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Protein

Myeloid-derived growth factor

Gene

MYDGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).By similarity1 Publication

Caution

Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted (PubMed:11714798, PubMed:12538725).2 Publications

GO - Biological processi

Keywordsi

Biological processAngiogenesis, Apoptosis

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid-derived growth factor1 PublicationImported
Short name:
MYDGF1 Publication
Alternative name(s):
Interleukin-251 Publication
Short name:
IL-251 Publication
Stromal cell-derived growth factor SF201 Publication
Gene namesi
Name:MYDGFImported
Synonyms:C19orf10Imported, IL251 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000074842.7
HGNCiHGNC:16948 MYDGF
MIMi606746 gene
neXtProtiNX_Q969H8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56005
OpenTargetsiENSG00000074842
PharmGKBiPA29827

Polymorphism and mutation databases

BioMutaiC19orf10
DMDMi61221730

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000002100832 – 173Myeloid-derived growth factorAdd BLAST142

Proteomic databases

EPDiQ969H8
MaxQBiQ969H8
PaxDbiQ969H8
PeptideAtlasiQ969H8
PRIDEiQ969H8
ProteomicsDBi75767
TopDownProteomicsiQ969H8

2D gel databases

UCD-2DPAGEiQ969H8

PTM databases

iPTMnetiQ969H8
PhosphoSitePlusiQ969H8
SwissPalmiQ969H8

Expressioni

Tissue specificityi

Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).2 Publications

Inductioni

Up-regulated in response to myocardial infarction (MI).1 Publication

Gene expression databases

BgeeiENSG00000074842
CleanExiHS_C19orf10
HS_IL25
ExpressionAtlasiQ969H8 baseline and differential
GenevisibleiQ969H8 HS

Organism-specific databases

HPAiHPA041872
HPA046744

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121028, 9 interactors
IntActiQ969H8, 12 interactors
STRINGi9606.ENSP00000262947

Structurei

3D structure databases

ProteinModelPortaliQ969H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MYDGF family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDN Eukaryota
ENOG41126BF LUCA
GeneTreeiENSGT00390000000777
HOGENOMiHOG000236299
HOVERGENiHBG051127
InParanoidiQ969H8
OMAiGGTNEKW
PhylomeDBiQ969H8
TreeFamiTF332795

Family and domain databases

InterProiView protein in InterPro
IPR018887 MYDGF
PANTHERiPTHR31230 PTHR31230, 1 hit
PfamiView protein in Pfam
PF10572 UPF0556, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS
60 70 80 90 100
FSHNVGPGDK YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK
110 120 130 140 150
SYLYFTQFKA EVRGAEIEYA MAYSKAAFER ESDVPLKTEE FEVTKTAVAH
160 170
RPGAFKAELS KLVIVAKASR TEL
Length:173
Mass (Da):18,795
Last modified:December 1, 2001 - v1
Checksum:iDD8910DEFEA5E3FC
GO

Sequence cautioni

The sequence AAC27824 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC33800 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06018312G → R. Corresponds to variant dbSNP:rs2270090Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005594 Genomic DNA Translation: AAC33800.1 Sequence problems.
AC005339 Genomic DNA Translation: AAC27824.1 Sequence problems.
CH471139 Genomic DNA Translation: EAW69202.1
CH471139 Genomic DNA Translation: EAW69203.1
BC003639 mRNA Translation: AAH03639.2
BC010129 mRNA Translation: AAH10129.1
BC014655 mRNA Translation: AAH14655.1
AL365373 mRNA Translation: CAB96947.1
AL365374 mRNA Translation: CAB96948.1
CCDSiCCDS12133.1
RefSeqiNP_061980.1, NM_019107.3
UniGeneiHs.465645

Genome annotation databases

EnsembliENST00000262947; ENSP00000262947; ENSG00000074842
GeneIDi56005
KEGGihsa:56005
UCSCiuc002may.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMYDGF_HUMAN
AccessioniPrimary (citable) accession number: Q969H8
Secondary accession number(s): D6W628
, O75256, O75272, Q9BTK7, Q9NP69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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