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Q969I3

- GLYL1_HUMAN

UniProt

Q969I3 - GLYL1_HUMAN

Protein

Glycine N-acyltransferase-like protein 1

Gene

GLYATL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.1 Publication

    Catalytic activityi

    Acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.1 Publication

    GO - Molecular functioni

    1. glutamine N-acyltransferase activity Source: UniProtKB-EC
    2. glycine N-acyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_6812. Conjugation of salicylate with glycine.
    REACT_6933. Conjugation of benzoate with glycine.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine N-acyltransferase-like protein 1 (EC:2.3.1.68)
    Alternative name(s):
    Acyl-CoA:glycine N-acyltransferase-like protein 1
    Glutamine N-acyltransferase
    Gene namesi
    Name:GLYATL1
    Synonyms:GNAT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:30519. GLYATL1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671727.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Glycine N-acyltransferase-like protein 1PRO_0000281874Add
    BLAST

    Proteomic databases

    MaxQBiQ969I3.
    PaxDbiQ969I3.
    PRIDEiQ969I3.

    Expressioni

    Tissue specificityi

    Expressed in liver and kidney and, at lower levels, in pancreas, testis, ovary and stomach.1 Publication

    Gene expression databases

    ArrayExpressiQ969I3.
    BgeeiQ969I3.
    CleanExiHS_GLYATL1.
    GenevestigatoriQ969I3.

    Organism-specific databases

    HPAiHPA039501.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000300079.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969I3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycine N-acyltransferase family.Curated

    Phylogenomic databases

    eggNOGiNOG121427.
    HOGENOMiHOG000263599.
    HOVERGENiHBG107953.
    OMAiEASCEWH.
    PhylomeDBiQ969I3.
    TreeFamiTF353258.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR010313. Glycine_N-acyltransferase.
    IPR013652. Glycine_N-acyltransferase_C.
    IPR015938. Glycine_N-acyltransferase_N.
    [Graphical view]
    PANTHERiPTHR15298. PTHR15298. 1 hit.
    PfamiPF08444. Gly_acyl_tr_C. 1 hit.
    PF06021. Gly_acyl_tr_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969I3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MILLNNSHKL LALYKSLARS IPESLKVYGS VYHINHGNPF NMEVLVDSWP    50
    EYQMVIIRPQ KQEMTDDMDS YTNVYRMFSK EPQKSEEVLK NCEIVNWKQR 100
    LQIQGLQESL GEGIRVATFS KSVKVEHSRA LLLVTEDILK LNASSKSKLG 150
    SWAETGHPDD EFESETPNFK YAQLDVSYSG LVNDNWKRGK NERSLHYIKR 200
    CIEDLPAACM LGPEGVPVSW VTMDPSCEVG MAYSMEKYRR TGNMARVMVR 250
    YMKYLRQKNI PFYISVLEEN EDSRRFVGQF GFFEASCEWH QWTCYPQNLV 300
    PF 302
    Length:302
    Mass (Da):35,101
    Last modified:December 1, 2001 - v1
    Checksum:iD6E7513A9B8769B0
    GO
    Isoform 2 (identifier: Q969I3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: MILLNNSHKLLALYKSLARSIPES → MFKLCSNKMV...LRIIEFLLQG

    Note: No experimental confirmation available.

    Show »
    Length:333
    Mass (Da):38,639
    Checksum:i872E4BA8FD52BDDF
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2424MILLN…SIPES → MFKLCSNKMVSQEGSEVELL VSPGARSEHGRYLQDPIVSI DLSEWLRIIEFLLQG in isoform 2. 1 PublicationVSP_024076Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ084381 mRNA. Translation: AAZ31239.1.
    AK055818 mRNA. Translation: BAB71023.1.
    AK091965 mRNA. Translation: BAC03779.1.
    AP001652 Genomic DNA. No translation available.
    BC008353 mRNA. Translation: AAH08353.1.
    AF087878 mRNA. Translation: AAP97178.1.
    CCDSiCCDS31556.1. [Q969I3-2]
    CCDS55768.1. [Q969I3-1]
    RefSeqiNP_001207423.1. NM_001220494.2. [Q969I3-1]
    NP_001207425.1. NM_001220496.2. [Q969I3-1]
    NP_542392.2. NM_080661.4. [Q969I3-2]
    UniGeneiHs.38085.
    Hs.616909.

