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Q969H0

- FBXW7_HUMAN

UniProt

Q969H0 - FBXW7_HUMAN

Protein

F-box/WD repeat-containing protein 7

Gene

FBXW7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.5 Publications

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: UniProtKB
    2. cellular response to UV Source: UniProtKB
    3. lipid homeostasis Source: BHF-UCL
    4. lung development Source: Ensembl
    5. negative regulation of DNA endoreduplication Source: BHF-UCL
    6. negative regulation of hepatocyte proliferation Source: BHF-UCL
    7. negative regulation of Notch signaling pathway Source: BHF-UCL
    8. negative regulation of SREBP signaling pathway Source: BHF-UCL
    9. negative regulation of triglyceride biosynthetic process Source: BHF-UCL
    10. Notch signaling pathway Source: Reactome
    11. positive regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
    12. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
    13. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: BHF-UCL
    14. protein stabilization Source: BHF-UCL
    15. protein ubiquitination Source: UniProtKB
    16. regulation of lipid storage Source: BHF-UCL
    17. regulation of protein localization Source: BHF-UCL
    18. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
    19. sister chromatid cohesion Source: BHF-UCL
    20. vasculature development Source: BHF-UCL
    21. vasculogenesis Source: Ensembl
    22. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_160305. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.
    REACT_16907. Association of TriC/CCT with target proteins during biosynthesis.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    SignaLinkiQ969H0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/WD repeat-containing protein 7
    Alternative name(s):
    Archipelago homolog
    Short name:
    hAgo
    F-box and WD-40 domain-containing protein 7
    F-box protein FBX30
    SEL-10
    hCdc4
    Gene namesi
    Name:FBXW7
    Synonyms:FBW7, FBX30, SEL10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:16712. FBXW7.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. Golgi apparatus Source: Ensembl
    3. nucleolus Source: UniProtKB
    4. nucleoplasm Source: UniProtKB
    5. nucleus Source: HPA
    6. protein complex Source: UniProtKB
    7. SCF ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28054.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707F-box/WD repeat-containing protein 7PRO_0000050994Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei227 – 2271Phosphoserine; by SGK11 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ969H0.
    PaxDbiQ969H0.
    PRIDEiQ969H0.

    PTM databases

    PhosphoSiteiQ969H0.

    Expressioni

    Tissue specificityi

    Isoform 1 is widely expressed. Isoform 4 is expressed in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ969H0.
    BgeeiQ969H0.
    CleanExiHS_FBXW7.
    GenevestigatoriQ969H0.

    Organism-specific databases

    HPAiCAB013793.
    CAB029987.
    HPA045958.

    Interactioni

    Subunit structurei

    Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1. Interacts with MYC (when phosphorylated). Isoform 1 interacts with USP28, leading to counteract ubiquitination of MYC. Isoform 4 interacts (via WD repeats) with SV40 large T antigen (via CPD region). Forms a trimeric complex with NOTCH1 and SGK1.8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-359574,EBI-359574
    CCDC6Q162049EBI-359574,EBI-1045350
    CDK2P249412EBI-6502391,EBI-375096
    MYCP011064EBI-359574,EBI-447544
    SKP1P632085EBI-359574,EBI-307486
    STOML1Q9UBI43EBI-6502391,EBI-2681162

    Protein-protein interaction databases

    BioGridi120581. 93 interactions.
    DIPiDIP-27613N.
    IntActiQ969H0. 18 interactions.
    MINTiMINT-276696.
    STRINGi9606.ENSP00000281708.

