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Protein

Loss of heterozygosity 12 chromosomal region 1 protein

Gene

LOH12CR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Loss of heterozygosity 12 chromosomal region 1 protein
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17950. LOH12CR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30421.

Polymorphism and mutation databases

BioMutaiLOH12CR1.
DMDMi74731048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 196195Loss of heterozygosity 12 chromosomal region 1 proteinPRO_0000318596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei71 – 711PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineCombined sources

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ969J3.
MaxQBiQ969J3.
PaxDbiQ969J3.
PRIDEiQ969J3.

PTM databases

iPTMnetiQ969J3.
PhosphoSiteiQ969J3.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ969J3.
CleanExiHS_LOH12CR1.
ExpressionAtlasiQ969J3. baseline and differential.
GenevisibleiQ969J3. HS.

Organism-specific databases

HPAiHPA039509.
HPA043627.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PUF60Q9UHX14EBI-747707,EBI-1053259

Protein-protein interaction databases

BioGridi125600. 9 interactions.
IntActiQ969J3. 2 interactions.
MINTiMINT-1453811.
STRINGi9606.ENSP00000321546.

Structurei

3D structure databases

ProteinModelPortaliQ969J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LOH12CR1 family.Curated

Phylogenomic databases

eggNOGiKOG4515. Eukaryota.
ENOG410YDKQ. LUCA.
GeneTreeiENSGT00390000015016.
HOGENOMiHOG000007522.
HOVERGENiHBG108081.
InParanoidiQ969J3.
OMAiLEPFSMR.
PhylomeDBiQ969J3.
TreeFamiTF316379.

Family and domain databases

InterProiIPR018780. Tumour_suppressor_LOH1CR12.
[Graphical view]
PfamiPF10158. LOH1CR12. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969J3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSEQSSEAE SRPNDLNSSV TPSPAKHRAK MDDIVVVAQG SQASRNVSND
60 70 80 90 100
PDVIKLQEIP TFQPLLKGLL SGQTSPTNAK LEKLDSQQVL QLCLRYQDHL
110 120 130 140 150
HQCAEAVAFD QNALVKRIKE MDLSVETLFS FMQERQKRYA KYAEQIQKVN
160 170 180 190
EMSAILRRIQ MGIDQTVPLL DRLNSMLPEG ERLEPFSMKP DRELRL
Length:196
Mass (Da):22,222
Last modified:December 1, 2001 - v1
Checksum:iCC369C1971B4FEB8
GO
Isoform 2 (identifier: Q969J3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-67: Missing.

Show »
Length:148
Mass (Da):17,000
Checksum:i513E08D4300A45AD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411S → C.
Corresponds to variant rs3741795 [ dbSNP | Ensembl ].
VAR_038840
Natural varianti191 – 1911D → N.
Corresponds to variant rs3751262 [ dbSNP | Ensembl ].
VAR_038841

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 6748Missing in isoform 2. 1 PublicationVSP_031254Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037865 mRNA. Translation: AAK71328.1.
AY037866 mRNA. Translation: AAK71329.1.
AK075028 mRNA. Translation: BAC11360.1.
CH471094 Genomic DNA. Translation: EAW96257.1.
CH471094 Genomic DNA. Translation: EAW96258.1.
BC013668 mRNA. Translation: AAH13668.1.
CCDSiCCDS8649.1. [Q969J3-1]
RefSeqiNP_001287671.1. NM_001300742.1.
NP_477517.1. NM_058169.4. [Q969J3-1]
XP_011518854.1. XM_011520552.1. [Q969J3-2]
XP_011547173.1. XM_011548871.1. [Q969J3-2]
UniGeneiHs.720779.

Genome annotation databases

EnsembliENST00000298571; ENSP00000298571; ENSG00000165714. [Q969J3-2]
ENST00000314565; ENSP00000321546; ENSG00000165714. [Q969J3-1]
ENST00000627374; ENSP00000486120; ENSG00000280689. [Q969J3-1]
ENST00000627461; ENSP00000486584; ENSG00000280689. [Q969J3-2]
GeneIDi118426.
KEGGihsa:118426.
UCSCiuc001ral.3. human. [Q969J3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037865 mRNA. Translation: AAK71328.1.
AY037866 mRNA. Translation: AAK71329.1.
AK075028 mRNA. Translation: BAC11360.1.
CH471094 Genomic DNA. Translation: EAW96257.1.
CH471094 Genomic DNA. Translation: EAW96258.1.
BC013668 mRNA. Translation: AAH13668.1.
CCDSiCCDS8649.1. [Q969J3-1]
RefSeqiNP_001287671.1. NM_001300742.1.
NP_477517.1. NM_058169.4. [Q969J3-1]
XP_011518854.1. XM_011520552.1. [Q969J3-2]
XP_011547173.1. XM_011548871.1. [Q969J3-2]
UniGeneiHs.720779.

3D structure databases

ProteinModelPortaliQ969J3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125600. 9 interactions.
IntActiQ969J3. 2 interactions.
MINTiMINT-1453811.
STRINGi9606.ENSP00000321546.

PTM databases

iPTMnetiQ969J3.
PhosphoSiteiQ969J3.

Polymorphism and mutation databases

BioMutaiLOH12CR1.
DMDMi74731048.

Proteomic databases

EPDiQ969J3.
MaxQBiQ969J3.
PaxDbiQ969J3.
PRIDEiQ969J3.

Protocols and materials databases

DNASUi118426.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298571; ENSP00000298571; ENSG00000165714. [Q969J3-2]
ENST00000314565; ENSP00000321546; ENSG00000165714. [Q969J3-1]
ENST00000627374; ENSP00000486120; ENSG00000280689. [Q969J3-1]
ENST00000627461; ENSP00000486584; ENSG00000280689. [Q969J3-2]
GeneIDi118426.
KEGGihsa:118426.
UCSCiuc001ral.3. human. [Q969J3-1]

Organism-specific databases

CTDi118426.
GeneCardsiLOH12CR1.
HGNCiHGNC:17950. LOH12CR1.
HPAiHPA039509.
HPA043627.
neXtProtiNX_Q969J3.
PharmGKBiPA30421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4515. Eukaryota.
ENOG410YDKQ. LUCA.
GeneTreeiENSGT00390000015016.
HOGENOMiHOG000007522.
HOVERGENiHBG108081.
InParanoidiQ969J3.
OMAiLEPFSMR.
PhylomeDBiQ969J3.
TreeFamiTF316379.

Miscellaneous databases

ChiTaRSiLOH12CR1. human.
GenomeRNAii118426.
NextBioi80266.
PROiQ969J3.

Gene expression databases

BgeeiQ969J3.
CleanExiHS_LOH12CR1.
ExpressionAtlasiQ969J3. baseline and differential.
GenevisibleiQ969J3. HS.

Family and domain databases

InterProiIPR018780. Tumour_suppressor_LOH1CR12.
[Graphical view]
PfamiPF10158. LOH1CR12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus."
    Montpetit A., Boily G., Sinnett D.
    Eur. J. Hum. Genet. 10:62-71(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  13. "Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development."
    Broncel M., Serwa R.A., Ciepla P., Krause E., Dallman M.J., Magee A.I., Tate E.W.
    Angew. Chem. Int. Ed. 54:5948-5951(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiL12R1_HUMAN
AccessioniPrimary (citable) accession number: Q969J3
Secondary accession number(s): Q96QS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.