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Q969H8

- CS010_HUMAN

UniProt

Q969H8 - CS010_HUMAN

Protein

UPF0556 protein C19orf10

Gene

C19orf10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
    2. cellular protein metabolic process Source: Reactome
    3. endoplasmic reticulum unfolded protein response Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0556 protein C19orf10
    Alternative name(s):
    Interleukin-25
    Short name:
    IL-25
    Stromal cell-derived growth factor SF20
    Gene namesi
    Name:C19orf10
    Synonyms:IL25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16948. C19orf10.

    Subcellular locationi

    Secreted 1 Publication. Endoplasmic reticulum-Golgi intermediate compartment 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29827.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 31311 PublicationAdd
    BLAST
    Chaini32 – 173142UPF0556 protein C19orf10PRO_0000021008Add
    BLAST

    Proteomic databases

    MaxQBiQ969H8.
    PaxDbiQ969H8.
    PeptideAtlasiQ969H8.
    PRIDEiQ969H8.

    2D gel databases

    UCD-2DPAGEQ969H8.

    PTM databases

    PhosphoSiteiQ969H8.

    Expressioni

    Tissue specificityi

    Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties.1 Publication

    Gene expression databases

    ArrayExpressiQ969H8.
    BgeeiQ969H8.
    CleanExiHS_C19orf10.
    HS_IL25.
    GenevestigatoriQ969H8.

    Organism-specific databases

    HPAiHPA041872.
    HPA046744.

    Interactioni

    Protein-protein interaction databases

    BioGridi121028. 5 interactions.
    IntActiQ969H8. 3 interactions.
    MINTiMINT-1421098.
    STRINGi9606.ENSP00000262947.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969H8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0556 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46744.
    HOGENOMiHOG000236299.
    HOVERGENiHBG051127.
    InParanoidiQ969H8.
    OMAiEIEYGMA.
    PhylomeDBiQ969H8.
    TreeFamiTF332795.

    Family and domain databases

    InterProiIPR018887. UPF0556.
    [Graphical view]
    PfamiPF10572. UPF0556. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q969H8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS    50
    FSHNVGPGDK YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK 100
    SYLYFTQFKA EVRGAEIEYA MAYSKAAFER ESDVPLKTEE FEVTKTAVAH 150
    RPGAFKAELS KLVIVAKASR TEL 173
    Length:173
    Mass (Da):18,795
    Last modified:December 1, 2001 - v1
    Checksum:iDD8910DEFEA5E3FC
    GO

    Sequence cautioni

    The sequence AAC27824.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAC33800.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121G → R.
    Corresponds to variant rs2270090 [ dbSNP | Ensembl ].
    VAR_060183

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems.
    AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems.
    CH471139 Genomic DNA. Translation: EAW69202.1.
    CH471139 Genomic DNA. Translation: EAW69203.1.
    BC003639 mRNA. Translation: AAH03639.2.
    BC010129 mRNA. Translation: AAH10129.1.
    BC014655 mRNA. Translation: AAH14655.1.
    AL365373 mRNA. Translation: CAB96947.1.
    AL365374 mRNA. Translation: CAB96948.1.
    CCDSiCCDS12133.1.
    RefSeqiNP_061980.1. NM_019107.3.
    UniGeneiHs.465645.

    Genome annotation databases

    EnsembliENST00000262947; ENSP00000262947; ENSG00000074842.
    GeneIDi56005.
    KEGGihsa:56005.
    UCSCiuc002may.3. human.

    Polymorphism databases

    DMDMi61221730.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005594 Genomic DNA. Translation: AAC33800.1 . Sequence problems.
    AC005339 Genomic DNA. Translation: AAC27824.1 . Sequence problems.
    CH471139 Genomic DNA. Translation: EAW69202.1 .
    CH471139 Genomic DNA. Translation: EAW69203.1 .
    BC003639 mRNA. Translation: AAH03639.2 .
    BC010129 mRNA. Translation: AAH10129.1 .
    BC014655 mRNA. Translation: AAH14655.1 .
    AL365373 mRNA. Translation: CAB96947.1 .
    AL365374 mRNA. Translation: CAB96948.1 .
    CCDSi CCDS12133.1.
    RefSeqi NP_061980.1. NM_019107.3.
    UniGenei Hs.465645.

    3D structure databases

    ProteinModelPortali Q969H8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121028. 5 interactions.
    IntActi Q969H8. 3 interactions.
    MINTi MINT-1421098.
    STRINGi 9606.ENSP00000262947.

    PTM databases

    PhosphoSitei Q969H8.

    Polymorphism databases

    DMDMi 61221730.

    2D gel databases

    UCD-2DPAGE Q969H8.

    Proteomic databases

    MaxQBi Q969H8.
    PaxDbi Q969H8.
    PeptideAtlasi Q969H8.
    PRIDEi Q969H8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262947 ; ENSP00000262947 ; ENSG00000074842 .
    GeneIDi 56005.
    KEGGi hsa:56005.
    UCSCi uc002may.3. human.

    Organism-specific databases

    CTDi 56005.
    GeneCardsi GC19M004608.
    H-InvDB HIX0014670.
    HGNCi HGNC:16948. C19orf10.
    HPAi HPA041872.
    HPA046744.
    MIMi 606746. gene.
    neXtProti NX_Q969H8.
    PharmGKBi PA29827.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46744.
    HOGENOMi HOG000236299.
    HOVERGENi HBG051127.
    InParanoidi Q969H8.
    OMAi EIEYGMA.
    PhylomeDBi Q969H8.
    TreeFami TF332795.

    Enzyme and pathway databases

    Reactomei REACT_18273. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    GenomeRNAii 56005.
    NextBioi 61458.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969H8.
    Bgeei Q969H8.
    CleanExi HS_C19orf10.
    HS_IL25.
    Genevestigatori Q969H8.

    Family and domain databases

    InterProi IPR018887. UPF0556.
    [Graphical view ]
    Pfami PF10572. UPF0556. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation."
      Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H., Kitamura T.
      J. Immunol. 167:6338-6347(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone marrow.
    2. Cited for: RETRACTION.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Skin.
    6. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-173.
    7. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
      Xu G., Shin S.B., Jaffrey S.R.
      Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 32-44.
      Tissue: Leukemic T-cell.
    8. "The identification and characterization of a novel protein, c19orf10, in the synovium."
      Weiler T., Du Q., Krokhin O., Ens W., Standing K., El-Gabalawy H., Wilkins J.A.
      Arthritis Res. Ther. 9:R30-R30(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCS010_HUMAN
    AccessioniPrimary (citable) accession number: Q969H8
    Secondary accession number(s): D6W628
    , O75256, O75272, Q9BTK7, Q9NP69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families
    6. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3