SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q969G5

- PRDBP_HUMAN

UniProt

Q969G5 - PRDBP_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein kinase C delta-binding protein

Gene
PRKCDBP, SRBC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to have an immune potentiation function By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C delta-binding protein
Alternative name(s):
Cavin-3
Serum deprivation response factor-related gene product that binds to C-kinase
Short name:
hSRBC
Gene namesi
Name:PRKCDBP
Synonyms:SRBC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9400. PRKCDBP.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: MGI
  2. protein complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA33764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Protein kinase C delta-binding proteinPRO_0000331412Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651Phosphoserine3 Publications
Modified residuei166 – 1661Phosphoserine3 Publications

Post-translational modificationi

In vitro, phosphorylated by PRKCD.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ969G5.
PaxDbiQ969G5.
PeptideAtlasiQ969G5.
PRIDEiQ969G5.

PTM databases

PhosphoSiteiQ969G5.

Expressioni

Tissue specificityi

Strongly expressed in mammary and epithelial cells.1 Publication

Inductioni

Down-regulated in breast and lung cancer cell lines.1 Publication

Gene expression databases

ArrayExpressiQ969G5.
BgeeiQ969G5.
CleanExiHS_PRKCDBP.
GenevestigatoriQ969G5.

Organism-specific databases

HPAiHPA055136.

Interactioni

Subunit structurei

Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
EPS15L1Q9UBC22EBI-3893101,EBI-2556746

Protein-protein interaction databases

BioGridi125187. 25 interactions.
DIPiDIP-60484N.
IntActiQ969G5. 5 interactions.
STRINGi9606.ENSP00000307292.

Structurei

3D structure databases

ProteinModelPortaliQ969G5.

Family & Domainsi

Sequence similaritiesi

Belongs to the PTRF/SDPR family.

Phylogenomic databases

eggNOGiNOG43715.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiQ969G5.
OrthoDBiEOG7GTT5J.
PhylomeDBiQ969G5.
TreeFamiTF331031.

Family and domain databases

InterProiIPR026752. Cavin_fam.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969G5-1 [UniParc]FASTAAdd to Basket

« Hide

MRESALERGP VPEAPAGGPV HAVTVVTLLE KLASMLETLR ERQGGLARRQ    50
GGLAGSVRRI QSGLGALSRS HDTTSNTLAQ LLAKAERVSS HANAAQERAV 100
RRAAQVQRLE ANHGLLVARG KLHVLLFKEE GEVPASAFQK APEPLGPADQ 150
SELGPEQLEA EVGESSDEEP VESRAQRLRR TGLQKVQSLR RALSGRKGPA 200
APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT EEDPGRPGAA 250
EEALLQMESV A 261
Length:261
Mass (Da):27,701
Last modified:January 11, 2011 - v3
Checksum:iE806A01DA992C53B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81R → P.3 Publications
Corresponds to variant rs2682123 [ dbSNP | Ensembl ].
VAR_042851
Natural varianti104 – 1041A → T.
Corresponds to variant rs10839551 [ dbSNP | Ensembl ].
VAR_042852
Natural varianti158 – 1581L → P.
Corresponds to variant rs1051992 [ dbSNP | Ensembl ].
VAR_042853
Natural varianti255 – 2551L → F.
Corresponds to variant rs12294600 [ dbSNP | Ensembl ].
VAR_042854

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF339881 mRNA. Translation: AAK97572.1.
AF408198 Genomic DNA. Translation: AAK97528.1.
AC068733 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68733.1.
BC011585 mRNA. Translation: AAH11585.1.
CCDSiCCDS7762.1.
RefSeqiNP_659477.2. NM_145040.2.
UniGeneiHs.434044.

Genome annotation databases

EnsembliENST00000303927; ENSP00000307292; ENSG00000170955.
GeneIDi112464.
KEGGihsa:112464.
UCSCiuc001mcu.1. human.

Polymorphism databases

DMDMi317373527.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF339881 mRNA. Translation: AAK97572.1 .
AF408198 Genomic DNA. Translation: AAK97528.1 .
AC068733 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68733.1 .
BC011585 mRNA. Translation: AAH11585.1 .
CCDSi CCDS7762.1.
RefSeqi NP_659477.2. NM_145040.2.
UniGenei Hs.434044.

3D structure databases

ProteinModelPortali Q969G5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125187. 25 interactions.
DIPi DIP-60484N.
IntActi Q969G5. 5 interactions.
STRINGi 9606.ENSP00000307292.

PTM databases

PhosphoSitei Q969G5.

Polymorphism databases

DMDMi 317373527.

Proteomic databases

MaxQBi Q969G5.
PaxDbi Q969G5.
PeptideAtlasi Q969G5.
PRIDEi Q969G5.

Protocols and materials databases

DNASUi 112464.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303927 ; ENSP00000307292 ; ENSG00000170955 .
GeneIDi 112464.
KEGGi hsa:112464.
UCSCi uc001mcu.1. human.

Organism-specific databases

CTDi 112464.
GeneCardsi GC11M006340.
HGNCi HGNC:9400. PRKCDBP.
HPAi HPA055136.
neXtProti NX_Q969G5.
PharmGKBi PA33764.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43715.
HOGENOMi HOG000115686.
HOVERGENi HBG108288.
InParanoidi Q969G5.
OrthoDBi EOG7GTT5J.
PhylomeDBi Q969G5.
TreeFami TF331031.

Miscellaneous databases

ChiTaRSi PRKCDBP. human.
GenomeRNAii 112464.
NextBioi 78586.
PROi Q969G5.

Gene expression databases

ArrayExpressi Q969G5.
Bgeei Q969G5.
CleanExi HS_PRKCDBP.
Genevestigatori Q969G5.

Family and domain databases

InterProi IPR026752. Cavin_fam.
[Graphical view ]
PANTHERi PTHR15240. PTHR15240. 1 hit.
Pfami PF15237. PTRF_SDPR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers."
    Xu X.L., Wu L.C., Du F., Davis A., Peyton M., Tomizawa Y., Maitra A., Tomlinson G., Gazdar A.F., Weissman B.E., Bowcock A.M., Baer R., Minna J.D.
    Cancer Res. 61:7943-7949(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INDUCTION, TISSUE SPECIFICITY, VARIANT PRO-8.
    Tissue: Epithelium.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-8.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-8.
    Tissue: Skin.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPRDBP_HUMAN
AccessioniPrimary (citable) accession number: Q969G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi