini231 – 543313CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164741581.

Polymorphism and mutation databases

BioMutaiGJA10.
DMDMi74751723.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Gap junction alpha-10 proteinPRO_0000312989Add
BLAST

Proteomic databases

PaxDbiQ969M2.
PRIDEiQ969M2.

Expressioni

Tissue specificityi

Expressed in skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiQ969M2.
CleanExiHS_GJA10.
GenevisibleiQ969M2. HS.

Organism-specific databases

HPAiHPA021145.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000358358.

Structurei

3D structure databases

ProteinModelPortaliQ969M2.
SMRiQ969M2. Positions 3-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQJ. Eukaryota.
ENOG4110KSA. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiQ969M2.
KOiK07631.
OMAiEVHSHST.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ969M2.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWNLLGGI LEEVHSHSTI VGKIWLTILF IFRMLVLRVA AEDVWDDEQS
60 70 80 90 100
AFACNTRQPG CNNICYDDAF PISLIRFWVL QIIFVSSPSL VYMGHALYRL
110 120 130 140 150
RAFEKDRQRK KSHLRAQMEN PDLDLEEQQR IDRELRRLEE QKRIHKVPLK
160 170 180 190 200
GCLLRTYVLH ILTRSVLEVG FMIGQYILYG FQMHPLYKCT QPPCPNAVDC
210 220 230 240 250
FVSRPTEKTI FMLFMHSIAA ISLLLNILEI FHLGIRKIMR TLYKKSSSEG
260 270 280 290 300
IEDETGPPFH LKKYSVAQQC MICSSLPERI SPLQANNQQQ VIRVNVPKSK
310 320 330 340 350
TMWQIPQPRQ LEVDPSNGKK DWSEKDQHSG QLHVHSPCPW AGSAGNQHLG
360 370 380 390 400
QQSDHSSFGL QNTMSQSWLG TTTAPRNCPS FAVGTWEQSQ DPEPSGEPLT
410 420 430 440 450
DLHSHCRDSE GSMRESGVWI DRSRPGSRKA SFLSRLLSEK RHLHSDSGSS
460 470 480 490 500
GSRNSSCLDF PHWENSPSPL PSVTGHRTSM VRQAALPIME LSQELFHSGC
510 520 530 540
FLFPFFLPGV CMYVCVDREA DGGGDYLWRD KIIHSIHSVK FNS
Length:543
Mass (Da):61,872
Last modified:December 1, 2001 - v1
Checksum:iB3115A282957207D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296766 mRNA. Translation: AAK51676.1.
AJ414565 Genomic DNA. Translation: CAC93847.1.
AL353692 Genomic DNA. Translation: CAI16242.1.
CH471051 Genomic DNA. Translation: EAW48537.1.
CCDSiCCDS5025.1.
RefSeqiNP_115991.1. NM_032602.1.
UniGeneiHs.334499.

Genome annotation databases

EnsembliENST00000369352; ENSP00000358358; ENSG00000135355.
GeneIDi84694.
KEGGihsa:84694.
UCSCiuc011eaa.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296766 mRNA. Translation: AAK51676.1.
AJ414565 Genomic DNA. Translation: CAC93847.1.
AL353692 Genomic DNA. Translation: CAI16242.1.
CH471051 Genomic DNA. Translation: EAW48537.1.
CCDSiCCDS5025.1.
RefSeqiNP_115991.1. NM_032602.1.
UniGeneiHs.334499.

3D structure databases

ProteinModelPortaliQ969M2.
SMRiQ969M2. Positions 3-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358358.

Polymorphism and mutation databases

BioMutaiGJA10.
DMDMi74751723.

Proteomic databases

PaxDbiQ969M2.
PRIDEiQ969M2.

Protocols and materials databases

DNASUi84694.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369352; ENSP00000358358; ENSG00000135355.
GeneIDi84694.
KEGGihsa:84694.
UCSCiuc011eaa.3. human.

Organism-specific databases

CTDi84694.
GeneCardsiGJA10.
HGNCiHGNC:16995. GJA10.
HPAiHPA021145.
MIMi611924. gene.
neXtProtiNX_Q969M2.
PharmGKBiPA164741581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQJ. Eukaryota.
ENOG4110KSA. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiQ969M2.
KOiK07631.
OMAiEVHSHST.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ969M2.
TreeFamiTF329606.

Enzyme and pathway databases

ReactomeiR-HSA-112303. Electric Transmission Across Gap Junctions.
R-HSA-190861. Gap junction assembly.

Miscellaneous databases

GeneWikiiGJA10.
GenomeRNAii84694.
PROiQ969M2.
SOURCEiSearch...

Gene expression databases

BgeeiQ969M2.
CleanExiHS_GJA10.
GenevisibleiQ969M2. HS.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and expression of connexin-62: a novel human connexin with high homology to mouse connexin-57 and porcine connexin-60."
    Houseman M.J., Kelsell D.P., Mueller R.F.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural and functional diversity of connexin genes in the mouse and human genome."
    Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G.
    Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues."
    Soehl G., Nielsen P.A., Eiberger J., Willecke K.
    Cell Commun. Adhes. 10:27-36(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCXA10_HUMAN
AccessioniPrimary (citable) accession number: Q969M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.