Q969H0 (FBXW7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box/WD repeat-containing protein 7

Alternative name(s):
Archipelago homolog
Short name=hAgo
F-box and WD-40 domain-containing protein 7
F-box protein FBX30
SEL-10
hCdc4

Gene names

Name:	FBXW7
Synonyms:	FBW7, FBX30, SEL10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	707 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Ref.3 Ref.8 Ref.9 Ref.11 Ref.12
Subunit structure	Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1. Interacts with MYC (when phosphorylated). Isoform 1 interacts with USP28, leading to counteract ubiquitination of MYC. Isoform 4 interacts (via WD repeats) with SV40 large T antigen (via CPD region). Forms a trimeric complex with NOTCH1 and SGK1. Ref.3 Ref.4 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.14
Subcellular location	Isoform 1: Nucleus › nucleoplasm Ref.12. Isoform 2: Cytoplasm Ref.12. Isoform 4: Nucleus › nucleolus Ref.12. Nucleus By similarity Ref.12.
Tissue specificity	Isoform 1 is widely expressed. Isoform 4 is expressed in brain. Ref.4
Sequence similarities	Contains 1 F-box domain. Contains 7 WD repeats.
Sequence caution	The sequence BAA91986.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Host-virus interaction Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Traceable author statement. Source: Reactome SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from direct assay Ref.9. Source: UniProtKB cellular response to UV Inferred from direct assay Ref.11. Source: UniProtKB lipid homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL lung development Inferred from electronic annotation. Source: Compara negative regulation of DNA endoreduplication Inferred from mutant phenotype PubMed 15917200. Source: BHF-UCL negative regulation of Notch signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of SREBP signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of hepatocyte proliferation Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of triglyceride biosynthetic process Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of ERK1 and ERK2 cascade Inferred from mutant phenotype PubMed 20208556. Source: BHF-UCL positive regulation of epidermal growth factor-activated receptor activity Inferred from direct assay PubMed 20208556. Source: BHF-UCL positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from direct assay PubMed 20208556. Source: BHF-UCL protein stabilization Inferred from direct assay PubMed 20208556. Source: BHF-UCL protein ubiquitination Inferred from direct assay Ref.9. Source: UniProtKB regulation of lipid storage Inferred from sequence or structural similarity. Source: BHF-UCL regulation of protein localization Inferred from sequence or structural similarity. Source: BHF-UCL response to DNA damage stimulus Inferred from direct assay Ref.11. Source: UniProtKB sister chromatid cohesion Inferred from mutant phenotype PubMed 15917200. Source: BHF-UCL vasculature development Traceable author statement PubMed 21123947. Source: BHF-UCL vasculogenesis Inferred from electronic annotation. Source: Compara virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara SCF ubiquitin ligase complex Inferred from direct assay Ref.9. Source: UniProtKB endoplasmic reticulum Inferred from electronic annotation. Source: Compara nucleolus Inferred from direct assay Ref.12. Source: UniProtKB nucleoplasm Inferred from direct assay Ref.12. Source: UniProtKB protein complex Inferred from direct assay Ref.11. Source: UniProtKB
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDK2	P24941	2	EBI-6502391,EBI-375096
MYC	P01106	2	EBI-359574,EBI-447544
STOML1	Q9UBI4	3	EBI-6502391,EBI-2681162

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q969H0-1)

Also known as: Archipelago alpha; FBW7alpha; 110K; common;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q969H0-2)

Also known as: Archipelago beta; FBW7beta; 69K;

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     81-166: NNRFISVDED...LSSPFYTKTT → MCVPRSGLIL...FYGTLKMIFY

Isoform 3 (identifier: Q969H0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: MNQELLSVGS...LSSPFYTKTT → VLILSCICLY...FYGTLKMIFY

Note: Incomplete sequence.

