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Q969G5 (PRDBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein kinase C delta-binding protein
Alternative name(s):
Cavin-3
Serum deprivation response factor-related gene product that binds to C-kinase
Short name=hSRBC
Gene names
Name:PRKCDBP
Synonyms:SRBC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to have an immune potentiation function By similarity.

Subunit structure

Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding By similarity.

Tissue specificity

Strongly expressed in mammary and epithelial cells. Ref.1

Induction

Down-regulated in breast and lung cancer cell lines. Ref.1

Post-translational modification

In vitro, phosphorylated by PRKCD.

Sequence similarities

Belongs to the PTRF/SDPR family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DiseaseTumor suppressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction PubMed 19262564. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EPS15L1Q9UBC22EBI-3893101,EBI-2556746

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Protein kinase C delta-binding protein
PRO_0000331412

Amino acid modifications

Modified residue1651Phosphoserine Ref.8 Ref.9 Ref.10
Modified residue1661Phosphoserine Ref.8 Ref.9 Ref.10

Natural variations

Natural variant81R → P. Ref.1 Ref.3 Ref.4
Corresponds to variant rs2682123 [ dbSNP | Ensembl ].
VAR_042851
Natural variant1041A → T.
Corresponds to variant rs10839551 [ dbSNP | Ensembl ].
VAR_042852
Natural variant1581L → P.
Corresponds to variant rs1051992 [ dbSNP | Ensembl ].
VAR_042853
Natural variant2551L → F.
Corresponds to variant rs12294600 [ dbSNP | Ensembl ].
VAR_042854

Sequences

Sequence LengthMass (Da)Tools
Q969G5 [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: E806A01DA992C53B

FASTA26127,701
        10         20         30         40         50         60 
MRESALERGP VPEAPAGGPV HAVTVVTLLE KLASMLETLR ERQGGLARRQ GGLAGSVRRI 

        70         80         90        100        110        120 
QSGLGALSRS HDTTSNTLAQ LLAKAERVSS HANAAQERAV RRAAQVQRLE ANHGLLVARG 

       130        140        150        160        170        180 
KLHVLLFKEE GEVPASAFQK APEPLGPADQ SELGPEQLEA EVGESSDEEP VESRAQRLRR 

       190        200        210        220        230        240 
TGLQKVQSLR RALSGRKGPA APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT 

       250        260 
EEDPGRPGAA EEALLQMESV A 

« Hide

References

« Hide 'large scale' references
[1]"Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers."
Xu X.L., Wu L.C., Du F., Davis A., Peyton M., Tomizawa Y., Maitra A., Tomlinson G., Gazdar A.F., Weissman B.E., Bowcock A.M., Baer R., Minna J.D.
Cancer Res. 61:7943-7949(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INDUCTION, TISSUE SPECIFICITY, VARIANT PRO-8.
Tissue: Epithelium.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-8.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-8.
Tissue: Skin.
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF339881 mRNA. Translation: AAK97572.1.
AF408198 Genomic DNA. Translation: AAK97528.1.
AC068733 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68733.1.
BC011585 mRNA. Translation: AAH11585.1.
CCDSCCDS7762.1.
RefSeqNP_659477.2. NM_145040.2.
UniGeneHs.434044.

3D structure databases

ProteinModelPortalQ969G5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125187. 25 interactions.
DIPDIP-60484N.
IntActQ969G5. 5 interactions.
STRING9606.ENSP00000307292.

PTM databases

PhosphoSiteQ969G5.

Polymorphism databases

DMDM317373527.

Proteomic databases

MaxQBQ969G5.
PaxDbQ969G5.
PeptideAtlasQ969G5.
PRIDEQ969G5.

Protocols and materials databases

DNASU112464.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303927; ENSP00000307292; ENSG00000170955.
GeneID112464.
KEGGhsa:112464.
UCSCuc001mcu.1. human.

Organism-specific databases

CTD112464.
GeneCardsGC11M006340.
HGNCHGNC:9400. PRKCDBP.
HPAHPA055136.
neXtProtNX_Q969G5.
PharmGKBPA33764.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43715.
HOGENOMHOG000115686.
HOVERGENHBG108288.
InParanoidQ969G5.
OrthoDBEOG7GTT5J.
PhylomeDBQ969G5.
TreeFamTF331031.

Gene expression databases

ArrayExpressQ969G5.
BgeeQ969G5.
CleanExHS_PRKCDBP.
GenevestigatorQ969G5.

Family and domain databases

InterProIPR026752. Cavin_fam.
[Graphical view]
PANTHERPTHR15240. PTHR15240. 1 hit.
PfamPF15237. PTRF_SDPR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPRKCDBP. human.
GenomeRNAi112464.
NextBio78586.
PROQ969G5.

Entry information

Entry namePRDBP_HUMAN
AccessionPrimary (citable) accession number: Q969G5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM