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Protein

Glycine N-acyltransferase-like protein 1

Gene

GLYATL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.1 Publication

Catalytic activityi

Acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.1 Publication

GO - Molecular functioni

  • glutamine N-acyltransferase activity Source: UniProtKB
  • glycine N-acyltransferase activity Source: InterPro

GO - Biological processi

  • glutamine metabolic process Source: UniProtKB

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.13 2681
ReactomeiR-HSA-177128 Conjugation of salicylate with glycine
R-HSA-177135 Conjugation of benzoate with glycine

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-acyltransferase-like protein 1 (EC:2.3.1.68)
Alternative name(s):
Acyl-CoA:glycine N-acyltransferase-like protein 1
Glutamine N-acyltransferase
Gene namesi
Name:GLYATL1
Synonyms:GNAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166840.13
HGNCiHGNC:30519 GLYATL1
MIMi614761 gene
neXtProtiNX_Q969I3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi92292
OpenTargetsiENSG00000166840
PharmGKBiPA142671727

Chemistry databases

DrugBankiDB00145 Glycine

Polymorphism and mutation databases

BioMutaiGLYATL1
DMDMi74731045

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818741 – 302Glycine N-acyltransferase-like protein 1Add BLAST302

Proteomic databases

EPDiQ969I3
MaxQBiQ969I3
PaxDbiQ969I3
PeptideAtlasiQ969I3
PRIDEiQ969I3

PTM databases

iPTMnetiQ969I3
PhosphoSitePlusiQ969I3

Expressioni

Tissue specificityi

Expressed in liver and kidney and, at lower levels, in pancreas, testis, ovary and stomach.1 Publication

Gene expression databases

BgeeiENSG00000166840
CleanExiHS_GLYATL1
ExpressionAtlasiQ969I3 baseline and differential
GenevisibleiQ969I3 HS

Organism-specific databases

HPAiHPA039501

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300079

Structurei

3D structure databases

ProteinModelPortaliQ969I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycine N-acyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG410J98B Eukaryota
ENOG4111RDK LUCA
GeneTreeiENSGT00390000004997
HOGENOMiHOG000263599
HOVERGENiHBG107953
InParanoidiQ969I3
KOiK22442
OMAiRVMVRYM
OrthoDBiEOG091G0GJJ
PhylomeDBiQ969I3
TreeFamiTF353258

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR010313 Glycine_N-acyltransferase
IPR013652 Glycine_N-acyltransferase_C
IPR015938 Glycine_N-acyltransferase_N
PANTHERiPTHR15298 PTHR15298, 1 hit
PfamiView protein in Pfam
PF08444 Gly_acyl_tr_C, 1 hit
PF06021 Gly_acyl_tr_N, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969I3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILLNNSHKL LALYKSLARS IPESLKVYGS VYHINHGNPF NMEVLVDSWP
60 70 80 90 100
EYQMVIIRPQ KQEMTDDMDS YTNVYRMFSK EPQKSEEVLK NCEIVNWKQR
110 120 130 140 150
LQIQGLQESL GEGIRVATFS KSVKVEHSRA LLLVTEDILK LNASSKSKLG
160 170 180 190 200
SWAETGHPDD EFESETPNFK YAQLDVSYSG LVNDNWKRGK NERSLHYIKR
210 220 230 240 250
CIEDLPAACM LGPEGVPVSW VTMDPSCEVG MAYSMEKYRR TGNMARVMVR
260 270 280 290 300
YMKYLRQKNI PFYISVLEEN EDSRRFVGQF GFFEASCEWH QWTCYPQNLV

PF
Length:302
Mass (Da):35,101
Last modified:December 1, 2001 - v1
Checksum:iD6E7513A9B8769B0
GO
Isoform 2 (identifier: Q969I3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MILLNNSHKLLALYKSLARSIPES → MFKLCSNKMV...LRIIEFLLQG

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):38,639
Checksum:i872E4BA8FD52BDDF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0240761 – 24MILLN…SIPES → MFKLCSNKMVSQEGSEVELL VSPGARSEHGRYLQDPIVSI DLSEWLRIIEFLLQG in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ084381 mRNA Translation: AAZ31239.1
AK055818 mRNA Translation: BAB71023.1
AK091965 mRNA Translation: BAC03779.1
AP001652 Genomic DNA No translation available.
BC008353 mRNA Translation: AAH08353.1
AF087878 mRNA Translation: AAP97178.1
CCDSiCCDS31556.1 [Q969I3-2]
CCDS55768.1 [Q969I3-1]
RefSeqiNP_001207423.1, NM_001220494.2 [Q969I3-1]
NP_001207425.1, NM_001220496.2 [Q969I3-1]
NP_542392.2, NM_080661.4 [Q969I3-2]
UniGeneiHs.38085
Hs.733188

Genome annotation databases

EnsembliENST00000300079; ENSP00000300079; ENSG00000166840 [Q969I3-2]
ENST00000317391; ENSP00000322223; ENSG00000166840 [Q969I3-1]
ENST00000612196; ENSP00000479741; ENSG00000166840 [Q969I3-1]
GeneIDi92292
KEGGihsa:92292
UCSCiuc001nnf.4 human [Q969I3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGLYL1_HUMAN
AccessioniPrimary (citable) accession number: Q969I3
Secondary accession number(s): A6NDT0, Q7Z510, Q8NAW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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