Isoform 4 (identifier: Q969H0-4)

Also known as: Archipelago gamma; FBW7gamma; Hippocampal;

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     119-167: DQESDDFDQS...SSPFYTKTTK → MSKPGKPTLN...AQGLPFCRRR

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 707

707

F-box/WD repeat-containing protein 7

PRO_0000050994

Regions

Domain

278 – 324

47

F-box

Repeat

378 – 418

41

WD 1

Repeat

420 – 456

37

WD 2

Repeat

459 – 498

40

WD 3

Repeat

500 – 536

37

WD 4

Repeat

539 – 578

40

WD 5

Repeat

580 – 618

39

WD 6

Repeat

622 – 659

38

WD 7

Amino acid modifications

Modified residue

227

1

Phosphoserine; by SGK1 Ref.14

Natural variations

Alternative sequence

1 – 166

166

MNQEL…YTKTT → VLILSCICLYCGVLLPVLLP NLPFLTCLSMSTLESVTYLP EKGLYCQRLPSSRTHGGTES LKGKNTENMGFYGTLKMIFY in isoform 3.

VSP_009481

Alternative sequence

1 – 118

118

Missing in isoform 4.

VSP_009482

Alternative sequence

1 – 80

80

Missing in isoform 2.

VSP_009483

Alternative sequence

81 – 166

86

NNRFI…YTKTT → MCVPRSGLILSCICLYCGVL LPVLLPNLPFLTCLSMSTLE SVTYLPEKGLYCQRLPSSRT HGGTESLKGKNTENMGFYGT LKMIFY in isoform 2.

VSP_009484

Alternative sequence

119 – 167

49

DQESD…TKTTK → MSKPGKPTLNHGLVPVDLKS AKEPLPHQTVMKIFSISIIA QGLPFCRRR in isoform 4.

VSP_009485

Natural variant

115

1

E → K.
Corresponds to variant rs6816935 [ dbSNP | Ensembl ].

VAR_017812

Natural variant

117

1

E → K in a breast cancer sample; somatic mutation. Ref.16

VAR_033030

Natural variant

133

1

R → G.
Corresponds to variant rs6842544 [ dbSNP | Ensembl ].

VAR_017813

Natural variant

144

1

T → R.
Corresponds to variant rs7660281 [ dbSNP | Ensembl ].

VAR_017814

Natural variant

465

1

R → C in a acute lymphoblastic leukemia cell line. Ref.2

VAR_017815

Natural variant

465

1

R → H in a colorectal cancer sample; somatic mutation. Ref.15

VAR_035880

Natural variant

505

1

R → L in an ovarian cancer cell line. Ref.2 Ref.15

VAR_017816

Natural variant

582

1

S → L in a colorectal cancer sample; somatic mutation. Ref.15

VAR_035881

Natural variant

668

1

S → G.
Corresponds to variant rs7679116 [ dbSNP | Ensembl ].

VAR_017817

Experimental info

Sequence conflict

344

1

P → L in AAH37320. Ref.7

Sequence conflict

377

1

K → N in AAH37320. Ref.7

Sequence conflict

508

1

Q → R in AAH37320. Ref.7

Secondary structure

1

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707

Helix Strand Turn

Details...

Helix

265 – 272

8

Turn

280 – 282

3

Helix

286 – 293

8

Helix

298 – 304

7

Helix

309 – 315

7

Helix

319 – 325

7

Turn

326 – 329

4

Helix

350 – 367

18

Beta strand

374 – 377

4

Beta strand

384 – 390

7

Beta strand

393 – 398

6

Beta strand

403 – 407

5

Turn

408 – 410

3

Beta strand

413 – 416

4

Beta strand

424 – 430

7

Beta strand

433 – 438

6

Beta strand

443 – 447

5

Turn

448 – 451

4

Beta strand

452 – 457

6

Beta strand

464 – 470

7

Beta strand

473 – 478

6

Beta strand

481 – 490

10

Beta strand

493 – 498

6

Beta strand

504 – 509

6

Beta strand

514 – 518

5

Beta strand

523 – 527

5

Helix

528 – 530

3

Beta strand

532 – 537

6

Beta strand

544 – 549

6

Beta strand

551 – 558

8

Beta strand

563 – 567

5

Turn

568 – 570

3

Beta strand

573 – 577

5

Beta strand

584 – 590

7

Beta strand

593 – 598

6

Beta strand

603 – 607

5

Turn

608 – 610

3

Beta strand

613 – 617

5

Beta strand

627 – 632

6

Beta strand

634 – 641

8

Beta strand

644 – 650

7

Turn

651 – 653

3

Beta strand

656 – 662

7

Helix

666 – 668

3

Beta strand

671 – 677

7

Beta strand

679 – 687

9

Beta strand

689 – 693

5

Beta strand

696 – 701

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Archipelago alpha) (FBW7alpha) (110K) (common) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: E4A357F76DFD8203	FASTA	707	79,663
	10 20 30 40 50 60 MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV 70 80 90 100 110 120 GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ 130 140 150 160 170 180 ESDDFDQSDD SSREDEHTHT NSVTNSSSIV DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS 190 200 210 220 230 240 FSLGKKPCKV SEYTSTTGLV PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM 250 260 270 280 290 300 FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD 310 320 330 340 350 360 LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR 370 380 390 400 410 420 IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH 430 440 450 460 470 480 TGGVWSSQMR DNIIISGSTD RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD 490 500 510 520 530 540 ATLRVWDIET GQCLHVLMGH VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH 550 560 570 580 590 600 TNRVYSLQFD GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD 610 620 630 640 650 660 STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL 670 680 690 700 VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL DFDVDMK
	Isoform 2 (Archipelago beta) (FBW7beta) (69K) [UniParc]. Checksum: 3D4107C053381BED	FASTA	627	70,324
	10 20 30 40 50 60 MCVPRSGLIL SCICLYCGVL LPVLLPNLPF LTCLSMSTLE SVTYLPEKGL YCQRLPSSRT 70 80 90 100 110 120 HGGTESLKGK NTENMGFYGT LKMIFYKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV 130 140 150 160 170 180 PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL LALDELIDSC 190 200 210 220 230 240 EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL 250 260 270 280 290 300 WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD 310 320 330 340 350 360 DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD 370 380 390 400 410 420 RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH 430 440 450 460 470 480 VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD GIHVVSGSLD 490 500 510 520 530 540 TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD STVKIWDIKT GQCLQTLQGP 550 560 570 580 590 600 NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL VTLESGGSGG VVWRIRASNT 610 620 KLVCAVGSRN GTEETKLLVL DFDVDMK
	Isoform 3 [UniParc]. Checksum: 0D1FB546A715CFC5	FASTA	621	69,692
	10 20 30 40 50 60 VLILSCICLY CGVLLPVLLP NLPFLTCLSM STLESVTYLP EKGLYCQRLP SSRTHGGTES 70 80 90 100 110 120 LKGKNTENMG FYGTLKMIFY KMKRKLDHGS EVRSFSLGKK PCKVSEYTST TGLVPCSATP 130 140 150 160 170 180 TTFGDLRAAN GQGQQRRRIT SVQPPTGLQE WLKMFQSWSG PEKLLALDEL IDSCEPTQVK 190 200 210 220 230 240 HMMQVIEPQF QRDFISLLPK ELALYVLSFL EPKDLLQAAQ TCRYWRILAE DNLLWREKCK 250 260 270 280 290 300 EEGIDEPLHI KRRKVIKPGF IHSPWKSAYI RQHRIDTNWR RGELKSPKVL KGHDDHVITC 310 320 330 340 350 360 LQFCGNRIVS GSDDNTLKVW SAVTGKCLRT LVGHTGGVWS SQMRDNIIIS GSTDRTLKVW 370 380 390 400 410 420 NAETGECIHT LYGHTSTVRC MHLHEKRVVS GSRDATLRVW DIETGQCLHV LMGHVAAVRC 430 440 450 460 470 480 VQYDGRRVVS GAYDFMVKVW DPETETCLHT LQGHTNRVYS LQFDGIHVVS GSLDTSIRVW 490 500 510 520 530 540 DVETGNCIHT LTGHQSLTSG MELKDNILVS GNADSTVKIW DIKTGQCLQT LQGPNKHQSA 550 560 570 580 590 600 VTCLQFNKNF VITSSDDGTV KLWDLKTGEF IRNLVTLESG GSGGVVWRIR ASNTKLVCAV 610 620 GSRNGTEETK LLVLDFDVDM K
	Isoform 4 (Archipelago gamma) (FBW7gamma) (Hippocampal) [UniParc]. Checksum: 2AFB6E8A36E6E8DE	FASTA	589	66,120
