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Protein

Gap junction alpha-10 protein

Gene

GJA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-112303. Electric Transmission Across Gap Junctions.
R-HSA-190861. Gap junction assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-10 protein
Alternative name(s):
Connexin-62
Short name:
Cx62
Gene namesi
Name:GJA10
Synonyms:CX62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135355.3.
HGNCiHGNC:16995. GJA10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 76ExtracellularSequence analysisAdd BLAST39
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 165CytoplasmicSequence analysisAdd BLAST68
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 209ExtracellularSequence analysisAdd BLAST23
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 543CytoplasmicSequence analysisAdd BLAST313

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135355.
PharmGKBiPA164741581.

Polymorphism and mutation databases

BioMutaiGJA10.
DMDMi74751723.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129891 – 543Gap junction alpha-10 proteinAdd BLAST543

Proteomic databases

PaxDbiQ969M2.
PeptideAtlasiQ969M2.
PRIDEiQ969M2.

Expressioni

Tissue specificityi

Expressed in skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSG00000135355.
CleanExiHS_GJA10.
GenevisibleiQ969M2. HS.

Organism-specific databases

HPAiHPA021145.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000358358.

Structurei

3D structure databases

ProteinModelPortaliQ969M2.
SMRiQ969M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQJ. Eukaryota.
ENOG4110KSA. LUCA.
GeneTreeiENSGT00900000140773.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiQ969M2.
KOiK07631.
OMAiGCLLRTY.
OrthoDBiEOG091G06LA.
PhylomeDBiQ969M2.
TreeFamiTF329606.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q969M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWNLLGGI LEEVHSHSTI VGKIWLTILF IFRMLVLRVA AEDVWDDEQS
60 70 80 90 100
AFACNTRQPG CNNICYDDAF PISLIRFWVL QIIFVSSPSL VYMGHALYRL
110 120 130 140 150
RAFEKDRQRK KSHLRAQMEN PDLDLEEQQR IDRELRRLEE QKRIHKVPLK
160 170 180 190 200
GCLLRTYVLH ILTRSVLEVG FMIGQYILYG FQMHPLYKCT QPPCPNAVDC
210 220 230 240 250
FVSRPTEKTI FMLFMHSIAA ISLLLNILEI FHLGIRKIMR TLYKKSSSEG
260 270 280 290 300
IEDETGPPFH LKKYSVAQQC MICSSLPERI SPLQANNQQQ VIRVNVPKSK
310 320 330 340 350
TMWQIPQPRQ LEVDPSNGKK DWSEKDQHSG QLHVHSPCPW AGSAGNQHLG
360 370 380 390 400
QQSDHSSFGL QNTMSQSWLG TTTAPRNCPS FAVGTWEQSQ DPEPSGEPLT
410 420 430 440 450
DLHSHCRDSE GSMRESGVWI DRSRPGSRKA SFLSRLLSEK RHLHSDSGSS
460 470 480 490 500
GSRNSSCLDF PHWENSPSPL PSVTGHRTSM VRQAALPIME LSQELFHSGC
510 520 530 540
FLFPFFLPGV CMYVCVDREA DGGGDYLWRD KIIHSIHSVK FNS
Length:543
Mass (Da):61,872
Last modified:December 1, 2001 - v1
Checksum:iB3115A282957207D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296766 mRNA. Translation: AAK51676.1.
AJ414565 Genomic DNA. Translation: CAC93847.1.
AL353692 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48537.1.
CCDSiCCDS5025.1.
RefSeqiNP_115991.1. NM_032602.1.
UniGeneiHs.334499.

Genome annotation databases

EnsembliENST00000369352; ENSP00000358358; ENSG00000135355.
GeneIDi84694.
KEGGihsa:84694.
UCSCiuc011eaa.3. human.

Similar proteinsi

Entry informationi

Entry nameiCXA10_HUMAN
AccessioniPrimary (citable) accession number: Q969M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families