Reviewed, UniProtKB/Swiss-Prot Q969H0 (FBXW7_HUMAN)

Names and origin

Protein names

Recommended name:
    F-box/WD repeat-containing protein 7
Alternative name(s):
    F-box and WD-40 domain-containing protein 7
    F-box protein FBX30
      Short name=hCdc4
    Archipelago homolog
      Short name=hAgo
    SEL-10

Gene names

Name:	FBXW7
Synonyms:	FBW7, FBX30, SEL10

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	707 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Ref.3 Ref.8
Subunit structure	Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1A and FBXW7. Interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1A. Ref.3 Ref.8 Ref.4
Subcellular location	Nucleus By similarity.
Tissue specificity	Isoform 1 is widely expressed. Isoform 4 is expressed in brain. Ref.4
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.9
Sequence similarities	Contains 1 F-box domain. Contains 7 WD repeats.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW protein ubiquitination Ref.4 Inferred from direct assay. Source: MGI
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Ref.4 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MYC	P01106	1	EBI-359574,EBI-447544
SKP1	P63208	1	EBI-359574,EBI-307486

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q969H0-1)

Also known as: Archipelago alpha; 110K; common;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q969H0-2)

Also known as: Archipelago beta; 69K;

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     81-166: NNRFISVDED...LSSPFYTKTT → MCVPRSGLIL...FYGTLKMIFY

Isoform 3 (identifier: Q969H0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: MNQELLSVGS...LSSPFYTKTT → VLILSCICLY...FYGTLKMIFY

Note: Incomplete sequence.

Isoform 4 (identifier: Q969H0-4)

Also known as: Hippocampal;

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     119-167: DQESDDFDQS...SSPFYTKTTK → MSKPGKPTLN...AQGLPFCRRR

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 707

707

F-box/WD repeat-containing protein 7

PRO_0000050994

Regions

Domain

278 – 324

47

F-box

Repeat

378 – 418

41

WD 1

Repeat

420 – 456

37

WD 2

Repeat

459 – 498

40

WD 3

Repeat

500 – 536

37

WD 4

Repeat

539 – 578

40

WD 5

Repeat

580 – 618

39

WD 6

Repeat

622 – 659

38

WD 7

Amino acid modifications

Modified residue

26

1

Phosphoserine Ref.9

Natural variations

Alternative sequence

1 – 166

166

MNQEL…YTKTT → VLILSCICLYCGVLLPVLLP NLPFLTCLSMSTLESVTYLP EKGLYCQRLPSSRTHGGTES LKGKNTENMGFYGTLKMIFY in isoform 3.

VSP_009481

Alternative sequence

1 – 118

118

Missing in isoform 4.

VSP_009482

Alternative sequence

1 – 80

80

Missing in isoform 2.

VSP_009483

Alternative sequence

81 – 166

86

NNRFI…YTKTT → MCVPRSGLILSCICLYCGVL LPVLLPNLPFLTCLSMSTLE SVTYLPEKGLYCQRLPSSRT HGGTESLKGKNTENMGFYGT LKMIFY in isoform 2.

VSP_009484

Alternative sequence

119 – 167

49

DQESD…TKTTK → MSKPGKPTLNHGLVPVDLKS AKEPLPHQTVMKIFSISIIA QGLPFCRRR in isoform 4.

VSP_009485

Natural variant

115

1

E → K: dbSNP rs6816935.

VAR_017812

Natural variant

117

1

E → K in a breast cancer sample; somatic mutation. Ref.11

VAR_033030

Natural variant

133

1

R → G: dbSNP rs6842544.

VAR_017813

Natural variant

144

1

T → R: dbSNP rs7660281.

VAR_017814

Natural variant

465

1

R → C in a acute lymphoblastic leukemia cell line. Ref.2

VAR_017815

Natural variant

465

1

R → H in a colorectal cancer sample; somatic mutation. Ref.10

VAR_035880

Natural variant

505

1

R → L in an ovarian cancer cell line. Ref.2 Ref.10

VAR_017816

Natural variant

582

1

S → L in a colorectal cancer sample; somatic mutation. Ref.10

VAR_035881

Natural variant

668

1

S → G: dbSNP rs7679116.