	10 20 30 40 50 60 MSKPGKPTLN HGLVPVDLKS AKEPLPHQTV MKIFSISIIA QGLPFCRRRM KRKLDHGSEV 70 80 90 100 110 120 RSFSLGKKPC KVSEYTSTTG LVPCSATPTT FGDLRAANGQ GQQRRRITSV QPPTGLQEWL 130 140 150 160 170 180 KMFQSWSGPE KLLALDELID SCEPTQVKHM MQVIEPQFQR DFISLLPKEL ALYVLSFLEP 190 200 210 220 230 240 KDLLQAAQTC RYWRILAEDN LLWREKCKEE GIDEPLHIKR RKVIKPGFIH SPWKSAYIRQ 250 260 270 280 290 300 HRIDTNWRRG ELKSPKVLKG HDDHVITCLQ FCGNRIVSGS DDNTLKVWSA VTGKCLRTLV 310 320 330 340 350 360 GHTGGVWSSQ MRDNIIISGS TDRTLKVWNA ETGECIHTLY GHTSTVRCMH LHEKRVVSGS 370 380 390 400 410 420 RDATLRVWDI ETGQCLHVLM GHVAAVRCVQ YDGRRVVSGA YDFMVKVWDP ETETCLHTLQ 430 440 450 460 470 480 GHTNRVYSLQ FDGIHVVSGS LDTSIRVWDV ETGNCIHTLT GHQSLTSGME LKDNILVSGN 490 500 510 520 530 540 ADSTVKIWDI KTGQCLQTLQ GPNKHQSAVT CLQFNKNFVI TSSDDGTVKL WDLKTGEFIR 550 560 570 580 NLVTLESGGS GGVVWRIRAS NTKLVCAVGS RNGTEETKLL VLDFDVDMK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of mammalian F-box proteins." Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W. Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
[2]	"Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines." Moberg K.H., Bell D.W., Wahrer D.C.R., Haber D.A., Hariharan I.K. Nature 413:311-316(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS CYS-465 AND LEU-505.
[3]	"Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line." Strohmaier H., Spruck C.H., Kaiser P., Won K.-A., Sangfelt O., Reed S.I. Nature 413:316-322(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, IDENTIFICATION IN SCF COMPLEX, INTERACTION WITH CYCLIN E.
[4]	"SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production." Li J., Pauley A.M., Myers R.L., Shuang R., Brashler J.R., Yan R., Buhl A.E., Ruble C., Gurney M.E. J. Neurochem. 82:1540-1548(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, INTERACTION WITH PSEN1.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Placenta.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Salivary gland.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain.
[8]	"SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation." Wu G., Lyapina S., Das I., Li J., Gurney M., Pauley A., Chui I., Deshaies R.J., Kitajewski J. Mol. Cell. Biol. 21:7403-7415(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH NOTCH1; NOTCH4 AND SKP1.
[9]	"Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7." Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., Ishida N., Okumura F., Nakayama K., Nakayama K.I. EMBO J. 23:2116-2125(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, COMPONENT OF THE SCF(FBXW7) COMPLEX, INTERACTION WITH MYC.
[10]	"The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4." Welcker M., Clurman B.E. J. Biol. Chem. 280:7654-7658(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SV40 LARGE T ANTIGEN.
[11]	"Fbw7 and Usp28 regulate myc protein stability in response to DNA damage." Popov N., Herold S., Llamazares M., Schulein C., Eilers M. Cell Cycle 6:2327-2331(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MYC AND USP28.
[12]	"The ubiquitin-specific protease USP28 is required for MYC stability." Popov N., Wanzel M., Madiredjo M., Zhang D., Beijersbergen R., Bernards R., Moll R., Elledge S.J., Eilers M. Nat. Cell Biol. 9:765-774(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MYC AND USP28, SUBCELLULAR LOCATION.
[13]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[14]	"Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase." Mo J.S., Ann E.J., Yoon J.H., Jung J., Choi Y.H., Kim H.Y., Ahn J.S., Kim S.M., Kim M.Y., Hong J.A., Seo M.S., Lang F., Choi E.J., Park H.S. J. Cell Sci. 124:100-112(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-227 BY SGK1, INTERACTION WITH SGK1 AND NOTCH1.
[15]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-465; LEU-505 AND LEU-582.
[16]	"Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas." Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L. Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LYS-117.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY033553 mRNA. Translation: AAK57547.1.
AF383178 mRNA. Translation: AAK60269.1.
AY008274 mRNA. Translation: AAG16640.1.
AF411971 mRNA. Translation: AAL06290.1.
AF411972 mRNA. Translation: AAL06291.1.
AY049984 mRNA. Translation: AAL07271.1.
AK001933 mRNA. Translation: BAA91986.1. Different initiation.
CR749305 mRNA. Translation: CAH18160.1.
BC037320 mRNA. Translation: AAH37320.1.
BC117244 mRNA. Translation: AAI17245.1.
BC117246 mRNA. Translation: AAI17247.1.
BC143944 mRNA. Translation: AAI43945.1.