    Structurei

    Secondary structure

    1
    707
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi265 – 2728
    Turni280 – 2823
    Helixi286 – 2938
    Helixi298 – 3047
    Helixi309 – 3157
    Helixi319 – 3257
    Turni326 – 3294
    Helixi350 – 36718
    Beta strandi374 – 3774
    Beta strandi384 – 3907
    Beta strandi393 – 3986
    Beta strandi403 – 4075
    Turni408 – 4103
    Beta strandi413 – 4164
    Beta strandi424 – 4307
    Beta strandi433 – 4386
    Beta strandi443 – 4475
    Turni448 – 4514
    Beta strandi452 – 4576
    Beta strandi464 – 4707
    Beta strandi473 – 4786
    Beta strandi481 – 49010
    Beta strandi493 – 4986
    Beta strandi504 – 5096
    Beta strandi514 – 5185
    Beta strandi523 – 5275
    Helixi528 – 5303
    Beta strandi532 – 5376
    Beta strandi544 – 5496
    Beta strandi551 – 5588
    Beta strandi563 – 5675
    Turni568 – 5703
    Beta strandi573 – 5775
    Beta strandi584 – 5907
    Beta strandi593 – 5986
    Beta strandi603 – 6075
    Turni608 – 6103
    Beta strandi613 – 6175
    Beta strandi627 – 6326
    Beta strandi634 – 6418
    Beta strandi644 – 6507
    Turni651 – 6533
    Beta strandi656 – 6627
    Helixi666 – 6683
    Beta strandi671 – 6777
    Beta strandi679 – 6879
    Beta strandi689 – 6935
    Beta strandi696 – 7016

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2OVPX-ray2.90B263-707[»]
    2OVQX-ray2.60B263-707[»]
    2OVRX-ray2.50B263-707[»]
    ProteinModelPortaliQ969H0.
    SMRiQ969H0. Positions 263-706.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ969H0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini278 – 32447F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati378 – 41841WD 1Add
    BLAST
    Repeati420 – 45637WD 2Add
    BLAST
    Repeati459 – 49840WD 3Add
    BLAST
    Repeati500 – 53637WD 4Add
    BLAST
    Repeati539 – 57840WD 5Add
    BLAST
    Repeati580 – 61839WD 6Add
    BLAST
    Repeati622 – 65938WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOVERGENiHBG051596.
    InParanoidiQ969H0.
    KOiK10260.
    OMAiDTSYSRQ.
    OrthoDBiEOG7VX8VF.
    PhylomeDBiQ969H0.
    TreeFamiTF101074.

    Family and domain databases

    Gene3Di2.130.10.10. 3 hits.
    InterProiIPR001810. F-box_dom.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00256. FBOX. 1 hit.
    SM00320. WD40. 8 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    PS00678. WD_REPEATS_1. 5 hits.
    PS50082. WD_REPEATS_2. 7 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q969H0-1) [UniParc]FASTAAdd to Basket

    Also known as: Archipelago alpha, FBW7alpha, 110K, common

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE    50
    EHTARNGEVV GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE 100
    DEEHAGEQDE EDEEEEEMDQ ESDDFDQSDD SSREDEHTHT NSVTNSSSIV 150
    DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV 200
    PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL 250
    LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD 300
    LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP 350
    WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD 400
    NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD RTLKVWNAET 450
    GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH 500
    VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD 550
    GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD 600
    STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD 650
    LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL 700
    DFDVDMK 707
    Length:707
    Mass (Da):79,663
    Last modified:December 1, 2001 - v1
    Checksum:iE4A357F76DFD8203
    GO
    Isoform 2 (identifier: Q969H0-2) [UniParc]FASTAAdd to Basket

    Also known as: Archipelago beta, FBW7beta, 69K

    The sequence of this isoform differs from the canonical sequence as follows:
         1-80: Missing.
         81-166: NNRFISVDED...LSSPFYTKTT → MCVPRSGLIL...FYGTLKMIFY

    Show »
    Length:627
    Mass (Da):70,324
    Checksum:i3D4107C053381BED
    GO
    Isoform 3 (identifier: Q969H0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-166: MNQELLSVGS...LSSPFYTKTT → VLILSCICLY...FYGTLKMIFY

    Note: Incomplete sequence.

