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Q969H8 (CS010_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UPF0556 protein C19orf10
Alternative name(s):
Interleukin-25
Short name=IL-25
Stromal cell-derived growth factor SF20
Gene names
Name:C19orf10
Synonyms:IL25
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted. Endoplasmic reticulum-Golgi intermediate compartment Ref.8.

Tissue specificity

Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties. Ref.8

Sequence similarities

Belongs to the UPF0556 family.

Caution

Was originally (Ref.1) thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted.

Sequence caution

The sequence AAC27824.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAC33800.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Ref.7
Chain32 – 173142UPF0556 protein C19orf10
PRO_0000021008

Natural variations

Natural variant121G → R.
Corresponds to variant rs2270090 [ dbSNP | Ensembl ].
VAR_060183

Sequences

Sequence LengthMass (Da)Tools
Q969H8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: DD8910DEFEA5E3FC

FASTA17318,795
        10         20         30         40         50         60 
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS FSHNVGPGDK 

        70         80         90        100        110        120 
YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK SYLYFTQFKA EVRGAEIEYA 

       130        140        150        160        170 
MAYSKAAFER ESDVPLKTEE FEVTKTAVAH RPGAFKAELS KLVIVAKASR TEL 

« Hide

References

« Hide 'large scale' references
[1]"SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation."
Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H., Kitamura T.
J. Immunol. 167:6338-6347(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Bone marrow.
[2]Erratum
Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H., Kitamura T.
J. Immunol. 170:1593-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: RETRACTION.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Skin.
[6]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-173.
[7]"Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
Xu G., Shin S.B., Jaffrey S.R.
Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 32-44.
Tissue: Leukemic T-cell.
[8]"The identification and characterization of a novel protein, c19orf10, in the synovium."
Weiler T., Du Q., Krokhin O., Ens W., Standing K., El-Gabalawy H., Wilkins J.A.
Arthritis Res. Ther. 9:R30-R30(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems.
AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems.
CH471139 Genomic DNA. Translation: EAW69202.1.
CH471139 Genomic DNA. Translation: EAW69203.1.
BC003639 mRNA. Translation: AAH03639.2.
BC010129 mRNA. Translation: AAH10129.1.
BC014655 mRNA. Translation: AAH14655.1.
AL365373 mRNA. Translation: CAB96947.1.
AL365374 mRNA. Translation: CAB96948.1.
RefSeqNP_061980.1. NM_019107.3.
UniGeneHs.465645.

3D structure databases

ProteinModelPortalQ969H8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121028. 4 interactions.
IntActQ969H8. 3 interactions.
MINTMINT-1421098.
STRING9606.ENSP00000262947.

PTM databases

PhosphoSiteQ969H8.

Polymorphism databases

DMDM61221730.

2D gel databases

UCD-2DPAGEQ969H8.

Proteomic databases

PaxDbQ969H8.
PeptideAtlasQ969H8.
PRIDEQ969H8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262947; ENSP00000262947; ENSG00000074842.
GeneID56005.
KEGGhsa:56005.
UCSCuc002may.3. human.

Organism-specific databases

CTD56005.
GeneCardsGC19M004608.
H-InvDBHIX0014670.
HGNCHGNC:16948. C19orf10.
HPAHPA041872.
HPA046744.
MIM606746. gene.
neXtProtNX_Q969H8.
PharmGKBPA29827.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46744.
HOGENOMHOG000236299.
HOVERGENHBG051127.
InParanoidQ969H8.
OMAEIEYGMA.
PhylomeDBQ969H8.
TreeFamTF332795.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ969H8.
BgeeQ969H8.
CleanExHS_C19orf10.
HS_IL25.
GenevestigatorQ969H8.

Family and domain databases

InterProIPR018887. UPF0556.
[Graphical view]
PfamPF10572. UPF0556. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi56005.
NextBio61458.
SOURCESearch...

Entry information

Entry nameCS010_HUMAN
AccessionPrimary (citable) accession number: Q969H8
Secondary accession number(s): D6W628 expand/collapse secondary AC list , O75256, O75272, Q9BTK7, Q9NP69
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM