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Q969I0

- Q969I0_HUMAN

UniProt

Q969I0 - Q969I0_HUMAN

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Protein
Submitted name:

KRT8 protein

Gene

KRT8

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. cell differentiation involved in embryonic placenta development Source: Ensembl
  2. extrinsic apoptotic signaling pathway Source: Ensembl
  3. hepatocyte apoptotic process Source: Ensembl
  4. response to hydrostatic pressure Source: Ensembl
  5. response to other organism Source: Ensembl
  6. sarcomere organization Source: Ensembl
  7. tumor necrosis factor-mediated signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
KRT8 proteinImported
Gene namesi
Name:KRT8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. costamere Source: Ensembl
  3. dystrophin-associated glycoprotein complex Source: Ensembl
  4. keratin filament Source: Ensembl
  5. sarcolemma Source: Ensembl
  6. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filamentUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ969I0.

Expressioni

Gene expression databases

BgeeiQ969I0.
ExpressionAtlasiQ969I0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ969I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intermediate filament family.UniRule annotation

Keywords - Domaini

Coiled coilSAAS annotation

Phylogenomic databases

HOVERGENiHBG013015.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q969I0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
LETKWSLLQQ QKTARSNMDN MFESYINNLR RQLETLGQEK LKLEAELGNM
60 70 80 90 100
QGLVEDFKNK YEDEINKRTE MENEFVLIKK DVDEAYMNKV ELESRLEGLT
110 120 130 140 150
DEINFLRQLY EEEIRELQSQ ISDTSVVLSM DNSRSLDMDS IIAEVKAQYE
160 170 180 190 200
DIANRSRAEA ESMYQIKYEE LQSLAGKHGD DLRRTKTEIS EMNRNISRLQ
210 220 230 240 250
AEIEGLKGQR ASLEAAIADA EQRGELAIKD ANAKLSELEA ALQRAKQDMA
260 270 280 290 300
RQLREYQELM NVKLALDIEI ATYRKLLEGE ESRLESGMQN MSIHTKTTSG
310 320 330 340 350
YAGGLSSAYG GLTSPGLSYS LGSSFGSGAG SSSFSRTSSS RAVVVKKIET
360
RDGKLVSESS DVLPK
Length:365
Mass (Da):41,108
Last modified:May 24, 2005 - v2
Checksum:i57CD83091D0635E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011373 mRNA. Translation: AAH11373.2.
UniGeneiHs.533782.
Hs.708445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011373 mRNA. Translation: AAH11373.2 .
UniGenei Hs.533782.
Hs.708445.

3D structure databases

ProteinModelPortali Q969I0.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q969I0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG013015.

Miscellaneous databases

ChiTaRSi KRT8. human.

Gene expression databases

Bgeei Q969I0.
ExpressionAtlasi Q969I0. baseline and differential.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.

Entry informationi

Entry nameiQ969I0_HUMAN
AccessioniPrimary (citable) accession number: Q969I0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.