Q969L4 (LSM10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
U7 snRNA-associated Sm-like protein LSm10

Gene names

Name:

LSM10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. Ref.4
Subunit structure	Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN. Ref.1 Ref.3
Subcellular location	Nucleus Ref.1.
Post-translational modification	Not methylated. Methylation is not necessary for interaction with SMN. Ref.3
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW S phase of mitotic cell cycle Inferred from mutant phenotype Ref.4. Source: UniProtKB histone mRNA metabolic process Traceable author statement. Source: Reactome mRNA processing Traceable author statement. Source: Reactome termination of RNA polymerase II transcription Traceable author statement. Source: Reactome
Cellular_component	Cajal body Inferred from direct assay Ref.1. Source: UniProtKB U7 snRNP Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	histone pre-mRNA DCP binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM3	P62310	4	EBI-373268,EBI-348239

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 123	123	U7 snRNA-associated Sm-like protein LSm10		PRO_0000125585

Sequences

	Sequence		Length	Mass (Da)
	Q969L4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: B994B1DC6776BB02	FASTA	123	14,080
	10 20 30 40 50 60 MAVSHSVKER TISENSLIIL LQGLQGRVTT VDLRDESVAH GRIDNVDAFM NIRLAKVTYT 70 80 90 100 110 120 DRWGHQVKLD DLFVTGRNVR YVHIPDDVNI TSTIEQQLQI IHRVRNFGGK GQGRWEFPPK NCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein." Pillai R.S., Will C.L., Luehrmann R., Schuemperli D., Mueller B. EMBO J. 20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE U7 SNRNP COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[3]	"Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes." Azzouz T.N., Pillai R.S., Dapp C., Chari A., Meister G., Kambach C., Fischer U., Schuemperli D. J. Biol. Chem. 280:34435-34440(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CLNS1A AND SMN, LACK OF METHYLATION.
[4]	"ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase." Wagner E.J., Marzluff W.F. Mol. Cell. Biol. 26:6702-6712(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF394685 mRNA. Translation: AAL07689.1. BC007623 mRNA. Translation: AAH07623.1.
IPI	IPI00056416.
RefSeq	NP_116270.1. NM_032881.1.
UniGene	Hs.603131.
3D structure databases
ProteinModelPortal	Q969L4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q969L4. 1 interaction.
MINT	MINT-1485790.
STRING	9606.ENSP00000319341.
PTM databases
PhosphoSite	Q969L4.
Polymorphism databases
DMDM	20177959.
Proteomic databases
PaxDb	Q969L4.
PRIDE	Q969L4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315732; ENSP00000319341; ENSG00000181817.
GeneID	84967.
KEGG	hsa:84967.
UCSC	uc001cao.1. human.
Organism-specific databases
CTD	84967.
GeneCards	GC01M036856.
HGNC	HGNC:17562. LSM10.
HPA	HPA048469.
neXtProt	NX_Q969L4.
PharmGKB	PA134977215.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146625.
HOGENOM	HOG000230640.
HOVERGEN	HBG052366.
InParanoid	Q969L4.
OMA	WGHQVEL.
OrthoDB	EOG4HQDKT.
PhylomeDB	Q969L4.
Enzyme and pathway databases
Reactome	REACT_1675. mRNA Processing. REACT_1788. Transcription. REACT_71. Gene Expression. REACT_78. Post-Elongation Processing of the Transcript.
Gene expression databases
Bgee	Q969L4.
CleanEx	HS_LSM10.
Genevestigator	Q969L4.
GermOnline	ENSG00000181817. Homo sapiens.
Family and domain databases
InterPro	IPR010920. LSM_dom. IPR001163. Ribonucl_LSM. [Graphical view]
Pfam	PF01423. LSM. 1 hit. [Graphical view]
SUPFAM	SSF50182. Sm_like_riboprot. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	LSM10. human.
GenomeRNAi	84967.
NextBio	75496.

Entry information

Entry name

LSM10_HUMAN

Accession

Primary (citable) accession number: Q969L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.