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Protein

Zinc finger protein with KRAB and SCAN domains 4

Gene

ZKSCAN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the transcriptional activation of MDM2 and EP300 genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 342C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158672-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 4
Alternative name(s):
P373c6.1
Zinc finger protein 307
Zinc finger protein 427
Gene namesi
Name:ZKSCAN4
Synonyms:ZNF307, ZNF427
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13854. ZKSCAN4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi387032.
OpenTargetsiENSG00000187626.
PharmGKBiPA162409784.

Polymorphism and mutation databases

BioMutaiZKSCAN4.
DMDMi23396993.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475251 – 545Zinc finger protein with KRAB and SCAN domains 4Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ969J2.
MaxQBiQ969J2.
PaxDbiQ969J2.
PeptideAtlasiQ969J2.
PRIDEiQ969J2.

PTM databases

iPTMnetiQ969J2.
PhosphoSitePlusiQ969J2.

Expressioni

Tissue specificityi

Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000187626.
CleanExiHS_ZKSCAN4.
ExpressionAtlasiQ969J2. baseline and differential.
GenevisibleiQ969J2. HS.

Organism-specific databases

HPAiHPA009637.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CABP5Q9NP863EBI-2818641,EBI-10311131
LXNQ9BS403EBI-2818641,EBI-1044504
SCAND1P570863EBI-2818641,EBI-745846
TRIM39Q9HCM93EBI-2818641,EBI-739510
ZKSCAN7Q9P0L13EBI-2818641,EBI-743851
ZNF496Q96IT13EBI-2818641,EBI-743906
ZSCAN32I3L3J23EBI-2818641,EBI-10178206

Protein-protein interaction databases

BioGridi132179. 29 interactors.
IntActiQ969J2. 11 interactors.
STRINGi9606.ENSP00000366509.

Structurei

3D structure databases

ProteinModelPortaliQ969J2.
SMRiQ969J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 135SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini221 – 317KRABPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 342C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ969J2.
KOiK09229.
OMAiCREDAMV.
OrthoDBiEOG091G040B.
PhylomeDBiQ969J2.
TreeFamiTF350830.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAREPRKNAA LDAQSAEDQT GLLTVKVEKE EASALTAEVR APCSPARGPE
60 70 80 90 100
RSRQRFRGFR YPEAAGPREA LSRLRELCGQ WLQPEMHSKE QILELLVLEQ
110 120 130 140 150
FLTILPGNLQ SWVREQHPES GEEVVVLLEY LERQLDEPAP QVPVGDQGQE
160 170 180 190 200
LLCCKMALLT QTQGSQSSQC QPMKALFKHE SLGSQPLHDR VLQVPGLAQG
210 220 230 240 250
GCCREDAMVA SRLTPGSQGL LKMEDVALTL TPGWTQLDSS QVNLYRDEKQ
260 270 280 290 300
ENHSSLVSLG GEIQTKSRDL PPVKKLPEKE HGKICHLRED IAQIPTHAEA
310 320 330 340 350
GEQEGRLQRK QKNAIGSRRH YCHECGKSFA QSSGLTKHRR IHTGEKPYEC
360 370 380 390 400
EDCGKTFIGS SALVIHQRVH TGEKPYECEE CGKVFSHSSN LIKHQRTHTG
410 420 430 440 450
EKPYECDDCG KTFSQSCSLL EHHKIHTGEK PYQCNMCGKA FRRNSHLLRH
460 470 480 490 500
QRIHGDKNVQ NPEHGESWES QGRTESQWEN TEAPVSYKCN ECERSFTRNR
510 520 530 540
SLIEHQKIHT GEKPYQCDTC GKGFTRTSYL VQHQRSHVGK KTLSQ
Length:545
Mass (Da):61,579
Last modified:December 1, 2001 - v1
Checksum:iCCFB6B5D976926ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05995133S → F.Corresponds to variant rs9986596dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY781778 mRNA. Translation: AAV41023.1.
AK315783 mRNA. Translation: BAG38129.1.
AL022393 Genomic DNA. Translation: CAC69823.1.
CH471081 Genomic DNA. Translation: EAX03142.1.
BC014031 mRNA. Translation: AAH14031.1.
CCDSiCCDS4647.1.
RefSeqiNP_061983.2. NM_019110.4.
XP_005249152.1. XM_005249095.3.
UniGeneiHs.44720.
Hs.739171.

Genome annotation databases

EnsembliENST00000377294; ENSP00000366509; ENSG00000187626.
GeneIDi387032.
KEGGihsa:387032.
UCSCiuc003nks.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY781778 mRNA. Translation: AAV41023.1.
AK315783 mRNA. Translation: BAG38129.1.
AL022393 Genomic DNA. Translation: CAC69823.1.
CH471081 Genomic DNA. Translation: EAX03142.1.
BC014031 mRNA. Translation: AAH14031.1.
CCDSiCCDS4647.1.
RefSeqiNP_061983.2. NM_019110.4.
XP_005249152.1. XM_005249095.3.
UniGeneiHs.44720.
Hs.739171.

3D structure databases

ProteinModelPortaliQ969J2.
SMRiQ969J2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132179. 29 interactors.
IntActiQ969J2. 11 interactors.
STRINGi9606.ENSP00000366509.

PTM databases

iPTMnetiQ969J2.
PhosphoSitePlusiQ969J2.

Polymorphism and mutation databases

BioMutaiZKSCAN4.
DMDMi23396993.

Proteomic databases

EPDiQ969J2.
MaxQBiQ969J2.
PaxDbiQ969J2.
PeptideAtlasiQ969J2.
PRIDEiQ969J2.

Protocols and materials databases

DNASUi387032.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377294; ENSP00000366509; ENSG00000187626.
GeneIDi387032.
KEGGihsa:387032.
UCSCiuc003nks.2. human.

Organism-specific databases

CTDi387032.
DisGeNETi387032.
GeneCardsiZKSCAN4.
HGNCiHGNC:13854. ZKSCAN4.
HPAiHPA009637.
MIMi611643. gene.
neXtProtiNX_Q969J2.
OpenTargetsiENSG00000187626.
PharmGKBiPA162409784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ969J2.
KOiK09229.
OMAiCREDAMV.
OrthoDBiEOG091G040B.
PhylomeDBiQ969J2.
TreeFamiTF350830.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158672-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii387032.
PROiQ969J2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187626.
CleanExiHS_ZKSCAN4.
ExpressionAtlasiQ969J2. baseline and differential.
GenevisibleiQ969J2. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZKSC4_HUMAN
AccessioniPrimary (citable) accession number: Q969J2
Secondary accession number(s): B2RE32, Q5U7L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.