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Q969I3 (GLYL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine N-acyltransferase-like protein 1

EC=2.3.1.68
Alternative name(s):
Acyl-CoA:glycine N-acyltransferase-like protein 1
Glutamine N-acyltransferase
Gene names
Name:GLYATL1
Synonyms:GNAT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor. Ref.6

Catalytic activity

Acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine. Ref.6

Tissue specificity

Expressed in liver and kidney and, at lower levels, in pancreas, testis, ovary and stomach. Ref.1

Sequence similarities

Belongs to the glycine N-acyltransferase family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutamine N-acyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

glycine N-acyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q969I3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q969I3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MILLNNSHKLLALYKSLARSIPES → MFKLCSNKMV...LRIIEFLLQG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Glycine N-acyltransferase-like protein 1
PRO_0000281874

Natural variations

Alternative sequence1 – 2424MILLN…SIPES → MFKLCSNKMVSQEGSEVELL VSPGARSEHGRYLQDPIVSI DLSEWLRIIEFLLQG in isoform 2.
VSP_024076

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: D6E7513A9B8769B0

FASTA30235,101
        10         20         30         40         50         60 
MILLNNSHKL LALYKSLARS IPESLKVYGS VYHINHGNPF NMEVLVDSWP EYQMVIIRPQ 

        70         80         90        100        110        120 
KQEMTDDMDS YTNVYRMFSK EPQKSEEVLK NCEIVNWKQR LQIQGLQESL GEGIRVATFS 

       130        140        150        160        170        180 
KSVKVEHSRA LLLVTEDILK LNASSKSKLG SWAETGHPDD EFESETPNFK YAQLDVSYSG 

       190        200        210        220        230        240 
LVNDNWKRGK NERSLHYIKR CIEDLPAACM LGPEGVPVSW VTMDPSCEVG MAYSMEKYRR 

       250        260        270        280        290        300 
TGNMARVMVR YMKYLRQKNI PFYISVLEEN EDSRRFVGQF GFFEASCEWH QWTCYPQNLV 


PF 

« Hide

Isoform 2 [UniParc].

Checksum: 872E4BA8FD52BDDF
Show »

FASTA33338,639

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel human glycine-n-acyltransferase gene GLYATL1, which activates transcriptional activity of HSE pathway."
Zhang H., Qu Y., Lang Q., Li J., Zhong Z., Xie F., Ye G., Wan B., Yu L.
Int. J. Mol. Sci. 8:433-444(2008)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Liver.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Kidney.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[5]"Cloning of a new human cDNA homology to human putative glycine-N-acyltransferase mRNA."
Cui W.C., Yu L., Gong R.M., Chu J.H., Yu Y.F., Zhao S.Y.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-159.
[6]"Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma."
Matsuo M., Terai K., Kameda N., Matsumoto A., Kurokawa Y., Funase Y., Nishikawa K., Sugaya N., Hiruta N., Kishimoto T.
Biochem. Biophys. Res. Commun. 420:901-906(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ084381 mRNA. Translation: AAZ31239.1.
AK055818 mRNA. Translation: BAB71023.1.
AK091965 mRNA. Translation: BAC03779.1.
AP001652 Genomic DNA. No translation available.
BC008353 mRNA. Translation: AAH08353.1.
AF087878 mRNA. Translation: AAP97178.1.
RefSeqNP_001207423.1. NM_001220494.1.
NP_001207425.1. NM_001220496.1.
NP_542392.2. NM_080661.3.
UniGeneHs.38085.
Hs.616909.

3D structure databases

ProteinModelPortalQ969I3.
SMRQ969I3. Positions 206-286.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000300079.

Chemistry

DrugBankDB00145. Glycine.

Polymorphism databases

DMDM74731045.

Proteomic databases

PaxDbQ969I3.
PRIDEQ969I3.

Protocols and materials databases

DNASU92292.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300079; ENSP00000300079; ENSG00000166840. [Q969I3-2]
ENST00000317391; ENSP00000322223; ENSG00000166840. [Q969I3-1]
GeneID92292.
KEGGhsa:92292.
UCSCuc001nnf.3. human. [Q969I3-1]
uc001nnh.2. human. [Q969I3-2]

Organism-specific databases

CTD92292.
GeneCardsGC11P058696.
HGNCHGNC:30519. GLYATL1.
HPAHPA039501.
MIM614761. gene.
neXtProtNX_Q969I3.
PharmGKBPA142671727.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG121427.
HOGENOMHOG000263599.
HOVERGENHBG107953.
OMAEASCEWH.
PhylomeDBQ969I3.
TreeFamTF353258.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ969I3.
BgeeQ969I3.
CleanExHS_GLYATL1.
GenevestigatorQ969I3.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view]
PANTHERPTHR15298. PTHR15298. 1 hit.
PfamPF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi92292.
NextBio77674.
PROQ969I3.
SOURCESearch...

Entry information

Entry nameGLYL1_HUMAN
AccessionPrimary (citable) accession number: Q969I3
Secondary accession number(s): A6NDT0, Q7Z510, Q8NAW8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM