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Protein

Interleukin-22 receptor subunit alpha-2

Gene

IL22RA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei99Critical for IL22-bindingBy similarity1
Sitei151Critical for IL22-bindingBy similarity1

GO - Molecular functioni

  • interleukin-22 binding Source: UniProtKB
  • interleukin-22 receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ969J5.
SIGNORiQ969J5.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-2
Short name:
IL-22 receptor subunit alpha-2
Short name:
IL-22R-alpha-2
Short name:
IL-22RA2
Alternative name(s):
Cytokine receptor class-II member 10
Cytokine receptor family 2 member 10
Short name:
CRF2-10
Cytokine receptor family type 2, soluble 1
Short name:
CRF2-S1
Interleukin-22-binding protein
Short name:
IL-22BP
Short name:
IL22BP
ZcytoR16
Gene namesi
Name:IL22RA2
ORF Names:UNQ5793/PRO19598/PRO19822
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14901. IL22RA2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi116379.
OpenTargetsiENSG00000164485.
PharmGKBiPA134983729.

Polymorphism and mutation databases

BioMutaiIL22RA2.
DMDMi61213728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001101622 – 263Interleukin-22 receptor subunit alpha-2Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi238 ↔ 2591 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ969J5.
PRIDEiQ969J5.

PTM databases

PhosphoSitePlusiQ969J5.

Expressioni

Tissue specificityi

Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.3 Publications

Gene expression databases

BgeeiENSG00000164485.
CleanExiHS_IL22RA2.
GenevisibleiQ969J5. HS.

Organism-specific databases

HPAiCAB034906.
HPA030582.

Interactioni

GO - Molecular functioni

  • interleukin-22 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125503. 2 interactors.
IntActiQ969J5. 3 interactors.
MINTiMINT-7010488.
STRINGi9606.ENSP00000296980.

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 39Combined sources8
Beta strandi42 – 48Combined sources7
Beta strandi59 – 66Combined sources8
Beta strandi105 – 113Combined sources9
Beta strandi116 – 119Combined sources4
Helixi122 – 124Combined sources3
Beta strandi131 – 139Combined sources9
Helixi154 – 157Combined sources4
Beta strandi164 – 166Combined sources3
Beta strandi177 – 179Combined sources3
Helixi184 – 187Combined sources4
Helixi195 – 198Combined sources4
Beta strandi202 – 207Combined sources6
Beta strandi216 – 223Combined sources8
Beta strandi239 – 245Combined sources7
Turni246 – 249Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G9VX-ray2.76A/C21-263[»]
ProteinModelPortaliQ969J5.
SMRiQ969J5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ969J5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 68Fibronectin type-III 1Add BLAST43
Domaini100 – 161Fibronectin type-III 2Add BLAST62
Domaini162 – 263Fibronectin type-III 3Add BLAST102

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 3 fibronectin type-III domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVX1. Eukaryota.
ENOG410YNE2. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000082681.
HOVERGENiHBG052067.
InParanoidiQ969J5.
KOiK05139.
OMAiPYYGRVR.
OrthoDBiEOG091G068P.
PhylomeDBiQ969J5.
TreeFamiTF332537.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969J5-1) [UniParc]FASTAAdd to basket
Also known as: Long, CRF2-10L, CRF2-s1-long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMPKHCFLGF LISFFLTGVA GTQSTHESLK PQRVQFQSRN FHNILQWQPG
60 70 80 90 100
RALTGNSSVY FVQYKIMFSC SMKSSHQKPS GCWQHISCNF PGCRTLAKYG
110 120 130 140 150
QRQWKNKEDC WGTQELSCDL TSETSDIQEP YYGRVRAASA GSYSEWSMTP
160 170 180 190 200
RFTPWWETKI DPPVMNITQV NGSLLVILHA PNLPYRYQKE KNVSIEDYYE
210 220 230 240 250
LLYRVFIINN SLEKEQKVYE GAHRAVEIEA LTPHSSYCVV AEIYQPMLDR
260
RSQRSEERCV EIP
Length:263
Mass (Da):30,550
Last modified:December 1, 2001 - v1
Checksum:iC96ECEC5D78AC79B
GO
Isoform 2 (identifier: Q969J5-2) [UniParc]FASTAAdd to basket
Also known as: Short, CRF2-10, CRF2-s1-short

The sequence of this isoform differs from the canonical sequence as follows:
     67-98: Missing.

Show »
Length:231
Mass (Da):26,980
Checksum:i24A6912BFF75100F
GO
Isoform 3 (identifier: Q969J5-3) [UniParc]FASTAAdd to basket
Also known as: CRF2-10S

The sequence of this isoform differs from the canonical sequence as follows:
     67-98: Missing.
     158-162: TKIDP → RAKGL
     163-263: Missing.