IPI

IPI00056349.
IPI00059165.
IPI00075075.
IPI00402151.

RefSeq

NP_001013433.1. NM_001013415.1.
NP_060785.2. NM_018315.4.
NP_361014.1. NM_033632.3.

UniGene

Hs.561245.
Hs.717081.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OVP	X-ray	2.90	B	263-707	[»]
2OVQ	X-ray	2.60	B	263-707	[»]
2OVR	X-ray	2.50	B	263-707	[»]

ProteinModelPortal

Q969H0.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-27613N.

IntAct

Q969H0. 14 interactions.

MINT

MINT-276696.

STRING

9606.ENSP00000281708.

PTM databases

PhosphoSite

Q969H0.

Polymorphism databases

DMDM

44887885.

Proteomic databases

PaxDb

Q969H0.

PRIDE

Q969H0.

Protocols and materials databases

DNASU

55294.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000263981; ENSP00000263981; ENSG00000109670.
ENST00000281708; ENSP00000281708; ENSG00000109670.
ENST00000296555; ENSP00000296555; ENSG00000109670.

GeneID

55294.

KEGG

hsa:55294.

UCSC

uc003imq.3. human.
uc003imr.3. human.
uc003ims.3. human.

Organism-specific databases

CTD

55294.

GeneCards

GC04M153242.

HGNC

HGNC:16712. FBXW7.

HPA

CAB013793.
CAB029987.

MIM

606278. gene.

neXtProt

NX_Q969H0.

PharmGKB

PA28054.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG2319.

HOVERGEN

HBG051596.

InParanoid

Q969H0.

KO

K10260.

OMA

EECLHTL.

OrthoDB

EOG4MKNFW.

PhylomeDB

Q969H0.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.
REACT_17015. Metabolism of proteins.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

Q969H0.

Bgee

Q969H0.

CleanEx

HS_FBXW7.

Genevestigator

Q969H0.

GermOnline

ENSG00000109670. Homo sapiens.

Family and domain databases

Gene3D

2.130.10.10. 3 hits.

InterPro

IPR001810. F-box_dom_cyclin-like.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]

Pfam

PF00400. WD40. 7 hits.
[Graphical view]

PRINTS

PR00320. GPROTEINBRPT.

SMART

SM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]

SUPFAM

SSF81383. F-box_dom_Skp2-like. 1 hit.
SSF50978. WD40_like. 1 hit.

PROSITE

PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q969H0.

GenomeRNAi

55294.

NextBio

59488.

SOURCE

Search...

Entry information

Entry name

FBXW7_HUMAN

Accession

Primary (citable) accession number: Q969H0
Secondary accession number(s): B7ZLP9 , Q68DR0, Q96A16, Q96LE0, Q96RI2, Q9NUX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.