    Show »
    Length:621
    Mass (Da):69,692
    Checksum:i0D1FB546A715CFC5
    GO
    Isoform 4 (identifier: Q969H0-4) [UniParc]FASTAAdd to Basket

    Also known as: Archipelago gamma, FBW7gamma, Hippocampal

    The sequence of this isoform differs from the canonical sequence as follows:
         1-118: Missing.
         119-167: DQESDDFDQS...SSPFYTKTTK → MSKPGKPTLN...AQGLPFCRRR

    Show »
    Length:589
    Mass (Da):66,120
    Checksum:i2AFB6E8A36E6E8DE
    GO

    Sequence cautioni

    The sequence BAA91986.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti344 – 3441P → L in AAH37320. (PubMed:15489334)Curated
    Sequence conflicti377 – 3771K → N in AAH37320. (PubMed:15489334)Curated
    Sequence conflicti508 – 5081Q → R in AAH37320. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti115 – 1151E → K.
    Corresponds to variant rs6816935 [ dbSNP | Ensembl ].
    VAR_017812
    Natural varianti117 – 1171E → K in a breast cancer sample; somatic mutation. 1 Publication
    VAR_033030
    Natural varianti133 – 1331R → G.
    Corresponds to variant rs6842544 [ dbSNP | Ensembl ].
    VAR_017813
    Natural varianti144 – 1441T → R.
    Corresponds to variant rs7660281 [ dbSNP | Ensembl ].
    VAR_017814
    Natural varianti465 – 4651R → C in a acute lymphoblastic leukemia cell line. 1 Publication
    VAR_017815
    Natural varianti465 – 4651R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035880
    Natural varianti505 – 5051R → L in an ovarian cancer cell line. 2 Publications
    VAR_017816
    Natural varianti582 – 5821S → L in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035881
    Natural varianti668 – 6681S → G.
    Corresponds to variant rs7679116 [ dbSNP | Ensembl ].
    VAR_017817

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 166166MNQEL…YTKTT → VLILSCICLYCGVLLPVLLP NLPFLTCLSMSTLESVTYLP EKGLYCQRLPSSRTHGGTES LKGKNTENMGFYGTLKMIFY in isoform 3. 2 PublicationsVSP_009481Add
    BLAST
    Alternative sequencei1 – 118118Missing in isoform 4. 1 PublicationVSP_009482Add
    BLAST
    Alternative sequencei1 – 8080Missing in isoform 2. 2 PublicationsVSP_009483Add
    BLAST
    Alternative sequencei81 – 16686NNRFI…YTKTT → MCVPRSGLILSCICLYCGVL LPVLLPNLPFLTCLSMSTLE SVTYLPEKGLYCQRLPSSRT HGGTESLKGKNTENMGFYGT LKMIFY in isoform 2. 2 PublicationsVSP_009484Add
    BLAST
    Alternative sequencei119 – 16749DQESD…TKTTK → MSKPGKPTLNHGLVPVDLKS AKEPLPHQTVMKIFSISIIA QGLPFCRRR in isoform 4. 1 PublicationVSP_009485Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033553 mRNA. Translation: AAK57547.1.
    AF383178 mRNA. Translation: AAK60269.1.
    AY008274 mRNA. Translation: AAG16640.1.
    AF411971 mRNA. Translation: AAL06290.1.
    AF411972 mRNA. Translation: AAL06291.1.
    AY049984 mRNA. Translation: AAL07271.1.
    AK001933 mRNA. Translation: BAA91986.1. Different initiation.
    CR749305 mRNA. Translation: CAH18160.1.
    BC037320 mRNA. Translation: AAH37320.1.
    BC117244 mRNA. Translation: AAI17245.1.
    BC117246 mRNA. Translation: AAI17247.1.
    BC143944 mRNA. Translation: AAI43945.1.
    CCDSiCCDS34078.1. [Q969H0-4]
    CCDS3777.1. [Q969H0-1]
    CCDS3778.1. [Q969H0-2]
    RefSeqiNP_001013433.1. NM_001013415.1. [Q969H0-4]
    NP_060785.2. NM_018315.4. [Q969H0-2]
    NP_361014.1. NM_033632.3. [Q969H0-1]
    UniGeneiHs.561245.
    Hs.717081.

