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Q969H0

- FBXW7_HUMAN

UniProt

Q969H0 - FBXW7_HUMAN

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Protein
F-box/WD repeat-containing protein 7
Gene
FBXW7, FBW7, FBX30, SEL10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.5 Publications

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. protein binding Source: IntAct
  3. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. Notch signaling pathway Source: Reactome
  2. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  3. cellular response to DNA damage stimulus Source: UniProtKB
  4. cellular response to UV Source: UniProtKB
  5. lipid homeostasis Source: BHF-UCL
  6. lung development Source: Ensembl
  7. negative regulation of DNA endoreduplication Source: BHF-UCL
  8. negative regulation of Notch signaling pathway Source: BHF-UCL
  9. negative regulation of SREBP signaling pathway Source: BHF-UCL
  10. negative regulation of hepatocyte proliferation Source: BHF-UCL
  11. negative regulation of triglyceride biosynthetic process Source: BHF-UCL
  12. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  13. positive regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
  14. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: BHF-UCL
  15. protein stabilization Source: BHF-UCL
  16. protein ubiquitination Source: UniProtKB
  17. regulation of lipid storage Source: BHF-UCL
  18. regulation of protein localization Source: BHF-UCL
  19. sister chromatid cohesion Source: BHF-UCL
  20. vasculature development Source: BHF-UCL
  21. vasculogenesis Source: Ensembl
  22. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_160305. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.
REACT_16907. Association of TriC/CCT with target proteins during biosynthesis.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ969H0.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 7
Alternative name(s):
Archipelago homolog
Short name:
hAgo
F-box and WD-40 domain-containing protein 7
F-box protein FBX30
SEL-10
hCdc4
Gene namesi
Name:FBXW7
Synonyms:FBW7, FBX30, SEL10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:16712. FBXW7.

Subcellular locationi

Isoform 1 : Nucleusnucleoplasm 1 Publication
Isoform 2 : Cytoplasm 1 Publication
Isoform 4 : Nucleusnucleolus 1 Publication
Nucleus By similarity 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. SCF ubiquitin ligase complex Source: UniProtKB
  3. endoplasmic reticulum Source: Ensembl
  4. nucleolus Source: UniProtKB
  5. nucleoplasm Source: UniProtKB
  6. nucleus Source: HPA
  7. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707F-box/WD repeat-containing protein 7
PRO_0000050994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271Phosphoserine; by SGK11 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ969H0.
PaxDbiQ969H0.
PRIDEiQ969H0.

PTM databases

PhosphoSiteiQ969H0.

Expressioni

Tissue specificityi

Isoform 1 is widely expressed. Isoform 4 is expressed in brain.1 Publication

Gene expression databases

ArrayExpressiQ969H0.
BgeeiQ969H0.
CleanExiHS_FBXW7.
GenevestigatoriQ969H0.

Organism-specific databases

HPAiCAB013793.
CAB029987.
HPA045958.

Interactioni

Subunit structurei

Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1. Interacts with MYC (when phosphorylated). Isoform 1 interacts with USP28, leading to counteract ubiquitination of MYC. Isoform 4 interacts (via WD repeats) with SV40 large T antigen (via CPD region). Forms a trimeric complex with NOTCH1 and SGK1.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-359574,EBI-359574
CCDC6Q162049EBI-359574,EBI-1045350
CDK2P249412EBI-6502391,EBI-375096
MYCP011064EBI-359574,EBI-447544
SKP1P632085EBI-359574,EBI-307486
STOML1Q9UBI43EBI-6502391,EBI-2681162

Protein-protein interaction databases

BioGridi120581. 92 interactions.
DIPiDIP-27613N.
IntActiQ969H0. 17 interactions.
MINTiMINT-276696.
STRINGi9606.ENSP00000281708.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi265 – 2728
Turni280 – 2823
Helixi286 – 2938
Helixi298 – 3047
Helixi309 – 3157
Helixi319 – 3257
Turni326 – 3294
Helixi350 – 36718
Beta strandi374 – 3774
Beta strandi384 – 3907
Beta strandi393 – 3986
Beta strandi403 – 4075
Turni408 – 4103
Beta strandi413 – 4164
Beta strandi424 – 4307
Beta strandi433 – 4386
Beta strandi443 – 4475
Turni448 – 4514
Beta strandi452 – 4576
Beta strandi464 – 4707
Beta strandi473 – 4786
Beta strandi481 – 49010
Beta strandi493 – 4986
Beta strandi504 – 5096
Beta strandi514 – 5185
Beta strandi523 – 5275
Helixi528 – 5303
Beta strandi532 – 5376
Beta strandi544 – 5496
Beta strandi551 – 5588
Beta strandi563 – 5675
Turni568 – 5703
Beta strandi573 – 5775
Beta strandi584 – 5907
Beta strandi593 – 5986
Beta strandi603 – 6075
Turni608 – 6103
Beta strandi613 – 6175
Beta strandi627 – 6326
Beta strandi634 – 6418
Beta strandi644 – 6507
Turni651 – 6533
Beta strandi656 – 6627
Helixi666 – 6683
Beta strandi671 – 6777
Beta strandi679 – 6879
Beta strandi689 – 6935
Beta strandi696 – 7016

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OVPX-ray2.90B263-707[»]
2OVQX-ray2.60B263-707[»]
2OVRX-ray2.50B263-707[»]
ProteinModelPortaliQ969H0.
SMRiQ969H0. Positions 263-706.

Miscellaneous databases

EvolutionaryTraceiQ969H0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini278 – 32447F-box
Add
BLAST
Repeati378 – 41841WD 1
Add
BLAST
Repeati420 – 45637WD 2
Add
BLAST
Repeati459 – 49840WD 3
Add
BLAST
Repeati500 – 53637WD 4
Add
BLAST
Repeati539 – 57840WD 5
Add
BLAST
Repeati580 – 61839WD 6
Add
BLAST
Repeati622 – 65938WD 7
Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.
Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOVERGENiHBG051596.
InParanoidiQ969H0.
KOiK10260.
OMAiDTSYSRQ.
OrthoDBiEOG7VX8VF.
PhylomeDBiQ969H0.
TreeFamiTF101074.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q969H0-1) [UniParc]FASTAAdd to Basket

Also known as: Archipelago alpha, FBW7alpha, 110K, common

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE    50
EHTARNGEVV GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE 100
DEEHAGEQDE EDEEEEEMDQ ESDDFDQSDD SSREDEHTHT NSVTNSSSIV 150
DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV 200
PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL 250
LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD 300
LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP 350
WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD 400
NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD RTLKVWNAET 450
GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH 500
VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD 550
GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD 600
STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD 650
LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL 700
DFDVDMK 707
Length:707
Mass (Da):79,663
Last modified:December 1, 2001 - v1
Checksum:iE4A357F76DFD8203
GO
Isoform 2 (identifier: Q969H0-2) [UniParc]FASTAAdd to Basket

Also known as: Archipelago beta, FBW7beta, 69K

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     81-166: NNRFISVDED...LSSPFYTKTT → MCVPRSGLIL...FYGTLKMIFY

Show »
Length:627
Mass (Da):70,324
Checksum:i3D4107C053381BED
GO
Isoform 3 (identifier: Q969H0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: MNQELLSVGS...LSSPFYTKTT → VLILSCICLY...FYGTLKMIFY

Note: Incomplete sequence.

Show »
Length:621
Mass (Da):69,692
Checksum:i0D1FB546A715CFC5
GO
Isoform 4 (identifier: Q969H0-4) [UniParc]FASTAAdd to Basket

Also known as: Archipelago gamma, FBW7gamma, Hippocampal

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     119-167: DQESDDFDQS...SSPFYTKTTK → MSKPGKPTLN...AQGLPFCRRR

Show »
Length:589
Mass (Da):66,120
Checksum:i2AFB6E8A36E6E8DE
GO

Sequence cautioni

The sequence BAA91986.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151E → K.
Corresponds to variant rs6816935 [ dbSNP | Ensembl ].
VAR_017812
Natural varianti117 – 1171E → K in a breast cancer sample; somatic mutation. 1 Publication
VAR_033030
Natural varianti133 – 1331R → G.
Corresponds to variant rs6842544 [ dbSNP | Ensembl ].
VAR_017813
Natural varianti144 – 1441T → R.
Corresponds to variant rs7660281 [ dbSNP | Ensembl ].
VAR_017814
Natural varianti465 – 4651R → C in a acute lymphoblastic leukemia cell line. 1 Publication
VAR_017815
Natural varianti465 – 4651R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035880
Natural varianti505 – 5051R → L in an ovarian cancer cell line. 2 Publications
VAR_017816
Natural varianti582 – 5821S → L in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035881
Natural varianti668 – 6681S → G.
Corresponds to variant rs7679116 [ dbSNP | Ensembl ].
VAR_017817

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 166166MNQEL…YTKTT → VLILSCICLYCGVLLPVLLP NLPFLTCLSMSTLESVTYLP EKGLYCQRLPSSRTHGGTES LKGKNTENMGFYGTLKMIFY in isoform 3.
VSP_009481Add
BLAST
Alternative sequencei1 – 118118Missing in isoform 4.
VSP_009482Add
BLAST
Alternative sequencei1 – 8080Missing in isoform 2.
VSP_009483Add
BLAST
Alternative sequencei81 – 16686NNRFI…YTKTT → MCVPRSGLILSCICLYCGVL LPVLLPNLPFLTCLSMSTLE SVTYLPEKGLYCQRLPSSRT HGGTESLKGKNTENMGFYGT LKMIFY in isoform 2.
VSP_009484Add
BLAST
Alternative sequencei119 – 16749DQESD…TKTTK → MSKPGKPTLNHGLVPVDLKS AKEPLPHQTVMKIFSISIIA QGLPFCRRR in isoform 4.
VSP_009485Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti344 – 3441P → L in AAH37320. 1 Publication
Sequence conflicti377 – 3771K → N in AAH37320. 1 Publication
Sequence conflicti508 – 5081Q → R in AAH37320. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY033553 mRNA. Translation: AAK57547.1.
AF383178 mRNA. Translation: AAK60269.1.
AY008274 mRNA. Translation: AAG16640.1.
AF411971 mRNA. Translation: AAL06290.1.
AF411972 mRNA. Translation: AAL06291.1.
AY049984 mRNA. Translation: AAL07271.1.
AK001933 mRNA. Translation: BAA91986.1. Different initiation.
CR749305 mRNA. Translation: CAH18160.1.
BC037320 mRNA. Translation: AAH37320.1.
BC117244 mRNA. Translation: AAI17245.1.
BC117246 mRNA. Translation: AAI17247.1.
BC143944 mRNA. Translation: AAI43945.1.
CCDSiCCDS34078.1. [Q969H0-4]
CCDS3777.1. [Q969H0-1]
CCDS3778.1. [Q969H0-2]
RefSeqiNP_001013433.1. NM_001013415.1. [Q969H0-4]
NP_060785.2. NM_018315.4. [Q969H0-2]
NP_361014.1. NM_033632.3. [Q969H0-1]
UniGeneiHs.561245.
Hs.717081.

Genome annotation databases

EnsembliENST00000263981; ENSP00000263981; ENSG00000109670. [Q969H0-2]
ENST00000281708; ENSP00000281708; ENSG00000109670. [Q969H0-1]
ENST00000296555; ENSP00000296555; ENSG00000109670. [Q969H0-4]
ENST00000603548; ENSP00000474725; ENSG00000109670. [Q969H0-1]
ENST00000603841; ENSP00000474971; ENSG00000109670. [Q969H0-1]
GeneIDi55294.
KEGGihsa:55294.
UCSCiuc003imq.3. human. [Q969H0-2]
uc003imr.3. human. [Q969H0-4]
uc003ims.3. human. [Q969H0-1]

Polymorphism databases

DMDMi44887885.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY033553 mRNA. Translation: AAK57547.1 .
AF383178 mRNA. Translation: AAK60269.1 .
AY008274 mRNA. Translation: AAG16640.1 .
AF411971 mRNA. Translation: AAL06290.1 .
AF411972 mRNA. Translation: AAL06291.1 .
AY049984 mRNA. Translation: AAL07271.1 .
AK001933 mRNA. Translation: BAA91986.1 . Different initiation.
CR749305 mRNA. Translation: CAH18160.1 .
BC037320 mRNA. Translation: AAH37320.1 .
BC117244 mRNA. Translation: AAI17245.1 .
BC117246 mRNA. Translation: AAI17247.1 .
BC143944 mRNA. Translation: AAI43945.1 .
CCDSi CCDS34078.1. [Q969H0-4 ]
CCDS3777.1. [Q969H0-1 ]
CCDS3778.1. [Q969H0-2 ]
RefSeqi NP_001013433.1. NM_001013415.1. [Q969H0-4 ]
NP_060785.2. NM_018315.4. [Q969H0-2 ]
NP_361014.1. NM_033632.3. [Q969H0-1 ]
UniGenei Hs.561245.
Hs.717081.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OVP X-ray 2.90 B 263-707 [» ]
2OVQ X-ray 2.60 B 263-707 [» ]
2OVR X-ray 2.50 B 263-707 [» ]
ProteinModelPortali Q969H0.
SMRi Q969H0. Positions 263-706.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120581. 92 interactions.
DIPi DIP-27613N.
IntActi Q969H0. 17 interactions.
MINTi MINT-276696.
STRINGi 9606.ENSP00000281708.

PTM databases

PhosphoSitei Q969H0.

Polymorphism databases

DMDMi 44887885.

Proteomic databases

MaxQBi Q969H0.
PaxDbi Q969H0.
PRIDEi Q969H0.

Protocols and materials databases

DNASUi 55294.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263981 ; ENSP00000263981 ; ENSG00000109670 . [Q969H0-2 ]
ENST00000281708 ; ENSP00000281708 ; ENSG00000109670 . [Q969H0-1 ]
ENST00000296555 ; ENSP00000296555 ; ENSG00000109670 . [Q969H0-4 ]
ENST00000603548 ; ENSP00000474725 ; ENSG00000109670 . [Q969H0-1 ]
ENST00000603841 ; ENSP00000474971 ; ENSG00000109670 . [Q969H0-1 ]
GeneIDi 55294.
KEGGi hsa:55294.
UCSCi uc003imq.3. human. [Q969H0-2 ]
uc003imr.3. human. [Q969H0-4 ]
uc003ims.3. human. [Q969H0-1 ]

Organism-specific databases

CTDi 55294.
GeneCardsi GC04M153242.
HGNCi HGNC:16712. FBXW7.
HPAi CAB013793.
CAB029987.
HPA045958.
MIMi 606278. gene.
neXtProti NX_Q969H0.
PharmGKBi PA28054.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOVERGENi HBG051596.
InParanoidi Q969H0.
KOi K10260.
OMAi DTSYSRQ.
OrthoDBi EOG7VX8VF.
PhylomeDBi Q969H0.
TreeFami TF101074.

Enzyme and pathway databases

Reactomei REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_160305. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.
REACT_16907. Association of TriC/CCT with target proteins during biosynthesis.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinki Q969H0.

Miscellaneous databases

EvolutionaryTracei Q969H0.
GeneWikii FBXW7.
GenomeRNAii 55294.
NextBioi 59488.
PROi Q969H0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q969H0.
Bgeei Q969H0.
CleanExi HS_FBXW7.
Genevestigatori Q969H0.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
  2. "Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines."
    Moberg K.H., Bell D.W., Wahrer D.C.R., Haber D.A., Hariharan I.K.
    Nature 413:311-316(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS CYS-465 AND LEU-505.
  3. "Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line."
    Strohmaier H., Spruck C.H., Kaiser P., Won K.-A., Sangfelt O., Reed S.I.
    Nature 413:316-322(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, IDENTIFICATION IN SCF COMPLEX, INTERACTION WITH CYCLIN E.
  4. "SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production."
    Li J., Pauley A.M., Myers R.L., Shuang R., Brashler J.R., Yan R., Buhl A.E., Ruble C., Gurney M.E.
    J. Neurochem. 82:1540-1548(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, INTERACTION WITH PSEN1.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Salivary gland.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.
  8. "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation."
    Wu G., Lyapina S., Das I., Li J., Gurney M., Pauley A., Chui I., Deshaies R.J., Kitajewski J.
    Mol. Cell. Biol. 21:7403-7415(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NOTCH1; NOTCH4 AND SKP1.
  9. "Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7."
    Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., Ishida N., Okumura F., Nakayama K., Nakayama K.I.
    EMBO J. 23:2116-2125(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COMPONENT OF THE SCF(FBXW7) COMPLEX, INTERACTION WITH MYC.
  10. "The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4."
    Welcker M., Clurman B.E.
    J. Biol. Chem. 280:7654-7658(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SV40 LARGE T ANTIGEN.
  11. "Fbw7 and Usp28 regulate myc protein stability in response to DNA damage."
    Popov N., Herold S., Llamazares M., Schulein C., Eilers M.
    Cell Cycle 6:2327-2331(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MYC AND USP28.
  12. Cited for: FUNCTION, INTERACTION WITH MYC AND USP28, SUBCELLULAR LOCATION.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  14. "Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase."
    Mo J.S., Ann E.J., Yoon J.H., Jung J., Choi Y.H., Kim H.Y., Ahn J.S., Kim S.M., Kim M.Y., Hong J.A., Seo M.S., Lang F., Choi E.J., Park H.S.
    J. Cell Sci. 124:100-112(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-227 BY SGK1, INTERACTION WITH SGK1 AND NOTCH1.
  15. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-465; LEU-505 AND LEU-582.
  16. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
    Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.
    Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LYS-117.

Entry informationi

Entry nameiFBXW7_HUMAN
AccessioniPrimary (citable) accession number: Q969H0
Secondary accession number(s): B7ZLP9
, Q68DR0, Q96A16, Q96LE0, Q96RI2, Q9NUX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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