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Q969I6

- S38A4_HUMAN

UniProt

Q969I6 - S38A4_HUMAN

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Protein

Sodium-coupled neutral amino acid transporter 4

Gene

SLC38A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.2 Publications

pH dependencei

Optimum pH is 7.5-8.5.1 Publication

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: Ensembl
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. ion transport Source: Reactome
  3. sodium ion transport Source: UniProtKB-KW
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.18.6.17. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 4
Alternative name(s):
Amino acid transporter A3
Na(+)-coupled neutral amino acid transporter 4
Solute carrier family 38 member 4
System A amino acid transporter 3
System N amino acid transporter 3
Gene namesi
Name:SLC38A4
Synonyms:ATA3, NAT3, SNAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:14679. SLC38A4.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Sodium-coupled neutral amino acid transporter 4PRO_0000247860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi249 ↔ 321By similarity
Glycosylationi260 – 2601N-linked (GlcNAc...)1 Publication
Glycosylationi264 – 2641N-linked (GlcNAc...)1 Publication
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ969I6.
PRIDEiQ969I6.

PTM databases

PhosphoSiteiQ969I6.

Expressioni

Tissue specificityi

Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels.3 Publications

Gene expression databases

BgeeiQ969I6.
CleanExiHS_SLC38A4.
ExpressionAtlasiQ969I6. baseline and differential.
GenevestigatoriQ969I6.

Organism-specific databases

HPAiHPA038910.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266579.

Structurei

3D structure databases

ProteinModelPortaliQ969I6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 104104ExtracellularSequence AnalysisAdd
BLAST
Topological domaini126 – 15126CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini173 – 19523ExtracellularSequence AnalysisAdd
BLAST
Topological domaini217 – 2204CytoplasmicSequence Analysis
Topological domaini242 – 33291ExtracellularSequence AnalysisAdd
BLAST
Topological domaini354 – 36916CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini391 – 41121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini433 – 45321CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini475 – 4762ExtracellularSequence Analysis
Topological domaini498 – 51417CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini536 – 54712ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence AnalysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence AnalysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence AnalysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence AnalysisAdd
BLAST
Transmembranei477 – 49721HelicalSequence AnalysisAdd
BLAST
Transmembranei515 – 53521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ969I6.
KOiK14991.
OMAiDDKCQPK.
OrthoDBiEOG7WHH9J.
PhylomeDBiQ969I6.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969I6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPMELRNVN IEPDDESSSG ESAPDSYIGI GNSEKAAMSS QFANEDTESQ
60 70 80 90 100
KFLTNGFLGK KKLADYADEH HPGTTSFGMS SFNLSNAIMG SGILGLSYAM
110 120 130 140 150
ANTGIILFII MLLAVAILSL YSVHLLLKTA KEGGSLIYEK LGEKAFGWPG
160 170 180 190 200
KIGAFVSITM QNIGAMSSYL FIIKYELPEV IRAFMGLEEN TGEWYLNGNY
210 220 230 240 250
LIIFVSVGII LPLSLLKNLG YLGYTSGFSL TCMVFFVSVV IYKKFQIPCP
260 270 280 290 300
LPVLDHSVGN LSFNNTLPMH VVMLPNNSES SDVNFMMDYT HRNPAGLDEN
310 320 330 340 350
QAKGSLHDSG VEYEAHSDDK CEPKYFVFNS RTAYAIPILV FAFVCHPEVL
360 370 380 390 400
PIYSELKDRS RRKMQTVSNI SITGMLVMYL LAALFGYLTF YGEVEDELLH
410 420 430 440 450
AYSKVYTLDI PLLMVRLAVL VAVTLTVPIV LFPIRTSVIT LLFPKRPFSW
460 470 480 490 500
IRHFLIAAVL IALNNVLVIL VPTIKYIFGF IGASSATMLI FILPAVFYLK
510 520 530 540
LVKKETFRSP QKVGALIFLV VGIFFMIGSM ALIIIDWIYD PPNSKHH
Length:547
Mass (Da):60,764
Last modified:December 1, 2001 - v1
Checksum:iD47289AA386F3373
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291G → R.
Corresponds to variant rs2429467 [ dbSNP | Ensembl ].
VAR_048123
Natural varianti366 – 3661T → M.
Corresponds to variant rs11183610 [ dbSNP | Ensembl ].
VAR_048124

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305814 mRNA. Translation: AAK43528.1.
AF193836 mRNA. Translation: AAK71508.1.
AB055003 mRNA. Translation: BAB84090.1.
AK291168 mRNA. Translation: BAF83857.1.
CH471111 Genomic DNA. Translation: EAW57919.1.
BC069819 mRNA. Translation: AAH69819.1.
BC101827 mRNA. Translation: AAI01828.1.
BC104913 mRNA. Translation: AAI04914.1.
CCDSiCCDS8750.1.
RefSeqiNP_001137296.1. NM_001143824.1.
NP_060488.2. NM_018018.4.
XP_005269054.1. XM_005268997.2.
UniGeneiHs.446077.

