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Protein

Glycine N-acyltransferase-like protein 1

Gene

GLYATL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.1 Publication

Catalytic activityi

Acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.1 Publication

GO - Molecular functioni

  1. glutamine N-acyltransferase activity Source: UniProtKB-EC
  2. glycine N-acyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_6812. Conjugation of salicylate with glycine.
REACT_6933. Conjugation of benzoate with glycine.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-acyltransferase-like protein 1 (EC:2.3.1.68)
Alternative name(s):
Acyl-CoA:glycine N-acyltransferase-like protein 1
Glutamine N-acyltransferase
Gene namesi
Name:GLYATL1
Synonyms:GNAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:30519. GLYATL1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Glycine N-acyltransferase-like protein 1PRO_0000281874Add
BLAST

Proteomic databases

MaxQBiQ969I3.
PaxDbiQ969I3.
PRIDEiQ969I3.

Expressioni

Tissue specificityi

Expressed in liver and kidney and, at lower levels, in pancreas, testis, ovary and stomach.1 Publication

Gene expression databases

BgeeiQ969I3.
CleanExiHS_GLYATL1.
ExpressionAtlasiQ969I3. baseline and differential.
GenevestigatoriQ969I3.

Organism-specific databases

HPAiHPA039501.

Interactioni

Protein-protein interaction databases

BioGridi124929. 1 interaction.
STRINGi9606.ENSP00000300079.

Structurei

3D structure databases

ProteinModelPortaliQ969I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycine N-acyltransferase family.Curated

Phylogenomic databases

eggNOGiNOG121427.
GeneTreeiENSGT00390000004997.
HOGENOMiHOG000263599.
HOVERGENiHBG107953.
InParanoidiQ969I3.
OMAiEASCEWH.
PhylomeDBiQ969I3.
TreeFamiTF353258.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view]
PANTHERiPTHR15298. PTHR15298. 1 hit.
PfamiPF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969I3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILLNNSHKL LALYKSLARS IPESLKVYGS VYHINHGNPF NMEVLVDSWP
60 70 80 90 100
EYQMVIIRPQ KQEMTDDMDS YTNVYRMFSK EPQKSEEVLK NCEIVNWKQR
110 120 130 140 150
LQIQGLQESL GEGIRVATFS KSVKVEHSRA LLLVTEDILK LNASSKSKLG
160 170 180 190 200
SWAETGHPDD EFESETPNFK YAQLDVSYSG LVNDNWKRGK NERSLHYIKR
210 220 230 240 250
CIEDLPAACM LGPEGVPVSW VTMDPSCEVG MAYSMEKYRR TGNMARVMVR
260 270 280 290 300
YMKYLRQKNI PFYISVLEEN EDSRRFVGQF GFFEASCEWH QWTCYPQNLV

PF
Length:302
Mass (Da):35,101
Last modified:December 1, 2001 - v1
Checksum:iD6E7513A9B8769B0
GO
Isoform 2 (identifier: Q969I3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MILLNNSHKLLALYKSLARSIPES → MFKLCSNKMV...LRIIEFLLQG

Note: No experimental confirmation available.

Show »
Length:333
Mass (Da):38,639
Checksum:i872E4BA8FD52BDDF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424MILLN…SIPES → MFKLCSNKMVSQEGSEVELL VSPGARSEHGRYLQDPIVSI DLSEWLRIIEFLLQG in isoform 2. 1 PublicationVSP_024076Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ084381 mRNA. Translation: AAZ31239.1.
AK055818 mRNA. Translation: BAB71023.1.
AK091965 mRNA. Translation: BAC03779.1.
AP001652 Genomic DNA. No translation available.
BC008353 mRNA. Translation: AAH08353.1.
AF087878 mRNA. Translation: AAP97178.1.
CCDSiCCDS31556.1. [Q969I3-2]
CCDS55768.1. [Q969I3-1]
RefSeqiNP_001207423.1. NM_001220494.2. [Q969I3-1]
NP_001207425.1. NM_001220496.2. [Q969I3-1]
NP_542392.2. NM_080661.4. [Q969I3-2]
UniGeneiHs.38085.
Hs.616909.