VAR_017817

Experimental info

Sequence conflict

344

1

P → L in AAH37320. Ref.7

Sequence conflict

377

1

K → N in AAH37320. Ref.7

Sequence conflict

508

1

Q → R in AAH37320. Ref.7

Secondary structure

1

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707

Helix Strand Turn

Details...

Helix

265 – 272

8

Helix

280 – 283

4

Helix

286 – 293

8

Helix

298 – 305

8

Helix

309 – 315

7

Helix

318 – 327

10

Helix

350 – 366

17

Beta strand

374 – 377

4

Beta strand

384 – 390

7

Beta strand

393 – 401

9

Beta strand

403 – 407

5

Turn

408 – 410

3

Beta strand

413 – 416

4

Beta strand

424 – 438

15

Beta strand

441 – 447

7

Turn

448 – 450

3

Beta strand

453 – 458

6

Beta strand

466 – 470

5

Beta strand

473 – 477

5

Beta strand

481 – 487

7

Turn

488 – 490

3

Beta strand

495 – 498

4

Beta strand

504 – 509

6

Beta strand

514 – 518

5

Beta strand

523 – 527

5

Helix

528 – 530

3

Beta strand

532 – 537

6

Beta strand

544 – 549

6

Beta strand

551 – 558

8

Beta strand

563 – 567

5

Turn

568 – 570

3

Beta strand

573 – 577

5

Beta strand

584 – 590

7

Beta strand

593 – 598

6

Beta strand

603 – 607

5

Turn

608 – 611

4

Beta strand

612 – 617

6

Beta strand

627 – 632

6

Beta strand

634 – 641

8

Beta strand

644 – 650

7

Turn

651 – 653

3

Beta strand

656 – 662

7

Turn

664 – 669

6

Beta strand

671 – 677

7

Beta strand

679 – 687

9

Beta strand

696 – 701

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Archipelago alpha) (110K) (common) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: E4A357F76DFD8203	FASTA	707	79,663
	10 20 30 40 50 60 MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV 70 80 90 100 110 120 GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ 130 140 150 160 170 180 ESDDFDQSDD SSREDEHTHT NSVTNSSSIV DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS 190 200 210 220 230 240 FSLGKKPCKV SEYTSTTGLV PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM 250 260 270 280 290 300 FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD 310 320 330 340 350 360 LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR 370 380 390 400 410 420 IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH 430 440 450 460 470 480 TGGVWSSQMR DNIIISGSTD RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD 490 500 510 520 530 540 ATLRVWDIET GQCLHVLMGH VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH 550 560 570 580 590 600 TNRVYSLQFD GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD 610 620 630 640 650 660 STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL 670 680 690 700 VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL DFDVDMK
	Isoform 2 (Archipelago beta) (69K). Checksum: 3D4107C053381BED	FASTA	627	70,324
	10 20 30 40 50 60 MCVPRSGLIL SCICLYCGVL LPVLLPNLPF LTCLSMSTLE SVTYLPEKGL YCQRLPSSRT 70 80 90 100 110 120 HGGTESLKGK NTENMGFYGT LKMIFYKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV 130 140 150 160 170 180 PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL LALDELIDSC 190 200 210 220 230 240 EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL 250 260 270 280 290 300 WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD 310 320 330 340 350 360 DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD 370 380 390 400 410 420 RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH 430 440 450 460 470 480 VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD GIHVVSGSLD 490 500 510 520 530 540 TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD STVKIWDIKT GQCLQTLQGP 550 560 570 580 590 600 NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL VTLESGGSGG VVWRIRASNT 610 620 KLVCAVGSRN GTEETKLLVL DFDVDMK
	Isoform 3. Checksum: 0D1FB546A715CFC5	FASTA	621	69,692
