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Q969L4

- LSM10_HUMAN

UniProt

Q969L4 - LSM10_HUMAN

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Protein

U7 snRNA-associated Sm-like protein LSm10

Gene

LSM10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.1 Publication

GO - Molecular functioni

  1. histone pre-mRNA DCP binding Source: UniProtKB

GO - Biological processi

  1. gene expression Source: Reactome
  2. histone mRNA metabolic process Source: Reactome
  3. mRNA 3'-end processing Source: Reactome
  4. positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
  5. RNA splicing Source: UniProtKB-KW
  6. termination of RNA polymerase II transcription Source: Reactome
  7. transcription from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
REACT_185. SLBP independent Processing of Histone Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
U7 snRNA-associated Sm-like protein LSm10
Gene namesi
Name:LSM10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:17562. LSM10.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Cajal body Source: UniProtKB
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HPA
  4. U7 snRNP Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977215.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123U7 snRNA-associated Sm-like protein LSm10PRO_0000125585Add
BLAST

Post-translational modificationi

Not methylated. Methylation is not necessary for interaction with SMN.

Proteomic databases

MaxQBiQ969L4.
PaxDbiQ969L4.
PRIDEiQ969L4.

PTM databases

PhosphoSiteiQ969L4.

Expressioni

Gene expression databases

BgeeiQ969L4.
CleanExiHS_LSM10.
GenevestigatoriQ969L4.

Organism-specific databases

HPAiHPA048469.

Interactioni

Subunit structurei

Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LSM3P623104EBI-373268,EBI-348239

Protein-protein interaction databases

BioGridi124397. 8 interactions.
IntActiQ969L4. 1 interaction.
MINTiMINT-1485790.
STRINGi9606.ENSP00000319341.

Structurei

3D structure databases

ProteinModelPortaliQ969L4.
SMRiQ969L4. Positions 17-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiNOG146625.
GeneTreeiENSGT00510000048364.
HOGENOMiHOG000230640.
HOVERGENiHBG052366.
InParanoidiQ969L4.
OMAiRNFGSEG.
OrthoDBiEOG7TF7CV.
PhylomeDBiQ969L4.
TreeFamiTF332356.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q969L4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVSHSVKER TISENSLIIL LQGLQGRVTT VDLRDESVAH GRIDNVDAFM
60 70 80 90 100
NIRLAKVTYT DRWGHQVKLD DLFVTGRNVR YVHIPDDVNI TSTIEQQLQI
110 120
IHRVRNFGGK GQGRWEFPPK NCK
Length:123
Mass (Da):14,080
Last modified:December 1, 2001 - v1
Checksum:iB994B1DC6776BB02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394685 mRNA. Translation: AAL07689.1.
BC007623 mRNA. Translation: AAH07623.1.
CCDSiCCDS408.1.
RefSeqiNP_116270.1. NM_032881.1.
UniGeneiHs.603131.

Genome annotation databases

EnsembliENST00000315732; ENSP00000319341; ENSG00000181817.
GeneIDi84967.
KEGGihsa:84967.
UCSCiuc001cao.1. human.

Polymorphism databases

DMDMi20177959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394685 mRNA. Translation: AAL07689.1 .
BC007623 mRNA. Translation: AAH07623.1 .
CCDSi CCDS408.1.
RefSeqi NP_116270.1. NM_032881.1.
UniGenei Hs.603131.

3D structure databases

ProteinModelPortali Q969L4.
SMRi Q969L4. Positions 17-94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124397. 8 interactions.
IntActi Q969L4. 1 interaction.
MINTi MINT-1485790.
STRINGi 9606.ENSP00000319341.

PTM databases

PhosphoSitei Q969L4.

Polymorphism databases

DMDMi 20177959.

Proteomic databases

MaxQBi Q969L4.
PaxDbi Q969L4.
PRIDEi Q969L4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315732 ; ENSP00000319341 ; ENSG00000181817 .
GeneIDi 84967.
KEGGi hsa:84967.
UCSCi uc001cao.1. human.

Organism-specific databases

CTDi 84967.
GeneCardsi GC01M036856.
HGNCi HGNC:17562. LSM10.
HPAi HPA048469.
neXtProti NX_Q969L4.
PharmGKBi PA134977215.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146625.
GeneTreei ENSGT00510000048364.
HOGENOMi HOG000230640.
HOVERGENi HBG052366.
InParanoidi Q969L4.
OMAi RNFGSEG.
OrthoDBi EOG7TF7CV.
PhylomeDBi Q969L4.
TreeFami TF332356.

Enzyme and pathway databases

Reactomei REACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
REACT_185. SLBP independent Processing of Histone Pre-mRNAs.

Miscellaneous databases

ChiTaRSi LSM10. human.
GeneWikii LSM10.
GenomeRNAii 84967.
NextBioi 75496.
PROi Q969L4.

Gene expression databases

Bgeei Q969L4.
CleanExi HS_LSM10.
Genevestigatori Q969L4.

Family and domain databases

InterProi IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
[Graphical view ]
Pfami PF01423. LSM. 1 hit.
[Graphical view ]
SUPFAMi SSF50182. SSF50182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein."
    Pillai R.S., Will C.L., Luehrmann R., Schuemperli D., Mueller B.
    EMBO J. 20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE U7 SNRNP COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes."
    Azzouz T.N., Pillai R.S., Dapp C., Chari A., Meister G., Kambach C., Fischer U., Schuemperli D.
    J. Biol. Chem. 280:34435-34440(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLNS1A AND SMN, LACK OF METHYLATION.
  4. "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase."
    Wagner E.J., Marzluff W.F.
    Mol. Cell. Biol. 26:6702-6712(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLSM10_HUMAN
AccessioniPrimary (citable) accession number: Q969L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3