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Q969I3

- GLYL1_HUMAN

UniProt

Q969I3 - GLYL1_HUMAN

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Protein

Glycine N-acyltransferase-like protein 1

Gene
GLYATL1, GNAT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.1 Publication

Catalytic activityi

Acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.1 Publication

GO - Molecular functioni

  1. glutamine N-acyltransferase activity Source: UniProtKB-EC
  2. glycine N-acyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_6812. Conjugation of salicylate with glycine.
REACT_6933. Conjugation of benzoate with glycine.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-acyltransferase-like protein 1 (EC:2.3.1.68)
Alternative name(s):
Acyl-CoA:glycine N-acyltransferase-like protein 1
Glutamine N-acyltransferase
Gene namesi
Name:GLYATL1
Synonyms:GNAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:30519. GLYATL1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Glycine N-acyltransferase-like protein 1PRO_0000281874Add
BLAST

Proteomic databases

MaxQBiQ969I3.
PaxDbiQ969I3.
PRIDEiQ969I3.

Expressioni

Tissue specificityi

Expressed in liver and kidney and, at lower levels, in pancreas, testis, ovary and stomach.1 Publication

Gene expression databases

ArrayExpressiQ969I3.
BgeeiQ969I3.
CleanExiHS_GLYATL1.
GenevestigatoriQ969I3.

Organism-specific databases

HPAiHPA039501.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300079.

Structurei

3D structure databases

ProteinModelPortaliQ969I3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG121427.
HOGENOMiHOG000263599.
HOVERGENiHBG107953.
OMAiEASCEWH.
PhylomeDBiQ969I3.
TreeFamiTF353258.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view]
PANTHERiPTHR15298. PTHR15298. 1 hit.
PfamiPF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969I3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MILLNNSHKL LALYKSLARS IPESLKVYGS VYHINHGNPF NMEVLVDSWP    50
EYQMVIIRPQ KQEMTDDMDS YTNVYRMFSK EPQKSEEVLK NCEIVNWKQR 100
LQIQGLQESL GEGIRVATFS KSVKVEHSRA LLLVTEDILK LNASSKSKLG 150
SWAETGHPDD EFESETPNFK YAQLDVSYSG LVNDNWKRGK NERSLHYIKR 200
CIEDLPAACM LGPEGVPVSW VTMDPSCEVG MAYSMEKYRR TGNMARVMVR 250
YMKYLRQKNI PFYISVLEEN EDSRRFVGQF GFFEASCEWH QWTCYPQNLV 300
PF 302
Length:302
Mass (Da):35,101
Last modified:December 1, 2001 - v1
Checksum:iD6E7513A9B8769B0
GO
Isoform 2 (identifier: Q969I3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MILLNNSHKLLALYKSLARSIPES → MFKLCSNKMV...LRIIEFLLQG

Note: No experimental confirmation available.

Show »
Length:333
Mass (Da):38,639
Checksum:i872E4BA8FD52BDDF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424MILLN…SIPES → MFKLCSNKMVSQEGSEVELL VSPGARSEHGRYLQDPIVSI DLSEWLRIIEFLLQG in isoform 2. VSP_024076Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ084381 mRNA. Translation: AAZ31239.1.
AK055818 mRNA. Translation: BAB71023.1.
AK091965 mRNA. Translation: BAC03779.1.
AP001652 Genomic DNA. No translation available.
BC008353 mRNA. Translation: AAH08353.1.
AF087878 mRNA. Translation: AAP97178.1.
CCDSiCCDS31556.1. [Q969I3-2]
CCDS55768.1. [Q969I3-1]
RefSeqiNP_001207423.1. NM_001220494.2. [Q969I3-1]
NP_001207425.1. NM_001220496.2. [Q969I3-1]
NP_542392.2. NM_080661.4. [Q969I3-2]
UniGeneiHs.38085.
Hs.616909.

Genome annotation databases

EnsembliENST00000300079; ENSP00000300079; ENSG00000166840. [Q969I3-2]
ENST00000317391; ENSP00000322223; ENSG00000166840. [Q969I3-1]
GeneIDi92292.
KEGGihsa:92292.
UCSCiuc001nnf.3. human. [Q969I3-1]
uc001nnh.2. human. [Q969I3-2]

Polymorphism databases

DMDMi74731045.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ084381 mRNA. Translation: AAZ31239.1 .
AK055818 mRNA. Translation: BAB71023.1 .
AK091965 mRNA. Translation: BAC03779.1 .
AP001652 Genomic DNA. No translation available.
BC008353 mRNA. Translation: AAH08353.1 .
AF087878 mRNA. Translation: AAP97178.1 .
CCDSi CCDS31556.1. [Q969I3-2 ]
CCDS55768.1. [Q969I3-1 ]
RefSeqi NP_001207423.1. NM_001220494.2. [Q969I3-1 ]
NP_001207425.1. NM_001220496.2. [Q969I3-1 ]
NP_542392.2. NM_080661.4. [Q969I3-2 ]
UniGenei Hs.38085.
Hs.616909.

3D structure databases

ProteinModelPortali Q969I3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000300079.

Chemistry

DrugBanki DB00145. Glycine.

Polymorphism databases

DMDMi 74731045.

Proteomic databases

MaxQBi Q969I3.
PaxDbi Q969I3.
PRIDEi Q969I3.

Protocols and materials databases

DNASUi 92292.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300079 ; ENSP00000300079 ; ENSG00000166840 . [Q969I3-2 ]
ENST00000317391 ; ENSP00000322223 ; ENSG00000166840 . [Q969I3-1 ]
GeneIDi 92292.
KEGGi hsa:92292.
UCSCi uc001nnf.3. human. [Q969I3-1 ]
uc001nnh.2. human. [Q969I3-2 ]

Organism-specific databases

CTDi 92292.
GeneCardsi GC11P058696.
HGNCi HGNC:30519. GLYATL1.
HPAi HPA039501.
MIMi 614761. gene.
neXtProti NX_Q969I3.
PharmGKBi PA142671727.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG121427.
HOGENOMi HOG000263599.
HOVERGENi HBG107953.
OMAi EASCEWH.
PhylomeDBi Q969I3.
TreeFami TF353258.

Enzyme and pathway databases

Reactomei REACT_6812. Conjugation of salicylate with glycine.
REACT_6933. Conjugation of benzoate with glycine.

Miscellaneous databases

GenomeRNAii 92292.
NextBioi 77674.
PROi Q969I3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q969I3.
Bgeei Q969I3.
CleanExi HS_GLYATL1.
Genevestigatori Q969I3.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view ]
PANTHERi PTHR15298. PTHR15298. 1 hit.
Pfami PF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human glycine-n-acyltransferase gene GLYATL1, which activates transcriptional activity of HSE pathway."
    Zhang H., Qu Y., Lang Q., Li J., Zhong Z., Xie F., Ye G., Wan B., Yu L.
    Int. J. Mol. Sci. 8:433-444(2008)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  5. "Cloning of a new human cDNA homology to human putative glycine-N-acyltransferase mRNA."
    Cui W.C., Yu L., Gong R.M., Chu J.H., Yu Y.F., Zhao S.Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-159.
  6. "Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma."
    Matsuo M., Terai K., Kameda N., Matsumoto A., Kurokawa Y., Funase Y., Nishikawa K., Sugaya N., Hiruta N., Kishimoto T.
    Biochem. Biophys. Res. Commun. 420:901-906(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiGLYL1_HUMAN
AccessioniPrimary (citable) accession number: Q969I3
Secondary accession number(s): A6NDT0, Q7Z510, Q8NAW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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