Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial import receptor subunit TOM40B

Gene

TOMM40L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential channel-forming protein implicated in import of protein precursors into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40B
Alternative name(s):
Protein TOMM40-like
Gene namesi
Name:TOMM40L
Synonyms:TOMM40B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158882.12.
HGNCiHGNC:25756. TOMM40L.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158882.
PharmGKBiPA142670714.

Polymorphism and mutation databases

DMDMi74751722.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515361 – 308Mitochondrial import receptor subunit TOM40BAdd BLAST308

Proteomic databases

EPDiQ969M1.
MaxQBiQ969M1.
PaxDbiQ969M1.
PeptideAtlasiQ969M1.
PRIDEiQ969M1.

PTM databases

iPTMnetiQ969M1.
PhosphoSitePlusiQ969M1.

Expressioni

Gene expression databases

BgeeiENSG00000158882.
CleanExiHS_TOMM40L.
GenevisibleiQ969M1. HS.

Organism-specific databases

HPAiHPA051304.

Interactioni

Subunit structurei

Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity).By similarity

Protein-protein interaction databases

BioGridi123906. 7 interactors.
IntActiQ969M1. 1 interactor.
MINTiMINT-4650450.
STRINGi9606.ENSP00000356966.

Structurei

3D structure databases

ProteinModelPortaliQ969M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni281 – 308Required for mitochondrial targetingBy similarityAdd BLAST28

Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296. Eukaryota.
ENOG410XS2U. LUCA.
GeneTreeiENSGT00390000003308.
HOGENOMiHOG000007440.
HOVERGENiHBG054707.
InParanoidiQ969M1.
KOiK11518.
OMAiMINSRCI.
OrthoDBiEOG091G0MNA.
PhylomeDBiQ969M1.
TreeFamiTF106204.

Family and domain databases

InterProiView protein in InterPro
IPR027246. Porin_Euk/Tom40.
PfamiView protein in Pfam
PF01459. Porin_3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNTLGLAPM GTLPRRSPRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL
60 70 80 90 100
VVNKVLSSHF QVAHTIHMSA LGLPGYHLHA AYAGDWQLSP TEVFPTVVGD
110 120 130 140 150
MDSSGSLNAQ VLLLLAERLR AKAVFQTQQA KFLTWQFDGE YRGDDYTATL
160 170 180 190 200
TLGNPDLIGE SVIMVAHFLQ SLTHRLVLGG ELVYHRRPGE EGAILTLAGK
210 220 230 240 250
YSAVHWVATL NVGSGGAHAS YYHRANEQVQ VGVEFEANTR LQDTTFSFGY
260 270 280 290 300
HLTLPQANMV FRGLVDSNWC VGAVLEKKMP PLPVTLALGA FLNHWRNRFH

CGFSITVG
Length:308
Mass (Da):33,917
Last modified:December 1, 2001 - v1
Checksum:iB4347CD0610434D3
GO
Isoform 2 (identifier: Q969M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-126: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):30,289
Checksum:iF14BE80F40C82D83
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035815100D → N in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05488593 – 126Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027704 mRNA. Translation: BAB55309.1.
AK297848 mRNA. Translation: BAH12676.1.
BX537951 mRNA. Translation: CAD97918.1.
AL590714 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW52611.1.
CH471121 Genomic DNA. Translation: EAW52615.1.
CH471121 Genomic DNA. Translation: EAW52616.1.
BC014946 mRNA. Translation: AAH14946.1.
CCDSiCCDS1227.1. [Q969M1-1]
CCDS65700.1. [Q969M1-2]
RefSeqiNP_001273302.1. NM_001286373.1. [Q969M1-2]
NP_115550.2. NM_032174.5. [Q969M1-1]
XP_006711635.1. XM_006711572.2. [Q969M1-1]
XP_016857970.1. XM_017002481.1. [Q969M1-1]
XP_016857971.1. XM_017002482.1. [Q969M1-2]
UniGeneiHs.321653.

Genome annotation databases

EnsembliENST00000367987; ENSP00000356966; ENSG00000158882. [Q969M1-1]
ENST00000367988; ENSP00000356967; ENSG00000158882. [Q969M1-1]
ENST00000545897; ENSP00000443233; ENSG00000158882. [Q969M1-2]
GeneIDi84134.
KEGGihsa:84134.
UCSCiuc001fzd.5. human. [Q969M1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM40L_HUMAN
AccessioniPrimary (citable) accession number: Q969M1
Secondary accession number(s): B7Z4U0, D3DVG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families