Genome annotation databases

EnsembliENST00000300079; ENSP00000300079; ENSG00000166840. [Q969I3-2]
ENST00000317391; ENSP00000322223; ENSG00000166840. [Q969I3-1]
ENST00000612196; ENSP00000479741; ENSG00000166840. [Q969I3-1]
GeneIDi92292.
KEGGihsa:92292.
UCSCiuc001nnf.3. human. [Q969I3-1]
uc001nnh.2. human. [Q969I3-2]

Polymorphism databases

DMDMi74731045.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ084381 mRNA. Translation: AAZ31239.1.
AK055818 mRNA. Translation: BAB71023.1.
AK091965 mRNA. Translation: BAC03779.1.
AP001652 Genomic DNA. No translation available.
BC008353 mRNA. Translation: AAH08353.1.
AF087878 mRNA. Translation: AAP97178.1.
CCDSiCCDS31556.1. [Q969I3-2]
CCDS55768.1. [Q969I3-1]
RefSeqiNP_001207423.1. NM_001220494.2. [Q969I3-1]
NP_001207425.1. NM_001220496.2. [Q969I3-1]
NP_542392.2. NM_080661.4. [Q969I3-2]
UniGeneiHs.38085.
Hs.616909.

3D structure databases

ProteinModelPortaliQ969I3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124929. 1 interaction.
STRINGi9606.ENSP00000300079.

Chemistry

DrugBankiDB00145. Glycine.

Polymorphism databases

DMDMi74731045.

Proteomic databases

MaxQBiQ969I3.
PaxDbiQ969I3.
PRIDEiQ969I3.

Protocols and materials databases

DNASUi92292.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300079; ENSP00000300079; ENSG00000166840. [Q969I3-2]
ENST00000317391; ENSP00000322223; ENSG00000166840. [Q969I3-1]
ENST00000612196; ENSP00000479741; ENSG00000166840. [Q969I3-1]
GeneIDi92292.
KEGGihsa:92292.
UCSCiuc001nnf.3. human. [Q969I3-1]
uc001nnh.2. human. [Q969I3-2]

Organism-specific databases

CTDi92292.
GeneCardsiGC11P058676.
HGNCiHGNC:30519. GLYATL1.
HPAiHPA039501.
MIMi614761. gene.
neXtProtiNX_Q969I3.
PharmGKBiPA142671727.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG121427.
GeneTreeiENSGT00390000004997.
HOGENOMiHOG000263599.
HOVERGENiHBG107953.
InParanoidiQ969I3.
OMAiEASCEWH.
PhylomeDBiQ969I3.
TreeFamiTF353258.

Enzyme and pathway databases

ReactomeiREACT_6812. Conjugation of salicylate with glycine.
REACT_6933. Conjugation of benzoate with glycine.

Miscellaneous databases

GenomeRNAii92292.
NextBioi77674.
PROiQ969I3.
SOURCEiSearch...

Gene expression databases

BgeeiQ969I3.
CleanExiHS_GLYATL1.
ExpressionAtlasiQ969I3. baseline and differential.
GenevestigatoriQ969I3.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view]
PANTHERiPTHR15298. PTHR15298. 1 hit.
PfamiPF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human glycine-n-acyltransferase gene GLYATL1, which activates transcriptional activity of HSE pathway."
    Zhang H., Qu Y., Lang Q., Li J., Zhong Z., Xie F., Ye G., Wan B., Yu L.
    Int. J. Mol. Sci. 8:433-444(2008)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  5. "Cloning of a new human cDNA homology to human putative glycine-N-acyltransferase mRNA."
    Cui W.C., Yu L., Gong R.M., Chu J.H., Yu Y.F., Zhao S.Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-159.
  6. "Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma."
    Matsuo M., Terai K., Kameda N., Matsumoto A., Kurokawa Y., Funase Y., Nishikawa K., Sugaya N., Hiruta N., Kishimoto T.
    Biochem. Biophys. Res. Commun. 420:901-906(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiGLYL1_HUMAN
AccessioniPrimary (citable) accession number: Q969I3
Secondary accession number(s): A6NDT0, Q7Z510, Q8NAW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.