Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q969I6

- S38A4_HUMAN

UniProt

Q969I6 - S38A4_HUMAN

Protein

Sodium-coupled neutral amino acid transporter 4

Gene

SLC38A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.2 Publications

    pH dependencei

    Optimum pH is 7.5-8.5.1 Publication

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: Ensembl
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. ion transport Source: Reactome
    3. sodium ion transport Source: UniProtKB-KW
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.18.6.17. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 4
    Alternative name(s):
    Amino acid transporter A3
    Na(+)-coupled neutral amino acid transporter 4
    Solute carrier family 38 member 4
    System A amino acid transporter 3
    System N amino acid transporter 3
    Gene namesi
    Name:SLC38A4
    Synonyms:ATA3, NAT3, SNAT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14679. SLC38A4.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37908.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 547547Sodium-coupled neutral amino acid transporter 4PRO_0000247860Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi249 ↔ 321By similarity
    Glycosylationi260 – 2601N-linked (GlcNAc...)1 Publication
    Glycosylationi264 – 2641N-linked (GlcNAc...)1 Publication
    Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ969I6.
    PRIDEiQ969I6.

    PTM databases

    PhosphoSiteiQ969I6.

    Expressioni

    Tissue specificityi

    Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels.3 Publications

    Gene expression databases

    ArrayExpressiQ969I6.
    BgeeiQ969I6.
    CleanExiHS_SLC38A4.
    GenevestigatoriQ969I6.

    Organism-specific databases

    HPAiHPA038910.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000266579.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969I6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 104104ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 15126CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 19523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 2204CytoplasmicSequence Analysis
    Topological domaini242 – 33291ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini354 – 36916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini391 – 41121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini433 – 45321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini475 – 4762ExtracellularSequence Analysis
    Topological domaini498 – 51417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini536 – 54712ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei454 – 47421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei477 – 49721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei515 – 53521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    HOGENOMiHOG000013088.
    HOVERGENiHBG059571.
    InParanoidiQ969I6.
    KOiK14991.
    OMAiDDKCQPK.
    OrthoDBiEOG7WHH9J.
    PhylomeDBiQ969I6.
    TreeFamiTF328787.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q969I6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPMELRNVN IEPDDESSSG ESAPDSYIGI GNSEKAAMSS QFANEDTESQ    50
    KFLTNGFLGK KKLADYADEH HPGTTSFGMS SFNLSNAIMG SGILGLSYAM 100
    ANTGIILFII MLLAVAILSL YSVHLLLKTA KEGGSLIYEK LGEKAFGWPG 150
    KIGAFVSITM QNIGAMSSYL FIIKYELPEV IRAFMGLEEN TGEWYLNGNY 200
    LIIFVSVGII LPLSLLKNLG YLGYTSGFSL TCMVFFVSVV IYKKFQIPCP 250
    LPVLDHSVGN LSFNNTLPMH VVMLPNNSES SDVNFMMDYT HRNPAGLDEN 300
    QAKGSLHDSG VEYEAHSDDK CEPKYFVFNS RTAYAIPILV FAFVCHPEVL 350
    PIYSELKDRS RRKMQTVSNI SITGMLVMYL LAALFGYLTF YGEVEDELLH 400
    AYSKVYTLDI PLLMVRLAVL VAVTLTVPIV LFPIRTSVIT LLFPKRPFSW 450
    IRHFLIAAVL IALNNVLVIL VPTIKYIFGF IGASSATMLI FILPAVFYLK 500
    LVKKETFRSP QKVGALIFLV VGIFFMIGSM ALIIIDWIYD PPNSKHH 547
    Length:547
    Mass (Da):60,764
    Last modified:December 1, 2001 - v1
    Checksum:iD47289AA386F3373
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291G → R.
    Corresponds to variant rs2429467 [ dbSNP | Ensembl ].
    VAR_048123
    Natural varianti366 – 3661T → M.
    Corresponds to variant rs11183610 [ dbSNP | Ensembl ].
    VAR_048124

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305814 mRNA. Translation: AAK43528.1.
    AF193836 mRNA. Translation: AAK71508.1.
    AB055003 mRNA. Translation: BAB84090.1.
    AK291168 mRNA. Translation: BAF83857.1.
    CH471111 Genomic DNA. Translation: EAW57919.1.
    BC069819 mRNA. Translation: AAH69819.1.
    BC101827 mRNA. Translation: AAI01828.1.
    BC104913 mRNA. Translation: AAI04914.1.
    CCDSiCCDS8750.1.
    RefSeqiNP_001137296.1. NM_001143824.1.
    NP_060488.2. NM_018018.4.
    XP_005269054.1. XM_005268997.2.
    UniGeneiHs.446077.

    Genome annotation databases

    EnsembliENST00000266579; ENSP00000266579; ENSG00000139209.
    ENST00000447411; ENSP00000389843; ENSG00000139209.
    GeneIDi55089.
    KEGGihsa:55089.
    UCSCiuc001rpi.2. human.

    Polymorphism databases

    DMDMi74731046.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305814 mRNA. Translation: AAK43528.1 .
    AF193836 mRNA. Translation: AAK71508.1 .
    AB055003 mRNA. Translation: BAB84090.1 .
    AK291168 mRNA. Translation: BAF83857.1 .
    CH471111 Genomic DNA. Translation: EAW57919.1 .
    BC069819 mRNA. Translation: AAH69819.1 .
    BC101827 mRNA. Translation: AAI01828.1 .
    BC104913 mRNA. Translation: AAI04914.1 .
    CCDSi CCDS8750.1.
    RefSeqi NP_001137296.1. NM_001143824.1.
    NP_060488.2. NM_018018.4.
    XP_005269054.1. XM_005268997.2.
    UniGenei Hs.446077.

    3D structure databases

    ProteinModelPortali Q969I6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000266579.

    Chemistry

    GuidetoPHARMACOLOGYi 1171.

    Protein family/group databases

    TCDBi 2.A.18.6.17. the amino acid/auxin permease (aaap) family.

    PTM databases

    PhosphoSitei Q969I6.

    Polymorphism databases

    DMDMi 74731046.

    Proteomic databases

    PaxDbi Q969I6.
    PRIDEi Q969I6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266579 ; ENSP00000266579 ; ENSG00000139209 .
    ENST00000447411 ; ENSP00000389843 ; ENSG00000139209 .
    GeneIDi 55089.
    KEGGi hsa:55089.
    UCSCi uc001rpi.2. human.

    Organism-specific databases

    CTDi 55089.
    GeneCardsi GC12M047138.
    HGNCi HGNC:14679. SLC38A4.
    HPAi HPA038910.
    MIMi 608065. gene.
    neXtProti NX_Q969I6.
    PharmGKBi PA37908.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0814.
    HOGENOMi HOG000013088.
    HOVERGENi HBG059571.
    InParanoidi Q969I6.
    KOi K14991.
    OMAi DDKCQPK.
    OrthoDBi EOG7WHH9J.
    PhylomeDBi Q969I6.
    TreeFami TF328787.

    Enzyme and pathway databases

    Reactomei REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    GenomeRNAii 55089.
    NextBioi 58661.
    PROi Q969I6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969I6.
    Bgeei Q969I6.
    CleanExi HS_SLC38A4.
    Genevestigatori Q969I6.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A."
      Hatanaka T., Huang W., Ling R., Prasad P.D., Sugawara M., Leibach F.H., Ganapathy V.
      Biochim. Biophys. Acta 1510:10-17(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
      Tissue: Hepatoma.
    2. "A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization."
      Gu S., Adan-Rice D., Leach R.J., Jiang J.X.
      Genomics 74:262-272(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. "Molecular cloning and characterization of a novel system A amino acid transporter from human liver."
      Matsuo H., Kanai Y., Kim D.K., Cha S.H., Chairoungdua A., Fukuda J., Endou H.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    7. "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family."
      Mackenzie B., Erickson J.D.
      Pflugers Arch. 447:784-795(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, GENE NOMENCLATURE.
    8. "SNAT4 isoform of system A amino acid transporter is expressed in human placenta."
      Desforges M., Lacey H.A., Glazier J.D., Greenwood S.L., Mynett K.J., Speake P.F., Sibley C.P.
      Am. J. Physiol. 290:C305-C312(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    9. "Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein."
      Shi Q., Padmanabhan R., Villegas C.J., Gu S., Jiang J.X.
      J. Biol. Chem. 286:38086-38094(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY, GLYCOSYLATION AT ASN-260 AND ASN-264.

    Entry informationi

    Entry nameiS38A4_HUMAN
    AccessioniPrimary (citable) accession number: Q969I6
    Secondary accession number(s): A8K553
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3