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Q969L4

- LSM10_HUMAN

UniProt

Q969L4 - LSM10_HUMAN

Protein

U7 snRNA-associated Sm-like protein LSm10

Gene

LSM10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.1 Publication

    GO - Molecular functioni

    1. histone pre-mRNA DCP binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. gene expression Source: Reactome
    2. histone mRNA metabolic process Source: Reactome
    3. mitotic S phase Source: UniProtKB
    4. mRNA 3'-end processing Source: Reactome
    5. RNA splicing Source: UniProtKB-KW
    6. termination of RNA polymerase II transcription Source: Reactome
    7. transcription from RNA polymerase II promoter Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
    REACT_185. SLBP independent Processing of Histone Pre-mRNAs.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U7 snRNA-associated Sm-like protein LSm10
    Gene namesi
    Name:LSM10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17562. LSM10.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Cajal body Source: UniProtKB
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA
    4. U7 snRNP Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977215.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 123123U7 snRNA-associated Sm-like protein LSm10PRO_0000125585Add
    BLAST

    Post-translational modificationi

    Not methylated. Methylation is not necessary for interaction with SMN.

    Proteomic databases

    MaxQBiQ969L4.
    PaxDbiQ969L4.
    PRIDEiQ969L4.

    PTM databases

    PhosphoSiteiQ969L4.

    Expressioni

    Gene expression databases

    BgeeiQ969L4.
    CleanExiHS_LSM10.
    GenevestigatoriQ969L4.

    Organism-specific databases

    HPAiHPA048469.

    Interactioni

    Subunit structurei

    Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LSM3P623104EBI-373268,EBI-348239

    Protein-protein interaction databases

    BioGridi124397. 8 interactions.
    IntActiQ969L4. 1 interaction.
    MINTiMINT-1485790.
    STRINGi9606.ENSP00000319341.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969L4.
    SMRiQ969L4. Positions 17-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the snRNP Sm proteins family.Curated

    Phylogenomic databases

    eggNOGiNOG146625.
    HOGENOMiHOG000230640.
    HOVERGENiHBG052366.
    InParanoidiQ969L4.
    OMAiRNFGSEG.
    OrthoDBiEOG7TF7CV.
    PhylomeDBiQ969L4.
    TreeFamiTF332356.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    [Graphical view]
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q969L4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVSHSVKER TISENSLIIL LQGLQGRVTT VDLRDESVAH GRIDNVDAFM    50
    NIRLAKVTYT DRWGHQVKLD DLFVTGRNVR YVHIPDDVNI TSTIEQQLQI 100
    IHRVRNFGGK GQGRWEFPPK NCK 123
    Length:123
    Mass (Da):14,080
    Last modified:December 1, 2001 - v1
    Checksum:iB994B1DC6776BB02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394685 mRNA. Translation: AAL07689.1.
    BC007623 mRNA. Translation: AAH07623.1.
    CCDSiCCDS408.1.
    RefSeqiNP_116270.1. NM_032881.1.
    UniGeneiHs.603131.

    Genome annotation databases

    EnsembliENST00000315732; ENSP00000319341; ENSG00000181817.
    GeneIDi84967.
    KEGGihsa:84967.
    UCSCiuc001cao.1. human.

    Polymorphism databases

    DMDMi20177959.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF394685 mRNA. Translation: AAL07689.1 .
    BC007623 mRNA. Translation: AAH07623.1 .
    CCDSi CCDS408.1.
    RefSeqi NP_116270.1. NM_032881.1.
    UniGenei Hs.603131.

    3D structure databases

    ProteinModelPortali Q969L4.
    SMRi Q969L4. Positions 17-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124397. 8 interactions.
    IntActi Q969L4. 1 interaction.
    MINTi MINT-1485790.
    STRINGi 9606.ENSP00000319341.

    PTM databases

    PhosphoSitei Q969L4.

    Polymorphism databases

    DMDMi 20177959.

    Proteomic databases

    MaxQBi Q969L4.
    PaxDbi Q969L4.
    PRIDEi Q969L4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315732 ; ENSP00000319341 ; ENSG00000181817 .
    GeneIDi 84967.
    KEGGi hsa:84967.
    UCSCi uc001cao.1. human.

    Organism-specific databases

    CTDi 84967.
    GeneCardsi GC01M036856.
    HGNCi HGNC:17562. LSM10.
    HPAi HPA048469.
    neXtProti NX_Q969L4.
    PharmGKBi PA134977215.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146625.
    HOGENOMi HOG000230640.
    HOVERGENi HBG052366.
    InParanoidi Q969L4.
    OMAi RNFGSEG.
    OrthoDBi EOG7TF7CV.
    PhylomeDBi Q969L4.
    TreeFami TF332356.

    Enzyme and pathway databases

    Reactomei REACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
    REACT_185. SLBP independent Processing of Histone Pre-mRNAs.

    Miscellaneous databases

    ChiTaRSi LSM10. human.
    GeneWikii LSM10.
    GenomeRNAii 84967.
    NextBioi 75496.
    PROi Q969L4.

    Gene expression databases

    Bgeei Q969L4.
    CleanExi HS_LSM10.
    Genevestigatori Q969L4.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    [Graphical view ]
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein."
      Pillai R.S., Will C.L., Luehrmann R., Schuemperli D., Mueller B.
      EMBO J. 20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE U7 SNRNP COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes."
      Azzouz T.N., Pillai R.S., Dapp C., Chari A., Meister G., Kambach C., Fischer U., Schuemperli D.
      J. Biol. Chem. 280:34435-34440(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLNS1A AND SMN, LACK OF METHYLATION.
    4. "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase."
      Wagner E.J., Marzluff W.F.
      Mol. Cell. Biol. 26:6702-6712(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiLSM10_HUMAN
    AccessioniPrimary (citable) accession number: Q969L4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3