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Q969L4 (LSM10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U7 snRNA-associated Sm-like protein LSm10
Gene names
Name:LSM10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length123 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. Ref.4

Subunit structure

Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN. Ref.1 Ref.3

Subcellular location

Nucleus Ref.1.

Post-translational modification

Not methylated. Methylation is not necessary for interaction with SMN. Ref.3

Sequence similarities

Belongs to the snRNP Sm proteins family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LSM3P623104EBI-373268,EBI-348239

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 123123U7 snRNA-associated Sm-like protein LSm10
PRO_0000125585

Sequences

Sequence LengthMass (Da)Tools
Q969L4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: B994B1DC6776BB02

FASTA12314,080
        10         20         30         40         50         60 
MAVSHSVKER TISENSLIIL LQGLQGRVTT VDLRDESVAH GRIDNVDAFM NIRLAKVTYT 

        70         80         90        100        110        120 
DRWGHQVKLD DLFVTGRNVR YVHIPDDVNI TSTIEQQLQI IHRVRNFGGK GQGRWEFPPK 


NCK 

« Hide

References

« Hide 'large scale' references
[1]"Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein."
Pillai R.S., Will C.L., Luehrmann R., Schuemperli D., Mueller B.
EMBO J. 20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE U7 SNRNP COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[3]"Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes."
Azzouz T.N., Pillai R.S., Dapp C., Chari A., Meister G., Kambach C., Fischer U., Schuemperli D.
J. Biol. Chem. 280:34435-34440(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CLNS1A AND SMN, LACK OF METHYLATION.
[4]"ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase."
Wagner E.J., Marzluff W.F.
Mol. Cell. Biol. 26:6702-6712(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF394685 mRNA. Translation: AAL07689.1.
BC007623 mRNA. Translation: AAH07623.1.
RefSeqNP_116270.1. NM_032881.1.
UniGeneHs.603131.

3D structure databases

ProteinModelPortalQ969L4.
SMRQ969L4. Positions 17-95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124397. 8 interactions.
IntActQ969L4. 1 interaction.
MINTMINT-1485790.
STRING9606.ENSP00000319341.

PTM databases

PhosphoSiteQ969L4.

Polymorphism databases

DMDM20177959.

Proteomic databases

PaxDbQ969L4.
PRIDEQ969L4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315732; ENSP00000319341; ENSG00000181817.
GeneID84967.
KEGGhsa:84967.
UCSCuc001cao.1. human.

Organism-specific databases

CTD84967.
GeneCardsGC01M036856.
HGNCHGNC:17562. LSM10.
HPAHPA048469.
neXtProtNX_Q969L4.
PharmGKBPA134977215.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146625.
HOGENOMHOG000230640.
HOVERGENHBG052366.
InParanoidQ969L4.
OMAGQGRQEF.
OrthoDBEOG7TF7CV.
PhylomeDBQ969L4.
TreeFamTF332356.

Enzyme and pathway databases

ReactomeREACT_1788. Transcription.
REACT_71. Gene Expression.
REACT_78. Post-Elongation Processing of the Transcript.

Gene expression databases

BgeeQ969L4.
CleanExHS_LSM10.
GenevestigatorQ969L4.

Family and domain databases

InterProIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
SUPFAMSSF50182. SSF50182. 1 hit.
ProtoNetSearch...

Other

ChiTaRSLSM10. human.
GeneWikiLSM10.
GenomeRNAi84967.
NextBio75496.
PROQ969L4.

Entry information

Entry nameLSM10_HUMAN
AccessionPrimary (citable) accession number: Q969L4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM