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Protein

Caveolae-associated protein 3

Gene

CAVIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBiological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolae-associated protein 3Imported
Alternative name(s):
Cavin-3
Protein kinase C delta-binding protein
Serum deprivation response factor-related gene product that binds to C-kinase
Short name:
hSRBC
Gene namesi
Name:CAVIN3Imported
Synonyms:PRKCDBP, SRBC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170955.9.
HGNCiHGNC:9400. CAVIN3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi112464.
OpenTargetsiENSG00000170955.
PharmGKBiPA33764.

Polymorphism and mutation databases

BioMutaiPRKCDBP.
DMDMi317373527.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314121 – 261Caveolae-associated protein 3Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei165PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei173PhosphoserineBy similarity1

Post-translational modificationi

In vitro, phosphorylated by PRKCD.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ969G5.
MaxQBiQ969G5.
PaxDbiQ969G5.
PeptideAtlasiQ969G5.
PRIDEiQ969G5.

PTM databases

iPTMnetiQ969G5.
PhosphoSitePlusiQ969G5.

Expressioni

Tissue specificityi

Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells.2 Publications

Inductioni

Down-regulated in breast and lung cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000170955.
CleanExiHS_PRKCDBP.
ExpressionAtlasiQ969G5. baseline and differential.
GenevisibleiQ969G5. HS.

Organism-specific databases

HPAiHPA055136.
HPA073327.

Interactioni

Subunit structurei

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2. Interacts with CAVIN1 (By similarity). Interacts (via leucine-zipper domain) with CAV1 in a cholesterol-sensitive manner (PubMed:19262564). Interacts with EPS15L1 (PubMed:19262564).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125187. 51 interactors.
DIPiDIP-60484N.
IntActiQ969G5. 44 interactors.
STRINGi9606.ENSP00000307292.

Structurei

3D structure databases

ProteinModelPortaliQ969G5.
SMRiQ969G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 84Interaction with CAVIN1By similarityAdd BLAST84
Regioni20 – 78Leucine-zipper1 PublicationAdd BLAST59
Regioni135 – 203Interaction with CAV1By similarityAdd BLAST69

Domaini

The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.1 Publication

Sequence similaritiesi

Belongs to the CAVIN family.Curated

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiQ969G5.
PhylomeDBiQ969G5.
TreeFamiTF331031.

Family and domain databases

InterProiView protein in InterPro
IPR033300. CAVIN3.
IPR026752. Cavin_fam.
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF9. PTHR15240:SF9. 1 hit.
PfamiView protein in Pfam
PF15237. PTRF_SDPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q969G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRESALERGP VPEAPAGGPV HAVTVVTLLE KLASMLETLR ERQGGLARRQ
60 70 80 90 100
GGLAGSVRRI QSGLGALSRS HDTTSNTLAQ LLAKAERVSS HANAAQERAV
110 120 130 140 150
RRAAQVQRLE ANHGLLVARG KLHVLLFKEE GEVPASAFQK APEPLGPADQ
160 170 180 190 200
SELGPEQLEA EVGESSDEEP VESRAQRLRR TGLQKVQSLR RALSGRKGPA
210 220 230 240 250
APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT EEDPGRPGAA
260
EEALLQMESV A
Length:261
Mass (Da):27,701
Last modified:January 11, 2011 - v3
Checksum:iE806A01DA992C53B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0428518R → P3 PublicationsCorresponds to variant dbSNP:rs2682123Ensembl.1
Natural variantiVAR_042852104A → T. Corresponds to variant dbSNP:rs10839551Ensembl.1
Natural variantiVAR_042853158L → P. Corresponds to variant dbSNP:rs1051992Ensembl.1
Natural variantiVAR_042854255L → F. Corresponds to variant dbSNP:rs12294600Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339881 mRNA. Translation: AAK97572.1.
AF408198 Genomic DNA. Translation: AAK97528.1.
AC068733 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68733.1.
BC011585 mRNA. Translation: AAH11585.1.
CCDSiCCDS7762.1.
RefSeqiNP_659477.2. NM_145040.2.
UniGeneiHs.434044.

Genome annotation databases

EnsembliENST00000303927; ENSP00000307292; ENSG00000170955.
GeneIDi112464.
KEGGihsa:112464.
UCSCiuc001mcu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAVN3_HUMAN
AccessioniPrimary (citable) accession number: Q969G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 11, 2011
Last modified: September 27, 2017
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families