Q969I3 (GLYL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine N-acyltransferase-like protein 1
EC=2.3.1.68

Alternative name(s):
Acyl-CoA:glycine N-acyltransferase-like protein 1
Glutamine N-acyltransferase

Gene names

Name:	GLYATL1
Synonyms:	GNAT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor. Ref.6
Catalytic activity	Acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine. Ref.6
Tissue specificity	Expressed in liver and kidney and, at lower levels, in pancreas, testis, ovary and stomach. Ref.1
Sequence similarities	Belongs to the glycine N-acyltransferase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from electronic annotation. Source: InterPro
Molecular_function	glutamine N-acyltransferase activity Inferred from electronic annotation. Source: EC glycine N-acyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q969I3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q969I3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MILLNNSHKLLALYKSLARSIPES → MFKLCSNKMV...LRIIEFLLQG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Glycine N-acyltransferase-like protein 1		PRO_0000281874
Natural variations
	Alternative sequence	1 – 24	24	MILLN…SIPES → MFKLCSNKMVSQEGSEVELL VSPGARSEHGRYLQDPIVSI DLSEWLRIIEFLLQG in isoform 2.		VSP_024076

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: D6E7513A9B8769B0	FASTA	302	35,101
	10 20 30 40 50 60 MILLNNSHKL LALYKSLARS IPESLKVYGS VYHINHGNPF NMEVLVDSWP EYQMVIIRPQ 70 80 90 100 110 120 KQEMTDDMDS YTNVYRMFSK EPQKSEEVLK NCEIVNWKQR LQIQGLQESL GEGIRVATFS 130 140 150 160 170 180 KSVKVEHSRA LLLVTEDILK LNASSKSKLG SWAETGHPDD EFESETPNFK YAQLDVSYSG 190 200 210 220 230 240 LVNDNWKRGK NERSLHYIKR CIEDLPAACM LGPEGVPVSW VTMDPSCEVG MAYSMEKYRR 250 260 270 280 290 300 TGNMARVMVR YMKYLRQKNI PFYISVLEEN EDSRRFVGQF GFFEASCEWH QWTCYPQNLV PF
	Isoform 2 [UniParc]. Checksum: 872E4BA8FD52BDDF	FASTA	333	38,639
	10 20 30 40 50 60 MFKLCSNKMV SQEGSEVELL VSPGARSEHG RYLQDPIVSI DLSEWLRIIE FLLQGLKVYG 70 80 90 100 110 120 SVYHINHGNP FNMEVLVDSW PEYQMVIIRP QKQEMTDDMD SYTNVYRMFS KEPQKSEEVL 130 140 150 160 170 180 KNCEIVNWKQ RLQIQGLQES LGEGIRVATF SKSVKVEHSR ALLLVTEDIL KLNASSKSKL 190 200 210 220 230 240 GSWAETGHPD DEFESETPNF KYAQLDVSYS GLVNDNWKRG KNERSLHYIK RCIEDLPAAC 250 260 270 280 290 300 MLGPEGVPVS WVTMDPSCEV GMAYSMEKYR RTGNMARVMV RYMKYLRQKN IPFYISVLEE 310 320 330 NEDSRRFVGQ FGFFEASCEW HQWTCYPQNL VPF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human glycine-n-acyltransferase gene GLYATL1, which activates transcriptional activity of HSE pathway." Zhang H., Qu Y., Lang Q., Li J., Zhong Z., Xie F., Ye G., Wan B., Yu L. Int. J. Mol. Sci. 8:433-444(2008) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Kidney.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[5]	"Cloning of a new human cDNA homology to human putative glycine-N-acyltransferase mRNA." Cui W.C., Yu L., Gong R.M., Chu J.H., Yu Y.F., Zhao S.Y. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-159.
[6]	"Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma." Matsuo M., Terai K., Kameda N., Matsumoto A., Kurokawa Y., Funase Y., Nishikawa K., Sugaya N., Hiruta N., Kishimoto T. Biochem. Biophys. Res. Commun. 420:901-906(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ084381 mRNA. Translation: AAZ31239.1. AK055818 mRNA. Translation: BAB71023.1. AK091965 mRNA. Translation: BAC03779.1. AP001652 Genomic DNA. No translation available. BC008353 mRNA. Translation: AAH08353.1. AF087878 mRNA. Translation: AAP97178.1.
IPI	IPI00056369. IPI00168156.
RefSeq	NP_001207423.1. NM_001220494.1. NP_001207425.1. NM_001220496.1. NP_542392.2. NM_080661.3.
UniGene	Hs.38085. Hs.616909.
3D structure databases
ProteinModelPortal	Q969I3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000300079.
Polymorphism databases
DMDM	74731045.
Proteomic databases
PaxDb	Q969I3.
PRIDE	Q969I3.
Protocols and materials databases
DNASU	92292.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300079; ENSP00000300079; ENSG00000166840. ENST00000317391; ENSP00000322223; ENSG00000166840.
GeneID	92292.
KEGG	hsa:92292.
UCSC	uc001nnf.3. human. uc001nnh.2. human.
Organism-specific databases
CTD	92292.
GeneCards	GC11P058696.
HGNC	HGNC:30519. GLYATL1.
HPA	HPA039501.
MIM	614761. gene.
neXtProt	NX_Q969I3.
PharmGKB	PA142671727.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG121427.
HOGENOM	HOG000263599.
HOVERGEN	HBG107953.
OMA	EASCEWH.
Gene expression databases
ArrayExpress	Q969I3.
Bgee	Q969I3.
CleanEx	HS_GLYATL1.
Genevestigator	Q969I3.
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR010313. Glycine_N-acyltransferase. IPR013652. Glycine_N-acyltransferase_C. IPR015938. Glycine_N-acyltransferase_N. [Graphical view]
PANTHER	PTHR15298. PTHR15298. 1 hit.
Pfam	PF08444. Gly_acyl_tr_C. 1 hit. PF06021. Gly_acyl_tr_N. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00145. Glycine.
GenomeRNAi	92292.
NextBio	77674.
SOURCE	Search...

Entry information

Entry name

GLYL1_HUMAN

Accession

Primary (citable) accession number: Q969I3
Secondary accession number(s): A6NDT0, Q7Z510, Q8NAW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.