MYDGF

Functionⁱ

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).By similarity1 Publication

GO - Biological processⁱ

angiogenesis Source: UniProtKB-KW
apoptotic process Source: UniProtKB-KW
IRE1-mediated unfolded protein response Source: Reactome
negative regulation of apoptotic process Source: UniProtKB
positive regulation of angiogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 25581518
positive regulation of endothelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 25581518
positive regulation of MAPK cascade Source: UniProtKB
positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
positive regulation of protein kinase B signaling Source: UniProtKB
positive regulation of protein phosphorylation Source: UniProtKB
positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

Complete GO annotation...

Keywordsⁱ

Biological process	Angiogenesis, Apoptosis

Biological process

Angiogenesis, Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381038. XBP1(S) activates chaperone genes.

Reactomeⁱ

R-HSA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myeloid-derived growth factor1 PublicationImported Short name: MYDGF1 Publication Alternative name(s): Interleukin-251 Publication Short name: IL-251 Publication Stromal cell-derived growth factor SF201 Publication
Gene namesⁱ	Name:MYDGFImported Synonyms:C19orf10Imported, IL251 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16948. MYDGF.

HGNCⁱ

HGNC:16948. MYDGF.

Subcellular locationⁱ

Note:

Secreted into blood plasma.1 Publication

GO - Cellular componentⁱ

endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
endoplasmic reticulum lumen Source: Reactome
extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
- 23376485
extracellular space
Source: UniProtKB
Inferred from direct assayⁱ
- 25581518

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56005.
Open Targets More...OpenTargetsⁱ	ENSG00000074842.
PharmGKBⁱ	PA29827.

Polymorphism and mutation databases

BioMutaⁱ	C19orf10.
DMDMⁱ	61221730.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 31	1 PublicationAdd BLAST		31
ChainⁱPRO_0000021008	32 – 173	Myeloid-derived growth factorAdd BLAST		142

Proteomic databases

EPDⁱ	Q969H8.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q969H8.
PaxDbⁱ	Q969H8.
PeptideAtlas More...PeptideAtlasⁱ	Q969H8.
PRIDEⁱ	Q969H8.
TopDownProteomicsⁱ	Q969H8.

2D gel databases

UCD-2DPAGEⁱ	Q969H8.

UCD-2DPAGEⁱ

Q969H8.

PTM databases

iPTMnetⁱ	Q969H8.
PhosphoSitePlusⁱ	Q969H8.
SwissPalmⁱ	Q969H8.

Expressionⁱ

Tissue specificityⁱ

Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).2 Publications

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000074842.
CleanExⁱ	HS_C19orf10. HS_IL25.
ExpressionAtlasⁱ	Q969H8. baseline and differential.
Genevisibleⁱ	Q969H8. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041872. HPA046744.

HPAⁱ

HPA041872.
HPA046744.

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SGTA	O43765	5	EBI-718622,EBI-347996

With

Entry

#Exp.

IntAct

Notes

SGTA

O43765

5

EBI-718622,EBI-347996

Protein-protein interaction databases

BioGridⁱ	121028. 7 interactors.
IntActⁱ	Q969H8. 11 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1421098.
STRINGⁱ	9606.ENSP00000262947.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q969H8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the MYDGF family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IKDN. Eukaryota. ENOG41126BF. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000777.
HOGENOMⁱ	HOG000236299.
HOVERGENⁱ	HBG051127.
InParanoidⁱ	Q969H8.
OMAⁱ	GGTNEKW.
PhylomeDBⁱ	Q969H8.
TreeFamⁱ	TF332795.

Family and domain databases

InterProⁱ	View protein in InterPro IPR018887. MYDGF.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10572. UPF0556. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q969H8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS 
        60         70         80         90        100
FSHNVGPGDK YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK 
       110        120        130        140        150
SYLYFTQFKA EVRGAEIEYA MAYSKAAFER ESDVPLKTEE FEVTKTAVAH 
       160        170 
RPGAFKAELS KLVIVAKASR TEL

Length:173

Mass (Da):18,795

Last modified:December 1, 2001 - v1

Checksum:ⁱDD8910DEFEA5E3FC

GO

Sequence cautionⁱ

The sequence AAC27824 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAC33800 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_060183	12	G → R. Corresponds to variant dbSNP:rs2270090Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems. AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems. CH471139 Genomic DNA. Translation: EAW69202.1. CH471139 Genomic DNA. Translation: EAW69203.1. BC003639 mRNA. Translation: AAH03639.2. BC010129 mRNA. Translation: AAH10129.1. BC014655 mRNA. Translation: AAH14655.1. AL365373 mRNA. Translation: CAB96947.1. AL365374 mRNA. Translation: CAB96948.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12133.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_061980.1. NM_019107.3.
UniGeneⁱ	Hs.465645.

Genome annotation databases

Ensemblⁱ	ENST00000262947; ENSP00000262947; ENSG00000074842.
GeneIDⁱ	56005.
KEGGⁱ	hsa:56005.
UCSC genome browser More...UCSCⁱ	uc002may.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems. AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems. CH471139 Genomic DNA. Translation: EAW69202.1. CH471139 Genomic DNA. Translation: EAW69203.1. BC003639 mRNA. Translation: AAH03639.2. BC010129 mRNA. Translation: AAH10129.1. BC014655 mRNA. Translation: AAH14655.1. AL365373 mRNA. Translation: CAB96947.1. AL365374 mRNA. Translation: CAB96948.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12133.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_061980.1. NM_019107.3.
UniGeneⁱ	Hs.465645.

3D structure databases

ProteinModelPortalⁱ	Q969H8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121028. 7 interactors.
IntActⁱ	Q969H8. 11 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1421098.
STRINGⁱ	9606.ENSP00000262947.

PTM databases

iPTMnetⁱ	Q969H8.
PhosphoSitePlusⁱ	Q969H8.
SwissPalmⁱ	Q969H8.

Polymorphism and mutation databases

BioMutaⁱ	C19orf10.
DMDMⁱ	61221730.

2D gel databases

UCD-2DPAGEⁱ	Q969H8.

UCD-2DPAGEⁱ

Q969H8.

Proteomic databases

EPDⁱ	Q969H8.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q969H8.
PaxDbⁱ	Q969H8.
PeptideAtlas More...PeptideAtlasⁱ	Q969H8.
PRIDEⁱ	Q969H8.
TopDownProteomicsⁱ	Q969H8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000262947; ENSP00000262947; ENSG00000074842.
GeneIDⁱ	56005.
KEGGⁱ	hsa:56005.
UCSC genome browser More...UCSCⁱ	uc002may.4. human.

Organism-specific databases

CTDⁱ	56005.
DisGeNET More...DisGeNETⁱ	56005.
GeneCardsⁱ	MYDGF.
H-InvDBⁱ	HIX0014670.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16948. MYDGF.
Human Protein Atlas More...HPAⁱ	HPA041872. HPA046744.
MIMⁱ	606746. gene.
neXtProtⁱ	NX_Q969H8.
Open Targets More...OpenTargetsⁱ	ENSG00000074842.
PharmGKBⁱ	PA29827.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IKDN. Eukaryota. ENOG41126BF. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000777.
HOGENOMⁱ	HOG000236299.
HOVERGENⁱ	HBG051127.
InParanoidⁱ	Q969H8.
OMAⁱ	GGTNEKW.
PhylomeDBⁱ	Q969H8.
TreeFamⁱ	TF332795.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381038. XBP1(S) activates chaperone genes.

Reactomeⁱ

R-HSA-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

GenomeRNAiⁱ	56005.
Protein Ontology More...PROⁱ	PR:Q969H8.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000074842.
CleanExⁱ	HS_C19orf10. HS_IL25.
ExpressionAtlasⁱ	Q969H8. baseline and differential.
Genevisibleⁱ	Q969H8. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR018887. MYDGF.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10572. UPF0556. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYDGF_HUMAN
Accessionⁱ	Q969H8Primary (citable) accession number: Q969H8 Secondary accession number(s): D6W628 , O75256, O75272, Q9BTK7, Q9NP69
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	December 1, 2001
	Last modified:	June 7, 2017
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted (PubMed:11714798, PubMed:12538725).2 Publications

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q969H8 (MYDGF_HUMAN)

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Myeloid-derived growth factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