Show »
Length:130
Mass (Da):15,128
Checksum:iA165814C641F5E5B
GO

Sequence cautioni

The sequence AAQ89097 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02149316L → P.1 PublicationCorresponds to variant rs28385692dbSNPEnsembl.1
Natural variantiVAR_021494190E → K.1 PublicationCorresponds to variant rs28362173dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01310567 – 98Missing in isoform 2 and isoform 3. 6 PublicationsAdd BLAST32
Alternative sequenceiVSP_013106158 – 162TKIDP → RAKGL in isoform 3. 1 Publication5
Alternative sequenceiVSP_013107163 – 263Missing in isoform 3. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313161 mRNA. Translation: CAC85634.1.
AJ313162 mRNA. Translation: CAC85635.1.
AY040566 mRNA. Translation: AAK85714.1.
AY040567 mRNA. Translation: AAK85715.1.
AY040568 mRNA. Translation: AAK85716.1.
AJ297262 mRNA. Translation: CAC83097.1.
AY044429 mRNA. Translation: AAK91775.1.
AY358111 mRNA. Translation: AAQ88478.1.
AY358737 mRNA. Translation: AAQ89097.1. Different initiation.
AY779023 Genomic DNA. Translation: AAV31775.1.
AL050337 Genomic DNA. Translation: CAI21589.1.
AL050337 Genomic DNA. Translation: CAI21591.1.
AL050337 Genomic DNA. Translation: CAI21590.1.
CH471051 Genomic DNA. Translation: EAW47933.1.
BC125167 mRNA. Translation: AAI25168.1.
BC125168 mRNA. Translation: AAI25169.1.
CCDSiCCDS5182.1. [Q969J5-1]
CCDS5183.1. [Q969J5-2]
CCDS5184.1. [Q969J5-3]
RefSeqiNP_443194.1. NM_052962.2. [Q969J5-1]
NP_851826.1. NM_181309.1. [Q969J5-2]
NP_851827.1. NM_181310.1. [Q969J5-3]
UniGeneiHs.126891.

Genome annotation databases

EnsembliENST00000296980; ENSP00000296980; ENSG00000164485. [Q969J5-1]
ENST00000339602; ENSP00000340920; ENSG00000164485. [Q969J5-3]
ENST00000349184; ENSP00000296979; ENSG00000164485. [Q969J5-2]
GeneIDi116379.
KEGGihsa:116379.
UCSCiuc003qhl.4. human. [Q969J5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313161 mRNA. Translation: CAC85634.1.
AJ313162 mRNA. Translation: CAC85635.1.
AY040566 mRNA. Translation: AAK85714.1.
AY040567 mRNA. Translation: AAK85715.1.
AY040568 mRNA. Translation: AAK85716.1.
AJ297262 mRNA. Translation: CAC83097.1.
AY044429 mRNA. Translation: AAK91775.1.
AY358111 mRNA. Translation: AAQ88478.1.
AY358737 mRNA. Translation: AAQ89097.1. Different initiation.
AY779023 Genomic DNA. Translation: AAV31775.1.
AL050337 Genomic DNA. Translation: CAI21589.1.
AL050337 Genomic DNA. Translation: CAI21591.1.
AL050337 Genomic DNA. Translation: CAI21590.1.
CH471051 Genomic DNA. Translation: EAW47933.1.
BC125167 mRNA. Translation: AAI25168.1.
BC125168 mRNA. Translation: AAI25169.1.
CCDSiCCDS5182.1. [Q969J5-1]
CCDS5183.1. [Q969J5-2]
CCDS5184.1. [Q969J5-3]
RefSeqiNP_443194.1. NM_052962.2. [Q969J5-1]
NP_851826.1. NM_181309.1. [Q969J5-2]
NP_851827.1. NM_181310.1. [Q969J5-3]
UniGeneiHs.126891.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G9VX-ray2.76A/C21-263[»]
ProteinModelPortaliQ969J5.
SMRiQ969J5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125503. 2 interactors.
IntActiQ969J5. 3 interactors.
MINTiMINT-7010488.
STRINGi9606.ENSP00000296980.

PTM databases

PhosphoSitePlusiQ969J5.

Polymorphism and mutation databases

BioMutaiIL22RA2.
DMDMi61213728.

Proteomic databases

PaxDbiQ969J5.
PRIDEiQ969J5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296980; ENSP00000296980; ENSG00000164485. [Q969J5-1]
ENST00000339602; ENSP00000340920; ENSG00000164485. [Q969J5-3]
ENST00000349184; ENSP00000296979; ENSG00000164485. [Q969J5-2]
GeneIDi116379.
KEGGihsa:116379.
UCSCiuc003qhl.4. human. [Q969J5-1]

Organism-specific databases

CTDi116379.
DisGeNETi116379.
GeneCardsiIL22RA2.
HGNCiHGNC:14901. IL22RA2.
HPAiCAB034906.
HPA030582.
MIMi606648. gene.
neXtProtiNX_Q969J5.
OpenTargetsiENSG00000164485.
PharmGKBiPA134983729.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVX1. Eukaryota.
ENOG410YNE2. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000082681.
HOVERGENiHBG052067.
InParanoidiQ969J5.
KOiK05139.
OMAiPYYGRVR.
OrthoDBiEOG091G068P.
PhylomeDBiQ969J5.
TreeFamiTF332537.

Enzyme and pathway databases

ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ969J5.
SIGNORiQ969J5.

Miscellaneous databases

ChiTaRSiIL22RA2. human.
EvolutionaryTraceiQ969J5.
GenomeRNAii116379.
PROiQ969J5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164485.
CleanExiHS_IL22RA2.
GenevisibleiQ969J5. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiI22R2_HUMAN
AccessioniPrimary (citable) accession number: Q969J5
Secondary accession number(s): Q08AH7
, Q6UWM1, Q96A41, Q96QR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.