Q969H8 (CS010_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0556 protein C19orf10

Alternative name(s):
Interleukin-25
Short name=IL-25
Stromal cell-derived growth factor SF20

Gene names

Name:	C19orf10
Synonyms:	IL25

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted. Endoplasmic reticulum-Golgi intermediate compartment Ref.8.
Tissue specificity	Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties. Ref.8
Sequence similarities	Belongs to the UPF0556 family.
Caution	Was originally (Ref.1) thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted.
Sequence caution	The sequence AAC27824.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAC33800.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	activation of signaling protein activity involved in unfolded protein response Traceable author statement. Source: Reactome cellular protein metabolic process Traceable author statement. Source: Reactome endoplasmic reticulum unfolded protein response Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum lumen Traceable author statement. Source: Reactome endoplasmic reticulum-Golgi intermediate compartment Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Ref.7
	Chain	32 – 173	142	UPF0556 protein C19orf10		PRO_0000021008
Natural variations
	Natural variant	12	1	G → R. Corresponds to variant rs2270090 [ dbSNP | Ensembl ].		VAR_060183

Sequences

	Sequence		Length	Mass (Da)
	Q969H8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: DD8910DEFEA5E3FC	FASTA	173	18,795
	10 20 30 40 50 60 MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS FSHNVGPGDK 70 80 90 100 110 120 YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK SYLYFTQFKA EVRGAEIEYA 130 140 150 160 170 MAYSKAAFER ESDVPLKTEE FEVTKTAVAH RPGAFKAELS KLVIVAKASR TEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation." Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H., Kitamura T. J. Immunol. 167:6338-6347(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow.
[2]	Erratum Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H., Kitamura T. J. Immunol. 170:1593-1593(2003) [PubMed] [Europe PMC] [Abstract] Cited for: RETRACTION.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Skin.
[6]	The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-173.
[7]	"Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini." Xu G., Shin S.B., Jaffrey S.R. Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 32-44. Tissue: Leukemic T-cell.
[8]	"The identification and characterization of a novel protein, c19orf10, in the synovium." Weiler T., Du Q., Krokhin O., Ens W., Standing K., El-Gabalawy H., Wilkins J.A. Arthritis Res. Ther. 9:R30-R30(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems. AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems. CH471139 Genomic DNA. Translation: EAW69202.1. CH471139 Genomic DNA. Translation: EAW69203.1. BC003639 mRNA. Translation: AAH03639.2. BC010129 mRNA. Translation: AAH10129.1. BC014655 mRNA. Translation: AAH14655.1. AL365373 mRNA. Translation: CAB96947.1. AL365374 mRNA. Translation: CAB96948.1.
RefSeq	NP_061980.1. NM_019107.3.
UniGene	Hs.465645.
3D structure databases
ProteinModelPortal	Q969H8.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	121028. 4 interactions.
IntAct	Q969H8. 3 interactions.
MINT	MINT-1421098.
STRING	9606.ENSP00000262947.
PTM databases
PhosphoSite	Q969H8.
Polymorphism databases
DMDM	61221730.
2D gel databases
UCD-2DPAGE	Q969H8.
Proteomic databases
PaxDb	Q969H8.
PeptideAtlas	Q969H8.
PRIDE	Q969H8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262947; ENSP00000262947; ENSG00000074842.
GeneID	56005.
KEGG	hsa:56005.
UCSC	uc002may.3. human.
Organism-specific databases
CTD	56005.
GeneCards	GC19M004608.
H-InvDB	HIX0014670.
HGNC	HGNC:16948. C19orf10.
HPA	HPA041872. HPA046744.
MIM	606746. gene.
neXtProt	NX_Q969H8.
PharmGKB	PA29827.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46744.
HOGENOM	HOG000236299.
HOVERGEN	HBG051127.
InParanoid	Q969H8.
OMA	EIEYGMA.
PhylomeDB	Q969H8.
TreeFam	TF332795.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	Q969H8.
Bgee	Q969H8.
CleanEx	HS_C19orf10. HS_IL25.
Genevestigator	Q969H8.
Family and domain databases
InterPro	IPR018887. UPF0556. [Graphical view]
Pfam	PF10572. UPF0556. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56005.
NextBio	61458.
SOURCE	Search...

Entry information

Entry name

CS010_HUMAN

Accession

Primary (citable) accession number: Q969H8
Secondary accession number(s): D6W628 , O75256, O75272, Q9BTK7, Q9NP69

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	December 1, 2001
Last modified:	April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.