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Q969H8

- CS010_HUMAN

UniProt

Q969H8 - CS010_HUMAN

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Protein

UPF0556 protein C19orf10

Gene

C19orf10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
  2. cellular protein metabolic process Source: Reactome
  3. endoplasmic reticulum unfolded protein response Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0556 protein C19orf10
Alternative name(s):
Interleukin-25
Short name:
IL-25
Stromal cell-derived growth factor SF20
Gene namesi
Name:C19orf10
Synonyms:IL25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16948. C19orf10.

Subcellular locationi

Secreted 1 Publication. Endoplasmic reticulum-Golgi intermediate compartment 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 31311 PublicationAdd
BLAST
Chaini32 – 173142UPF0556 protein C19orf10PRO_0000021008Add
BLAST

Proteomic databases

MaxQBiQ969H8.
PaxDbiQ969H8.
PeptideAtlasiQ969H8.
PRIDEiQ969H8.

2D gel databases

UCD-2DPAGEQ969H8.

PTM databases

PhosphoSiteiQ969H8.

Expressioni

Tissue specificityi

Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties.1 Publication

Gene expression databases

BgeeiQ969H8.
CleanExiHS_C19orf10.
HS_IL25.
ExpressionAtlasiQ969H8. baseline and differential.
GenevestigatoriQ969H8.

Organism-specific databases

HPAiHPA041872.
HPA046744.

Interactioni

Protein-protein interaction databases

BioGridi121028. 5 interactions.
IntActiQ969H8. 3 interactions.
MINTiMINT-1421098.
STRINGi9606.ENSP00000262947.

Structurei

3D structure databases

ProteinModelPortaliQ969H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0556 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46744.
GeneTreeiENSGT00390000000777.
HOGENOMiHOG000236299.
HOVERGENiHBG051127.
InParanoidiQ969H8.
OMAiEIEYGMA.
PhylomeDBiQ969H8.
TreeFamiTF332795.

Family and domain databases

InterProiIPR018887. UPF0556.
[Graphical view]
PfamiPF10572. UPF0556. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969H8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS
60 70 80 90 100
FSHNVGPGDK YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK
110 120 130 140 150
SYLYFTQFKA EVRGAEIEYA MAYSKAAFER ESDVPLKTEE FEVTKTAVAH
160 170
RPGAFKAELS KLVIVAKASR TEL
Length:173
Mass (Da):18,795
Last modified:December 1, 2001 - v1
Checksum:iDD8910DEFEA5E3FC
GO

Sequence cautioni

The sequence AAC27824.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAC33800.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121G → R.
Corresponds to variant rs2270090 [ dbSNP | Ensembl ].
VAR_060183

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005594 Genomic DNA. Translation: AAC33800.1. Sequence problems.
AC005339 Genomic DNA. Translation: AAC27824.1. Sequence problems.
CH471139 Genomic DNA. Translation: EAW69202.1.
CH471139 Genomic DNA. Translation: EAW69203.1.
BC003639 mRNA. Translation: AAH03639.2.
BC010129 mRNA. Translation: AAH10129.1.
BC014655 mRNA. Translation: AAH14655.1.
AL365373 mRNA. Translation: CAB96947.1.
AL365374 mRNA. Translation: CAB96948.1.
CCDSiCCDS12133.1.
RefSeqiNP_061980.1. NM_019107.3.
UniGeneiHs.465645.

Genome annotation databases

EnsembliENST00000262947; ENSP00000262947; ENSG00000074842.
GeneIDi56005.
KEGGihsa:56005.
UCSCiuc002may.3. human.

Polymorphism databases

DMDMi61221730.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005594 Genomic DNA. Translation: AAC33800.1 . Sequence problems.
AC005339 Genomic DNA. Translation: AAC27824.1 . Sequence problems.
CH471139 Genomic DNA. Translation: EAW69202.1 .
CH471139 Genomic DNA. Translation: EAW69203.1 .
BC003639 mRNA. Translation: AAH03639.2 .
BC010129 mRNA. Translation: AAH10129.1 .
BC014655 mRNA. Translation: AAH14655.1 .
AL365373 mRNA. Translation: CAB96947.1 .
AL365374 mRNA. Translation: CAB96948.1 .
CCDSi CCDS12133.1.
RefSeqi NP_061980.1. NM_019107.3.
UniGenei Hs.465645.

3D structure databases

ProteinModelPortali Q969H8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121028. 5 interactions.
IntActi Q969H8. 3 interactions.
MINTi MINT-1421098.
STRINGi 9606.ENSP00000262947.

PTM databases

PhosphoSitei Q969H8.

Polymorphism databases

DMDMi 61221730.

2D gel databases

UCD-2DPAGE Q969H8.

Proteomic databases

MaxQBi Q969H8.
PaxDbi Q969H8.
PeptideAtlasi Q969H8.
PRIDEi Q969H8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262947 ; ENSP00000262947 ; ENSG00000074842 .
GeneIDi 56005.
KEGGi hsa:56005.
UCSCi uc002may.3. human.

Organism-specific databases

CTDi 56005.
GeneCardsi GC19M004608.
H-InvDB HIX0014670.
HGNCi HGNC:16948. C19orf10.
HPAi HPA041872.
HPA046744.
MIMi 606746. gene.
neXtProti NX_Q969H8.
PharmGKBi PA29827.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46744.
GeneTreei ENSGT00390000000777.
HOGENOMi HOG000236299.
HOVERGENi HBG051127.
InParanoidi Q969H8.
OMAi EIEYGMA.
PhylomeDBi Q969H8.
TreeFami TF332795.

Enzyme and pathway databases

Reactomei REACT_18273. XBP1(S) activates chaperone genes.

Miscellaneous databases

GenomeRNAii 56005.
NextBioi 61458.
SOURCEi Search...

Gene expression databases

Bgeei Q969H8.
CleanExi HS_C19orf10.
HS_IL25.
ExpressionAtlasi Q969H8. baseline and differential.
Genevestigatori Q969H8.

Family and domain databases

InterProi IPR018887. UPF0556.
[Graphical view ]
Pfami PF10572. UPF0556. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation."
    Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H., Kitamura T.
    J. Immunol. 167:6338-6347(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow.
  2. Cited for: RETRACTION.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Skin.
  6. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-173.
  7. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
    Xu G., Shin S.B., Jaffrey S.R.
    Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 32-44.
    Tissue: Leukemic T-cell.
  8. "The identification and characterization of a novel protein, c19orf10, in the synovium."
    Weiler T., Du Q., Krokhin O., Ens W., Standing K., El-Gabalawy H., Wilkins J.A.
    Arthritis Res. Ther. 9:R30-R30(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCS010_HUMAN
AccessioniPrimary (citable) accession number: Q969H8
Secondary accession number(s): D6W628
, O75256, O75272, Q9BTK7, Q9NP69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1, but this work has been later retracted.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3