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Q969I0

- Q969I0_HUMAN

UniProt

Q969I0 - Q969I0_HUMAN

Protein
Submitted name:

KRT8 protein

Gene

KRT8

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. cell differentiation involved in embryonic placenta development Source: Ensembl
    2. extrinsic apoptotic signaling pathway Source: Ensembl
    3. hepatocyte apoptotic process Source: Ensembl
    4. response to hydrostatic pressure Source: Ensembl
    5. response to other organism Source: Ensembl
    6. sarcomere organization Source: Ensembl
    7. tumor necrosis factor-mediated signaling pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    KRT8 proteinImported
    Gene namesi
    Name:KRT8Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. costamere Source: Ensembl
    2. dystrophin-associated glycoprotein complex Source: Ensembl
    3. keratin filament Source: Ensembl
    4. sarcolemma Source: Ensembl
    5. Z disc Source: Ensembl

    Keywords - Cellular componenti

    Intermediate filamentUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ969I0.

    Expressioni

    Gene expression databases

    BgeeiQ969I0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969I0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the intermediate filament family.UniRule annotation

    Keywords - Domaini

    Coiled coilSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG013015.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q969I0-1 [UniParc]FASTAAdd to Basket

    « Hide

    LETKWSLLQQ QKTARSNMDN MFESYINNLR RQLETLGQEK LKLEAELGNM    50
    QGLVEDFKNK YEDEINKRTE MENEFVLIKK DVDEAYMNKV ELESRLEGLT 100
    DEINFLRQLY EEEIRELQSQ ISDTSVVLSM DNSRSLDMDS IIAEVKAQYE 150
    DIANRSRAEA ESMYQIKYEE LQSLAGKHGD DLRRTKTEIS EMNRNISRLQ 200
    AEIEGLKGQR ASLEAAIADA EQRGELAIKD ANAKLSELEA ALQRAKQDMA 250
    RQLREYQELM NVKLALDIEI ATYRKLLEGE ESRLESGMQN MSIHTKTTSG 300
    YAGGLSSAYG GLTSPGLSYS LGSSFGSGAG SSSFSRTSSS RAVVVKKIET 350
    RDGKLVSESS DVLPK 365
    Length:365
    Mass (Da):41,108
    Last modified:May 24, 2005 - v2
    Checksum:i57CD83091D0635E8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC011373 mRNA. Translation: AAH11373.2.
    UniGeneiHs.533782.
    Hs.708445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC011373 mRNA. Translation: AAH11373.2 .
    UniGenei Hs.533782.
    Hs.708445.

    3D structure databases

    ProteinModelPortali Q969I0.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q969I0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG013015.

    Gene expression databases

    Bgeei Q969I0.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PlacentaImported.

    Entry informationi

    Entry nameiQ969I0_HUMAN
    AccessioniPrimary (citable) accession number: Q969I0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.