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Protein

Myeloid-derived growth factor

Gene

MYDGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074842-MONOMER.
ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid-derived growth factor1 PublicationImported
Short name:
MYDGF1 Publication
Alternative name(s):
Interleukin-251 Publication
Short name:
IL-251 Publication
Stromal cell-derived growth factor SF201 Publication
Gene namesi
Name:MYDGFImported
Synonyms:C19orf10Imported, IL251 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16948. MYDGF.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
  • endoplasmic reticulum lumen Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56005.
OpenTargetsiENSG00000074842.
PharmGKBiPA29827.

Polymorphism and mutation databases

BioMutaiC19orf10.
DMDMi61221730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000002100832 – 173Myeloid-derived growth factorAdd BLAST142

Proteomic databases

EPDiQ969H8.
MaxQBiQ969H8.
PaxDbiQ969H8.
PeptideAtlasiQ969H8.
PRIDEiQ969H8.
TopDownProteomicsiQ969H8.

2D gel databases

UCD-2DPAGEQ969H8.

PTM databases

iPTMnetiQ969H8.
PhosphoSitePlusiQ969H8.
SwissPalmiQ969H8.

Expressioni

Tissue specificityi

Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).2 Publications

Inductioni

Up-regulated in response to myocardial infarction (MI).1 Publication

Gene expression databases

BgeeiENSG00000074842.
CleanExiHS_C19orf10.
HS_IL25.
ExpressionAtlasiQ969H8. baseline and differential.
GenevisibleiQ969H8. HS.

Organism-specific databases

HPAiHPA041872.
HPA046744.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437655EBI-718622,EBI-347996

Protein-protein interaction databases

BioGridi121028. 7 interactors.
IntActiQ969H8. 7 interactors.
MINTiMINT-1421098.
STRINGi9606.ENSP00000262947.

Structurei

3D structure databases

ProteinModelPortaliQ969H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MYDGF family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDN. Eukaryota.
ENOG41126BF. LUCA.
GeneTreeiENSGT00390000000777.
HOGENOMiHOG000236299.
HOVERGENiHBG051127.
InParanoidiQ969H8.
OMAiNEKWQMS.
PhylomeDBiQ969H8.
TreeFamiTF332795.

Family and domain databases

InterProiIPR018887. MYDGF.
[Graphical view]
PfamiPF10572. UPF0556. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS
60 70 80 90 100
FSHNVGPGDK YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK
110 120 130 140 150
SYLYFTQFKA EVRGAEIEYA MAYSKAAFER ESDVPLKTEE FEVTKTAVAH
160 170
RPGAFKAELS KLVIVAKASR TEL
Length:173
Mass (Da):18,795
Last modified:December 1, 2001 - v1
Checksum:iDD8910DEFEA5E3FC
GO

Sequence cautioni

The sequence AAC27824 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC33800 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06018312G → R.Corresponds to variant rs2270090dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems.
AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems.
CH471139 Genomic DNA. Translation: EAW69202.1.
CH471139 Genomic DNA. Translation: EAW69203.1.
BC003639 mRNA. Translation: AAH03639.2.
BC010129 mRNA. Translation: AAH10129.1.
BC014655 mRNA. Translation: AAH14655.1.
AL365373 mRNA. Translation: CAB96947.1.
AL365374 mRNA. Translation: CAB96948.1.
CCDSiCCDS12133.1.
RefSeqiNP_061980.1. NM_019107.3.
UniGeneiHs.465645.

Genome annotation databases

EnsembliENST00000262947; ENSP00000262947; ENSG00000074842.
GeneIDi56005.
KEGGihsa:56005.
UCSCiuc002may.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems.
AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems.
CH471139 Genomic DNA. Translation: EAW69202.1.
CH471139 Genomic DNA. Translation: EAW69203.1.
BC003639 mRNA. Translation: AAH03639.2.
BC010129 mRNA. Translation: AAH10129.1.
BC014655 mRNA. Translation: AAH14655.1.
AL365373 mRNA. Translation: CAB96947.1.
AL365374 mRNA. Translation: CAB96948.1.
CCDSiCCDS12133.1.
RefSeqiNP_061980.1. NM_019107.3.
UniGeneiHs.465645.

3D structure databases

ProteinModelPortaliQ969H8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121028. 7 interactors.
IntActiQ969H8. 7 interactors.
MINTiMINT-1421098.
STRINGi9606.ENSP00000262947.

PTM databases

iPTMnetiQ969H8.
PhosphoSitePlusiQ969H8.
SwissPalmiQ969H8.

Polymorphism and mutation databases

BioMutaiC19orf10.
DMDMi61221730.

2D gel databases

UCD-2DPAGEQ969H8.

Proteomic databases

EPDiQ969H8.
MaxQBiQ969H8.
PaxDbiQ969H8.
PeptideAtlasiQ969H8.
PRIDEiQ969H8.
TopDownProteomicsiQ969H8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262947; ENSP00000262947; ENSG00000074842.
GeneIDi56005.
KEGGihsa:56005.
UCSCiuc002may.4. human.

Organism-specific databases

CTDi56005.
DisGeNETi56005.
GeneCardsiMYDGF.
H-InvDBHIX0014670.
HGNCiHGNC:16948. MYDGF.
HPAiHPA041872.
HPA046744.
MIMi606746. gene.
neXtProtiNX_Q969H8.
OpenTargetsiENSG00000074842.
PharmGKBiPA29827.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKDN. Eukaryota.
ENOG41126BF. LUCA.
GeneTreeiENSGT00390000000777.
HOGENOMiHOG000236299.
HOVERGENiHBG051127.
InParanoidiQ969H8.
OMAiNEKWQMS.
PhylomeDBiQ969H8.
TreeFamiTF332795.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074842-MONOMER.
ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

GenomeRNAii56005.
PROiQ969H8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000074842.
CleanExiHS_C19orf10.
HS_IL25.
ExpressionAtlasiQ969H8. baseline and differential.
GenevisibleiQ969H8. HS.

Family and domain databases

InterProiIPR018887. MYDGF.
[Graphical view]
PfamiPF10572. UPF0556. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYDGF_HUMAN
AccessioniPrimary (citable) accession number: Q969H8
Secondary accession number(s): D6W628
, O75256, O75272, Q9BTK7, Q9NP69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted (PubMed:11714798, PubMed:12538725).2 Publications

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.