	10 20 30 40 50 60 VLILSCICLY CGVLLPVLLP NLPFLTCLSM STLESVTYLP EKGLYCQRLP SSRTHGGTES 70 80 90 100 110 120 LKGKNTENMG FYGTLKMIFY KMKRKLDHGS EVRSFSLGKK PCKVSEYTST TGLVPCSATP 130 140 150 160 170 180 TTFGDLRAAN GQGQQRRRIT SVQPPTGLQE WLKMFQSWSG PEKLLALDEL IDSCEPTQVK 190 200 210 220 230 240 HMMQVIEPQF QRDFISLLPK ELALYVLSFL EPKDLLQAAQ TCRYWRILAE DNLLWREKCK 250 260 270 280 290 300 EEGIDEPLHI KRRKVIKPGF IHSPWKSAYI RQHRIDTNWR RGELKSPKVL KGHDDHVITC 310 320 330 340 350 360 LQFCGNRIVS GSDDNTLKVW SAVTGKCLRT LVGHTGGVWS SQMRDNIIIS GSTDRTLKVW 370 380 390 400 410 420 NAETGECIHT LYGHTSTVRC MHLHEKRVVS GSRDATLRVW DIETGQCLHV LMGHVAAVRC 430 440 450 460 470 480 VQYDGRRVVS GAYDFMVKVW DPETETCLHT LQGHTNRVYS LQFDGIHVVS GSLDTSIRVW 490 500 510 520 530 540 DVETGNCIHT LTGHQSLTSG MELKDNILVS GNADSTVKIW DIKTGQCLQT LQGPNKHQSA 550 560 570 580 590 600 VTCLQFNKNF VITSSDDGTV KLWDLKTGEF IRNLVTLESG GSGGVVWRIR ASNTKLVCAV 610 620 GSRNGTEETK LLVLDFDVDM K
	Isoform 4 (Hippocampal). Checksum: 2AFB6E8A36E6E8DE	FASTA	589	66,120
	10 20 30 40 50 60 MSKPGKPTLN HGLVPVDLKS AKEPLPHQTV MKIFSISIIA QGLPFCRRRM KRKLDHGSEV 70 80 90 100 110 120 RSFSLGKKPC KVSEYTSTTG LVPCSATPTT FGDLRAANGQ GQQRRRITSV QPPTGLQEWL 130 140 150 160 170 180 KMFQSWSGPE KLLALDELID SCEPTQVKHM MQVIEPQFQR DFISLLPKEL ALYVLSFLEP 190 200 210 220 230 240 KDLLQAAQTC RYWRILAEDN LLWREKCKEE GIDEPLHIKR RKVIKPGFIH SPWKSAYIRQ 250 260 270 280 290 300 HRIDTNWRRG ELKSPKVLKG HDDHVITCLQ FCGNRIVSGS DDNTLKVWSA VTGKCLRTLV 310 320 330 340 350 360 GHTGGVWSSQ MRDNIIISGS TDRTLKVWNA ETGECIHTLY GHTSTVRCMH LHEKRVVSGS 370 380 390 400 410 420 RDATLRVWDI ETGQCLHVLM GHVAAVRCVQ YDGRRVVSGA YDFMVKVWDP ETETCLHTLQ 430 440 450 460 470 480 GHTNRVYSLQ FDGIHVVSGS LDTSIRVWDV ETGNCIHTLT GHQSLTSGME LKDNILVSGN 490 500 510 520 530 540 ADSTVKIWDI KTGQCLQTLQ GPNKHQSAVT CLQFNKNFVI TSSDDGTVKL WDLKTGEFIR 550 560 570 580 NLVTLESGGS GGVVWRIRAS NTKLVCAVGS RNGTEETKLL VLDFDVDMK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of mammalian F-box proteins." Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W. Curr. Biol. 9:1180-1182(1999) [PubMed: 10531037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
[2]	"Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines." Moberg K.H., Bell D.W., Wahrer D.C.R., Haber D.A., Hariharan I.K. Nature 413:311-316(2001) [PubMed: 11565033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS CYS-465 AND LEU-505.
[3]	"Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line." Strohmaier H., Spruck C.H., Kaiser P., Won K.-A., Sangfelt O., Reed S.I. Nature 413:316-322(2001) [PubMed: 11565034] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, IDENTIFICATION IN SCF COMPLEX, INTERACTION WITH CYCLIN E.
[4]	"SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production." Li J., Pauley A.M., Myers R.L., Shuang R., Brashler J.R., Yan R., Buhl A.E., Ruble C., Gurney M.E. J. Neurochem. 82:1540-1548(2002) [PubMed: 12354302] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, INTERACTION WITH PSEN1.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Placenta.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Salivary gland.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain.
[8]	"SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation." Wu G., Lyapina S., Das I., Li J., Gurney M., Pauley A., Chui I., Deshaies R.J., Kitajewski J. Mol. Cell. Biol. 21:7403-7415(2001) [PubMed: 11585921] [Abstract] Cited for: FUNCTION, INTERACTION WITH NOTCH1; NOTCH4 AND SKP1A.
[9]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, MASS SPECTROMETRY.
[10]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-465; LEU-505 AND LEU-582.
[11]	"Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas." Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L. Breast Cancer Res. 9:R5-R5(2007) [PubMed: 17224074] [Abstract] Cited for: VARIANT LYS-117.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY033553 mRNA. Translation: AAK57547.1.
AF383178 mRNA. Translation: AAK60269.1.
AY008274 mRNA. Translation: AAG16640.1.
AF411971 mRNA. Translation: AAL06290.1.
AF411972 mRNA. Translation: AAL06291.1.
AY049984 mRNA. Translation: AAL07271.1.
AK001933 mRNA. Translation: BAA91986.1. Different initiation.
CR749305 mRNA. Translation: CAH18160.1.
BC037320 mRNA. Translation: AAH37320.1.
BC117244 mRNA. Translation: AAI17245.1.
BC117246 mRNA. Translation: AAI17247.1.
BC143944 mRNA. Translation: AAI43945.1.

IPI

IPI00056349.
IPI00059165.
IPI00075075.
IPI00402151.

RefSeq

NP_001013433.1.
NP_060785.2.
NP_361014.1.

UniGene

Hs.679796

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OVP	X-ray	2.90	B	263-707	[»]
2OVQ	X-ray	2.60	B	263-707	[»]
2OVR	X-ray	2.50	B	263-707	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-27613N.

IntAct

Q969H0. 9 interactions.

STRING

Q969H0.

PTM databases

PhosphoSite

Q969H0.

Proteomic databases

PRIDE

Q969H0.

Genome annotation databases

Ensembl

ENST00000281708; ENSP00000281708; ENSG00000109670; Homo sapiens. [Genome view]
ENST00000393956; ENSP00000377528; ENSG00000109670; Homo sapiens. [Genome view]

GeneID

55294.

KEGG

hsa:55294.

UCSC

uc003imr.1. human.
uc003ims.1. human.

Organism-specific databases

CTD

55294.

GeneCards

GC04M153461.

H-InvDB

HIX0004570.

HGNC

HGNC:16712. FBXW7.

HPA

CAB013793.

MIM

606278. gene.

PharmGKB

PA28054.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG627825.

HOVERGEN

Q969H0.

InParanoid

Q969H0.

OMA

SSQIDEE.

OrthoDB

EOG9XWJH9.

PhylomeDB

Q969H0.

Enzyme and pathway databases

Reactome

REACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpress

Q969H0.

Bgee

Q969H0.

CleanEx

HS_FBXW7.

Genevestigator

Q969H0.

GermOnline

ENSG00000109670. Homo sapiens.

Family and domain databases

InterPro

IPR001810. F-box.
IPR020472. G-protein_beta_WD-40_rep_reg.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019782. WD40_repeat_2.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR019781. WD40_repeat_sg.
[Graphical view]

Gene3D

G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.

Pfam

PF00646. F-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]

PRINTS

PR00320. GPROTEINBRPT.

SMART

SM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]

PROSITE

PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

ProtoNet

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Other Resources

NextBio

59488.

SOURCE

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Entry information

Entry name

FBXW7_HUMAN

Accession

Primary (citable) accession number: Q969H0
Secondary accession number(s): B7ZLP9 , Q68DR0, Q96A16, Q96LE0, Q96RI2, Q9NUX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	December 1, 2001
Last modified:	February 9, 2010
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.