UniProtKB - Q969H8 (MYDGF_HUMAN)
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Protein
Myeloid-derived growth factor
Gene
MYDGF
Organism
Homo sapiens (Human)
Status
Functioni
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).By similarity1 Publication
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- apoptotic process Source: UniProtKB-KW
- IRE1-mediated unfolded protein response Source: Reactome
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of protein kinase B signaling Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Biological process | Angiogenesis, Apoptosis |
Enzyme and pathway databases
Reactomei | R-HSA-381038. XBP1(S) activates chaperone genes. |
Names & Taxonomyi
Protein namesi | Recommended name: Myeloid-derived growth factor1 PublicationImportedShort name: MYDGF1 Publication Alternative name(s): Interleukin-251 Publication Short name: IL-251 Publication Stromal cell-derived growth factor SF201 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000074842.7. |
HGNCi | HGNC:16948. MYDGF. |
MIMi | 606746. gene. |
neXtProti | NX_Q969H8. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56005. |
OpenTargetsi | ENSG00000074842. |
PharmGKBi | PA29827. |
Polymorphism and mutation databases
BioMutai | C19orf10. |
DMDMi | 61221730. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | 1 PublicationAdd BLAST | 31 | |
ChainiPRO_0000021008 | 32 – 173 | Myeloid-derived growth factorAdd BLAST | 142 |
Proteomic databases
EPDi | Q969H8. |
MaxQBi | Q969H8. |
PaxDbi | Q969H8. |
PeptideAtlasi | Q969H8. |
PRIDEi | Q969H8. |
TopDownProteomicsi | Q969H8. |
2D gel databases
UCD-2DPAGEi | Q969H8. |
PTM databases
iPTMneti | Q969H8. |
PhosphoSitePlusi | Q969H8. |
SwissPalmi | Q969H8. |
Expressioni
Tissue specificityi
Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).2 Publications
Inductioni
Up-regulated in response to myocardial infarction (MI).1 Publication
Gene expression databases
Bgeei | ENSG00000074842. |
CleanExi | HS_C19orf10. HS_IL25. |
ExpressionAtlasi | Q969H8. baseline and differential. |
Genevisiblei | Q969H8. HS. |
Organism-specific databases
HPAi | HPA041872. HPA046744. |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 121028. 9 interactors. |
IntActi | Q969H8. 15 interactors. |
STRINGi | 9606.ENSP00000262947. |
Family & Domainsi
Sequence similaritiesi
Belongs to the MYDGF family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410IKDN. Eukaryota. ENOG41126BF. LUCA. |
GeneTreei | ENSGT00390000000777. |
HOGENOMi | HOG000236299. |
HOVERGENi | HBG051127. |
InParanoidi | Q969H8. |
OMAi | GGTNEKW. |
PhylomeDBi | Q969H8. |
TreeFami | TF332795. |
Family and domain databases
InterProi | View protein in InterPro IPR018887. MYDGF. |
PANTHERi | PTHR31230. PTHR31230. 1 hit. |
Pfami | View protein in Pfam PF10572. UPF0556. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q969H8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS
60 70 80 90 100
FSHNVGPGDK YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK
110 120 130 140 150
SYLYFTQFKA EVRGAEIEYA MAYSKAAFER ESDVPLKTEE FEVTKTAVAH
160 170
RPGAFKAELS KLVIVAKASR TEL
Sequence cautioni
The sequence AAC27824 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC33800 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060183 | 12 | G → R. Corresponds to variant dbSNP:rs2270090Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems. AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems. CH471139 Genomic DNA. Translation: EAW69202.1. CH471139 Genomic DNA. Translation: EAW69203.1. BC003639 mRNA. Translation: AAH03639.2. BC010129 mRNA. Translation: AAH10129.1. BC014655 mRNA. Translation: AAH14655.1. AL365373 mRNA. Translation: CAB96947.1. AL365374 mRNA. Translation: CAB96948.1. |
CCDSi | CCDS12133.1. |
RefSeqi | NP_061980.1. NM_019107.3. |
UniGenei | Hs.465645. |
Genome annotation databases
Ensembli | ENST00000262947; ENSP00000262947; ENSG00000074842. |
GeneIDi | 56005. |
KEGGi | hsa:56005. |
UCSCi | uc002may.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | MYDGF_HUMAN | |
Accessioni | Q969H8Primary (citable) accession number: Q969H8 Secondary accession number(s): D6W628 Q9NP69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | March 28, 2018 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Caution
Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted (PubMed:11714798, PubMed:12538725).2 Publications