    Genome annotation databases

    EnsembliENST00000300079; ENSP00000300079; ENSG00000166840. [Q969I3-2]
    ENST00000317391; ENSP00000322223; ENSG00000166840. [Q969I3-1]
    GeneIDi92292.
    KEGGihsa:92292.
    UCSCiuc001nnf.3. human. [Q969I3-1]
    uc001nnh.2. human. [Q969I3-2]

    Polymorphism databases

    DMDMi74731045.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ084381 mRNA. Translation: AAZ31239.1 .
    AK055818 mRNA. Translation: BAB71023.1 .
    AK091965 mRNA. Translation: BAC03779.1 .
    AP001652 Genomic DNA. No translation available.
    BC008353 mRNA. Translation: AAH08353.1 .
    AF087878 mRNA. Translation: AAP97178.1 .
    CCDSi CCDS31556.1. [Q969I3-2 ]
    CCDS55768.1. [Q969I3-1 ]
    RefSeqi NP_001207423.1. NM_001220494.2. [Q969I3-1 ]
    NP_001207425.1. NM_001220496.2. [Q969I3-1 ]
    NP_542392.2. NM_080661.4. [Q969I3-2 ]
    UniGenei Hs.38085.
    Hs.616909.

    3D structure databases

    ProteinModelPortali Q969I3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000300079.

    Chemistry

    DrugBanki DB00145. Glycine.

    Polymorphism databases

    DMDMi 74731045.

    Proteomic databases

    MaxQBi Q969I3.
    PaxDbi Q969I3.
    PRIDEi Q969I3.

    Protocols and materials databases

    DNASUi 92292.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300079 ; ENSP00000300079 ; ENSG00000166840 . [Q969I3-2 ]
    ENST00000317391 ; ENSP00000322223 ; ENSG00000166840 . [Q969I3-1 ]
    GeneIDi 92292.
    KEGGi hsa:92292.
    UCSCi uc001nnf.3. human. [Q969I3-1 ]
    uc001nnh.2. human. [Q969I3-2 ]

    Organism-specific databases

    CTDi 92292.
    GeneCardsi GC11P058696.
    HGNCi HGNC:30519. GLYATL1.
    HPAi HPA039501.
    MIMi 614761. gene.
    neXtProti NX_Q969I3.
    PharmGKBi PA142671727.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG121427.
    HOGENOMi HOG000263599.
    HOVERGENi HBG107953.
    OMAi EASCEWH.
    PhylomeDBi Q969I3.
    TreeFami TF353258.

    Enzyme and pathway databases

    Reactomei REACT_6812. Conjugation of salicylate with glycine.
    REACT_6933. Conjugation of benzoate with glycine.

    Miscellaneous databases

    GenomeRNAii 92292.
    NextBioi 77674.
    PROi Q969I3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969I3.
    Bgeei Q969I3.
    CleanExi HS_GLYATL1.
    Genevestigatori Q969I3.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR010313. Glycine_N-acyltransferase.
    IPR013652. Glycine_N-acyltransferase_C.
    IPR015938. Glycine_N-acyltransferase_N.
    [Graphical view ]
    PANTHERi PTHR15298. PTHR15298. 1 hit.
    Pfami PF08444. Gly_acyl_tr_C. 1 hit.
    PF06021. Gly_acyl_tr_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human glycine-n-acyltransferase gene GLYATL1, which activates transcriptional activity of HSE pathway."
      Zhang H., Qu Y., Lang Q., Li J., Zhong Z., Xie F., Ye G., Wan B., Yu L.
      Int. J. Mol. Sci. 8:433-444(2008)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    5. "Cloning of a new human cDNA homology to human putative glycine-N-acyltransferase mRNA."
      Cui W.C., Yu L., Gong R.M., Chu J.H., Yu Y.F., Zhao S.Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-159.
    6. "Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma."
      Matsuo M., Terai K., Kameda N., Matsumoto A., Kurokawa Y., Funase Y., Nishikawa K., Sugaya N., Hiruta N., Kishimoto T.
      Biochem. Biophys. Res. Commun. 420:901-906(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.

    Entry informationi

    Entry nameiGLYL1_HUMAN
    AccessioniPrimary (citable) accession number: Q969I3
    Secondary accession number(s): A6NDT0, Q7Z510, Q8NAW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3