Genome annotation databases

EnsembliENST00000266579; ENSP00000266579; ENSG00000139209.
ENST00000447411; ENSP00000389843; ENSG00000139209.
GeneIDi55089.
KEGGihsa:55089.
UCSCiuc001rpi.2. human.

Polymorphism databases

DMDMi74731046.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305814 mRNA. Translation: AAK43528.1 .
AF193836 mRNA. Translation: AAK71508.1 .
AB055003 mRNA. Translation: BAB84090.1 .
AK291168 mRNA. Translation: BAF83857.1 .
CH471111 Genomic DNA. Translation: EAW57919.1 .
BC069819 mRNA. Translation: AAH69819.1 .
BC101827 mRNA. Translation: AAI01828.1 .
BC104913 mRNA. Translation: AAI04914.1 .
CCDSi CCDS8750.1.
RefSeqi NP_001137296.1. NM_001143824.1.
NP_060488.2. NM_018018.4.
XP_005269054.1. XM_005268997.2.
UniGenei Hs.446077.

3D structure databases

ProteinModelPortali Q969I6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000266579.

Chemistry

GuidetoPHARMACOLOGYi 1171.

Protein family/group databases

TCDBi 2.A.18.6.17. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSitei Q969I6.

Polymorphism databases

DMDMi 74731046.

Proteomic databases

PaxDbi Q969I6.
PRIDEi Q969I6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266579 ; ENSP00000266579 ; ENSG00000139209 .
ENST00000447411 ; ENSP00000389843 ; ENSG00000139209 .
GeneIDi 55089.
KEGGi hsa:55089.
UCSCi uc001rpi.2. human.

Organism-specific databases

CTDi 55089.
GeneCardsi GC12M047138.
HGNCi HGNC:14679. SLC38A4.
HPAi HPA038910.
MIMi 608065. gene.
neXtProti NX_Q969I6.
PharmGKBi PA37908.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00760000119147.
HOGENOMi HOG000013088.
HOVERGENi HBG059571.
InParanoidi Q969I6.
KOi K14991.
OMAi DDKCQPK.
OrthoDBi EOG7WHH9J.
PhylomeDBi Q969I6.
TreeFami TF328787.

Enzyme and pathway databases

Reactomei REACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

GenomeRNAii 55089.
NextBioi 58661.
PROi Q969I6.
SOURCEi Search...

Gene expression databases

Bgeei Q969I6.
CleanExi HS_SLC38A4.
ExpressionAtlasi Q969I6. baseline and differential.
Genevestigatori Q969I6.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A."
    Hatanaka T., Huang W., Ling R., Prasad P.D., Sugawara M., Leibach F.H., Ganapathy V.
    Biochim. Biophys. Acta 1510:10-17(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    Tissue: Hepatoma.
  2. "A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization."
    Gu S., Adan-Rice D., Leach R.J., Jiang J.X.
    Genomics 74:262-272(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "Molecular cloning and characterization of a novel system A amino acid transporter from human liver."
    Matsuo H., Kanai Y., Kim D.K., Cha S.H., Chairoungdua A., Fukuda J., Endou H.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  7. "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family."
    Mackenzie B., Erickson J.D.
    Pflugers Arch. 447:784-795(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, GENE NOMENCLATURE.
  8. "SNAT4 isoform of system A amino acid transporter is expressed in human placenta."
    Desforges M., Lacey H.A., Glazier J.D., Greenwood S.L., Mynett K.J., Speake P.F., Sibley C.P.
    Am. J. Physiol. 290:C305-C312(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  9. "Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein."
    Shi Q., Padmanabhan R., Villegas C.J., Gu S., Jiang J.X.
    J. Biol. Chem. 286:38086-38094(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY, GLYCOSYLATION AT ASN-260 AND ASN-264.

Entry informationi

Entry nameiS38A4_HUMAN
AccessioniPrimary (citable) accession number: Q969I6
Secondary accession number(s): A8K553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3