    Genome annotation databases

    EnsembliENST00000263981; ENSP00000263981; ENSG00000109670. [Q969H0-2]
    ENST00000281708; ENSP00000281708; ENSG00000109670. [Q969H0-1]
    ENST00000296555; ENSP00000296555; ENSG00000109670. [Q969H0-4]
    ENST00000603548; ENSP00000474725; ENSG00000109670. [Q969H0-1]
    ENST00000603841; ENSP00000474971; ENSG00000109670. [Q969H0-1]
    GeneIDi55294.
    KEGGihsa:55294.
    UCSCiuc003imq.3. human. [Q969H0-2]
    uc003imr.3. human. [Q969H0-4]
    uc003ims.3. human. [Q969H0-1]

    Polymorphism databases

    DMDMi44887885.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033553 mRNA. Translation: AAK57547.1 .
    AF383178 mRNA. Translation: AAK60269.1 .
    AY008274 mRNA. Translation: AAG16640.1 .
    AF411971 mRNA. Translation: AAL06290.1 .
    AF411972 mRNA. Translation: AAL06291.1 .
    AY049984 mRNA. Translation: AAL07271.1 .
    AK001933 mRNA. Translation: BAA91986.1 . Different initiation.
    CR749305 mRNA. Translation: CAH18160.1 .
    BC037320 mRNA. Translation: AAH37320.1 .
    BC117244 mRNA. Translation: AAI17245.1 .
    BC117246 mRNA. Translation: AAI17247.1 .
    BC143944 mRNA. Translation: AAI43945.1 .
    CCDSi CCDS34078.1. [Q969H0-4 ]
    CCDS3777.1. [Q969H0-1 ]
    CCDS3778.1. [Q969H0-2 ]
    RefSeqi NP_001013433.1. NM_001013415.1. [Q969H0-4 ]
    NP_060785.2. NM_018315.4. [Q969H0-2 ]
    NP_361014.1. NM_033632.3. [Q969H0-1 ]
    UniGenei Hs.561245.
    Hs.717081.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2OVP X-ray 2.90 B 263-707 [» ]
    2OVQ X-ray 2.60 B 263-707 [» ]
    2OVR X-ray 2.50 B 263-707 [» ]
    ProteinModelPortali Q969H0.
    SMRi Q969H0. Positions 263-706.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120581. 93 interactions.
    DIPi DIP-27613N.
    IntActi Q969H0. 18 interactions.
    MINTi MINT-276696.
    STRINGi 9606.ENSP00000281708.

    PTM databases

    PhosphoSitei Q969H0.

    Polymorphism databases

    DMDMi 44887885.

    Proteomic databases

    MaxQBi Q969H0.
    PaxDbi Q969H0.
    PRIDEi Q969H0.

    Protocols and materials databases

    DNASUi 55294.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263981 ; ENSP00000263981 ; ENSG00000109670 . [Q969H0-2 ]
    ENST00000281708 ; ENSP00000281708 ; ENSG00000109670 . [Q969H0-1 ]
    ENST00000296555 ; ENSP00000296555 ; ENSG00000109670 . [Q969H0-4 ]
    ENST00000603548 ; ENSP00000474725 ; ENSG00000109670 . [Q969H0-1 ]
    ENST00000603841 ; ENSP00000474971 ; ENSG00000109670 . [Q969H0-1 ]
    GeneIDi 55294.
    KEGGi hsa:55294.
    UCSCi uc003imq.3. human. [Q969H0-2 ]
    uc003imr.3. human. [Q969H0-4 ]
    uc003ims.3. human. [Q969H0-1 ]

    Organism-specific databases

    CTDi 55294.
    GeneCardsi GC04M153242.
    HGNCi HGNC:16712. FBXW7.
    HPAi CAB013793.
    CAB029987.
    HPA045958.
    MIMi 606278. gene.
    neXtProti NX_Q969H0.
    PharmGKBi PA28054.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOVERGENi HBG051596.
    InParanoidi Q969H0.
    KOi K10260.
    OMAi DTSYSRQ.
    OrthoDBi EOG7VX8VF.
    PhylomeDBi Q969H0.
    TreeFami TF101074.

    Enzyme and pathway databases

    Reactomei REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_160305. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.
    REACT_16907. Association of TriC/CCT with target proteins during biosynthesis.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    SignaLinki Q969H0.

    Miscellaneous databases

    EvolutionaryTracei Q969H0.
    GeneWikii FBXW7.
    GenomeRNAii 55294.
    NextBioi 59488.
    PROi Q969H0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969H0.
    Bgeei Q969H0.
    CleanExi HS_FBXW7.
    Genevestigatori Q969H0.

    Family and domain databases

    Gene3Di 2.130.10.10. 3 hits.
    InterProi IPR001810. F-box_dom.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00256. FBOX. 1 hit.
    SM00320. WD40. 8 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    PS00678. WD_REPEATS_1. 5 hits.
    PS50082. WD_REPEATS_2. 7 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
    2. "Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines."
      Moberg K.H., Bell D.W., Wahrer D.C.R., Haber D.A., Hariharan I.K.
      Nature 413:311-316(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS CYS-465 AND LEU-505.
    3. "Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line."
      Strohmaier H., Spruck C.H., Kaiser P., Won K.-A., Sangfelt O., Reed S.I.
      Nature 413:316-322(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, IDENTIFICATION IN SCF COMPLEX, INTERACTION WITH CYCLIN E.
    4. "SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production."
      Li J., Pauley A.M., Myers R.L., Shuang R., Brashler J.R., Yan R., Buhl A.E., Ruble C., Gurney M.E.
      J. Neurochem. 82:1540-1548(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, INTERACTION WITH PSEN1.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Placenta.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Salivary gland.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain.
    8. "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation."
      Wu G., Lyapina S., Das I., Li J., Gurney M., Pauley A., Chui I., Deshaies R.J., Kitajewski J.
      Mol. Cell. Biol. 21:7403-7415(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NOTCH1; NOTCH4 AND SKP1.
    9. "Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7."
      Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., Ishida N., Okumura F., Nakayama K., Nakayama K.I.
      EMBO J. 23:2116-2125(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, COMPONENT OF THE SCF(FBXW7) COMPLEX, INTERACTION WITH MYC.
    10. "The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4."
      Welcker M., Clurman B.E.
      J. Biol. Chem. 280:7654-7658(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SV40 LARGE T ANTIGEN.
    11. "Fbw7 and Usp28 regulate myc protein stability in response to DNA damage."
      Popov N., Herold S., Llamazares M., Schulein C., Eilers M.
      Cell Cycle 6:2327-2331(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MYC AND USP28.
    12. Cited for: FUNCTION, INTERACTION WITH MYC AND USP28, SUBCELLULAR LOCATION.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    14. "Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase."
      Mo J.S., Ann E.J., Yoon J.H., Jung J., Choi Y.H., Kim H.Y., Ahn J.S., Kim S.M., Kim M.Y., Hong J.A., Seo M.S., Lang F., Choi E.J., Park H.S.
      J. Cell Sci. 124:100-112(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-227 BY SGK1, INTERACTION WITH SGK1 AND NOTCH1.
    15. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-465; LEU-505 AND LEU-582.
    16. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
      Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.
      Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LYS-117.

    Entry informationi

    Entry nameiFBXW7_HUMAN
    AccessioniPrimary (citable) accession number: Q969H0
    Secondary accession number(s): B7ZLP9
    , Q68DR0, Q96A16, Q96LE0, Q96RI2, Q9NUX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3