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Protein

Myeloid-derived growth factor

Gene

MYDGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).By similarity1 Publication

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
  2. cellular protein metabolic process Source: Reactome
  3. cellular response to brefeldin A Source: UniProtKB
  4. endoplasmic reticulum unfolded protein response Source: Reactome
  5. negative regulation of apoptotic process Source: UniProtKB
  6. positive regulation of angiogenesis Source: UniProtKB
  7. positive regulation of endothelial cell proliferation Source: UniProtKB
  8. positive regulation of MAPK cascade Source: UniProtKB
  9. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  10. positive regulation of protein kinase B signaling Source: UniProtKB
  11. positive regulation of protein phosphorylation Source: UniProtKB
  12. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Apoptosis

Enzyme and pathway databases

ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid-derived growth factor1 PublicationImported
Short name:
MYDGF1 Publication
Alternative name(s):
Interleukin-251 Publication
Short name:
IL-251 Publication
Stromal cell-derived growth factor SF201 Publication
Gene namesi
Name:MYDGFImported
Synonyms:C19orf10Imported, IL251 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16948. MYDGF.

Subcellular locationi

Secreted 2 Publications. Endoplasmic reticulum-Golgi intermediate compartment 1 Publication
Note: Secreted into blood plasma.1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular space Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 31311 PublicationAdd
BLAST
Chaini32 – 173142Myeloid-derived growth factorPRO_0000021008Add
BLAST

Proteomic databases

MaxQBiQ969H8.
PaxDbiQ969H8.
PeptideAtlasiQ969H8.
PRIDEiQ969H8.

2D gel databases

UCD-2DPAGEQ969H8.

PTM databases

PhosphoSiteiQ969H8.

Expressioni

Tissue specificityi

Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).2 Publications

Inductioni

Up-regulated in response to myocardial infarction (MI).1 Publication

Gene expression databases

BgeeiQ969H8.
CleanExiHS_C19orf10.
HS_IL25.
ExpressionAtlasiQ969H8. baseline and differential.
GenevestigatoriQ969H8.

Organism-specific databases

HPAiHPA041872.
HPA046744.

Interactioni

Protein-protein interaction databases

BioGridi121028. 8 interactions.
IntActiQ969H8. 3 interactions.
MINTiMINT-1421098.
STRINGi9606.ENSP00000262947.

Structurei

3D structure databases

ProteinModelPortaliQ969H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MYDGF family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46744.
GeneTreeiENSGT00390000000777.
HOGENOMiHOG000236299.
HOVERGENiHBG051127.
InParanoidiQ969H8.
OMAiEIEYGMA.
PhylomeDBiQ969H8.
TreeFamiTF332795.

Family and domain databases

InterProiIPR018887. UPF0556.
[Graphical view]
PfamiPF10572. UPF0556. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS
60 70 80 90 100
FSHNVGPGDK YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK
110 120 130 140 150
SYLYFTQFKA EVRGAEIEYA MAYSKAAFER ESDVPLKTEE FEVTKTAVAH
160 170
RPGAFKAELS KLVIVAKASR TEL
Length:173
Mass (Da):18,795
Last modified:December 1, 2001 - v1
Checksum:iDD8910DEFEA5E3FC
GO

Sequence cautioni

The sequence AAC27824.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAC33800.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121G → R.
Corresponds to variant rs2270090 [ dbSNP | Ensembl ].
VAR_060183

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems.
AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems.
CH471139 Genomic DNA. Translation: EAW69202.1.
CH471139 Genomic DNA. Translation: EAW69203.1.
BC003639 mRNA. Translation: AAH03639.2.
BC010129 mRNA. Translation: AAH10129.1.
BC014655 mRNA. Translation: AAH14655.1.
AL365373 mRNA. Translation: CAB96947.1.
AL365374 mRNA. Translation: CAB96948.1.
CCDSiCCDS12133.1.
RefSeqiNP_061980.1. NM_019107.3.
UniGeneiHs.465645.

Genome annotation databases

EnsembliENST00000262947; ENSP00000262947; ENSG00000074842.
GeneIDi56005.
KEGGihsa:56005.
UCSCiuc002may.3. human.

Polymorphism databases

DMDMi61221730.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems.
AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems.
CH471139 Genomic DNA. Translation: EAW69202.1.
CH471139 Genomic DNA. Translation: EAW69203.1.
BC003639 mRNA. Translation: AAH03639.2.
BC010129 mRNA. Translation: AAH10129.1.
BC014655 mRNA. Translation: AAH14655.1.
AL365373 mRNA. Translation: CAB96947.1.
AL365374 mRNA. Translation: CAB96948.1.
CCDSiCCDS12133.1.
RefSeqiNP_061980.1. NM_019107.3.
UniGeneiHs.465645.

3D structure databases

ProteinModelPortaliQ969H8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121028. 8 interactions.
IntActiQ969H8. 3 interactions.
MINTiMINT-1421098.
STRINGi9606.ENSP00000262947.

PTM databases

PhosphoSiteiQ969H8.

Polymorphism databases

DMDMi61221730.

2D gel databases

UCD-2DPAGEQ969H8.

Proteomic databases

MaxQBiQ969H8.
PaxDbiQ969H8.
PeptideAtlasiQ969H8.
PRIDEiQ969H8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262947; ENSP00000262947; ENSG00000074842.
GeneIDi56005.
KEGGihsa:56005.
UCSCiuc002may.3. human.

Organism-specific databases

CTDi56005.
GeneCardsiGC19M004608.
H-InvDBHIX0014670.
HGNCiHGNC:16948. MYDGF.
HPAiHPA041872.
HPA046744.
MIMi606746. gene.
neXtProtiNX_Q969H8.
PharmGKBiPA29827.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46744.
GeneTreeiENSGT00390000000777.
HOGENOMiHOG000236299.
HOVERGENiHBG051127.
InParanoidiQ969H8.
OMAiEIEYGMA.
PhylomeDBiQ969H8.
TreeFamiTF332795.

Enzyme and pathway databases

ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

Miscellaneous databases

GenomeRNAii56005.
NextBioi61458.
SOURCEiSearch...

Gene expression databases

BgeeiQ969H8.
CleanExiHS_C19orf10.
HS_IL25.
ExpressionAtlasiQ969H8. baseline and differential.
GenevestigatoriQ969H8.

Family and domain databases

InterProiIPR018887. UPF0556.
[Graphical view]
PfamiPF10572. UPF0556. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation."
    Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H., Kitamura T.
    J. Immunol. 167:6338-6347(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow.
  2. Cited for: RETRACTION.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Skin.
  6. The European IMAGE consortium
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-173.
  7. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
    Xu G., Shin S.B., Jaffrey S.R.
    Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 32-44.
    Tissue: Leukemic T-cell.
  8. "The identification and characterization of a novel protein, c19orf10, in the synovium."
    Weiler T., Du Q., Krokhin O., Ens W., Standing K., El-Gabalawy H., Wilkins J.A.
    Arthritis Res. Ther. 9:R30-R30(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiMYDGF_HUMAN
AccessioniPrimary (citable) accession number: Q969H8
Secondary accession number(s): D6W628
, O75256, O75272, Q9BTK7, Q9NP69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted (PubMed:11714798, PubMed:12538725).2 Publications

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.