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Protein

Ribonuclease P/MRP protein subunit POP5

Gene

POP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP.1 Publication

Miscellaneous

The last C-terminal 19 amino acids are not required for complex association and RNase activity.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein lipoylation Source: GO_Central
  • tRNA 5'-leader removal Source: FlyBase

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6784531. tRNA processing in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P/MRP protein subunit POP5 (EC:3.1.26.5)
Short name:
hPop5
Gene namesi
Name:POP5
ORF Names:AD-008, HSPC004, x0003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000167272.10.
HGNCiHGNC:17689. POP5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51367.
OpenTargetsiENSG00000167272.
PharmGKBiPA128394660.

Polymorphism and mutation databases

BioMutaiPOP5.
DMDMi74731042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002390071 – 163Ribonuclease P/MRP protein subunit POP5Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei154PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ969H6.
MaxQBiQ969H6.
PaxDbiQ969H6.
PeptideAtlasiQ969H6.
PRIDEiQ969H6.

PTM databases

iPTMnetiQ969H6.
PhosphoSitePlusiQ969H6.

Expressioni

Gene expression databases

BgeeiENSG00000167272.
CleanExiHS_POP5.
GenevisibleiQ969H6. HS.

Organism-specific databases

HPAiHPA047598.
HPA069204.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119502. 23 interactors.
CORUMiQ969H6.
IntActiQ969H6. 16 interactors.
STRINGi9606.ENSP00000350098.

Structurei

3D structure databases

ProteinModelPortaliQ969H6.
SMRiQ969H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4639. Eukaryota.
COG1369. LUCA.
GeneTreeiENSGT00390000012331.
HOGENOMiHOG000293345.
HOVERGENiHBG082157.
InParanoidiQ969H6.
KOiK03537.
OMAiATIIQCN.
OrthoDBiEOG091G0SGT.
PhylomeDBiQ969H6.
TreeFamiTF317496.

Family and domain databases

InterProiView protein in InterPro
IPR016819. RNase_P/MRP_POP5.
IPR002759. RNase_P/MRP_subunit.
PfamiView protein in Pfam
PF01900. RNase_P_Rpp14. 1 hit.
PIRSFiPIRSF023803. Ribonuclease_P_prd. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRFKHRYLL CELVSDDPRC RLSLDDRVLS SLVRDTIARV HGTFGAAACS
60 70 80 90 100
IGFAVRYLNA YTGIVLLRCR KEFYQLVWSA LPFITYLENK GHRYPCFFNT
110 120 130 140 150
LHVGGTIRTC QKFLIQYNRR QLLILLQNCT DEGEREAIQK SVTRSCLLEE
160
EEESGEEAAE AME
Length:163
Mass (Da):18,820
Last modified:December 1, 2001 - v1
Checksum:iDF436E60B3DD50C1
GO
Isoform 2 (identifier: Q969H6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-104: Missing.

Note: No experimental confirmation available.
Show »
Length:113
Mass (Da):12,826
Checksum:i1004F004EBE8E949
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47 – 48AA → P in AAF17213 (PubMed:10931946).Curated2
Sequence conflicti47 – 48AA → P in AAD20966 (PubMed:11042152).Curated2
Sequence conflicti99N → D in BAD96926 (Ref. 5) Curated1
Sequence conflicti102H → R in BAD96926 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04273355 – 104Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306296 mRNA. Translation: CAC59822.1.
AF117232 mRNA. Translation: AAF17213.1.
AF070660 mRNA. Translation: AAD20966.1.
AK303144 mRNA. Translation: BAG64248.1.
AK223206 mRNA. Translation: BAD96926.1.
AC063943 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98206.1.
BC012505 mRNA. Translation: AAH12505.1.
CCDSiCCDS9202.1. [Q969H6-1]
CCDS9203.1. [Q969H6-2]
RefSeqiNP_057002.2. NM_015918.3. [Q969H6-1]
NP_937845.1. NM_198202.1. [Q969H6-2]
UniGeneiHs.279913.

Genome annotation databases

EnsembliENST00000341039; ENSP00000341791; ENSG00000167272. [Q969H6-2]
ENST00000357500; ENSP00000350098; ENSG00000167272. [Q969H6-1]
GeneIDi51367.
KEGGihsa:51367.
UCSCiuc001tys.3. human. [Q969H6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPOP5_HUMAN
AccessioniPrimary (citable) accession number: Q969H6
Secondary accession number(s): A6NL80, Q53FS5, Q9Y2Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families