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Q969H0 (FBXW7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/WD repeat-containing protein 7
Alternative name(s):
Archipelago homolog
Short name=hAgo
F-box and WD-40 domain-containing protein 7
F-box protein FBX30
SEL-10
hCdc4
Gene names
Name:FBXW7
Synonyms:FBW7, FBX30, SEL10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Ref.3 Ref.8 Ref.9 Ref.11 Ref.12

Subunit structure

Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1. Interacts with MYC (when phosphorylated). Isoform 1 interacts with USP28, leading to counteract ubiquitination of MYC. Isoform 4 interacts (via WD repeats) with SV40 large T antigen (via CPD region). Forms a trimeric complex with NOTCH1 and SGK1. Ref.3 Ref.4 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.14

Subcellular location

Isoform 1: Nucleusnucleoplasm Ref.12.

Isoform 2: Cytoplasm Ref.12.

Isoform 4: Nucleusnucleolus Ref.12.

Nucleus By similarity Ref.12.

Tissue specificity

Isoform 1 is widely expressed. Isoform 4 is expressed in brain. Ref.4

Sequence similarities

Contains 1 F-box domain.

Contains 7 WD repeats.

Sequence caution

The sequence BAA91986.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processHost-virus interaction
Ubl conjugation pathway
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
WD repeat
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNotch signaling pathway

Traceable author statement. Source: Reactome

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Inferred from direct assay Ref.9. Source: UniProtKB

cellular response to DNA damage stimulus

Inferred from direct assay Ref.11. Source: UniProtKB

cellular response to UV

Inferred from direct assay Ref.11. Source: UniProtKB

lipid homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

lung development

Inferred from electronic annotation. Source: Ensembl

negative regulation of DNA endoreduplication

Inferred from mutant phenotype PubMed 15917200. Source: BHF-UCL

negative regulation of Notch signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of SREBP signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of hepatocyte proliferation

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of triglyceride biosynthetic process

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of ERK1 and ERK2 cascade

Inferred from mutant phenotype PubMed 20208556. Source: BHF-UCL

positive regulation of epidermal growth factor-activated receptor activity

Inferred from direct assay PubMed 20208556. Source: BHF-UCL

positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Inferred from direct assay PubMed 20208556. Source: BHF-UCL

protein stabilization

Inferred from direct assay PubMed 20208556. Source: BHF-UCL

protein ubiquitination

Inferred from direct assay Ref.9. Source: UniProtKB

regulation of lipid storage

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of protein localization

Inferred from sequence or structural similarity. Source: BHF-UCL

sister chromatid cohesion

Inferred from mutant phenotype PubMed 15917200. Source: BHF-UCL

vasculature development

Traceable author statement PubMed 21123947. Source: BHF-UCL

vasculogenesis

Inferred from electronic annotation. Source: Ensembl

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

SCF ubiquitin ligase complex

Inferred from direct assay Ref.9. Source: UniProtKB

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

nucleolus

Inferred from direct assay Ref.12. Source: UniProtKB

nucleoplasm

Inferred from direct assay Ref.12. Source: UniProtKB

nucleus

Inferred from direct assay. Source: HPA

protein complex

Inferred from direct assay Ref.11. Source: UniProtKB

   Molecular_functionidentical protein binding

Inferred from physical interaction PubMed 21620836PubMed 23791182. Source: IntAct

protein binding

Inferred from physical interaction PubMed 23082202. Source: IntAct

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q969H0-1)

Also known as: Archipelago alpha; FBW7alpha; 110K; common;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q969H0-2)

Also known as: Archipelago beta; FBW7beta; 69K;

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     81-166: NNRFISVDED...LSSPFYTKTT → MCVPRSGLIL...FYGTLKMIFY
Isoform 3 (identifier: Q969H0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: MNQELLSVGS...LSSPFYTKTT → VLILSCICLY...FYGTLKMIFY
Note: Incomplete sequence.
Isoform 4 (identifier: Q969H0-4)

Also known as: Archipelago gamma; FBW7gamma; Hippocampal;

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     119-167: DQESDDFDQS...SSPFYTKTTK → MSKPGKPTLN...AQGLPFCRRR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 707707F-box/WD repeat-containing protein 7
PRO_0000050994

Regions

Domain278 – 32447F-box
Repeat378 – 41841WD 1
Repeat420 – 45637WD 2
Repeat459 – 49840WD 3
Repeat500 – 53637WD 4
Repeat539 – 57840WD 5
Repeat580 – 61839WD 6
Repeat622 – 65938WD 7

Amino acid modifications

Modified residue2271Phosphoserine; by SGK1 Ref.14

Natural variations

Alternative sequence1 – 166166MNQEL…YTKTT → VLILSCICLYCGVLLPVLLP NLPFLTCLSMSTLESVTYLP EKGLYCQRLPSSRTHGGTES LKGKNTENMGFYGTLKMIFY in isoform 3.
VSP_009481
Alternative sequence1 – 118118Missing in isoform 4.
VSP_009482
Alternative sequence1 – 8080Missing in isoform 2.
VSP_009483
Alternative sequence81 – 16686NNRFI…YTKTT → MCVPRSGLILSCICLYCGVL LPVLLPNLPFLTCLSMSTLE SVTYLPEKGLYCQRLPSSRT HGGTESLKGKNTENMGFYGT LKMIFY in isoform 2.
VSP_009484
Alternative sequence119 – 16749DQESD…TKTTK → MSKPGKPTLNHGLVPVDLKS AKEPLPHQTVMKIFSISIIA QGLPFCRRR in isoform 4.
VSP_009485
Natural variant1151E → K.
Corresponds to variant rs6816935 [ dbSNP | Ensembl ].
VAR_017812
Natural variant1171E → K in a breast cancer sample; somatic mutation. Ref.16
VAR_033030
Natural variant1331R → G.
Corresponds to variant rs6842544 [ dbSNP | Ensembl ].
VAR_017813
Natural variant1441T → R.
Corresponds to variant rs7660281 [ dbSNP | Ensembl ].
VAR_017814
Natural variant4651R → C in a acute lymphoblastic leukemia cell line. Ref.2
VAR_017815
Natural variant4651R → H in a colorectal cancer sample; somatic mutation. Ref.15
VAR_035880
Natural variant5051R → L in an ovarian cancer cell line. Ref.2 Ref.15
VAR_017816
Natural variant5821S → L in a colorectal cancer sample; somatic mutation. Ref.15
VAR_035881
Natural variant6681S → G.
Corresponds to variant rs7679116 [ dbSNP | Ensembl ].
VAR_017817

Experimental info

Sequence conflict3441P → L in AAH37320. Ref.7
Sequence conflict3771K → N in AAH37320. Ref.7
Sequence conflict5081Q → R in AAH37320. Ref.7

Secondary structure

......................................................................................... 707
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Archipelago alpha) (FBW7alpha) (110K) (common) [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E4A357F76DFD8203

FASTA70779,663
        10         20         30         40         50         60 
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV 

        70         80         90        100        110        120 
GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ 

       130        140        150        160        170        180 
ESDDFDQSDD SSREDEHTHT NSVTNSSSIV DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS 

       190        200        210        220        230        240 
FSLGKKPCKV SEYTSTTGLV PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM 

       250        260        270        280        290        300 
FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD 

       310        320        330        340        350        360 
LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR 

       370        380        390        400        410        420 
IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH 

       430        440        450        460        470        480 
TGGVWSSQMR DNIIISGSTD RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD 

       490        500        510        520        530        540 
ATLRVWDIET GQCLHVLMGH VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH 

       550        560        570        580        590        600 
TNRVYSLQFD GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD 

       610        620        630        640        650        660 
STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL 

       670        680        690        700 
VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL DFDVDMK 

« Hide

Isoform 2 (Archipelago beta) (FBW7beta) (69K) [UniParc].

Checksum: 3D4107C053381BED
Show »

FASTA62770,324
Isoform 3 [UniParc].

Checksum: 0D1FB546A715CFC5
Show »

FASTA62169,692
Isoform 4 (Archipelago gamma) (FBW7gamma) (Hippocampal) [UniParc].

Checksum: 2AFB6E8A36E6E8DE
Show »

FASTA58966,120

References

« Hide 'large scale' references
[1]"A family of mammalian F-box proteins."
Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.
Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
[2]"Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines."
Moberg K.H., Bell D.W., Wahrer D.C.R., Haber D.A., Hariharan I.K.
Nature 413:311-316(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS CYS-465 AND LEU-505.
[3]"Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line."
Strohmaier H., Spruck C.H., Kaiser P., Won K.-A., Sangfelt O., Reed S.I.
Nature 413:316-322(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, IDENTIFICATION IN SCF COMPLEX, INTERACTION WITH CYCLIN E.
[4]"SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production."
Li J., Pauley A.M., Myers R.L., Shuang R., Brashler J.R., Yan R., Buhl A.E., Ruble C., Gurney M.E.
J. Neurochem. 82:1540-1548(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, INTERACTION WITH PSEN1.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Placenta.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Salivary gland.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain.
[8]"SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation."
Wu G., Lyapina S., Das I., Li J., Gurney M., Pauley A., Chui I., Deshaies R.J., Kitajewski J.
Mol. Cell. Biol. 21:7403-7415(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NOTCH1; NOTCH4 AND SKP1.
[9]"Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7."
Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., Ishida N., Okumura F., Nakayama K., Nakayama K.I.
EMBO J. 23:2116-2125(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, COMPONENT OF THE SCF(FBXW7) COMPLEX, INTERACTION WITH MYC.
[10]"The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4."
Welcker M., Clurman B.E.
J. Biol. Chem. 280:7654-7658(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SV40 LARGE T ANTIGEN.
[11]"Fbw7 and Usp28 regulate myc protein stability in response to DNA damage."
Popov N., Herold S., Llamazares M., Schulein C., Eilers M.
Cell Cycle 6:2327-2331(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MYC AND USP28.
[12]"The ubiquitin-specific protease USP28 is required for MYC stability."
Popov N., Wanzel M., Madiredjo M., Zhang D., Beijersbergen R., Bernards R., Moll R., Elledge S.J., Eilers M.
Nat. Cell Biol. 9:765-774(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MYC AND USP28, SUBCELLULAR LOCATION.
[13]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[14]"Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase."
Mo J.S., Ann E.J., Yoon J.H., Jung J., Choi Y.H., Kim H.Y., Ahn J.S., Kim S.M., Kim M.Y., Hong J.A., Seo M.S., Lang F., Choi E.J., Park H.S.
J. Cell Sci. 124:100-112(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-227 BY SGK1, INTERACTION WITH SGK1 AND NOTCH1.
[15]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-465; LEU-505 AND LEU-582.
[16]"Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.
Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LYS-117.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY033553 mRNA. Translation: AAK57547.1.
AF383178 mRNA. Translation: AAK60269.1.
AY008274 mRNA. Translation: AAG16640.1.
AF411971 mRNA. Translation: AAL06290.1.
AF411972 mRNA. Translation: AAL06291.1.
AY049984 mRNA. Translation: AAL07271.1.
AK001933 mRNA. Translation: BAA91986.1. Different initiation.
CR749305 mRNA. Translation: CAH18160.1.
BC037320 mRNA. Translation: AAH37320.1.
BC117244 mRNA. Translation: AAI17245.1.
BC117246 mRNA. Translation: AAI17247.1.
BC143944 mRNA. Translation: AAI43945.1.
CCDSCCDS34078.1. [Q969H0-4]
CCDS3777.1. [Q969H0-1]
CCDS3778.1. [Q969H0-2]
RefSeqNP_001013433.1. NM_001013415.1. [Q969H0-4]
NP_060785.2. NM_018315.4. [Q969H0-2]
NP_361014.1. NM_033632.3. [Q969H0-1]
UniGeneHs.561245.
Hs.717081.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2OVPX-ray2.90B263-707[»]
2OVQX-ray2.60B263-707[»]
2OVRX-ray2.50B263-707[»]
ProteinModelPortalQ969H0.
SMRQ969H0. Positions 263-706.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120581. 90 interactions.
DIPDIP-27613N.
IntActQ969H0. 17 interactions.
MINTMINT-276696.
STRING9606.ENSP00000281708.

PTM databases

PhosphoSiteQ969H0.

Polymorphism databases

DMDM44887885.

Proteomic databases

MaxQBQ969H0.
PaxDbQ969H0.
PRIDEQ969H0.

Protocols and materials databases

DNASU55294.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263981; ENSP00000263981; ENSG00000109670. [Q969H0-2]
ENST00000281708; ENSP00000281708; ENSG00000109670. [Q969H0-1]
ENST00000296555; ENSP00000296555; ENSG00000109670. [Q969H0-4]
ENST00000603548; ENSP00000474725; ENSG00000109670. [Q969H0-1]
ENST00000603841; ENSP00000474971; ENSG00000109670. [Q969H0-1]
GeneID55294.
KEGGhsa:55294.
UCSCuc003imq.3. human. [Q969H0-2]
uc003imr.3. human. [Q969H0-4]
uc003ims.3. human. [Q969H0-1]

Organism-specific databases

CTD55294.
GeneCardsGC04M153242.
HGNCHGNC:16712. FBXW7.
HPACAB013793.
CAB029987.
HPA045958.
MIM606278. gene.
neXtProtNX_Q969H0.
PharmGKBPA28054.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOVERGENHBG051596.
InParanoidQ969H0.
KOK10260.
OMADTSYSRQ.
OrthoDBEOG7VX8VF.
PhylomeDBQ969H0.
TreeFamTF101074.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_6900. Immune System.
SignaLinkQ969H0.

Gene expression databases

ArrayExpressQ969H0.
BgeeQ969H0.
CleanExHS_FBXW7.
GenevestigatorQ969H0.

Family and domain databases

Gene3D2.130.10.10. 3 hits.
InterProIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ969H0.
GeneWikiFBXW7.
GenomeRNAi55294.
NextBio59488.
PROQ969H0.
SOURCESearch...

Entry information

Entry nameFBXW7_HUMAN
AccessionPrimary (citable) accession number: Q969H0
Secondary accession number(s): B7ZLP9 expand/collapse secondary AC list , Q68DR0, Q96A16, Q96LE0, Q96RI2, Q9NUX6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM